FR2376857A1 - Procede de preparation d'acides 3-halogenosulfonyl-thiofene-carboxyliques et derives - Google Patents

Procede de preparation d'acides 3-halogenosulfonyl-thiofene-carboxyliques et derives

Info

Publication number
FR2376857A1
FR2376857A1 FR7739589A FR7739589A FR2376857A1 FR 2376857 A1 FR2376857 A1 FR 2376857A1 FR 7739589 A FR7739589 A FR 7739589A FR 7739589 A FR7739589 A FR 7739589A FR 2376857 A1 FR2376857 A1 FR 2376857A1
Authority
FR
France
Prior art keywords
derivatives
reacted
derivative
preparation
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7739589A
Other languages
English (en)
Other versions
FR2376857B3 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2700261A external-priority patent/DE2700261C2/de
Priority claimed from DE19772717477 external-priority patent/DE2717477C2/de
Application filed by BASF SE filed Critical BASF SE
Publication of FR2376857A1 publication Critical patent/FR2376857A1/fr
Application granted granted Critical
Publication of FR2376857B3 publication Critical patent/FR2376857B3/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Pour préparer les acides 3-halogénosulfonyl-thiofène-carboxyliques et dérivés de formule I, on fait réagir, dans un premier stade opératoire, un acide 3-cétothiofane-carboxylique ou dérivé de formule II avec un acide sulfonique ou dérivé de formule III, ce qui donne un acide 3-sulfato-dihydrothiofène-carboxylique ou dérivé répondant à l'une des formules IVa et IVb, qu'on fait réagir dans un deuxième stade opératoire avec un polysulfure alcalin, la réaction donnant un polysulfure d'acide 3,3' -bis-(dihydrothiofène-carboxylique) ou dérivé répondant à l'une des formules Va et Vb, qu'on fait réagir dans un troisième stade opératoire avec un chlorure ou bromure de l'acide sulfurique ou avec du chlore, la réaction donnant des polysulfures d acides 3,3'-bis-(thiofène-carboxyliques) ou dérivés répondant à l'une des formules VIa et VIb, lesquels sont mis à réagir dans un quatrième stade opératoire avec un halogène et de l'eau. Les dérivés du thiofène ainsi préparés servent à la préparation de médicaments, de substances édulcorantes et de produits phyto-sanitaires.
FR7739589A 1977-01-05 1977-12-29 Procede de preparation d'acides 3-halogenosulfonyl-thiofene-carboxyliques et derives Granted FR2376857A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2700261A DE2700261C2 (de) 1977-01-05 1977-01-05 Verfahren zur Herstellung von 3-Halogensulfonylthiophen-4-carbonsäureverbindungen
DE19772717477 DE2717477C2 (de) 1977-04-20 1977-04-20 Verfahren zur Herstellung von 3-Halogensulfonylthiophen-2-carbonsäureverbindungen

Publications (2)

Publication Number Publication Date
FR2376857A1 true FR2376857A1 (fr) 1978-08-04
FR2376857B3 FR2376857B3 (fr) 1980-09-26

Family

ID=25771425

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7739589A Granted FR2376857A1 (fr) 1977-01-05 1977-12-29 Procede de preparation d'acides 3-halogenosulfonyl-thiofene-carboxyliques et derives

Country Status (11)

Country Link
US (1) US4143050A (fr)
JP (1) JPS6034554B2 (fr)
AU (1) AU512465B2 (fr)
CA (1) CA1097358A (fr)
CH (1) CH631980A5 (fr)
DK (1) DK3078A (fr)
ES (1) ES465761A1 (fr)
FR (1) FR2376857A1 (fr)
GB (1) GB1591071A (fr)
NL (1) NL7800070A (fr)
SE (1) SE423388B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014308690B2 (en) 2013-08-21 2019-07-18 Verrica Pharmaceuticals, Inc. Compositions, methods and systems for the treatment of cutaneous disorders
IL270900B1 (en) 2017-06-06 2024-08-01 Verrica Pharmaceuticals Inc Treatment of skin disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2534689B2 (de) * 1974-09-16 1979-03-01 Basf Ag, 6700 Ludwigshafen 23-Dihydro-3-oxo-thieno-isothiazol-1,1-dioxide

Also Published As

Publication number Publication date
DK3078A (da) 1978-07-06
JPS6034554B2 (ja) 1985-08-09
CH631980A5 (de) 1982-09-15
NL7800070A (nl) 1978-07-07
FR2376857B3 (fr) 1980-09-26
JPS5384963A (en) 1978-07-26
AU512465B2 (en) 1980-10-09
SE7714971L (sv) 1978-07-06
GB1591071A (en) 1981-06-10
SE423388B (sv) 1982-05-03
CA1097358A (fr) 1981-03-10
AU3183577A (en) 1979-06-28
ES465761A1 (es) 1978-09-16
US4143050A (en) 1979-03-06

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