FR2290202A1 - Nouveaux derives piperidylideniques, leur procede de preparation et leur application en therapeutique - Google Patents

Nouveaux derives piperidylideniques, leur procede de preparation et leur application en therapeutique

Info

Publication number
FR2290202A1
FR2290202A1 FR7533631A FR7533631A FR2290202A1 FR 2290202 A1 FR2290202 A1 FR 2290202A1 FR 7533631 A FR7533631 A FR 7533631A FR 7533631 A FR7533631 A FR 7533631A FR 2290202 A1 FR2290202 A1 FR 2290202A1
Authority
FR
France
Prior art keywords
piperidylidenic
therapeutics
derivatives
preparation
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7533631A
Other languages
English (en)
Other versions
FR2290202B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
SmithKline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Corp filed Critical SmithKline Corp
Publication of FR2290202A1 publication Critical patent/FR2290202A1/fr
Application granted granted Critical
Publication of FR2290202B1 publication Critical patent/FR2290202B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR7533631A 1974-11-06 1975-11-04 Nouveaux derives piperidylideniques, leur procede de preparation et leur application en therapeutique Granted FR2290202A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52121674A 1974-11-06 1974-11-06

Publications (2)

Publication Number Publication Date
FR2290202A1 true FR2290202A1 (fr) 1976-06-04
FR2290202B1 FR2290202B1 (fr) 1980-05-23

Family

ID=24075868

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7533631A Granted FR2290202A1 (fr) 1974-11-06 1975-11-04 Nouveaux derives piperidylideniques, leur procede de preparation et leur application en therapeutique

Country Status (17)

Country Link
JP (1) JPS5826754B2 (fr)
AU (1) AU498298B2 (fr)
BE (1) BE835224A (fr)
CA (1) CA1055945A (fr)
CH (1) CH624403A5 (fr)
DE (1) DE2549841A1 (fr)
DK (1) DK139429B (fr)
ES (1) ES442357A1 (fr)
FR (1) FR2290202A1 (fr)
HU (1) HU174639B (fr)
IE (1) IE42137B1 (fr)
IL (1) IL48400A (fr)
LU (1) LU73714A1 (fr)
NL (1) NL7512974A (fr)
NZ (1) NZ179139A (fr)
PH (1) PH12158A (fr)
ZA (1) ZA756550B (fr)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2357251A1 (fr) * 1976-07-09 1978-02-03 Merck & Co Inc 1-methyl-4-(2-carboxy-1-thioxanthan-9-ylidene)-piperidine
FR2367761A1 (fr) * 1976-10-12 1978-05-12 Smithkline Corp Derives piperidylideniques de benzo-xanthenes,
FR2370050A1 (fr) * 1976-11-08 1978-06-02 Smithkline Corp Derives quinolizidylideniques de xanthenes, thioxanthenes et dibenzoxepines, leur procede de preparation et leur application en therapeutique
EP0179020A2 (fr) * 1984-10-19 1986-04-23 Ciba-Geigy Ag Thioxanthènes utiles dans la lutte contre les parasites
EP0371805A2 (fr) * 1988-11-30 1990-06-06 Ajinomoto Co., Inc. Dérivés de pipéridine et hypotenseurs les contenant
US5250681A (en) * 1988-06-02 1993-10-05 Ajinomoto Co., Inc. Piperidine derivatives and hypotensives containing the same
WO2003035646A2 (fr) * 2001-10-25 2003-05-01 Biofrontera Pharmaceuticals Gmbh Derives de 4-(thio- ou selenoxanthene-9-ylidene)-piperidine ou acridine et leur utilisation comme antagonistes selectifs du recepteur de 5-ht¿2b?
WO2005003131A1 (fr) * 2003-06-27 2005-01-13 Janssen Pharmaceutica N.V. Modulateurs du recepteur opioide $g(d) tricycliques
US7060711B2 (en) 2001-10-25 2006-06-13 Biofrontera Bioscience Gmbh Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
WO2006069275A1 (fr) * 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. Modulateurs des recepteurs opioides delta tricycliques
US7432257B2 (en) 2005-01-06 2008-10-07 Janssen Pharmaceutica N.V. Piperdinyl-phenoxazine and phenothiazine derivatives as δ-opioid modulators
US7439239B2 (en) 2004-12-22 2008-10-21 Janssen Pharmaceutica N.V. Tricyclic δ- opioid modulators
US7553850B2 (en) 2004-08-05 2009-06-30 Janssen Pharmaceutica Nv Tricyclic-bridged piperidinylidene derivatives as δ-opioid modulators
US7582650B2 (en) 2005-06-16 2009-09-01 Janssen Pharmaceutica N.V. Tricyclic opioid modulators
US7589104B2 (en) 2004-12-22 2009-09-15 Janssen Pharmaceutica Nv Tricyclic-bridged piperidinyline derivatives as §-opioid modulators

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ189108A (en) * 1977-12-29 1982-02-23 Kefalas As 2-methylthio-6-fluoro-9-(1-methyl-4-piperidylidene)-thioxanthene and pharmaceutical compositions intermediate 2-methylthio-6-fluoro-9-(1-methyl-4-piperidyl)-thioxanthen-9-ol
US8222419B2 (en) 2006-09-29 2012-07-17 Nippon Zoki Pharmaceutical Co., Ltd. Oxepin derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL260070A (fr) * 1960-02-25
NL122808C (fr) * 1961-09-29
DE1670118A1 (de) * 1966-07-22 1970-11-05 Boehringer Mannheim Gmbh Verfahren zur Herstellung neuer Derivate des 6,11-Dihydro-dibenz[b,e]oxepins und ihrer Salze
US3470188A (en) * 1967-01-05 1969-09-30 Smithkline Corp 9-cycloalkyl-lower alkyl-piperidylidene derivatives of xanthenes and thioxanthenes
JPS5018478A (fr) * 1973-05-17 1975-02-26

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2357251A1 (fr) * 1976-07-09 1978-02-03 Merck & Co Inc 1-methyl-4-(2-carboxy-1-thioxanthan-9-ylidene)-piperidine
FR2367761A1 (fr) * 1976-10-12 1978-05-12 Smithkline Corp Derives piperidylideniques de benzo-xanthenes,
FR2370050A1 (fr) * 1976-11-08 1978-06-02 Smithkline Corp Derives quinolizidylideniques de xanthenes, thioxanthenes et dibenzoxepines, leur procede de preparation et leur application en therapeutique
EP0179020A2 (fr) * 1984-10-19 1986-04-23 Ciba-Geigy Ag Thioxanthènes utiles dans la lutte contre les parasites
EP0179020A3 (fr) * 1984-10-19 1987-03-25 Ciba-Geigy Ag Thioxanthènes utiles dans la lutte contre les parasites
US4777177A (en) * 1984-10-19 1988-10-11 Ciba-Geigy Corporation Pesticidal thioxanthen-9-ylidenepiperidines
US5250681A (en) * 1988-06-02 1993-10-05 Ajinomoto Co., Inc. Piperidine derivatives and hypotensives containing the same
EP0371805A2 (fr) * 1988-11-30 1990-06-06 Ajinomoto Co., Inc. Dérivés de pipéridine et hypotenseurs les contenant
EP0371805A3 (fr) * 1988-11-30 1991-07-31 Ajinomoto Co., Inc. Dérivés de pipéridine et hypotenseurs les contenant
WO2003035646A2 (fr) * 2001-10-25 2003-05-01 Biofrontera Pharmaceuticals Gmbh Derives de 4-(thio- ou selenoxanthene-9-ylidene)-piperidine ou acridine et leur utilisation comme antagonistes selectifs du recepteur de 5-ht¿2b?
EP1306376A1 (fr) * 2001-10-25 2003-05-02 Biofrontera Pharmaceuticals AG Dérives de 4-(thio- or selenoxanthene-9-ylidene)-piperidine ou acridine et leur application comme antagonistes selectives de 5-HT2B
WO2003035646A3 (fr) * 2001-10-25 2003-09-04 Biofrontera Pharmaceuticals Gm Derives de 4-(thio- ou selenoxanthene-9-ylidene)-piperidine ou acridine et leur utilisation comme antagonistes selectifs du recepteur de 5-ht¿2b?
US7511064B2 (en) 2001-10-25 2009-03-31 Biofrontera Bioscience Gmbh Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
US7060711B2 (en) 2001-10-25 2006-06-13 Biofrontera Bioscience Gmbh Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
WO2005003131A1 (fr) * 2003-06-27 2005-01-13 Janssen Pharmaceutica N.V. Modulateurs du recepteur opioide $g(d) tricycliques
US7589103B2 (en) 2003-06-27 2009-09-15 Janssen Pharmaceutica N.V. Tricyclic-bridged piperidinylidene derivatives as 8-opioid modulators
US7982042B2 (en) 2003-06-27 2011-07-19 Janseen Pharmacautica NV Thiozanthene derivatives as delta-opioid modulators
EA015491B1 (ru) * 2003-06-27 2011-08-30 Янссен Фармацевтика Н.В. ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ
US8106207B2 (en) 2003-06-27 2012-01-31 Janssen Pharmaceutica, Nv Tricyclic δ-opioid modulators
US8350041B2 (en) 2003-06-27 2013-01-08 Janssen Pharmaceutica, Nv Tricyclic δ-opioid modulators
US7553850B2 (en) 2004-08-05 2009-06-30 Janssen Pharmaceutica Nv Tricyclic-bridged piperidinylidene derivatives as δ-opioid modulators
US7439239B2 (en) 2004-12-22 2008-10-21 Janssen Pharmaceutica N.V. Tricyclic δ- opioid modulators
WO2006069275A1 (fr) * 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. Modulateurs des recepteurs opioides delta tricycliques
US7589104B2 (en) 2004-12-22 2009-09-15 Janssen Pharmaceutica Nv Tricyclic-bridged piperidinyline derivatives as §-opioid modulators
US7652005B2 (en) 2004-12-22 2010-01-26 Janssen Pharmaceutica N.V. Tricyclic δ-opioid modulators
US7432257B2 (en) 2005-01-06 2008-10-07 Janssen Pharmaceutica N.V. Piperdinyl-phenoxazine and phenothiazine derivatives as δ-opioid modulators
US7582650B2 (en) 2005-06-16 2009-09-01 Janssen Pharmaceutica N.V. Tricyclic opioid modulators

Also Published As

Publication number Publication date
LU73714A1 (fr) 1976-06-11
HU174639B (hu) 1980-02-28
IL48400A0 (en) 1976-01-30
NZ179139A (en) 1978-04-28
ZA756550B (en) 1976-09-29
JPS5170768A (fr) 1976-06-18
BE835224A (fr) 1976-05-04
DK139429B (da) 1979-02-19
FR2290202B1 (fr) 1980-05-23
IE42137L (en) 1976-05-06
CA1055945A (fr) 1979-06-05
IL48400A (en) 1979-01-31
PH12158A (en) 1978-11-10
NL7512974A (nl) 1976-05-10
DE2549841A1 (de) 1976-05-13
AU498298B2 (en) 1979-03-01
ES442357A1 (es) 1977-04-01
DK139429C (fr) 1979-08-06
IE42137B1 (en) 1980-06-04
JPS5826754B2 (ja) 1983-06-04
AU8624775A (en) 1977-05-05
CH624403A5 (en) 1981-07-31
DE2549841C2 (fr) 1988-07-07
DK495775A (fr) 1976-05-07

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Legal Events

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CD Change of name or company name
ST Notification of lapse