FI96865B - Förfarande för framställning av en terapeutiskt användbar, väsentligen ren polypeptid - Google Patents

Förfarande för framställning av en terapeutiskt användbar, väsentligen ren polypeptid Download PDF

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Publication number
FI96865B
FI96865B FI904789A FI904789A FI96865B FI 96865 B FI96865 B FI 96865B FI 904789 A FI904789 A FI 904789A FI 904789 A FI904789 A FI 904789A FI 96865 B FI96865 B FI 96865B
Authority
FI
Finland
Prior art keywords
cys
gly
lys
fraction
flow rate
Prior art date
Application number
FI904789A
Other languages
English (en)
Finnish (fi)
Other versions
FI904789A0 (sv
FI96865C (sv
Inventor
Robert A Volkmann
Douglas Phillips
Nicholas A Saccomano
Original Assignee
Pfizer
Natural Product Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer, Natural Product Sciences Inc filed Critical Pfizer
Publication of FI904789A0 publication Critical patent/FI904789A0/sv
Priority to FI951573A priority Critical patent/FI951573A/sv
Publication of FI96865B publication Critical patent/FI96865B/sv
Application granted granted Critical
Publication of FI96865C publication Critical patent/FI96865C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y10S530/858—Proteins from animals other than mammals or birds insects; venom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Insects & Arthropods (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI904789A 1989-09-29 1990-09-28 Förfarande för framställning av en terapeutiskt användbar, väsentligen ren polypeptid FI96865C (sv)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI951573A FI951573A (sv) 1989-09-29 1995-04-03 Polypeptid användbar vid kontrollering av ryggradslösa skadedjur

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/415,139 US5122596A (en) 1989-09-29 1989-09-29 Polypeptides useful as blockers of calcium channels
US41513989 1989-09-29

Publications (3)

Publication Number Publication Date
FI904789A0 FI904789A0 (sv) 1990-09-28
FI96865B true FI96865B (sv) 1996-05-31
FI96865C FI96865C (sv) 1996-09-10

Family

ID=23644517

Family Applications (1)

Application Number Title Priority Date Filing Date
FI904789A FI96865C (sv) 1989-09-29 1990-09-28 Förfarande för framställning av en terapeutiskt användbar, väsentligen ren polypeptid

Country Status (27)

Country Link
US (1) US5122596A (sv)
EP (1) EP0425096B1 (sv)
JP (1) JPH0692440B2 (sv)
KR (1) KR930007435B1 (sv)
CN (1) CN1033976C (sv)
AT (1) ATE103611T1 (sv)
AU (1) AU626203B2 (sv)
CA (1) CA2026418C (sv)
CZ (1) CZ283651B6 (sv)
DD (1) DD297652A5 (sv)
DE (1) DE69007739T2 (sv)
DK (1) DK0425096T3 (sv)
EG (1) EG19316A (sv)
ES (1) ES2053118T3 (sv)
FI (1) FI96865C (sv)
HU (1) HU208705B (sv)
IE (1) IE64218B1 (sv)
IL (1) IL95765A (sv)
MY (1) MY106832A (sv)
NO (1) NO175208C (sv)
NZ (1) NZ235496A (sv)
PH (1) PH27403A (sv)
PL (1) PL164541B1 (sv)
PT (1) PT95424B (sv)
RU (1) RU2026866C1 (sv)
YU (1) YU184490A (sv)
ZA (1) ZA907782B (sv)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925664A (en) * 1986-10-20 1990-05-15 University Of Utah Spider toxins and methods for their use as blockers of calcium channels and amino acid receptor function
US5677288A (en) * 1991-05-15 1997-10-14 Cypros Pharmaceutical Corporation Use of aminoglycosides to protect against excitotoxic neuron damage
US5763568A (en) * 1992-01-31 1998-06-09 Zeneca Limited Insecticidal toxins derived from funnel web (atrax or hadronyche) spiders
GB9208110D0 (en) * 1992-04-13 1992-05-27 Isis Innovation Assay for antibodies that bind calcium channels
JP2571197B2 (ja) * 1992-07-27 1997-01-16 ファイザー インク． アゲレノプシス・アペルタ由来のカルシウムチャンネル阻害ポリペプチド
WO1994015960A1 (en) * 1993-01-07 1994-07-21 Eisai Co., Ltd. Peptide with glutamate liberation inhibitor and calcium channel inhibitor activities
ES2075796B1 (es) * 1993-08-17 1996-03-01 Pfizer Polipeptido de la agelenopsis aperta bloqueante de los canales de ca lcio
JP2792518B2 (ja) * 1994-01-19 1998-09-03 ファイザー・インコーポレーテッド ゲオリコサ・リオグランデからの孔形成ペプチド
US5512592A (en) * 1994-09-09 1996-04-30 Wake Forest University Method of producing cardiotonic effect and improving cardiac contractile function by administration of carnosine
US5776896A (en) * 1996-01-03 1998-07-07 Zeneca Limited Analgesic peptides from venom of grammostola spatulata and use thereof
US5756663A (en) * 1996-01-03 1998-05-26 Zeneca Limited Antiarrhythmic peptide from venom of spider Grammostola spatulata
WO1998036743A1 (en) * 1997-02-21 1998-08-27 Cypros Pharmaceutical Corporation Neuroprotective poly-guanidino compounds which block presynaptic n and p/q calcium channels
JP2006056805A (ja) * 2004-08-18 2006-03-02 Senmi Ekisu Co Ltd カルシウムチャンネル阻害剤
US8299211B2 (en) * 2005-09-30 2012-10-30 The Board Of Trustees Of The University Of Illinois Peptides and regulation of calcium channels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925664A (en) * 1986-10-20 1990-05-15 University Of Utah Spider toxins and methods for their use as blockers of calcium channels and amino acid receptor function
US4950739A (en) * 1988-02-10 1990-08-21 New York University Membrane calcium channels and factors and methods for blocking, isolating and purifying calcium channels
IL92819A0 (en) * 1988-12-23 1990-09-17 Merrell Dow Pharma Polypeptides isolated from the venom of the spider hololena curta
DD298412A5 (de) * 1989-04-28 1992-02-20 ������@���Kk�� Verfahren zur herstellung von polypeptiden, die geeignet sind als antagonisten exzitatorischer aminosaeure-neurotransmitter und/oder blocker der calciumkanaele

Also Published As

Publication number Publication date
NO904251L (no) 1991-04-02
DE69007739D1 (de) 1994-05-05
EP0425096B1 (en) 1994-03-30
DK0425096T3 (da) 1994-05-02
MY106832A (en) 1995-07-31
HUT55036A (en) 1991-04-29
NZ235496A (en) 1991-12-23
KR930007435B1 (ko) 1993-08-10
ZA907782B (en) 1992-05-27
IL95765A0 (en) 1991-06-30
YU184490A (sh) 1993-05-28
US5122596A (en) 1992-06-16
ES2053118T3 (es) 1994-07-16
CA2026418A1 (en) 1991-03-30
CN1033976C (zh) 1997-02-05
JPH03120299A (ja) 1991-05-22
JPH0692440B2 (ja) 1994-11-16
PL164541B1 (pl) 1994-08-31
PT95424B (pt) 1998-06-30
KR910006326A (ko) 1991-04-29
NO904251D0 (no) 1990-09-28
FI904789A0 (sv) 1990-09-28
HU906267D0 (en) 1991-03-28
DE69007739T2 (de) 1994-07-07
CN1051182A (zh) 1991-05-08
AU626203B2 (en) 1992-07-23
PL287113A1 (en) 1991-09-09
RU2026866C1 (ru) 1995-01-20
HU208705B (en) 1993-12-28
FI96865C (sv) 1996-09-10
PH27403A (en) 1993-06-21
CA2026418C (en) 1996-09-24
CZ470790A3 (cs) 1998-02-18
AU6366090A (en) 1991-04-11
CZ283651B6 (cs) 1998-05-13
NO175208B (sv) 1994-06-06
IE64218B1 (en) 1995-07-26
EP0425096A1 (en) 1991-05-02
IL95765A (en) 1995-07-31
PT95424A (pt) 1991-05-22
EG19316A (en) 1994-12-30
DD297652A5 (de) 1992-01-16
NO175208C (no) 1994-09-14
IE903491A1 (en) 1991-04-10
ATE103611T1 (de) 1994-04-15

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BB Publication of examined application
FG Patent granted

Owner name: NATURAL PRODUCT SCIENCES, INC.

Owner name: PFIZER INC.