MX9605694A - Metodo para estabilizar derivados de duocarmicina. - Google Patents
Metodo para estabilizar derivados de duocarmicina.Info
- Publication number
- MX9605694A MX9605694A MX9605694A MX9605694A MX9605694A MX 9605694 A MX9605694 A MX 9605694A MX 9605694 A MX9605694 A MX 9605694A MX 9605694 A MX9605694 A MX 9605694A MX 9605694 A MX9605694 A MX 9605694A
- Authority
- MX
- Mexico
- Prior art keywords
- duocarmycin derivatives
- stabilizing
- duocarmycin
- stabilized
- derivatives
- Prior art date
Links
- VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical class COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 title abstract 4
- 230000000087 stabilizing effect Effects 0.000 title 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003792 electrolyte Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000005846 sugar alcohols Polymers 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 229920003169 water-soluble polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Detergent Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Derivados de duocarmicina estabilizados representados por la formula (I): en la que R es alquilo inferior, alilo o bencilo y X es Cl o Br se preparan agregando por lo menos un compuesto seleccionado del grupo que consiste de un sacárido, un electrolito, un polímero soluble en agua, un alcohol polihidrico y un tensioactivo a una solucion que contiene los derivados de duocarmicina. También se proporcionan preparaciones farmacéuticas liofilizadas que contienen los derivados de duocarmicina estabilizados.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6106415A JPH07309761A (ja) | 1994-05-20 | 1994-05-20 | デュオカルマイシン誘導体の安定化法 |
| JP6/106415 | 1994-05-20 | ||
| JP6-106415 | 1994-05-20 | ||
| PCT/JP1995/000962 WO1995031971A1 (en) | 1994-05-20 | 1995-05-19 | Method for stabilizing duocarmycin derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9605694A true MX9605694A (es) | 1998-05-31 |
| MXPA96005694A MXPA96005694A (es) | 1998-10-23 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| EP0754030B1 (en) | 2000-12-20 |
| NZ285450A (en) | 1997-02-24 |
| WO1995031971A1 (en) | 1995-11-30 |
| BR9507640A (pt) | 1997-08-19 |
| ATE198149T1 (de) | 2001-01-15 |
| PL317229A1 (en) | 1997-03-17 |
| EP0754030A1 (en) | 1997-01-22 |
| DE69519667T2 (de) | 2001-04-26 |
| US5703080A (en) | 1997-12-30 |
| FI964624A0 (fi) | 1996-11-19 |
| NO964813D0 (no) | 1996-11-13 |
| HU9603521D0 (en) | 1997-03-28 |
| SK148496A3 (en) | 1997-06-04 |
| DE69519667D1 (de) | 2001-01-25 |
| CA2190635A1 (en) | 1995-11-30 |
| CN1148805A (zh) | 1997-04-30 |
| JPH07309761A (ja) | 1995-11-28 |
| FI964624A (fi) | 1996-11-19 |
| NO964813L (no) | 1996-11-13 |
| HUT78072A (hu) | 1999-08-30 |
| AU2455195A (en) | 1995-12-18 |
| CZ338696A3 (en) | 1997-05-14 |
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