FR2421610A1 - Pellicule medicamenteuse a base d'une substance active a action anti angineuse telle que la nitroglycerine ou l'isosorbide dimitrate - Google Patents

Pellicule medicamenteuse a base d'une substance active a action anti angineuse telle que la nitroglycerine ou l'isosorbide dimitrate

Info

Publication number
FR2421610A1
FR2421610A1 FR7908827A FR7908827A FR2421610A1 FR 2421610 A1 FR2421610 A1 FR 2421610A1 FR 7908827 A FR7908827 A FR 7908827A FR 7908827 A FR7908827 A FR 7908827A FR 2421610 A1 FR2421610 A1 FR 2421610A1
Authority
FR
France
Prior art keywords
active substance
action
dimitrate
anginous
nitroglycerin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7908827A
Other languages
English (en)
Other versions
FR2421610B1 (fr
Inventor
B N Elizaveta
E A Babaian
G A Gerasimova
A B Davydov
R I Utyamyshev
G L Khromov
V I Metelitsa
A M Vikhert
K L Savvateev
V K Piotrovsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VSESOJUZNYJ KARDIOLOGITSCHES
Original Assignee
VSESOJUZNYJ KARDIOLOGITSCHES
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VSESOJUZNYJ KARDIOLOGITSCHES filed Critical VSESOJUZNYJ KARDIOLOGITSCHES
Publication of FR2421610A1 publication Critical patent/FR2421610A1/fr
Application granted granted Critical
Publication of FR2421610B1 publication Critical patent/FR2421610B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne la médecine. La pellicule antiangineuse faisant l'objet de l'invention est caractérisée notamment en ce qu'elle se présente sous forme d'une plaque ou lame de 0,1 à 1,5 mm d'épaisseur composée d'un excipient biologiquement soluble et résorbable constitué par un homopolymère d'amide acrylique ou de vinylpyrrolidone, ou un copolymère de ceux-ci avec un acrylate, ce copolymère comprenant 99 à 70 % en poids d'amide acrylique et de vinylpyrrolidone pour 1 à 30 % en poids d'acrylate d'une masse moléculaire de 50 000 à 1 000 000, et d'une substance active à action antiangineuse. La figure 1 montre notamment à titre de comparaison, la variation DELTA SI % en fonction du temps de l'index systolique en % par rapport à la valeur initiale, dans le cas de la pellicule conforme à l'invention et dans celui d'un médicament connu. Les pellicules en question exercent une action prolongée, permettent une haute précision de dosage de la substance active et sont douées d'une bonne stabilité au stockage.
FR7908827A 1978-04-06 1979-04-06 Pellicule medicamenteuse a base d'une substance active a action anti angineuse telle que la nitroglycerine ou l'isosorbide dimitrate Granted FR2421610A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU782605039A SU806037A1 (ru) 1978-04-06 1978-04-06 Антиангинальное средство

Publications (2)

Publication Number Publication Date
FR2421610A1 true FR2421610A1 (fr) 1979-11-02
FR2421610B1 FR2421610B1 (fr) 1982-11-12

Family

ID=20759951

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7908827A Granted FR2421610A1 (fr) 1978-04-06 1979-04-06 Pellicule medicamenteuse a base d'une substance active a action anti angineuse telle que la nitroglycerine ou l'isosorbide dimitrate

Country Status (6)

Country Link
JP (1) JPS6024763B2 (fr)
CA (1) CA1127082A (fr)
DE (1) DE2913752A1 (fr)
FR (1) FR2421610A1 (fr)
GB (2) GB2078771B (fr)
SU (1) SU806037A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0054279A2 (fr) * 1980-12-16 1982-06-23 Forest Laboratories, Inc. Composition à libération retardée de nitroglycérine et sa méthode de préparation
EP0072251A2 (fr) * 1981-08-10 1983-02-16 LecTec Corporation Pansement amélioré contenant un médicament
EP0108218A2 (fr) * 1982-10-08 1984-05-16 Verex Laboratories, Inc. Forme de dosage orale solide à libération constante de composés pharmaceutiques très solubles dans l'eau
FR2542998A1 (fr) * 1983-03-24 1984-09-28 Rhone Poulenc Sante Nouvelle forme transdermale du dinitrate d'isosorbide
US5204109A (en) * 1989-12-28 1993-04-20 Nitto Denko Corporation Percutaneous gel preparation

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291015A (en) * 1979-08-14 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing a vasodilator
JPS57116011A (en) * 1981-01-08 1982-07-19 Nitto Electric Ind Co Ltd Pharmaceutical preparation
CA1218604A (fr) * 1981-07-08 1987-03-03 Alec D. Keith Vehicules de trinitroglycerol a decharge temporisee, et leurs domaines d'emploi
SU1011126A1 (ru) * 1981-07-14 1983-04-15 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Средство дл лечени сахарного диабета
US4482533A (en) * 1982-01-11 1984-11-13 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing propranolol
US4693887A (en) * 1983-09-15 1987-09-15 The Kendall Company Microphase separated hydrogels for controlled release of bioactive materials
JPS6066759A (ja) * 1983-09-21 1985-04-16 日東電工株式会社 医薬製剤
JPS60148471A (ja) * 1983-12-27 1985-08-05 マンヴイル　サービス　コーポレーション 王冠支持式キヤリヤ
US5364628A (en) * 1985-05-31 1994-11-15 Sandoz Ltd. Pharmaceutical compositions
JPS61280423A (ja) * 1985-06-05 1986-12-11 Kiyuukiyuu Yakuhin Kogyo Kk 口腔内粘膜貼付剤
US4764378A (en) * 1986-02-10 1988-08-16 Zetachron, Inc. Buccal drug dosage form
DE3823395A1 (de) * 1988-07-09 1990-03-15 Holzapfel Boeving Partner Werb Mit einem wirkstoff getraenktes tuch
EP0409383B1 (fr) * 1989-07-21 1994-04-06 Izhak Blank Compositions à base d'estradiol et procédés d'application topique
US5232703A (en) * 1989-07-21 1993-08-03 Izhak Blank Estradiol compositions and methods for topical application
WO2006135491A2 (fr) * 2005-06-08 2006-12-21 Basf Aktiengesellschaft Composition de porteur de medicament du procede de formation de film de la partir de cette composition
SG11201501014YA (en) * 2012-08-23 2015-03-30 Cardiolynx Ag Extended release compositions of an aminoalkyl nitrate

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE859931C (de) * 1944-05-24 1952-12-18 Roehm & Haas G M B H Galenische Praeparate
FR2213779A1 (fr) * 1973-01-13 1974-08-09 Byk Gulden Lomberg Chem Fab
FR2285896A1 (fr) * 1974-09-24 1976-04-23 Nippon Kayaku Kk Preparation pharmaceutique destinee a l'administration dans la cavite buccale
FR2326933A1 (fr) * 1975-10-10 1977-05-06 Squibb & Sons Inc Comprime a liberation controlee de medicament
DE2634004A1 (de) * 1976-07-29 1978-02-02 Bernhard Dr Lippold Verfahren zur beschleunigung der aufloesung und verbesserung der loeslichkeit von schlechtloeslichen zur oralen verabreichung bestimmten arzneistoffen

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE859931C (de) * 1944-05-24 1952-12-18 Roehm & Haas G M B H Galenische Praeparate
FR2213779A1 (fr) * 1973-01-13 1974-08-09 Byk Gulden Lomberg Chem Fab
FR2285896A1 (fr) * 1974-09-24 1976-04-23 Nippon Kayaku Kk Preparation pharmaceutique destinee a l'administration dans la cavite buccale
FR2326933A1 (fr) * 1975-10-10 1977-05-06 Squibb & Sons Inc Comprime a liberation controlee de medicament
DE2634004A1 (de) * 1976-07-29 1978-02-02 Bernhard Dr Lippold Verfahren zur beschleunigung der aufloesung und verbesserung der loeslichkeit von schlechtloeslichen zur oralen verabreichung bestimmten arzneistoffen

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0054279A2 (fr) * 1980-12-16 1982-06-23 Forest Laboratories, Inc. Composition à libération retardée de nitroglycérine et sa méthode de préparation
EP0054279A3 (en) * 1980-12-16 1982-09-22 Forest Laboratories, Inc. Composition with sustained release of nitroglycerine, and method of preparing it
EP0072251A2 (fr) * 1981-08-10 1983-02-16 LecTec Corporation Pansement amélioré contenant un médicament
EP0072251A3 (en) * 1981-08-10 1984-02-01 Lectec Corporation Improved bandage containing a medicament
EP0108218A2 (fr) * 1982-10-08 1984-05-16 Verex Laboratories, Inc. Forme de dosage orale solide à libération constante de composés pharmaceutiques très solubles dans l'eau
EP0108218A3 (fr) * 1982-10-08 1984-11-28 Verex Laboratories, Inc. Forme de dosage orale solide à libération constante de composés pharmaceutiques très solubles dans l'eau
FR2542998A1 (fr) * 1983-03-24 1984-09-28 Rhone Poulenc Sante Nouvelle forme transdermale du dinitrate d'isosorbide
EP0123585A2 (fr) * 1983-03-24 1984-10-31 Rhone-Poulenc Sante Nouvelle forme transdermale de médicaments
EP0123585A3 (en) * 1983-03-24 1985-10-02 Rhone-Poulenc Sante Transdermal drug form
US4746509A (en) * 1983-03-24 1988-05-24 Rhone-Poulenc Sante Transdermal medicament
US5204109A (en) * 1989-12-28 1993-04-20 Nitto Denko Corporation Percutaneous gel preparation

Also Published As

Publication number Publication date
GB2078771B (en) 1983-03-09
FR2421610B1 (fr) 1982-11-12
SU806037A1 (ru) 1981-02-23
CA1127082A (fr) 1982-07-06
JPS54154511A (en) 1979-12-05
GB2021610B (en) 1982-10-20
GB2078771A (en) 1982-01-13
DE2913752A1 (de) 1979-12-20
JPS6024763B2 (ja) 1985-06-14
GB2021610A (en) 1979-12-05

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