FR2437406A1 - Derives d'acide quinoleinecarboxylique substitue et leur utilisation comme agents antibacteriens - Google Patents

Derives d'acide quinoleinecarboxylique substitue et leur utilisation comme agents antibacteriens

Info

Publication number
FR2437406A1
FR2437406A1 FR7924447A FR7924447A FR2437406A1 FR 2437406 A1 FR2437406 A1 FR 2437406A1 FR 7924447 A FR7924447 A FR 7924447A FR 7924447 A FR7924447 A FR 7924447A FR 2437406 A1 FR2437406 A1 FR 2437406A1
Authority
FR
France
Prior art keywords
quinoleinecarboxylic
antibacterial agents
acid derivatives
substituted
hydrates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7924447A
Other languages
English (en)
Other versions
FR2437406B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Publication of FR2437406A1 publication Critical patent/FR2437406A1/fr
Application granted granted Critical
Publication of FR2437406B1 publication Critical patent/FR2437406B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

LA PRESENTE INVENTION SE RAPPORTE A DE NOUVEAUX COMPOSES INTERESSANTS COMME AGENTS ANTIBACTERIENS; PLUS PARTICULIEREMENT, ELLE CONCERNE DES DERIVES D'ACIDE QUINOLEINECARBOXYLIQUE, LEURS HYDRATES ET LEURS SELS D'ADDITION AVEC DES ACIDES; CES DERIVES SONT FORMES NOTAMMENT PAR L'ACIDE 1-ETHYL-1,4-DIHYDRO-6-FLUORO-7- (1-PIPERAZINYL) -4-OXO-1,8-NAPHTYLIDINE-3-CARBOXYLIQUE, SES HYDRATES ET SES SELS D'ADDITION AVEC LES ACIDES.
FR7924447A 1978-09-29 1979-10-01 Derives d'acide quinoleinecarboxylique substitue et leur utilisation comme agents antibacteriens Granted FR2437406A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53120216A JPS5845426B2 (ja) 1978-09-29 1978-09-29 置換キノリンカルボン酸誘導体

Publications (2)

Publication Number Publication Date
FR2437406A1 true FR2437406A1 (fr) 1980-04-25
FR2437406B1 FR2437406B1 (fr) 1983-06-03

Family

ID=14780757

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7924447A Granted FR2437406A1 (fr) 1978-09-29 1979-10-01 Derives d'acide quinoleinecarboxylique substitue et leur utilisation comme agents antibacteriens

Country Status (12)

Country Link
US (1) US4448962A (fr)
JP (1) JPS5845426B2 (fr)
AU (1) AU534089B2 (fr)
BE (1) BE879106A (fr)
CA (1) CA1214465A (fr)
DE (1) DE2939786C2 (fr)
ES (1) ES484578A1 (fr)
FR (1) FR2437406A1 (fr)
GB (1) GB2034698B (fr)
HU (1) HU179214B (fr)
IT (1) IT1166909B (fr)
SE (1) SE441597B (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2489821A1 (fr) * 1980-09-05 1982-03-12 Kyorin Seiyaku Kk Procede de preparation de derives d'acide quinoleinecarboxylique a proprietes antimicrobiennes
FR2496663A1 (fr) * 1980-12-24 1982-06-25 Bellon Labor Sa Roger Nouveaux derives de naphtyridine-1,8 utiles notamment comme medicaments antibacteriens
FR2501204A1 (fr) * 1981-03-06 1982-09-10 Kyorin Seiyaku Kk Derives d'un acide quinoleine-carboxylique, procede pour les preparer et medicament en contenant
FR2555584A1 (fr) * 1983-09-19 1985-05-31 Hokuriku Pharmaceutical Derives de l'acide fluoro-6-dihydro-1,4-oxo-4-piperazinyl substitue-7-quinoline-carboxylique-3 et procede pour leur preparation et compositions pharmaceutiques a action anti-bacteriennes a base desdits derives
EP0155006A2 (fr) * 1984-03-16 1985-09-18 FARMADES S.p.A. Composés à activité antibactérienne, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0166939A1 (fr) * 1984-06-04 1986-01-08 Bayer Ag Acides 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-pipérazinyl)-3-quinoline carboxyliques, procédé pour leur préparation et agents bactéricides les contenant
EP0181521A1 (fr) * 1984-10-19 1986-05-21 Otsuka Pharmaceutical Co., Ltd. Composés d'acide 1-phényl substitué-4-oxo-3-quinoléine carboxylique
US4684648A (en) * 1985-05-10 1987-08-04 Otsuka Pharmaceutical Company Limited Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds and compositions thereof
US4755513A (en) * 1985-01-30 1988-07-05 Otsuka Pharmaceutical Company, Limited Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds
EP2644596A1 (fr) * 2010-11-23 2013-10-02 Consejo Superior De Investigaciones Científicas (CSIC) Haptènes et agents immunoréactifs et leur utilisation pour l'obtention d'anticorps de famille et d'immunoessais pour quinolones

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR223983A1 (es) 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico
JPS604820B2 (ja) * 1979-02-26 1985-02-06 大塚製薬株式会社 キノリンカルボン酸誘導体
JPS5644066U (fr) * 1979-09-14 1981-04-21
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4670444B1 (en) * 1980-09-03 1999-02-09 Bayer Ag and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds
US4620007A (en) * 1980-09-03 1986-10-28 Bayer Aktiengesellschaft 6-fluoro-7-chloro-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
JPS57134482A (en) * 1981-02-13 1982-08-19 Dainippon Pharmaceut Co Ltd 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8- naphthyridine-3-carboxylic acid-3/2 hydrate and its preparation
SE440354B (sv) * 1981-02-19 1985-07-29 Kyorin Seiyaku Kk Kinolinkarboxylsyraderivat
JPS57203067A (en) * 1981-06-10 1982-12-13 Kanebo Ltd Novel quinolinecarboxylic acid derivatives, their preparations, and antibacterial agent comprising them as active ingredient
US4530928A (en) * 1982-01-13 1985-07-23 Merck & Co., Inc. Quinoline carboxylic acid complexes with guanidinium carbonate
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
US5281612A (en) * 1982-09-09 1994-01-25 Warner-Lambert Company Naphthyridine antibacterial agents
JPS59122470A (ja) * 1982-12-27 1984-07-14 Dai Ichi Seiyaku Co Ltd キノリン−３−カルボン酸誘導体の製造法
DE3248505A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(4- (oxoalkyl)-1-piperazinyl/-3-chinolincarbonsaeuren und ihre derivate, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3306771A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3306772A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinolonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
US4616019A (en) * 1984-01-26 1986-10-07 Abbott Laboratories Naphthyridine antibacterial compounds
US4774246A (en) * 1984-01-26 1988-09-27 Abbott Laboratories Quinoline antibacterial compounds
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
GB8414559D0 (en) * 1984-06-07 1984-07-11 Scras Pyridine derivatives
DE3443183A1 (de) * 1984-11-27 1986-05-28 Robert Bosch Gmbh, 7000 Stuttgart Verfahren und vorrichtung zum steuern der daempferhaerte eines stossdaempfers fuer fahrzeuge
EP0191185B1 (fr) * 1984-12-14 1990-03-07 Daiichi Seiyaku Co., Ltd. Dérivés de l'acide quinoléine-carboxylique
DE3508816A1 (de) * 1985-01-10 1986-07-10 Bayer Ag, 5090 Leverkusen 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren
US4851535A (en) * 1985-01-23 1989-07-25 Toyama Chemical Co., Ltd. Nicotinic acid derivatives
DE3509546A1 (de) * 1985-03-16 1986-09-25 Bayer Ag, 5090 Leverkusen 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4657913A (en) * 1985-04-18 1987-04-14 Warner-Lambert Company Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
DE3608745A1 (de) * 1985-07-24 1987-01-29 Bayer Ag Bakterizide zubereitungen zur anwendung auf dem gebiet der veterinaermedizin
IN166416B (fr) * 1985-09-18 1990-05-05 Pfizer
JPH0717642B2 (ja) * 1985-10-09 1995-03-01 富山化学工業株式会社 １，４―ジヒドロ―４―オキソナフチリジン誘導体またはその塩
DE3542002A1 (de) * 1985-11-28 1987-06-04 Bayer Ag 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
CA1306750C (fr) 1985-12-09 1992-08-25 Istvan Hermecz Procede pour la preparation d'acides quinoline carboxyliques
HU196218B (en) 1985-12-09 1988-10-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing quinoline carboxylic acid boric acid anhydrides
US4689325A (en) * 1985-12-23 1987-08-25 Abbott Laboratories Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives
US4687770A (en) * 1985-12-23 1987-08-18 Abbott Laboratories Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives
US5210193A (en) * 1986-01-17 1993-05-11 American Cyanamid Company Piperazine derivatives
US4940710A (en) * 1986-01-17 1990-07-10 American Cyanamid Company 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
US4692454A (en) * 1986-02-03 1987-09-08 Warner-Lambert Company Opthalmic use of quinolone antibiotics
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPH0811749B2 (ja) * 1986-03-06 1996-02-07 富山化学工業株式会社 新規なキノリン誘導体およびその塩
US5126340A (en) * 1986-10-16 1992-06-30 American Cyanamid Company 4-[(substituted)alkylcarbonyl]-4,5-dihydro and -4,5,6,7-tetrahydro-7-[(substituted)-phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitriles
US4963553A (en) * 1986-10-16 1990-10-16 American Cyanamid Co. 4-[(substituted) alkylcarbonyl]-4,5-dihydro- and -4,5,6,7-tetrahydro-7-[(substituted)phenyl]pyrazolo[1,5-a]pyrimidines
DE3641312A1 (de) * 1986-12-03 1988-06-09 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
JPS6416767A (en) * 1987-07-09 1989-01-20 Dainippon Pharmaceutical Co 8-halogenoquinoline derivative, its ester and salt
YU46099B (sh) * 1987-12-31 1992-12-21 Krka Tovarna Zdravil Postopek za pripravo 1-supstituirane 6-fluoro-4-okso-7- 1-piperazinil)-1
US4920120A (en) * 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
US5585491A (en) * 1988-01-25 1996-12-17 Otsuka Pharmaceutical Co., Ltd. Antibacterial agents
IL90635A0 (en) * 1988-07-15 1990-01-18 Abbott Lab Process for the preparation of quinoline antibacterial compounds
JPH01258666A (ja) * 1988-08-18 1989-10-16 Kyorin Pharmaceut Co Ltd 新規置換キノリンカルボン酸
JP2503547Y2 (ja) * 1989-03-13 1996-07-03 トヨタ自動車株式会社 ショックアブソ―バ
CA2058424A1 (fr) * 1989-07-21 1991-01-22 Akihiro Shibata Derives d'acide quinoleinecarboxylique
FR2655545B1 (fr) * 1989-12-11 1994-06-10 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
JPH0411946U (fr) * 1990-05-18 1992-01-30
ES2050594B1 (es) * 1991-12-31 1994-12-16 Ind Quimica Agropecuaria S A Procedimiento para la obtencion de acidos 6-fluoro-1,4-dihidro-4-oxo-7-piperazino-quinolin-3-carboxilicos sustituidos en 1-n.
TW301607B (fr) * 1993-03-09 1997-04-01 Takeda Pharm Industry Co Ltd
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
CZ12097A3 (en) * 1994-07-18 1997-09-17 Ube Industries Trifluoromethylquinolinecarboxylic acid derivatives and pharmaceutical composition containing thereof
US5626310A (en) * 1994-11-21 1997-05-06 Kelly Space & Technology, Inc. Space launch vehicles configured as gliders and towed to launch altitude by conventional aircraft
HUP0100051A3 (en) * 1997-09-15 2002-08-28 Procter & Gamble Antimicrobial quinolones, their compositions and uses
US6387928B1 (en) * 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
IL143535A0 (en) 1998-12-04 2002-04-21 Influx Inc Inhibitors of multidrug transporters
US6957105B2 (en) * 2002-03-26 2005-10-18 Cardiac Pacemakers, Inc. Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals
WO2007067489A1 (fr) * 2005-12-05 2007-06-14 Merck & Co., Inc. Modulateurs allosteriques positifs de recepteur de quinolone m1
US7973022B2 (en) * 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
US20070197548A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US20070196398A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone fatty acid salt compositions
JP2009531418A (ja) * 2006-03-28 2009-09-03 ザ プロクター アンド ギャンブル カンパニー キノロン中間体調製のためのカップリング方法
JP4876165B2 (ja) * 2006-03-28 2012-02-15 ザ プロクター アンド ギャンブル カンパニー キノロン中間体を調製するための水素化物還元法
WO2007110834A2 (fr) * 2006-03-28 2007-10-04 The Procter & Gamble Company Malates et formes polymorphes de l'acide (3s,5s)-7-[3-amino-5-méthyl-pipéridinyl]-1-cyclopropyl-1,4-dihydro-8-méthoxy-4-oxo-3-quinoléine-carboxylique
DE602007001620D1 (de) * 2006-04-10 2009-09-03 Ranbaxy Lab Ltd Verbesserter Herstellungsprozess für Aripipirazol
WO2009064836A2 (fr) * 2007-11-15 2009-05-22 University Of Maryland, Baltimore Inhibiteurs de la kynurénine-aminotransférase

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149104A (en) * 1961-01-03 1964-09-15 Sterling Drug Inc 4-hydroxy-7-styryl-1, 8-naphthyridine-3-carboxylic acids and esters
US3590036A (en) * 1968-11-18 1971-06-29 George Y Lesher Naphthyridine-3-carboxylic acids,their derivatives and preparation thereof
DE2103805C3 (de) * 1970-01-28 1980-03-20 Sumitomo Chemical Co., Ltd., Osaka (Japan) Verfahren zur Herstellung von N-substituierten 6,7-Methylendioxy-4chinolonen
US4017622A (en) * 1972-12-18 1977-04-12 Dainippon Pharmaceutical Co., Ltd. Piperazine derivatives
DE2362553A1 (de) * 1972-12-18 1974-06-20 Dainippon Pharmaceutical Co Neue piperazinderivate
JPS5049286A (fr) * 1973-09-04 1975-05-01
JPS5732061B2 (fr) * 1974-06-17 1982-07-08
JPS5732060B2 (fr) * 1974-02-12 1982-07-08
JPS587626B2 (ja) * 1974-02-13 1983-02-10 大日本製薬株式会社 ナフチリジン オヨビ キノリンユウドウタイノセイホウ
JPS5157836A (fr) * 1974-11-13 1976-05-20 Dainippon Pharmaceutical Co
JPS5365887A (en) * 1976-11-22 1978-06-12 Kyorin Seiyaku Kk Substituted quinoline*arboxylate and process for preparing same
JPS53141286A (en) * 1977-05-16 1978-12-08 Kyorin Seiyaku Kk Novel substituted quinolinecarboxylic acid
US4264604A (en) * 1977-07-01 1981-04-28 Ciba-Geigy Corporation Quinolonecarboxylic acid derivatives as bactericides
SE444566B (sv) * 1977-09-20 1986-04-21 Bellon Labor Sa Roger 7-dialkylamin-6-halogen-4-oxo-1,4-dihydrokinolin-3-karboxylsyra, forfarande for framstellning derav och farmaceutiskt preparat derav
US4292315A (en) * 1977-12-30 1981-09-29 Nichols Vorys Follicular phase estrogen or progestin with physiologic estrogen/progestin luteal phase replacement drug delivery system
JPS54138582A (en) * 1978-04-19 1979-10-27 Kyorin Seiyaku Kk Substituted quinolinecarboxylic acid
AR223983A1 (es) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico
US4352808A (en) * 1980-12-12 1982-10-05 Schering Corporation 3-Aralkyloxy-2,3-dihydro-2-(imidazolylmethyl)benzo(b)thiophenes and related derivatives, their use as antimicrobials and pharmaceutical formulations useful therefore

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2489821A1 (fr) * 1980-09-05 1982-03-12 Kyorin Seiyaku Kk Procede de preparation de derives d'acide quinoleinecarboxylique a proprietes antimicrobiennes
FR2496663A1 (fr) * 1980-12-24 1982-06-25 Bellon Labor Sa Roger Nouveaux derives de naphtyridine-1,8 utiles notamment comme medicaments antibacteriens
FR2501204A1 (fr) * 1981-03-06 1982-09-10 Kyorin Seiyaku Kk Derives d'un acide quinoleine-carboxylique, procede pour les preparer et medicament en contenant
FR2555584A1 (fr) * 1983-09-19 1985-05-31 Hokuriku Pharmaceutical Derives de l'acide fluoro-6-dihydro-1,4-oxo-4-piperazinyl substitue-7-quinoline-carboxylique-3 et procede pour leur preparation et compositions pharmaceutiques a action anti-bacteriennes a base desdits derives
EP0155006A2 (fr) * 1984-03-16 1985-09-18 FARMADES S.p.A. Composés à activité antibactérienne, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0155006A3 (en) * 1984-03-16 1986-11-20 Farmades S.P.A. Compounds having antibacterial activity, process for their preparation and pharmaceutical compositions containing them
US4588726A (en) * 1984-06-04 1986-05-13 Bayer Aktiengesellschaft 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-quinolinecarboxylic acid antibacterial agents
EP0166939A1 (fr) * 1984-06-04 1986-01-08 Bayer Ag Acides 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-pipérazinyl)-3-quinoline carboxyliques, procédé pour leur préparation et agents bactéricides les contenant
EP0181521A1 (fr) * 1984-10-19 1986-05-21 Otsuka Pharmaceutical Co., Ltd. Composés d'acide 1-phényl substitué-4-oxo-3-quinoléine carboxylique
US4755513A (en) * 1985-01-30 1988-07-05 Otsuka Pharmaceutical Company, Limited Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds
US4684648A (en) * 1985-05-10 1987-08-04 Otsuka Pharmaceutical Company Limited Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds and compositions thereof
EP2644596A1 (fr) * 2010-11-23 2013-10-02 Consejo Superior De Investigaciones Científicas (CSIC) Haptènes et agents immunoréactifs et leur utilisation pour l'obtention d'anticorps de famille et d'immunoessais pour quinolones
EP2644596A4 (fr) * 2010-11-23 2014-03-19 Consejo Superior Investigacion Haptènes et agents immunoréactifs et leur utilisation pour l'obtention d'anticorps de famille et d'immunoessais pour quinolones
US10150736B2 (en) 2010-11-23 2018-12-11 Consejo Superior De Investigaciones Cientificas (Csic) Haptens and immunoreactive agents and use thereof for producing family antibodies and immunoassays for quinolones

Also Published As

Publication number Publication date
SE7908065L (sv) 1980-03-30
GB2034698A (en) 1980-06-11
HU179214B (en) 1982-09-28
AU534089B2 (en) 1984-01-05
JPS5845426B2 (ja) 1983-10-08
IT7926120A0 (it) 1979-09-28
JPS5547658A (en) 1980-04-04
AU5142179A (en) 1981-04-16
GB2034698B (en) 1982-11-17
CA1214465A (fr) 1986-11-25
IT1166909B (it) 1987-05-06
BE879106A (fr) 1980-02-01
DE2939786C2 (de) 1986-10-09
ES484578A1 (es) 1980-05-16
US4448962A (en) 1984-05-15
DE2939786A1 (de) 1980-04-10
FR2437406B1 (fr) 1983-06-03
SE441597B (sv) 1985-10-21

Similar Documents

Publication Publication Date Title
FR2437406A1 (fr) Derives d'acide quinoleinecarboxylique substitue et leur utilisation comme agents antibacteriens
JPS5538382A (en) Amino acid derivative as antihypertensive drug
JPS5581845A (en) Amino acid derivative as antihypertensive
RO76614A (fr) Procede pour la preparation des derives de 3,4-dehydroproline et d'acide 4,5-dehydropipecolique
IE43598L (en) Erythromycin derivatives
RO70687A (fr) Procede pour la preparation des derives de l'acide phenoxyphenoxypropionique
BE847044A (fr) Derives de l'acide clavulanique,
FR2412567A1 (fr) N-acyl-2' et n-alkyl-2' o-demethyl-3 fortimicines a et b, utiles notamment comme antibiotiques
BE812772A (fr) Derives de l'acide 2-anilino-nicotinique
IE41440L (en) Thiatetracyclines
BE886370A (fr) Derives de l'acide 16-hydroxy-prostanoique 4,5-insatures
PT67004A (fr) Procede pour la preparation de derives de l'acide 7-acilamine-8-oxo-3-oxa-1-azabicicle-(4,2,0)-octane-2-carboxique
FR2313045A1 (fr) Compositions analgesiques renfermant un derive de l'acide indole-3-acetique
MC1255A1 (fr) L'acide 7-methoxy-5-oxo-5h-thiazolo(2,3-b)quinazoline-2-carboxylique et ses sels,leur preparation et leurs utilisations therapeutiques
MA18782A1 (fr) Purification de l'acide phosphorique .
BE848143A (fr) Procede de preparation de l'acide cis-2-hydroxy-2-phenyl-r-1-cyclohexanecarboxylique,
FR2670206B1 (fr) Procede de preparation de derives de l'acide dihydroxy-3,5 pentanouique.
FR2330692A1 (fr) Nouveaux derives de l'acide phosphorique utiles comme pesticides
PT98700A (pt) Processo para a preparacao de acidos aminometanofosfonico e de acidos aminometil-fosfinicos
RO70958A (fr) Procede de preparation des esters de l'acide o-ethyle-s-n-propyle-o-2,2,2-trihaloethyle-thionothiol)phosphorique
BE847046A (fr) Derives de l'acide clavulanique,
BE870889A (fr) Derives de l'acide citrique utiles comme assouplissants
BE861693A (fr) Procede de reduction de l'acide 2,5-dicetogluconique
FR2348700A1 (fr) Procede pour la preparation de derives para-substitues de l'acide alpha-phenyl-propionique,ainsi que ces derives
FR2669330B1 (fr) Procede de preparation de l'acide betha-mercaptopropionique.