FI964624A - Menetelmä duokarmysiinijohdannaisten stabiloimiseksi - Google Patents

Menetelmä duokarmysiinijohdannaisten stabiloimiseksi Download PDF

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Publication number
FI964624A
FI964624A FI964624A FI964624A FI964624A FI 964624 A FI964624 A FI 964624A FI 964624 A FI964624 A FI 964624A FI 964624 A FI964624 A FI 964624A FI 964624 A FI964624 A FI 964624A
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FI
Finland
Prior art keywords
pct
duocarmycin derivatives
stabilizing
sec
image
Prior art date
Application number
FI964624A
Other languages
English (en)
Swedish (sv)
Other versions
FI964624A0 (fi
Inventor
Masashi Nakakura
Yuji Ueno
Eiji Hayakawa
Tokuyuki Kuroda
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Publication of FI964624A publication Critical patent/FI964624A/fi
Publication of FI964624A0 publication Critical patent/FI964624A0/fi

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
FI964624A 1994-05-20 1996-11-19 Menetelmä duokarmysiinijohdannaisten stabiloimiseksi FI964624A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6106415A JPH07309761A (ja) 1994-05-20 1994-05-20 デュオカルマイシン誘導体の安定化法
PCT/JP1995/000962 WO1995031971A1 (en) 1994-05-20 1995-05-19 Method for stabilizing duocarmycin derivatives

Publications (2)

Publication Number Publication Date
FI964624A true FI964624A (fi) 1996-11-19
FI964624A0 FI964624A0 (fi) 1996-11-19

Family

ID=14433044

Family Applications (1)

Application Number Title Priority Date Filing Date
FI964624A FI964624A0 (fi) 1994-05-20 1996-11-19 Menetelmä duokarmysiinijohdannaisten stabiloimiseksi

Country Status (17)

Country Link
US (1) US5703080A (fi)
EP (1) EP0754030B1 (fi)
JP (1) JPH07309761A (fi)
CN (1) CN1148805A (fi)
AT (1) ATE198149T1 (fi)
AU (1) AU2455195A (fi)
BR (1) BR9507640A (fi)
CA (1) CA2190635A1 (fi)
CZ (1) CZ338696A3 (fi)
DE (1) DE69519667T2 (fi)
FI (1) FI964624A0 (fi)
HU (1) HUT78072A (fi)
NO (1) NO964813L (fi)
NZ (1) NZ285450A (fi)
PL (1) PL317229A1 (fi)
SK (1) SK148496A3 (fi)
WO (1) WO1995031971A1 (fi)

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US7714016B2 (en) 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
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Family Cites Families (7)

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US5084468A (en) * 1988-08-11 1992-01-28 Kyowa Hakko Kogyo Co., Ltd. Dc-88a derivatives
JP2510335B2 (ja) * 1989-07-03 1996-06-26 協和醗酵工業株式会社 Ｄｃ―８８ａ誘導体
KR910014122A (ko) * 1990-01-19 1991-08-31 디께다 가즈히꼬 에토포시드-2-디메틸아미노 화합물의 동결건조 제제
US5214065A (en) * 1990-06-11 1993-05-25 Kyowa Hakko Kogyo Co., Ltd. Dc-89 derivatives
JPH0669954B2 (ja) * 1990-12-07 1994-09-07 吉富製薬株式会社 抗腫瘍組成物
EP0499130A1 (en) * 1991-02-15 1992-08-19 Kyowa Hakko Kogyo Co., Ltd. DC-89 derivatives
JP3608802B2 (ja) * 1991-09-20 2005-01-12 第一サントリーファーマ株式会社 安定なカルシトニン医薬組成物及びその製造法

Also Published As

Publication number Publication date
AU2455195A (en) 1995-12-18
HU9603521D0 (en) 1997-03-28
PL317229A1 (en) 1997-03-17
CN1148805A (zh) 1997-04-30
EP0754030B1 (en) 2000-12-20
NO964813D0 (no) 1996-11-13
WO1995031971A1 (en) 1995-11-30
CZ338696A3 (en) 1997-05-14
HUT78072A (hu) 1999-08-30
JPH07309761A (ja) 1995-11-28
MX9605694A (es) 1998-05-31
SK148496A3 (en) 1997-06-04
ATE198149T1 (de) 2001-01-15
US5703080A (en) 1997-12-30
NO964813L (no) 1996-11-13
BR9507640A (pt) 1997-08-19
DE69519667T2 (de) 2001-04-26
CA2190635A1 (en) 1995-11-30
FI964624A0 (fi) 1996-11-19
EP0754030A1 (en) 1997-01-22
NZ285450A (en) 1997-02-24
DE69519667D1 (de) 2001-01-25

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