FR2409270A1 - Procede de preparation de l'acide 7-(d(-)-a-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-a-(4-hydroxyphenyl) acetamido)-3-(5-(1-methyl-1,2,3,4-tetrazolyl)thiomethyl)-3-cephem-4-carboxylique et de ses sels pharmaceutiquement acceptables, intermediaire pour leur preparation et procede de preparation de cet intermediaire - Google Patents

Procede de preparation de l'acide 7-(d(-)-a-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-a-(4-hydroxyphenyl) acetamido)-3-(5-(1-methyl-1,2,3,4-tetrazolyl)thiomethyl)-3-cephem-4-carboxylique et de ses sels pharmaceutiquement acceptables, intermediaire pour leur preparation et procede de preparation de cet intermediaire

Info

Publication number
FR2409270A1
FR2409270A1 FR7827249A FR7827249A FR2409270A1 FR 2409270 A1 FR2409270 A1 FR 2409270A1 FR 7827249 A FR7827249 A FR 7827249A FR 7827249 A FR7827249 A FR 7827249A FR 2409270 A1 FR2409270 A1 FR 2409270A1
Authority
FR
France
Prior art keywords
preparation
cephem
thiomethyl
acetamido
dioxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7827249A
Other languages
English (en)
Other versions
FR2409270B1 (fr
Inventor
Isamu Saikawa
Shuntaro Takano
Kaishu Momonoi
Isamu Takakura
Chiaki Kutani
Kiyoshi Tanaka
Kenshin Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP52115126A external-priority patent/JPS6056717B2/ja
Priority claimed from JP52115127A external-priority patent/JPS6056718B2/ja
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of FR2409270A1 publication Critical patent/FR2409270A1/fr
Application granted granted Critical
Publication of FR2409270B1 publication Critical patent/FR2409270B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

A.PROCEDE DE PREPARATION DE L'ACIDE 7-D(-)-A-(4-ETHYL-2,3-DIOXO-1-PIPERAZINECARBOXAMIDO) -A- (4-HYDROXYPHENYL) ACETAMIDO-3-5-(1-METHYL-1,2,3,4-TETRAZOLYL) THIOMETHYL--CEPHEM-4-CARBOXYLIQUE ET DE SES SELS PHARMACEUTIQUEMENT ACCEPTABLES. B.IL CONSISTE A TRAITER LE PRODUIT D'ADDITION DU N,N-DIMETHYL-ACETAMIDE ET DE L'ACIDE 7-D(-)-A-(4-ETHYL-2,3-DIOXO-1-PIPERAZINE-CARBOXAMIDO) -A- (4-HYDROXYPHENYL) ACETAMIDO-3-5-(1-METHYL-1,2,3,4-TETRAZOLYL) THIOMETHYL-- CEPHEM-4-CARBOXYLIQUE AVEC UN SOLVANT POUR ELIMINER LE N,N-DIMETHYLACETAMIDE. L'INVENTION CONCERNE EGALEMENT UN PROCEDE DE PREPARATION DE CE PRODUIT D'ADDITION. C.UTILISABLE DANS L'INDUSTRIE PHARMACEUTIQUE.
FR7827249A 1977-09-27 1978-09-22 Procede de preparation de l'acide 7-(d(-)-a-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-a-(4-hydroxyphenyl) acetamido)-3-(5-(1-methyl-1,2,3,4-tetrazolyl)thiomethyl)-3-cephem-4-carboxylique et de ses sels pharmaceutiquement acceptables, intermediaire pour leur preparation et procede de preparation de cet intermediaire Granted FR2409270A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP52115126A JPS6056717B2 (ja) 1977-09-27 1977-09-27 セフアロスポリンのｎ，ｎ−ジメチルアセトアミド付加体及びその製法
JP52115127A JPS6056718B2 (ja) 1977-09-27 1977-09-27 セフアロスポリンの製法

Publications (2)

Publication Number Publication Date
FR2409270A1 true FR2409270A1 (fr) 1979-06-15
FR2409270B1 FR2409270B1 (fr) 1983-01-14

Family

ID=26453712

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7827249A Granted FR2409270A1 (fr) 1977-09-27 1978-09-22 Procede de preparation de l'acide 7-(d(-)-a-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-a-(4-hydroxyphenyl) acetamido)-3-(5-(1-methyl-1,2,3,4-tetrazolyl)thiomethyl)-3-cephem-4-carboxylique et de ses sels pharmaceutiquement acceptables, intermediaire pour leur preparation et procede de preparation de cet intermediaire

Country Status (20)

Country Link
US (2) US4237280A (fr)
AR (1) AR223653A1 (fr)
AT (1) AT362502B (fr)
AU (1) AU513336B2 (fr)
CA (1) CA1102309A (fr)
CH (1) CH637967A5 (fr)
DD (1) DD141835A5 (fr)
DE (1) DE2841706C2 (fr)
DK (2) DK164705C (fr)
ES (1) ES473692A1 (fr)
FI (1) FI71743C (fr)
FR (1) FR2409270A1 (fr)
GB (1) GB2005676B (fr)
HU (1) HU177912B (fr)
IL (1) IL55607A (fr)
IN (1) IN149604B (fr)
MX (1) MX5571E (fr)
NL (1) NL7809736A (fr)
PT (1) PT68594A (fr)
SE (2) SE436360B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100388108B1 (ko) * 2000-08-11 2003-06-18 주식회사종근당 세팔로스포린계 항생제 중간체 신규 제조방법
CN102532168A (zh) * 2011-12-27 2012-07-04 山东鑫泉医药有限公司 头孢哌酮酸的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds
US3714157A (en) * 1970-10-23 1973-01-30 Bristol Myers Co PROCESS FOR THE DECOLORIZATION OF 7-[ alpha -(4-PYRIDYLTHIO)ACETAMIDO]CEPHALOSPORANIC ACID
US3781282A (en) * 1971-01-20 1973-12-25 W Garbrecht Cephalosporin process and product
US4112090A (en) * 1974-05-09 1978-09-05 Toyama Chemical Co., Ltd. Novel penicillins and cephalosporins and process for producing the same
US3954745A (en) * 1974-09-12 1976-05-04 Eli Lilly And Company Process for preparing cefazolin
US4117126A (en) * 1975-04-03 1978-09-26 Sumitomo Chemical Company, Ltd. 7-(α-(4-Hydroxy-1,5-naphthyridine-3-carbonamido)-α-phenylacetamido) cephalosporin derivatives
US4037922A (en) * 1975-07-07 1977-07-26 Corning Glass Works Optical waveguide cable
US4064345A (en) * 1975-12-12 1977-12-20 Bristol-Myers Company Cephalosporins derivatives 7-cyclized α-amino-3-heterothio
US4145418A (en) * 1976-01-06 1979-03-20 Takeda Chemical Industries, Ltd. Thienopyridine substituted cephalosporins
US4103008A (en) * 1976-04-07 1978-07-25 Ishimaru Toshiyasu 7[2(2,3 Dioxopiperazin-1-yl-carbonylamino)substituted 2 phenylacetamido]-3-2'-thiadiazolyl cephalosporanic acid derivatives

Also Published As

Publication number Publication date
AR223653A1 (es) 1981-09-15
DK164405C (da) 1992-11-16
SE447732B (sv) 1986-12-08
CH637967A5 (fr) 1983-08-31
HU177912B (en) 1982-01-28
DK164705C (da) 1992-12-21
DD141835A5 (de) 1980-05-21
FR2409270B1 (fr) 1983-01-14
DK164405B (da) 1992-06-22
ES473692A1 (es) 1979-12-16
GB2005676A (en) 1979-04-25
US4237280A (en) 1980-12-02
AU3992378A (en) 1980-03-27
DK164705B (da) 1992-08-03
PT68594A (en) 1978-10-01
SE7810106L (sv) 1979-03-28
IL55607A (en) 1981-10-30
NL7809736A (nl) 1979-03-29
DK197391A (da) 1991-12-06
IN149604B (fr) 1982-02-13
SE436360B (sv) 1984-12-03
AT362502B (de) 1981-05-25
SE8306226L (sv) 1983-11-11
FI71743B (fi) 1986-10-31
AU513336B2 (en) 1980-11-27
GB2005676B (en) 1982-06-23
CA1102309A (fr) 1981-06-02
DE2841706C2 (de) 1982-11-04
DK197391D0 (da) 1991-12-06
US4304909A (en) 1981-12-08
FI782912A (fi) 1979-03-28
DE2841706A1 (de) 1979-04-05
FI71743C (fi) 1987-02-09
SE8306226D0 (sv) 1983-11-11
MX5571E (es) 1983-10-18
DK426778A (da) 1979-03-28
ATA693878A (de) 1980-10-15

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