FR2383969A1 - Procede pour preparer des steroides de type acylthio-7a ene-4 one-3'' - Google Patents

Procede pour preparer des steroides de type acylthio-7a ene-4 one-3''

Info

Publication number
FR2383969A1
FR2383969A1 FR7807918A FR7807918A FR2383969A1 FR 2383969 A1 FR2383969 A1 FR 2383969A1 FR 7807918 A FR7807918 A FR 7807918A FR 7807918 A FR7807918 A FR 7807918A FR 2383969 A1 FR2383969 A1 FR 2383969A1
Authority
FR
France
Prior art keywords
acylthio
steroids
ene
preparing
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7807918A
Other languages
English (en)
Other versions
FR2383969B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Publication of FR2383969A1 publication Critical patent/FR2383969A1/fr
Application granted granted Critical
Publication of FR2383969B1 publication Critical patent/FR2383969B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procédé de préparation de stéroïdes de type acylthio-7 alpha ène-4 one-3. On fait réagir un acide thiocarboxylique avec un stéroïde de type diène-4,6 one-3 en présence d'un acide fort. Application à la préparation de la spirolactone, diurétique antagoniste de l'aldostérone.
FR7807918A 1977-03-17 1978-03-17 Procede pour preparer des steroides de type acylthio-7a ene-4 one-3'' Granted FR2383969A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2958677A JPS53116361A (en) 1977-03-17 1977-03-17 Preparation of 7 acylthioo44enee33oxosteroid

Publications (2)

Publication Number Publication Date
FR2383969A1 true FR2383969A1 (fr) 1978-10-13
FR2383969B1 FR2383969B1 (fr) 1980-06-13

Family

ID=12280169

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7807918A Granted FR2383969A1 (fr) 1977-03-17 1978-03-17 Procede pour preparer des steroides de type acylthio-7a ene-4 one-3''

Country Status (8)

Country Link
US (1) US4213902A (fr)
JP (1) JPS53116361A (fr)
CH (1) CH633563A5 (fr)
DE (1) DE2809838A1 (fr)
FR (1) FR2383969A1 (fr)
GB (1) GB1559151A (fr)
HU (1) HU182533B (fr)
NL (1) NL182223C (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU77457A1 (fr) * 1977-05-31 1979-01-19
JPS56128798A (en) * 1980-03-13 1981-10-08 Mitsubishi Chem Ind Ltd Preparation of 7alpha-acetylthiosteroid
DE3427090A1 (de) * 1984-07-19 1986-01-23 Schering AG, 1000 Berlin und 4709 Bergkamen 7(alpha)-thiosubstituierte 19-hydroxy-15(beta),16(beta)-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3544661A1 (de) * 1985-12-13 1987-06-19 Schering Ag Verfahren zur herstellung von 7(alpha)-acetylthiosteroiden
DE10162608B4 (de) * 2001-12-20 2005-09-01 Danfoss A/S Thermostatventilaufsatz
CN102617420A (zh) * 2012-03-05 2012-08-01 湖南大学 二芳炔硫醚的一锅合成方法
CN102617419B (zh) * 2012-03-05 2014-03-05 湖南大学 共轭烯炔硫醚的一锅合成方法
CN102617421B (zh) * 2012-03-05 2014-01-01 湖南大学 芳二炔硫醚的一锅合成方法
CN102617422A (zh) * 2012-03-05 2012-08-01 湖南大学 芳炔硫醚的一锅合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2248835A1 (de) * 1972-10-05 1974-04-11 Hoechst Ag Verfahren zur herstellung von beta-(3keto-7 alpha-thioacyl-17beta-hydroxy-4androsten-17 alpha-yl)-propionsaeure- gamma lactonen
CH631462A5 (de) * 1976-03-05 1982-08-13 Schering Ag Verfahren zur herstellung von neuen steroiden der androstan- oder oestranreihe.

Also Published As

Publication number Publication date
HU182533B (en) 1984-02-28
NL7802543A (nl) 1978-09-19
US4213902A (en) 1980-07-22
JPS6212237B2 (fr) 1987-03-17
GB1559151A (en) 1980-01-16
NL182223C (nl) 1988-02-01
JPS53116361A (en) 1978-10-11
DE2809838A1 (de) 1978-09-21
FR2383969B1 (fr) 1980-06-13
CH633563A5 (de) 1982-12-15
NL182223B (nl) 1987-09-01

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Legal Events

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