FR2382444A1 - Benzylpyrimidines, leurs preparation et leurs utilisations therapeutiques - Google Patents

Benzylpyrimidines, leurs preparation et leurs utilisations therapeutiques

Info

Publication number
FR2382444A1
FR2382444A1 FR7805971A FR7805971A FR2382444A1 FR 2382444 A1 FR2382444 A1 FR 2382444A1 FR 7805971 A FR7805971 A FR 7805971A FR 7805971 A FR7805971 A FR 7805971A FR 2382444 A1 FR2382444 A1 FR 2382444A1
Authority
FR
France
Prior art keywords
bacterial
preparation
compounds
activity
benzylpyrimidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7805971A
Other languages
English (en)
Other versions
FR2382444B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of FR2382444A1 publication Critical patent/FR2382444A1/fr
Application granted granted Critical
Publication of FR2382444B1 publication Critical patent/FR2382444B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Pour préparer ces composés I, on fait réagir un composé II avec un dérivé d'acide carboxylique III usuel pour la préparation des amides, de préférence dans un solvant, à 20-200 degrés C, et le cas échéant en présence d'un agent neutralisant les acides; si cette réaction donne un produit intermédiaire, on convertit ensuite celui-ci en le composé recherché. Les composés I ont une activité anti-bactérienne; combinés à des sulfonamides ayant des propriétés anti-bactériennes, ils renforcent cette activité par exemple dans des cas de maladies d'origine bactérienne des organes respiratoires, du système digestif et des voies urinaires, dans les infections du nez, de la gorge et des oreilles et dans toutes les maladies infectieuses systématiques.
FR7805971A 1977-03-05 1978-03-02 Benzylpyrimidines, leurs preparation et leurs utilisations therapeutiques Granted FR2382444A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772709634 DE2709634A1 (de) 1977-03-05 1977-03-05 Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
FR2382444A1 true FR2382444A1 (fr) 1978-09-29
FR2382444B1 FR2382444B1 (fr) 1980-08-29

Family

ID=6002850

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7805971A Granted FR2382444A1 (fr) 1977-03-05 1978-03-02 Benzylpyrimidines, leurs preparation et leurs utilisations therapeutiques

Country Status (20)

Country Link
US (1) US4189581A (fr)
JP (1) JPS53130681A (fr)
AT (1) AT361490B (fr)
BE (1) BE864484A (fr)
CA (1) CA1113932A (fr)
CH (1) CH634566A5 (fr)
DE (1) DE2709634A1 (fr)
DK (1) DK142848C (fr)
FI (1) FI780693A (fr)
FR (1) FR2382444A1 (fr)
GB (1) GB1596813A (fr)
IE (1) IE46420B1 (fr)
IL (1) IL54105A (fr)
IN (1) IN149534B (fr)
LU (1) LU79168A1 (fr)
NL (1) NL7802380A (fr)
NO (1) NO147483C (fr)
SE (1) SE7802343L (fr)
YU (1) YU47478A (fr)
ZA (1) ZA781242B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2609987A1 (fr) * 1987-01-26 1988-07-29 Carraz Gilbert Nouvel amide de l'amino-2-pyrimidine et compositions pharmaceutiques tranquillisantes et antisenescentes le contenant

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3045720A1 (de) 1980-12-04 1982-07-08 Basf Ag, 6700 Ludwigshafen N-pyrimidinyl-carbaminsaeureester, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4672065A (en) * 1982-11-19 1987-06-09 Chevron Research Company N-substituted phenoxyacetamide fungicides
ES2314106T3 (es) * 2001-10-17 2009-03-16 BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG Derivados de pirimidina, agentes farmaceuticos que contiene dichos compuestos, uso y metodo para su obtencion.
US6884880B2 (en) * 2002-08-21 2005-04-26 Ash Stevens, Inc. Process for the preparation of 9-β-anomeric nucleoside analogs
RO122912B8 (ro) * 2005-02-18 2010-09-30 Arpida Ag Procedeu de preparare a unui derivat de 2h-cromen
US7855285B2 (en) * 2005-06-14 2010-12-21 Brigham Young University Methods for selective N-9 glycosylation of purines
CA2620129C (fr) * 2005-09-01 2014-12-23 F. Hoffmann-La Roche Ag Diaminopyrimidines comme modulateurs p2x3 et p2x2/3

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH507243A (it) * 1969-04-01 1971-05-15 Dompe Farmaceutici Spa Procedimento per la preparazione di 2,4-diamino-5-(-3,4,5-trimetossibenzil)-pirimidina
US3919229A (en) * 1973-07-19 1975-11-11 Labaz Pyrimidine derivatives and process for preparing the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2609987A1 (fr) * 1987-01-26 1988-07-29 Carraz Gilbert Nouvel amide de l'amino-2-pyrimidine et compositions pharmaceutiques tranquillisantes et antisenescentes le contenant

Also Published As

Publication number Publication date
DK142848C (da) 1981-08-24
IL54105A0 (en) 1978-04-30
CA1113932A (fr) 1981-12-08
NO147483C (no) 1983-04-20
CH634566A5 (de) 1983-02-15
US4189581A (en) 1980-02-19
IN149534B (fr) 1982-01-09
NO780743L (no) 1978-09-06
NL7802380A (nl) 1978-09-07
LU79168A1 (de) 1978-06-28
FI780693A (fi) 1978-09-06
ATA154278A (de) 1980-08-15
IE46420B1 (en) 1983-06-01
AT361490B (de) 1981-03-10
DK97578A (da) 1978-09-06
IL54105A (en) 1982-04-30
DE2709634A1 (de) 1978-09-07
IE780400L (en) 1978-09-05
BE864484A (fr) 1978-09-04
GB1596813A (en) 1981-09-03
FR2382444B1 (fr) 1980-08-29
JPS53130681A (en) 1978-11-14
YU47478A (en) 1983-01-21
SE7802343L (sv) 1978-09-06
ZA781242B (en) 1979-03-28
DK142848B (da) 1981-02-09
NO147483B (no) 1983-01-10

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Legal Events

Date Code Title Description
ST Notification of lapse