FR2447913A1 - Procede de fabrication de la n-(4' pyridyl)-3,3-diphenylpropylamine - Google Patents

Procede de fabrication de la n-(4' pyridyl)-3,3-diphenylpropylamine

Info

Publication number
FR2447913A1
FR2447913A1 FR8001900A FR8001900A FR2447913A1 FR 2447913 A1 FR2447913 A1 FR 2447913A1 FR 8001900 A FR8001900 A FR 8001900A FR 8001900 A FR8001900 A FR 8001900A FR 2447913 A1 FR2447913 A1 FR 2447913A1
Authority
FR
France
Prior art keywords
phenyl
prepn
propylamine
pyridyl
spasmolytic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8001900A
Other languages
English (en)
Other versions
FR2447913B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Italiana Schoum SpA
Original Assignee
Italiana Schoum SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italiana Schoum SpA filed Critical Italiana Schoum SpA
Publication of FR2447913A1 publication Critical patent/FR2447913A1/fr
Application granted granted Critical
Publication of FR2447913B1 publication Critical patent/FR2447913B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDE DE FABRICATION DE LA N-(4PYRIDYL)-3,3-DIPHENYLPROPYLAMINE A PARTIR DE L'ACIDE CINNAMIQUE. CE PROCEDE CONSISTE A: A.FAIRE REAGIR L'ACIDE CINNAMIQUE AVEC DU BENZENE ANHYDRE EN PRESENCE D'ACIDES DE LEWIS SUIVANT UNE REACTION FRIEDEL-CRAFTS A UNE TEMPERATURE COMPRISE ENTRE 0C ET 80C; B.TRANSFORMER L'ACIDE DIPHENYLPROPIONIQUE OBTENU EN SON CHLORURE CORRESPONDANT PAR REACTION AVEC DES AGENTS DE CHLORURATION EN PRESENCE D'UN SOLVANT ANHYDRE A UNE TEMPERATURE COMPRISE ENTRE 50C ET 100C; C.FAIRE REAGIR LE CHLORURE D'ACYLE OBTENU AVEC LA 4-AMINOPYRIDINE DANS UN SOLVANT APROTIQUE SEC; ET D.REDUIRE L'AMINE OBTENUE APRES CRISTALLISATION A PARTIR DU METHANOL OU DE L'ETHANOL, EN L'AMINE CORRESPONDANTE PAR UN TRAITEMENT AU LIALH DANS UN SOLVANT APROTIQUE SEC. APPLICATION EN MEDECINE.
FR8001900A 1979-01-30 1980-01-29 Procede de fabrication de la n-(4' pyridyl)-3,3-diphenylpropylamine Granted FR2447913A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19708/79A IT1162708B (it) 1979-01-30 1979-01-30 Procedimento di preparazione della n-(4'-piridil)-3,3-difenilpropilammina

Publications (2)

Publication Number Publication Date
FR2447913A1 true FR2447913A1 (fr) 1980-08-29
FR2447913B1 FR2447913B1 (fr) 1983-12-09

Family

ID=11160556

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8001900A Granted FR2447913A1 (fr) 1979-01-30 1980-01-29 Procede de fabrication de la n-(4' pyridyl)-3,3-diphenylpropylamine

Country Status (7)

Country Link
JP (1) JPS603386B2 (fr)
BE (1) BE881319A (fr)
DE (1) DE3002909A1 (fr)
ES (1) ES8101553A1 (fr)
FR (1) FR2447913A1 (fr)
IT (1) IT1162708B (fr)
NL (1) NL8000490A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2465723A1 (fr) * 1979-05-30 1981-03-27 Italiana Schoum Spa Nouvelles diphenylpropylamino-pyridines utilisables comme medicaments

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1167197B (it) * 1983-07-25 1987-05-13 Bellon Roger Schoum Rbs Pharma Impiego della fenpiramina quale farmaco antiaggregante piastrinico,vasodilatatore,antitrombotico e antianginoso

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4180670A (en) * 1977-02-02 1979-12-25 John Wyeth & Brother Limited Amino pyridine derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4180670A (en) * 1977-02-02 1979-12-25 John Wyeth & Brother Limited Amino pyridine derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2465723A1 (fr) * 1979-05-30 1981-03-27 Italiana Schoum Spa Nouvelles diphenylpropylamino-pyridines utilisables comme medicaments

Also Published As

Publication number Publication date
ES488375A0 (es) 1980-12-16
BE881319A (fr) 1980-05-16
IT1162708B (it) 1987-04-01
NL8000490A (nl) 1980-08-01
IT7919708A0 (it) 1979-01-30
JPS603386B2 (ja) 1985-01-28
JPS55102565A (en) 1980-08-05
FR2447913B1 (fr) 1983-12-09
DE3002909A1 (de) 1980-07-31
ES8101553A1 (es) 1980-12-16

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CD Change of name or company name
ST Notification of lapse