FI96686B - Förfarande för framställning av farmakologiskt aktiva bensofusionerad-N-haltiga heterocykelderivat - Google Patents
Förfarande för framställning av farmakologiskt aktiva bensofusionerad-N-haltiga heterocykelderivat Download PDFInfo
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- FI96686B FI96686B FI900553A FI900553A FI96686B FI 96686 B FI96686 B FI 96686B FI 900553 A FI900553 A FI 900553A FI 900553 A FI900553 A FI 900553A FI 96686 B FI96686 B FI 96686B
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- methyl
- azabicyclo
- oct
- compound
- endo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Indole Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Hydrogenated Pyridines (AREA)
Claims (6)
1. Förfarande för framställning av farmakologiskt aktiva bensofusionerad-N-haltiga heterocykelderivat med den allmänna 5 formeln (I) R ^ I ,νγ\
10 I 1/¾ (I) \c- X - Y II o 15 där R är H- eller ^.4 alkyl; R! och R2 är H, halogen, Cx_4 alkyl, alkoxi, hydroxi, cyano, karbamoyl; R3 är H, C^-4 alkyl, fenyl eller den är inte närvarande;
20 O / A är CO, C = S eller S ; \ O B är kväve, dä grupp R3 inte är närvarande och D-B-bindning är en enkel bindning, eller den är koi; /··. 25 D är CO, CH2-CH2, CH - R4, dä B-D-bindning är en enkel bind- • · ning, eller D är C-R, dä D-B-bindning är en dubbelbindning, där # R4 är H, Cx_4 alkyl, fenyl, hydroxi; I · 9 X är syre, N-R eller den är inte närvarande; . Y är en av följande basiska grupp: t : : ... 30 * · · • · · « 1 « I « « • I i' : « 1 t * * * :;·: 35 * ... . * 57 96686 -(CH2>„-< a) ^Rv 5 10 'Pk I ich2)0 15 (chj < β c) W R6 20 där n är 2 eller 3; p är 0 eller 1 samtidigt eller inte; q är : ' ' 0, 2 eller 3; Rg och R7 är oberoende av varandra H, C-j^ alkyl, : bensyl tai, Rg kan vara -C = N - R, där R8 är H, 1 1 .-. 25 R8 Ml t**·. eller amino och deras alia optiska isomerer, tautomerera former Ml och blandningar och deras syraadditionssalter, innersalter eller kvaternära derivat, kännetecknat därav, att a) en förening med den allmänna formeln (II) • ♦ « « * · _ _ ·.. 30 t · · • · · ♦ R Kj I . 3s *>4- ll i/R= (II) 58 96686 där R, R1# R2, R3, A, B och D avser det samma som ovan, som pä förhand är aktiverad med ett aktiveringsmedel tili ett reaktivt derivat med den allmänna formeln (IV) 5 R ^ 1 Ri--I l/R) „© (IV) ^ Ä /B' rs M 10 0 där M är en metallatom vald bland litium, natrium eller kalium, omsätts med en förening med formeln (III) 15 O Q - C - X - Y (I11^ 20 där X och Y avser det samma som ovan och Q är en avgäende ’ grupp, i ett aprotiskt losningsmedel vid en temperatur mellan - 50°C och rumstemperatur, .***: 25 b) dä B är koi och X är syre eller N - R, omsätts en förening j**'. med formeln (V) » « · • · · % 30 Ri— I l/R, (v) ks, JK. Λ ,. D 'Nt-Q Il : . . 0 ,: 35 59 96686 där R, R1, R2, R3, A och D avser det samma som ovan och Q är hydroxyl eller ovan definierad, med en förening med formeln (VI) 5 H - X - Y (VI) där X och Y avser det samma som ovan eller 10 c) dä B är kväve, R är väte och gruppen R3 inte är närvarande, en förening med den allmänna formeln (VII) 15 _ ' I (VII) Ri Γ" I - nh-c-x-y II o 20 där Rlf R2, D, X och Y avser det samma som ovan, omsätts med en :' ' 1 förening med den allmänna formeln (VII)
25 O *...· Il Γ"! Q, - C - Q, <VIII) t«· 1 2 i»< t : : « • · » • « · 30 där Qn och Q2/ som sinsemellan är identiska eller olika, är • » · f « * *. avgäende grupper, i ett aprotiskt lösningsmedel och eventuell i , närvaro av en syraacceptor vid en temperatur mellan 20°C och 100°C. ,·. : 35 2. Förfarande enligt patentkravet 1, kännetecknat därav, att den framställda föreningen är: 60 96686 1.4- dihydro-2(H)-2-oxo-3-kinazolinkarboxylsyra-(endo-8-metyl-8-azabicyklo[3.2.1]okt-3-yl), ester N-(endo-8-metyl-8-azabicyklo[3.2.1]okt-3-yl)-1,4-dihydro-2(H)-2-oxo-kinazolin-3-karboxamid 5 7-klor-l,4-dihydro-2(H)-2-oxo-3-kinazolinkarboxylsyra-(endo-8-metyl-8-azabicyklo[3.2.1]okt-3-yl), ester 1.4- dihydro-6-flour-2(H)-2-oxo-3-kinazolinkarboxylsyra-(endo-8-metyl-8-azabicyklo[3.2.1]okt-3-yl), ester 1.4- dihydro-8-hydroxi-2(H)-2-oxo-3-kinazolinkarboxylsyra-(endo-10 8-metyl-8-azabicyklo[3.2.1]okt-3-yl), ester ja deras fysiologiskt godtagbara syraadditionssalter. «*· • · • · » · · ·* « • · • i« 14» t i : i « • · · « · « • · · »I» • · · • · · « 0 I *
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1931689 | 1989-02-06 | ||
IT8919316A IT1228293B (it) | 1989-02-06 | 1989-02-06 | Benzoderivati di composti eterociclici contenenti azoto. |
Publications (3)
Publication Number | Publication Date |
---|---|
FI900553A0 FI900553A0 (sv) | 1990-02-05 |
FI96686B true FI96686B (sv) | 1996-04-30 |
FI96686C FI96686C (sv) | 1996-08-12 |
Family
ID=11156671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI900553A FI96686C (sv) | 1989-02-06 | 1990-02-05 | Förfarande för framställning av farmakologiskt aktiva bensofusionerad-N-haltiga heterocykelderivat |
Country Status (23)
Country | Link |
---|---|
US (1) | US5106851A (sv) |
EP (1) | EP0382687B1 (sv) |
JP (1) | JPH03197462A (sv) |
KR (1) | KR900012919A (sv) |
AT (1) | ATE132140T1 (sv) |
AU (1) | AU623733B2 (sv) |
CA (1) | CA2009300A1 (sv) |
CZ (1) | CZ277886B6 (sv) |
DE (1) | DE69024381T2 (sv) |
DK (1) | DK0382687T3 (sv) |
ES (1) | ES2081966T3 (sv) |
FI (1) | FI96686C (sv) |
GR (1) | GR3018549T3 (sv) |
HU (2) | HUT54118A (sv) |
IL (1) | IL93257A (sv) |
IT (1) | IT1228293B (sv) |
MX (1) | MX19368A (sv) |
NO (1) | NO173500C (sv) |
PL (1) | PL162682B1 (sv) |
PT (1) | PT93066B (sv) |
RU (1) | RU2040524C1 (sv) |
YU (1) | YU21590A (sv) |
ZA (1) | ZA90825B (sv) |
Families Citing this family (29)
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GB2236751B (en) * | 1989-10-14 | 1993-04-28 | Wyeth John & Brother Ltd | Heterocyclic compounds |
HU211081B (en) * | 1990-12-18 | 1995-10-30 | Sandoz Ag | Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same |
JPH0692948A (ja) * | 1992-03-04 | 1994-04-05 | Snow Brand Milk Prod Co Ltd | 新規なアセタミド誘導体及びその用途 |
JP2699794B2 (ja) * | 1992-03-12 | 1998-01-19 | 三菱化学株式会社 | チエノ〔3,2−b〕ピリジン誘導体 |
JPH05310732A (ja) * | 1992-03-12 | 1993-11-22 | Mitsubishi Kasei Corp | シンノリン−3−カルボン酸誘導体 |
EP0670319A4 (en) * | 1992-11-20 | 1996-01-17 | Thaisho Pharmaceutical Co Ltd | HETEROCYCLIC COMPOUNDS. |
US5340826A (en) * | 1993-02-04 | 1994-08-23 | Pfizer Inc. | Pharmaceutical agents for treatment of urinary incontinence |
CA2184366A1 (en) * | 1994-02-28 | 1995-08-31 | Yutaka Ohuchi | Heterocyclic compound |
JP3829879B2 (ja) * | 1994-05-18 | 2006-10-04 | 大正製薬株式会社 | キノリンカルボン酸誘導体 |
AU708112B2 (en) * | 1994-08-25 | 1999-07-29 | University Of Virginia | 7-azabicyclo{2.2.1}-heptane and -heptene derivatives as cholinergic receptor ligands |
IL128096A0 (en) * | 1996-07-29 | 1999-11-30 | Pharmacia & Upjohn Ab | Arylcycloalkane carboxylic esters their use pharmaceutical compositions and preparation |
MXPA02005070A (es) * | 1999-11-18 | 2003-09-25 | Antexpharma Inc | 1-benzazepinas sustituidas y derivados de las mismas. |
FR2801310B1 (fr) * | 1999-11-24 | 2004-04-16 | Adir | NOUVEAUX DERIVES DE DIHYDROFURO-[3,4-b]QUINOLEIN-1-ONES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT |
US6451813B1 (en) | 2001-01-26 | 2002-09-17 | R. T. Alamo Ventures I, Llc | Treatment of gastroparesis in certain patient groups |
EP1401830A2 (en) * | 2001-06-19 | 2004-03-31 | Warner-Lambert Company LLC | Quinazolinediones as antibacterial agents |
WO2003091224A1 (fr) * | 2002-04-26 | 2003-11-06 | Nippon Shinyaku Co., Ltd. | Derive et medicament de quinazoline |
DE10255040A1 (de) * | 2002-11-26 | 2004-06-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Carbaminsäureester mit anticholinerger Wirksamkeit |
CA2545092C (en) * | 2003-11-24 | 2010-08-17 | Pfizer Inc. | Quinolonecarboxylic acid compounds having 5-ht4 receptor agonistic activity |
NZ584773A (en) * | 2004-09-17 | 2012-07-27 | Whitehead Biomedical Inst | Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity |
CN104193741B (zh) * | 2007-10-01 | 2016-08-24 | 阿尔法梅根有限责任公司 | 作为α7-烟碱乙酰胆碱受体配体的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物 |
US9145396B2 (en) | 2008-12-01 | 2015-09-29 | Targacept, Inc. | Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine |
HUE047888T2 (hu) * | 2011-03-18 | 2020-05-28 | Genzyme Corp | Glükozilceramid-szintáz-inhibitor |
MA37975B2 (fr) | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
WO2016007630A1 (en) | 2014-07-11 | 2016-01-14 | Alpharmagen, Llc | Quinuclidine compounds for modulating alpha7 -nicotinic acetylcholine receptor activity |
US11377452B2 (en) | 2017-01-16 | 2022-07-05 | Drexel University | Glutamate transporter activators and methods using same |
WO2021156769A1 (en) | 2020-02-03 | 2021-08-12 | Genzyme Corporation | Methods for treating neurological symptoms associated with lysosomal storage diseases |
JP2023534322A (ja) | 2020-07-24 | 2023-08-09 | ジェンザイム・コーポレーション | ベングルスタットを含む医薬組成物 |
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US4599336A (en) * | 1983-08-08 | 1986-07-08 | Hoffmann-La Roche Inc. | Derivatives of (E)-3-(4-oxo-4H-quinazolin-3-yl)-2-propenamide |
DE3429830A1 (de) * | 1983-08-26 | 1985-03-07 | Sandoz-Patent-GmbH, 7850 Lörrach | Automatische carbonsaeure- und sulfonsaeureester oder -amide |
US4849513A (en) * | 1983-12-20 | 1989-07-18 | California Institute Of Technology | Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups |
GB8623142D0 (en) * | 1986-09-26 | 1986-10-29 | Beecham Group Plc | Compounds |
DK623586A (da) * | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
JPS6463518A (en) * | 1987-09-02 | 1989-03-09 | Otsuka Pharma Co Ltd | Antiarrhythmic agent |
-
1989
- 1989-02-06 IT IT8919316A patent/IT1228293B/it active
-
1990
- 1990-01-24 CZ CS90335A patent/CZ277886B6/cs unknown
- 1990-02-02 MX MX1936890A patent/MX19368A/es unknown
- 1990-02-02 US US07/474,187 patent/US5106851A/en not_active Expired - Fee Related
- 1990-02-02 IL IL9325790A patent/IL93257A/en not_active IP Right Cessation
- 1990-02-05 HU HU90671A patent/HUT54118A/hu unknown
- 1990-02-05 PT PT93066A patent/PT93066B/pt not_active IP Right Cessation
- 1990-02-05 ES ES90830040T patent/ES2081966T3/es not_active Expired - Lifetime
- 1990-02-05 FI FI900553A patent/FI96686C/sv not_active IP Right Cessation
- 1990-02-05 EP EP90830040A patent/EP0382687B1/en not_active Expired - Lifetime
- 1990-02-05 KR KR1019900001319A patent/KR900012919A/ko not_active Application Discontinuation
- 1990-02-05 AT AT90830040T patent/ATE132140T1/de not_active IP Right Cessation
- 1990-02-05 JP JP2025889A patent/JPH03197462A/ja active Pending
- 1990-02-05 YU YU21590A patent/YU21590A/sh unknown
- 1990-02-05 PL PL28364290A patent/PL162682B1/pl unknown
- 1990-02-05 NO NO900542A patent/NO173500C/no unknown
- 1990-02-05 CA CA002009300A patent/CA2009300A1/en not_active Abandoned
- 1990-02-05 DE DE69024381T patent/DE69024381T2/de not_active Expired - Fee Related
- 1990-02-05 AU AU49086/90A patent/AU623733B2/en not_active Ceased
- 1990-02-05 DK DK90830040.3T patent/DK0382687T3/da active
- 1990-02-05 ZA ZA90825A patent/ZA90825B/xx unknown
-
1992
- 1992-05-08 RU SU925011529A patent/RU2040524C1/ru active
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1994
- 1994-11-21 HU HU94P/P00048P patent/HU210348A9/hu unknown
-
1995
- 1995-12-28 GR GR950403474T patent/GR3018549T3/el unknown
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Date | Code | Title | Description |
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FG | Patent granted |
Owner name: BOEHRINGER INGELHEIM ITALIA S.P.A |
|
BB | Publication of examined application | ||
MM | Patent lapsed | ||
MM | Patent lapsed |
Owner name: BOEHRINGER INGELHEIM ITALIA S.P.A. |