FR2290202A1 - Nouveaux derives piperidylideniques, leur procede de preparation et leur application en therapeutique - Google Patents
Nouveaux derives piperidylideniques, leur procede de preparation et leur application en therapeutiqueInfo
- Publication number
- FR2290202A1 FR2290202A1 FR7533631A FR7533631A FR2290202A1 FR 2290202 A1 FR2290202 A1 FR 2290202A1 FR 7533631 A FR7533631 A FR 7533631A FR 7533631 A FR7533631 A FR 7533631A FR 2290202 A1 FR2290202 A1 FR 2290202A1
- Authority
- FR
- France
- Prior art keywords
- piperidylidenic
- therapeutics
- derivatives
- preparation
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000027776 Extrapyramidal disease Diseases 0.000 abstract 1
- -1 N-methylpiperidylmagnesium halide Chemical class 0.000 abstract 1
- 230000000561 anti-psychotic effect Effects 0.000 abstract 1
- YRHRIQCWCFGUEQ-UHFFFAOYSA-N thioxanthen-9-one Chemical class C1=CC=C2C(=O)C3=CC=CC=C3SC2=C1 YRHRIQCWCFGUEQ-UHFFFAOYSA-N 0.000 abstract 1
- JNELGWHKGNBSMD-UHFFFAOYSA-N xanthone Chemical class C1=CC=C2C(=O)C3=CC=CC=C3OC2=C1 JNELGWHKGNBSMD-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
- C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52121674A | 1974-11-06 | 1974-11-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2290202A1 true FR2290202A1 (fr) | 1976-06-04 |
| FR2290202B1 FR2290202B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1980-05-23 |
Family
ID=24075868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7533631A Granted FR2290202A1 (fr) | 1974-11-06 | 1975-11-04 | Nouveaux derives piperidylideniques, leur procede de preparation et leur application en therapeutique |
Country Status (17)
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2357251A1 (fr) * | 1976-07-09 | 1978-02-03 | Merck & Co Inc | 1-methyl-4-(2-carboxy-1-thioxanthan-9-ylidene)-piperidine |
| FR2367761A1 (fr) * | 1976-10-12 | 1978-05-12 | Smithkline Corp | Derives piperidylideniques de benzo-xanthenes, |
| FR2370050A1 (fr) * | 1976-11-08 | 1978-06-02 | Smithkline Corp | Derives quinolizidylideniques de xanthenes, thioxanthenes et dibenzoxepines, leur procede de preparation et leur application en therapeutique |
| EP0179020A3 (de) * | 1984-10-19 | 1987-03-25 | Ciba-Geigy Ag | Thioxanthene in der Schädlingsbekämpfung |
| EP0371805A3 (en) * | 1988-11-30 | 1991-07-31 | Ajinomoto Co., Inc. | Piperidine derivatives and hypotensives containing the same |
| US5250681A (en) * | 1988-06-02 | 1993-10-05 | Ajinomoto Co., Inc. | Piperidine derivatives and hypotensives containing the same |
| EP1306376A1 (en) * | 2001-10-25 | 2003-05-02 | Biofrontera Pharmaceuticals AG | Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist |
| WO2005003131A1 (en) * | 2003-06-27 | 2005-01-13 | Janssen Pharmaceutica N.V. | Tricyclic delta opioid modulators |
| US7060711B2 (en) | 2001-10-25 | 2006-06-13 | Biofrontera Bioscience Gmbh | Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist |
| WO2006069275A1 (en) * | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | Tricyclic delta-opioid modulators |
| US7432257B2 (en) | 2005-01-06 | 2008-10-07 | Janssen Pharmaceutica N.V. | Piperdinyl-phenoxazine and phenothiazine derivatives as δ-opioid modulators |
| US7439239B2 (en) | 2004-12-22 | 2008-10-21 | Janssen Pharmaceutica N.V. | Tricyclic δ- opioid modulators |
| US7553850B2 (en) | 2004-08-05 | 2009-06-30 | Janssen Pharmaceutica Nv | Tricyclic-bridged piperidinylidene derivatives as δ-opioid modulators |
| US7582650B2 (en) | 2005-06-16 | 2009-09-01 | Janssen Pharmaceutica N.V. | Tricyclic opioid modulators |
| US7589104B2 (en) | 2004-12-22 | 2009-09-15 | Janssen Pharmaceutica Nv | Tricyclic-bridged piperidinyline derivatives as §-opioid modulators |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ189108A (en) * | 1977-12-29 | 1982-02-23 | Kefalas As | 2-methylthio-6-fluoro-9-(1-methyl-4-piperidylidene)-thioxanthene and pharmaceutical compositions intermediate 2-methylthio-6-fluoro-9-(1-methyl-4-piperidyl)-thioxanthen-9-ol |
| US8222419B2 (en) | 2006-09-29 | 2012-07-17 | Nippon Zoki Pharmaceutical Co., Ltd. | Oxepin derivative |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL260070A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1960-02-25 | |||
| NL283292A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1961-09-29 | |||
| DE1670118A1 (de) * | 1966-07-22 | 1970-11-05 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung neuer Derivate des 6,11-Dihydro-dibenz[b,e]oxepins und ihrer Salze |
| US3470188A (en) * | 1967-01-05 | 1969-09-30 | Smithkline Corp | 9-cycloalkyl-lower alkyl-piperidylidene derivatives of xanthenes and thioxanthenes |
| JPS5018478A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1973-05-17 | 1975-02-26 |
-
1975
- 1975-10-16 ZA ZA00756550A patent/ZA756550B/xx unknown
- 1975-10-31 AU AU86247/75A patent/AU498298B2/en not_active Expired
- 1975-10-31 CA CA238,781A patent/CA1055945A/en not_active Expired
- 1975-11-02 IL IL48400A patent/IL48400A/xx unknown
- 1975-11-03 NZ NZ179139A patent/NZ179139A/xx unknown
- 1975-11-03 PH PH17733A patent/PH12158A/en unknown
- 1975-11-03 HU HU75SI1494A patent/HU174639B/hu not_active IP Right Cessation
- 1975-11-04 BE BE161500A patent/BE835224A/xx not_active IP Right Cessation
- 1975-11-04 IE IE2398/75A patent/IE42137B1/en unknown
- 1975-11-04 FR FR7533631A patent/FR2290202A1/fr active Granted
- 1975-11-04 DK DK495775AA patent/DK139429B/da not_active IP Right Cessation
- 1975-11-04 LU LU73714A patent/LU73714A1/xx unknown
- 1975-11-05 JP JP50133564A patent/JPS5826754B2/ja not_active Expired
- 1975-11-05 NL NL7512974A patent/NL7512974A/xx not_active Application Discontinuation
- 1975-11-05 ES ES442357A patent/ES442357A1/es not_active Expired
- 1975-11-05 CH CH1432175A patent/CH624403A5/de not_active IP Right Cessation
- 1975-11-06 DE DE19752549841 patent/DE2549841A1/de active Granted
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2357251A1 (fr) * | 1976-07-09 | 1978-02-03 | Merck & Co Inc | 1-methyl-4-(2-carboxy-1-thioxanthan-9-ylidene)-piperidine |
| FR2367761A1 (fr) * | 1976-10-12 | 1978-05-12 | Smithkline Corp | Derives piperidylideniques de benzo-xanthenes, |
| FR2370050A1 (fr) * | 1976-11-08 | 1978-06-02 | Smithkline Corp | Derives quinolizidylideniques de xanthenes, thioxanthenes et dibenzoxepines, leur procede de preparation et leur application en therapeutique |
| EP0179020A3 (de) * | 1984-10-19 | 1987-03-25 | Ciba-Geigy Ag | Thioxanthene in der Schädlingsbekämpfung |
| US4777177A (en) * | 1984-10-19 | 1988-10-11 | Ciba-Geigy Corporation | Pesticidal thioxanthen-9-ylidenepiperidines |
| US5250681A (en) * | 1988-06-02 | 1993-10-05 | Ajinomoto Co., Inc. | Piperidine derivatives and hypotensives containing the same |
| EP0371805A3 (en) * | 1988-11-30 | 1991-07-31 | Ajinomoto Co., Inc. | Piperidine derivatives and hypotensives containing the same |
| WO2003035646A3 (en) * | 2001-10-25 | 2003-09-04 | Biofrontera Pharmaceuticals Gm | Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-ht2b receptor antagonist |
| EP1306376A1 (en) * | 2001-10-25 | 2003-05-02 | Biofrontera Pharmaceuticals AG | Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist |
| US7060711B2 (en) | 2001-10-25 | 2006-06-13 | Biofrontera Bioscience Gmbh | Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist |
| US7511064B2 (en) | 2001-10-25 | 2009-03-31 | Biofrontera Bioscience Gmbh | Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist |
| WO2005003131A1 (en) * | 2003-06-27 | 2005-01-13 | Janssen Pharmaceutica N.V. | Tricyclic delta opioid modulators |
| US8350041B2 (en) | 2003-06-27 | 2013-01-08 | Janssen Pharmaceutica, Nv | Tricyclic δ-opioid modulators |
| US8106207B2 (en) | 2003-06-27 | 2012-01-31 | Janssen Pharmaceutica, Nv | Tricyclic δ-opioid modulators |
| EA015491B1 (ru) * | 2003-06-27 | 2011-08-30 | Янссен Фармацевтика Н.В. | ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ |
| US7982042B2 (en) | 2003-06-27 | 2011-07-19 | Janseen Pharmacautica NV | Thiozanthene derivatives as delta-opioid modulators |
| US7589103B2 (en) | 2003-06-27 | 2009-09-15 | Janssen Pharmaceutica N.V. | Tricyclic-bridged piperidinylidene derivatives as 8-opioid modulators |
| US7553850B2 (en) | 2004-08-05 | 2009-06-30 | Janssen Pharmaceutica Nv | Tricyclic-bridged piperidinylidene derivatives as δ-opioid modulators |
| US7589104B2 (en) | 2004-12-22 | 2009-09-15 | Janssen Pharmaceutica Nv | Tricyclic-bridged piperidinyline derivatives as §-opioid modulators |
| US7652005B2 (en) | 2004-12-22 | 2010-01-26 | Janssen Pharmaceutica N.V. | Tricyclic δ-opioid modulators |
| US7439239B2 (en) | 2004-12-22 | 2008-10-21 | Janssen Pharmaceutica N.V. | Tricyclic δ- opioid modulators |
| WO2006069275A1 (en) * | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | Tricyclic delta-opioid modulators |
| US7432257B2 (en) | 2005-01-06 | 2008-10-07 | Janssen Pharmaceutica N.V. | Piperdinyl-phenoxazine and phenothiazine derivatives as δ-opioid modulators |
| US7582650B2 (en) | 2005-06-16 | 2009-09-01 | Janssen Pharmaceutica N.V. | Tricyclic opioid modulators |
Also Published As
| Publication number | Publication date |
|---|---|
| CH624403A5 (en) | 1981-07-31 |
| HU174639B (hu) | 1980-02-28 |
| DE2549841C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1988-07-07 |
| IL48400A0 (en) | 1976-01-30 |
| NZ179139A (en) | 1978-04-28 |
| DK139429C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-08-06 |
| PH12158A (en) | 1978-11-10 |
| DK495775A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-05-07 |
| LU73714A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-06-11 |
| AU8624775A (en) | 1977-05-05 |
| CA1055945A (en) | 1979-06-05 |
| IE42137L (en) | 1976-05-06 |
| FR2290202B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1980-05-23 |
| JPS5170768A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-06-18 |
| ES442357A1 (es) | 1977-04-01 |
| JPS5826754B2 (ja) | 1983-06-04 |
| IE42137B1 (en) | 1980-06-04 |
| IL48400A (en) | 1979-01-31 |
| AU498298B2 (en) | 1979-03-01 |
| ZA756550B (en) | 1976-09-29 |
| NL7512974A (nl) | 1976-05-10 |
| DE2549841A1 (de) | 1976-05-13 |
| BE835224A (fr) | 1976-05-04 |
| DK139429B (da) | 1979-02-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR2290202A1 (fr) | Nouveaux derives piperidylideniques, leur procede de preparation et leur application en therapeutique | |
| FR2286134A1 (fr) | Nouvelles urethannoxazolidines, et leur procede de preparation | |
| SE393516B (sv) | Apparat for framstellning av yoghurt, serskilt for anvendning i hushall | |
| BE843241A (fr) | Procede de preparation de nouveaux 2-piperinoalcoyl-1,4-benzodioxannes | |
| RO73008A (ro) | Procedeu pentru prepararea unor derivati de difenileter-4-trifluormetil-4-nitro halogenati | |
| BE822616A (fr) | Derives de 7alpha-methoxycephalosporine leur procede de preparation et leur application therapeutique | |
| IT1062796B (it) | Derivati arilamino pirimidinici,loro procedimento di preparazione e loro applicazione in terapia | |
| FR2319345A1 (fr) | Derives de thiazolidine, leur procede de preparation et leur application | |
| BE834400A (fr) | Nouveaux derives de pyridine, leur procede de preparation et leur utilisation | |
| FR2283687A1 (fr) | Nouveaux derives de cephalosporine, leur procede de preparation et leurs applications | |
| BE831794A (fr) | Derives de thiazolidine, leur procede de preparation et leurs application | |
| FR2294706A1 (fr) | Nouveaux derives de la xanthine, leur procede de preparation et leur utilisation | |
| CH546756A (fr) | Procede de preparation de nouveaux derives du benzofuranne. | |
| BE769469A (fr) | Nouveaux derives terpeniques, leur procede de preparation et leurs applications | |
| BE763609A (fr) | Nouveaux derives de la benzhydryl piperazine leur procede de preparation et leur application en therapeutique ( | |
| BE835524A (fr) | Derives thiazolyphtalides, leur procede de preparation et leur utilisation | |
| RO71309A (ro) | Procedeu pentru prepararea unor derivati de benzo-sulfonil-uree | |
| BE847352A (fr) | Nouveaux derives de thiazolidine, leur procede de preparation et leurs applications | |
| BE836925A (fr) | Nouveaux derives de thiouree, leur procede de preparation et leur application comme fongicides | |
| BG23746A3 (bg) | Метод за получаване на 4-амино 3,5-дихалоген-фенил-етаноламини | |
| BE835427A (fr) | Nouveaux methylenesteroides, et leur procede de preparation | |
| BE802021A (fr) | Procede de preparation de nouveaux derives du 1,1a | |
| BE825805A (fr) | Diaminoguanidines substituees, leur procede de preparation et leurs applications | |
| FR2347358A1 (fr) | Nouveaux derives de la piperazine, leur procede de preparation et leur application en therapeutique | |
| BE768956A (fr) | Nouveaux derives benzoxazoliques, leur procede de preparation et leur emploi |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CD | Change of name or company name | ||
| ST | Notification of lapse |