FR2440953A1 - Procede de preparation de derives de cyclo-1,3,2-oxazaphosphoryle - Google Patents
Procede de preparation de derives de cyclo-1,3,2-oxazaphosphoryleInfo
- Publication number
- FR2440953A1 FR2440953A1 FR7927426A FR7927426A FR2440953A1 FR 2440953 A1 FR2440953 A1 FR 2440953A1 FR 7927426 A FR7927426 A FR 7927426A FR 7927426 A FR7927426 A FR 7927426A FR 2440953 A1 FR2440953 A1 FR 2440953A1
- Authority
- FR
- France
- Prior art keywords
- oxazaphosphoryl
- derivatives
- formula
- cyclo
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 238000010504 bond cleavage reaction Methods 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'INVENTION CONCERNE UN NOUVEAU PROCEDE DE PREPARATION DE DERIVES DE CYCLO-1,3,2-OXAZAPHOSPHORYLE DE FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R ET R SONT RESPECTIVEMENT UN GROUPE ALKYLE INFERIEUR QUI PEUT PORTER COMME SUBSTITUANT(S) UN OU PLUSIEURS ATOMES D'HALOGENE OU UN OU PLUSIEURS GROUPES ALCANE-SULFONYLOXY INFERIEUR ET N EST UN NOMBRE ENTIER COMPRIS ENTRE 2 ET 6, PAR SCISSION PAR UN ACIDE DE LA LIAISON R-N DU COMPOSE REPRESENTE PAR LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R EST UN GROUPE A-ARYLALKYLE, EN UTILISANT UN ACIDE FORT, LE COMPOSE REPRESENTE PAR LA FORMULEII ETANT EFFICACE COMME AGENT ANTICANCEREUX.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53137685A JPS5826919B2 (ja) | 1978-11-07 | 1978-11-07 | シクロ↓−1,3,2↓−オキサアザホスホル誘導体の製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2440953A1 true FR2440953A1 (fr) | 1980-06-06 |
FR2440953B1 FR2440953B1 (fr) | 1984-09-14 |
Family
ID=15204405
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7927426A Granted FR2440953A1 (fr) | 1978-11-07 | 1979-11-07 | Procede de preparation de derives de cyclo-1,3,2-oxazaphosphoryle |
Country Status (12)
Country | Link |
---|---|
US (1) | US4238423A (fr) |
JP (1) | JPS5826919B2 (fr) |
AU (1) | AU515571B2 (fr) |
CA (1) | CA1125781A (fr) |
CH (1) | CH641186A5 (fr) |
DE (1) | DE2944106C2 (fr) |
ES (1) | ES485801A1 (fr) |
FR (1) | FR2440953A1 (fr) |
GB (1) | GB2034714B (fr) |
IT (1) | IT1119426B (fr) |
NL (1) | NL181433C (fr) |
SE (1) | SE439636B (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3111428A1 (de) | 1981-03-24 | 1982-10-07 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
US5258538A (en) * | 1985-08-26 | 1993-11-02 | Applied Biosystems, Inc. | 2,3-disubstituted-1,3,2-oxazaphosphacycloalkanes as nucleic acid linking agents |
DE19739159C1 (de) * | 1997-09-06 | 1999-01-28 | Asta Medica Ag | Verfahren zur Herstellung von Oxazaphosphorin-2-aminen |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2644905A1 (de) * | 1975-10-06 | 1977-04-14 | Polska Akad Nauk Centrum | Verfahren zur herstellung von optisch aktivem 2- eckige klammer auf bis-(2-chloraethyl)-amino eckige klammer zu -1-oxa-3-aza-2-phosphacyclohexanoxid-2 |
-
1978
- 1978-11-07 JP JP53137685A patent/JPS5826919B2/ja not_active Expired
-
1979
- 1979-10-31 CA CA338,856A patent/CA1125781A/fr not_active Expired
- 1979-10-31 DE DE2944106A patent/DE2944106C2/de not_active Expired
- 1979-11-02 AU AU52468/79A patent/AU515571B2/en not_active Ceased
- 1979-11-06 IT IT69163/79A patent/IT1119426B/it active
- 1979-11-06 NL NLAANVRAGE7908116,A patent/NL181433C/xx not_active IP Right Cessation
- 1979-11-06 US US06/091,786 patent/US4238423A/en not_active Expired - Lifetime
- 1979-11-06 CH CH992779A patent/CH641186A5/de not_active IP Right Cessation
- 1979-11-06 GB GB7938360A patent/GB2034714B/en not_active Expired
- 1979-11-06 SE SE7909157A patent/SE439636B/sv not_active IP Right Cessation
- 1979-11-07 ES ES485801A patent/ES485801A1/es not_active Expired
- 1979-11-07 FR FR7927426A patent/FR2440953A1/fr active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2644905A1 (de) * | 1975-10-06 | 1977-04-14 | Polska Akad Nauk Centrum | Verfahren zur herstellung von optisch aktivem 2- eckige klammer auf bis-(2-chloraethyl)-amino eckige klammer zu -1-oxa-3-aza-2-phosphacyclohexanoxid-2 |
Also Published As
Publication number | Publication date |
---|---|
US4238423A (en) | 1980-12-09 |
DE2944106C2 (de) | 1983-05-05 |
AU515571B2 (en) | 1981-04-09 |
GB2034714A (en) | 1980-06-11 |
JPS5826919B2 (ja) | 1983-06-06 |
SE439636B (sv) | 1985-06-24 |
IT1119426B (it) | 1986-03-10 |
NL181433C (nl) | 1987-08-17 |
DE2944106A1 (de) | 1980-05-08 |
FR2440953B1 (fr) | 1984-09-14 |
NL181433B (nl) | 1987-03-16 |
CH641186A5 (de) | 1984-02-15 |
GB2034714B (en) | 1983-04-13 |
CA1125781A (fr) | 1982-06-15 |
JPS5564594A (en) | 1980-05-15 |
IT7969163A0 (it) | 1979-11-06 |
SE7909157L (sv) | 1980-05-08 |
ES485801A1 (es) | 1980-07-01 |
NL7908116A (nl) | 1980-05-09 |
AU5246879A (en) | 1980-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |