FI962599A0 - Enantioselektiivinen menetelmä kiraalisten triaryylijohdannaisten ja niiden valmistuksessa käytettävien kiraalisten välituotteiden valmistamiseksi - Google Patents
Enantioselektiivinen menetelmä kiraalisten triaryylijohdannaisten ja niiden valmistuksessa käytettävien kiraalisten välituotteiden valmistamiseksiInfo
- Publication number
- FI962599A0 FI962599A0 FI962599A FI962599A FI962599A0 FI 962599 A0 FI962599 A0 FI 962599A0 FI 962599 A FI962599 A FI 962599A FI 962599 A FI962599 A FI 962599A FI 962599 A0 FI962599 A0 FI 962599A0
- Authority
- FI
- Finland
- Prior art keywords
- chiral
- preparation
- intermediates
- enantioselective process
- triaryl derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939326173A GB9326173D0 (en) | 1993-12-22 | 1993-12-22 | Chemical compounds and process |
| PCT/GB1994/002799 WO1995017386A1 (en) | 1993-12-22 | 1994-12-22 | An enantioselective process for the preparation of chiral triaryl derivatives and chiral intermediates for use therein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI962599A7 FI962599A7 (fi) | 1996-06-20 |
| FI962599L FI962599L (fi) | 1996-06-20 |
| FI962599A0 true FI962599A0 (fi) | 1996-06-20 |
Family
ID=10747020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI962599A FI962599A0 (fi) | 1993-12-22 | 1994-12-22 | Enantioselektiivinen menetelmä kiraalisten triaryylijohdannaisten ja niiden valmistuksessa käytettävien kiraalisten välituotteiden valmistamiseksi |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5608070A (cs) |
| EP (1) | EP0736010A1 (cs) |
| JP (1) | JPH09510691A (cs) |
| KR (1) | KR100328191B1 (cs) |
| AU (1) | AU689837B2 (cs) |
| CA (1) | CA2177817A1 (cs) |
| CZ (1) | CZ294296B6 (cs) |
| FI (1) | FI962599A0 (cs) |
| GB (2) | GB9326173D0 (cs) |
| HU (1) | HUT76284A (cs) |
| NZ (1) | NZ277529A (cs) |
| WO (1) | WO1995017386A1 (cs) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9212673D0 (en) * | 1992-06-15 | 1992-07-29 | Celltech Ltd | Chemical compounds |
| GB9222253D0 (en) * | 1992-10-23 | 1992-12-09 | Celltech Ltd | Chemical compounds |
| GB9304919D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| GB9304920D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| GB9326600D0 (en) * | 1993-12-22 | 1994-03-02 | Celltech Ltd | Chemical compounds |
| JP3806144B2 (ja) * | 1993-12-22 | 2006-08-09 | セルテック セラピューティックス リミテッド | 三置換フェニル誘導体、その調製方法とホスホジエステラーゼ（ｉｖ型）阻害剤としてのその使用 |
| US5786354A (en) * | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
| US6245774B1 (en) | 1994-06-21 | 2001-06-12 | Celltech Therapeutics Limited | Tri-substituted phenyl or pyridine derivatives |
| GB9412573D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| GB9412571D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| GB9412672D0 (en) * | 1994-06-23 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| GB9523675D0 (en) * | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| JP3465825B2 (ja) * | 1995-12-15 | 2003-11-10 | メルク フロスト カナダ アンド カンパニー | Ｐｄｅ▲ｉｖ▼阻害剤としてのトリアリールエタン誘導体 |
| GB9603723D0 (en) * | 1996-02-22 | 1996-04-24 | Merck & Co Inc | Diphenyl pyridyl derivatives as pde iv inhibitors |
| US5710170A (en) * | 1995-12-15 | 1998-01-20 | Merck Frosst Canada, Inc. | Tri-aryl ethane derivatives as PDE IV inhibitors |
| GB9526245D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9526243D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9526246D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| AR006550A1 (es) * | 1996-04-17 | 1999-09-08 | Merck & Co Inc | Metodo de preparacion de inhibidores de fosfodiesterasa iv |
| GB9608435D0 (en) * | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
| WO1997042172A1 (en) * | 1996-05-08 | 1997-11-13 | Merck & Co., Inc. | Method of preparing phosphodiesterase iv inhibitors |
| US5808082A (en) * | 1996-05-08 | 1998-09-15 | Merck & Co., Inc. | Method of preparing phosphodiesterase IV inhibitors |
| GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
| DE69712631D1 (de) * | 1996-09-17 | 2002-06-20 | Merck & Co Inc | Verfahren zur herstellung von phosphodiesterase iv inhibitoren |
| TW508353B (en) * | 1996-09-17 | 2002-11-01 | Merck & Co Inc | Method of preparing phosphodiesterase IV inhibitors |
| WO1998012340A1 (en) * | 1996-09-17 | 1998-03-26 | Merck & Co., Inc. | Process for bioreduction of bisaryl ketone to bisaryl alcohol |
| US5900368A (en) * | 1996-09-17 | 1999-05-04 | Merck & Co., Inc. | Process for bioreduction of bisaryl ketone to bisaryl alcohol |
| GB9622363D0 (en) * | 1996-10-28 | 1997-01-08 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9625184D0 (en) * | 1996-12-04 | 1997-01-22 | Celltech Therapeutics Ltd | Chemical compounds |
| US6057329A (en) * | 1996-12-23 | 2000-05-02 | Celltech Therapeutics Limited | Fused polycyclic 2-aminopyrimidine derivatives |
| GB9705361D0 (en) | 1997-03-14 | 1997-04-30 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9713087D0 (en) * | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
| JP2002504529A (ja) | 1998-02-27 | 2002-02-12 | ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンティッド バイ ザ シークレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 二置換ラベンダスティンａ類似体およびこれらの類似体を含む薬学的組成物 |
| US6316434B1 (en) | 1999-03-03 | 2001-11-13 | Merck Frosst Canada & Co. | Assay for emetic activity |
| US6200993B1 (en) * | 1999-05-05 | 2001-03-13 | Merck Frosst Canada & Co. | Heterosubstituted pyridine derivatives as PDE4 inhibitors |
| US6316472B1 (en) | 1999-05-13 | 2001-11-13 | Merck Frosst Canada & Co. | Heterosubstituted pyridine derivatives as PDE 4 inhibitors |
| GB9914258D0 (en) | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
| WO2001024763A2 (en) | 1999-10-01 | 2001-04-12 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| GB9924862D0 (en) | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
| US6410563B1 (en) | 1999-12-22 | 2002-06-25 | Merck Frosst Canada & Co. | Substituted 8-arylquinoline phosphodiesterase-4 inhibitors |
| MY123585A (en) * | 2000-03-23 | 2006-05-31 | Merck Canada Inc | Tri-aryl-substituted-ethane pde4 inhibitors. |
| US6639077B2 (en) | 2000-03-23 | 2003-10-28 | Merck Frosst Canada & Co. | Tri-aryl-substituted-ethane PDE4 inhibitors |
| CA2407780A1 (en) | 2000-05-25 | 2001-11-29 | Merck Frosst Canada & Co./Merck Frosst Canada & Cie | Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor |
| US6740666B2 (en) | 2000-12-20 | 2004-05-25 | Merck & Co., Inc. | Substituted 8-arylquinoline phosphodiesterase-4 inhibitors |
| JP4460221B2 (ja) | 2001-05-24 | 2010-05-12 | メルク フロスト カナダ リミテツド | １−ビアリール−１，８−ナフチリジン−４−オン系ホスホジエステラーゼ−４阻害薬 |
| WO2002096888A1 (de) * | 2001-05-29 | 2002-12-05 | Schering Aktiengesellschaft | Cdk inhibitorische pyrimidine, deren herstellung und verwendung als arzneimittel |
| JO2311B1 (en) | 2001-08-29 | 2005-09-12 | ميرك فروست كندا ليمتد | Alkyl inhibitors Ariel phosphodiesterase-4 |
| JP4621198B2 (ja) * | 2003-02-11 | 2011-01-26 | プロシディオン・リミテッド | トリ（シクロ）置換アミドグルコキナーゼ活性化化合物 |
| EP1928437A2 (en) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | アンジオテンシン調節による神経新生 |
| JP2010502722A (ja) | 2006-09-08 | 2010-01-28 | ブレインセルス，インコーポレイティド | ４−アシルアミノピリジン誘導体を含む組み合わせ |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2257272B1 (cs) * | 1974-01-15 | 1978-08-25 | Pharmascience Labo | |
| DE2413935A1 (de) * | 1974-03-20 | 1975-10-16 | Schering Ag | 4-(polyalkoxy-phenyl)-2-pyrrolidone |
| US4193926A (en) * | 1974-03-20 | 1980-03-18 | Schering Aktiengesellschaft | 4-(Polyalkoxy phenyl)-2-pyrrolidones |
| DE2541855A1 (de) * | 1975-09-18 | 1977-03-31 | Schering Ag | 4-(polyalkoxy-phenyl)-2-pyrrolidone ii |
| SU888821A3 (ru) * | 1976-12-03 | 1981-12-07 | Шеринг Аг (Инофирма) | Способ получени 5-(замещенный фенил)-оксазолидинонов или их серусодержащих аналогов |
| EP0006298B1 (en) * | 1978-06-15 | 1982-03-31 | Imperial Chemical Industries Plc | Anti-inflammatory 1-phenyl-2-aminoethanol derivatives, pharmaceutical compositions thereof for topical use, and processes for their manufacture |
| WO1987006576A1 (en) * | 1986-04-29 | 1987-11-05 | Pfizer Inc. | Calcium independent camp phosphodiesterase inhibitor antidepressant |
| US5128358A (en) * | 1988-01-19 | 1992-07-07 | Pfizer Inc. | Aryl substituted nitrogen heterocyclic antidepressants |
| US4921862A (en) * | 1986-05-29 | 1990-05-01 | Syntex (U.S.A.) Inc. | Carbostyril derivatives as combined thromboxane synthetase and cyclic-amp phosphodiesterase inhibitors |
| US4792561A (en) * | 1986-05-29 | 1988-12-20 | Syntex (U.S.A.) Inc. | Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors |
| US4971959A (en) * | 1987-04-14 | 1990-11-20 | Warner-Lambert Company | Trisubstituted phenyl analogs having activity for congestive heart failure |
| US5274002A (en) * | 1987-04-14 | 1993-12-28 | Warner-Lambert Company | Trisubstituted phenyl analogs having activity for congestive heart failure |
| DK0469013T3 (da) * | 1989-04-17 | 1995-10-02 | Byk Gulden Lomberg Chem Fab | Hidtil ukendte arylpyridaziner, fremstilling deraf, anvendelse deraf og lægemidler indeholdende disse |
| DE4003919A1 (de) * | 1990-02-09 | 1991-08-14 | Basf Ag | Heteroarylalkene, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung |
| GB9007762D0 (en) * | 1990-04-05 | 1990-06-06 | Beecham Group Plc | Novel compounds |
| WO1991016892A1 (en) * | 1990-04-27 | 1991-11-14 | Rorer International (Holdings), Inc. | Styryl compounds which inhibit egf receptor protein tyrosine kinase |
| ZW9091A1 (en) * | 1990-07-10 | 1992-04-29 | Smithkline Beecham Corp | Oxamides |
| US5124455A (en) * | 1990-08-08 | 1992-06-23 | American Home Products Corporation | Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents |
| JPH06501254A (ja) * | 1990-09-28 | 1994-02-10 | スミス・クライン・アンド・フレンチ・ラボラトリース・リミテッド | 医薬用フェニルピリジノール誘導体 |
| JPH06501941A (ja) * | 1990-10-16 | 1994-03-03 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | アリールピリダジノン |
| IE913855A1 (en) * | 1990-11-06 | 1992-05-22 | Smithkline Beecham Corp | Imidazolidinone compounds |
| GB9027055D0 (en) * | 1990-12-13 | 1991-02-06 | Sandoz Ltd | Organic compounds |
| IE71647B1 (en) * | 1991-01-28 | 1997-02-26 | Rhone Poulenc Rorer Ltd | Benzamide derivatives |
| EP0581805A1 (de) * | 1991-04-26 | 1994-02-09 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Neue pyridazine |
| US5191084A (en) * | 1991-05-01 | 1993-03-02 | American Home Products Corporation | Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents |
| PT100441A (pt) * | 1991-05-02 | 1993-09-30 | Smithkline Beecham Corp | Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso |
| EP0540165A1 (en) * | 1991-10-03 | 1993-05-05 | Zeneca Limited | Alkanoic acid derivatives |
| CA2080554A1 (en) * | 1991-10-15 | 1993-04-16 | Mitsubishi Chemical Corporation | Styrene derivatives |
| US5326898A (en) * | 1992-02-11 | 1994-07-05 | Allergan, Inc. | Substituted phenylethenyl compounds having retinoid-like biological activity |
| JP3195353B2 (ja) * | 1992-04-02 | 2001-08-06 | スミスクライン・ビーチャム・コーポレイション | 炎症疾患の治療および腫瘍壊死因子の産生阻害に有用な化合物 |
| EP0652868B1 (en) * | 1992-07-28 | 2004-11-10 | Aventis Pharma Limited | INHIBITORS OF c-AMP PHOSPHODIESTERASE |
| PT672031E (pt) * | 1992-12-02 | 2003-06-30 | Pfizer | Dieteres de catecol como inibidores selectivos de pde iv |
| TW263495B (cs) * | 1992-12-23 | 1995-11-21 | Celltech Ltd |
-
1993
- 1993-12-22 GB GB939326173A patent/GB9326173D0/en active Pending
-
1994
- 1994-12-21 US US08/361,439 patent/US5608070A/en not_active Expired - Lifetime
- 1994-12-22 CA CA002177817A patent/CA2177817A1/en not_active Abandoned
- 1994-12-22 GB GB9612213A patent/GB2299082B/en not_active Expired - Lifetime
- 1994-12-22 JP JP7517279A patent/JPH09510691A/ja active Pending
- 1994-12-22 FI FI962599A patent/FI962599A0/fi not_active IP Right Cessation
- 1994-12-22 AU AU12783/95A patent/AU689837B2/en not_active Ceased
- 1994-12-22 EP EP95903885A patent/EP0736010A1/en not_active Withdrawn
- 1994-12-22 CZ CZ19961819A patent/CZ294296B6/cs not_active IP Right Cessation
- 1994-12-22 HU HU9601725A patent/HUT76284A/hu unknown
- 1994-12-22 WO PCT/GB1994/002799 patent/WO1995017386A1/en active IP Right Grant
- 1994-12-22 NZ NZ277529A patent/NZ277529A/en not_active IP Right Cessation
- 1994-12-22 KR KR1019960703333A patent/KR100328191B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| GB9326173D0 (en) | 1994-02-23 |
| GB9612213D0 (en) | 1996-08-14 |
| FI962599A7 (fi) | 1996-06-20 |
| HUT76284A (en) | 1997-07-28 |
| GB2299082A (en) | 1996-09-25 |
| AU1278395A (en) | 1995-07-10 |
| CZ181996A3 (en) | 1997-02-12 |
| JPH09510691A (ja) | 1997-10-28 |
| HU9601725D0 (en) | 1996-08-28 |
| FI962599L (fi) | 1996-06-20 |
| EP0736010A1 (en) | 1996-10-09 |
| CA2177817A1 (en) | 1995-06-29 |
| GB2299082B (en) | 1998-06-17 |
| CZ294296B6 (cs) | 2004-11-10 |
| US5608070A (en) | 1997-03-04 |
| NZ277529A (en) | 1998-03-25 |
| AU689837B2 (en) | 1998-04-09 |
| WO1995017386A1 (en) | 1995-06-29 |
| KR100328191B1 (ko) | 2002-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |