FR2112480A1 - 1-oxo-2-(p-(carboxymethyl)-phenyl) isoindoline derivs - analgesics and anti-inflammatories - Google Patents
1-oxo-2-(p-(carboxymethyl)-phenyl) isoindoline derivs - analgesics and anti-inflammatoriesInfo
- Publication number
- FR2112480A1 FR2112480A1 FR7139823A FR7139823A FR2112480A1 FR 2112480 A1 FR2112480 A1 FR 2112480A1 FR 7139823 A FR7139823 A FR 7139823A FR 7139823 A FR7139823 A FR 7139823A FR 2112480 A1 FR2112480 A1 FR 2112480A1
- Authority
- FR
- France
- Prior art keywords
- inflammatories
- analgesics
- derivs
- isoindoline
- carboxymethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940035676 analgesics Drugs 0.000 title abstract 2
- 239000000730 antalgic agent Substances 0.000 title abstract 2
- 239000002260 anti-inflammatory agent Substances 0.000 title abstract 2
- 229940121363 anti-inflammatory agent Drugs 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- YAVXGZPCODWPJL-UHFFFAOYSA-N 2-[4-(3-oxo-1h-isoindol-2-yl)phenyl]acetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1N1C(=O)C2=CC=CC=C2C1 YAVXGZPCODWPJL-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- QGXNHCXKWFNKCG-UHFFFAOYSA-N 2-(bromomethyl)benzonitrile Chemical compound BrCC1=CC=CC=C1C#N QGXNHCXKWFNKCG-UHFFFAOYSA-N 0.000 abstract 2
- WNZQDUSMALZDQF-UHFFFAOYSA-N 2-benzofuran-1(3H)-one Chemical compound C1=CC=C2C(=O)OCC2=C1 WNZQDUSMALZDQF-UHFFFAOYSA-N 0.000 abstract 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 abstract 2
- YCWRFIYBUQBHJI-UHFFFAOYSA-N 2-(4-aminophenyl)acetonitrile Chemical compound NC1=CC=C(CC#N)C=C1 YCWRFIYBUQBHJI-UHFFFAOYSA-N 0.000 abstract 1
- WQBXDMCOVLBREU-UHFFFAOYSA-N 3h-2-benzofuran-1-thione Chemical compound C1=CC=C2C(=S)OCC2=C1 WQBXDMCOVLBREU-UHFFFAOYSA-N 0.000 abstract 1
- LGRFSURHDFAFJT-UHFFFAOYSA-N Phthalic anhydride Natural products C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- JHIWVOJDXOSYLW-UHFFFAOYSA-N butyl 2,2-difluorocyclopropane-1-carboxylate Chemical compound CCCCOC(=O)C1CC1(F)F JHIWVOJDXOSYLW-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- CFNDVXUTYPXOPG-UHFFFAOYSA-N ethyl 2-(4-aminophenyl)acetate Chemical compound CCOC(=O)CC1=CC=C(N)C=C1 CFNDVXUTYPXOPG-UHFFFAOYSA-N 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT3133470 | 1970-11-05 | ||
| IT3151470 | 1970-11-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2112480A1 true FR2112480A1 (en) | 1972-06-16 |
| FR2112480B1 FR2112480B1 (enrdf_load_stackoverflow) | 1975-08-01 |
Family
ID=26328923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7139823A Granted FR2112480A1 (en) | 1970-11-05 | 1971-11-05 | 1-oxo-2-(p-(carboxymethyl)-phenyl) isoindoline derivs - analgesics and anti-inflammatories |
Country Status (18)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2154525A1 (de) * | 1970-11-05 | 1972-06-15 | Carlo Erba S.P.A., Mailand (Italien) | Isoindolinderivate und Verfahren zu ihrer Herstellung |
| DE2755345A1 (de) * | 1977-04-05 | 1978-10-19 | Grelan Pharmaceutical Co | 2-oxo-phenylbuttersaeure-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate |
| JPS53145735U (enrdf_load_stackoverflow) * | 1977-04-23 | 1978-11-16 | ||
| JPS545333U (enrdf_load_stackoverflow) * | 1977-06-15 | 1979-01-13 | ||
| JPS5416115U (enrdf_load_stackoverflow) * | 1977-07-01 | 1979-02-01 | ||
| JPS5424235U (enrdf_load_stackoverflow) * | 1977-07-20 | 1979-02-17 | ||
| US5480362A (en) * | 1992-09-03 | 1996-01-02 | Honda Giken Kogyo Kabushiki Kaisha | Double planetary carrier |
| CN1302881C (zh) * | 2004-12-10 | 2007-03-07 | 华东理工大学 | 超高压超临界流体微射流技术制备超细粉体的方法及装置 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2034240C2 (de) * | 1968-03-27 | 1982-12-02 | CIBA-GEIGY AG, 4002 Basel | Isoindolinderivate, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung |
| JPS5035076A (enrdf_load_stackoverflow) * | 1973-08-01 | 1975-04-03 |
-
1971
- 1971-10-22 FI FI2988/71A patent/FI54294C/fi active
- 1971-10-25 IE IE1342/71A patent/IE35767B1/xx unknown
- 1971-10-27 IL IL38023A patent/IL38023A/en unknown
- 1971-10-28 ES ES396473A patent/ES396473A1/es not_active Expired
- 1971-10-29 YU YU2756/71A patent/YU34984B/xx unknown
- 1971-11-04 HU HUCA317A patent/HU164391B/hu unknown
- 1971-11-04 CA CA126,830A patent/CA978973A/en not_active Expired
- 1971-11-04 DD DD158754A patent/DD95379A5/xx unknown
- 1971-11-04 SE SE7114082A patent/SE374917B/xx unknown
- 1971-11-04 NO NO4082/71A patent/NO135785C/no unknown
- 1971-11-04 AT AT952271A patent/AT313894B/de not_active IP Right Cessation
- 1971-11-05 CH CH1247674A patent/CH559175A5/xx not_active IP Right Cessation
- 1971-11-05 CH CH1247574A patent/CH559174A5/xx not_active IP Right Cessation
- 1971-11-05 FR FR7139823A patent/FR2112480A1/fr active Granted
- 1971-11-05 DK DK541671A patent/DK154761C/da not_active IP Right Cessation
- 1971-11-05 CH CH1247774A patent/CH559176A5/xx not_active IP Right Cessation
- 1971-11-05 NL NLAANVRAGE7115288,A patent/NL170283C/xx not_active IP Right Cessation
- 1971-11-05 BE BE774985A patent/BE774985A/xx not_active IP Right Cessation
- 1971-11-05 CH CH1615771A patent/CH558353A/xx not_active IP Right Cessation
- 1971-11-05 JP JP46088188A patent/JPS5111627B1/ja active Pending
-
1974
- 1974-12-30 MY MY288/74A patent/MY7400288A/xx unknown
-
1975
- 1975-10-24 JP JP50128260A patent/JPS5168563A/ja active Granted
-
1976
- 1976-04-02 JP JP51037026A patent/JPS5231065A/ja active Granted
- 1976-04-02 JP JP51037028A patent/JPS5217463A/ja active Pending
- 1976-04-02 JP JP51037027A patent/JPS5231066A/ja active Granted
-
1978
- 1978-09-14 JP JP53113483A patent/JPS6019748B2/ja not_active Expired
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CD | Change of name or company name | ||
| TP | Transmission of property |