FI961804A - Endoteliinireseptoriantagonistit - Google Patents
Endoteliinireseptoriantagonistit Download PDFInfo
- Publication number
- FI961804A FI961804A FI961804A FI961804A FI961804A FI 961804 A FI961804 A FI 961804A FI 961804 A FI961804 A FI 961804A FI 961804 A FI961804 A FI 961804A FI 961804 A FI961804 A FI 961804A
- Authority
- FI
- Finland
- Prior art keywords
- receptor antagonists
- endothelin receptor
- endothelin
- antagonists
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Crystallography & Structural Chemistry (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93810760 | 1993-11-01 | ||
PCT/EP1994/003418 WO1995012611A1 (fr) | 1993-11-01 | 1994-10-17 | Antagonistes de recepteur d'endotheline |
Publications (2)
Publication Number | Publication Date |
---|---|
FI961804A0 FI961804A0 (fi) | 1996-04-26 |
FI961804A true FI961804A (fi) | 1996-04-30 |
Family
ID=8215056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI961804A FI961804A (fi) | 1993-11-01 | 1996-04-26 | Endoteliinireseptoriantagonistit |
Country Status (12)
Country | Link |
---|---|
US (1) | US5780498A (fr) |
EP (1) | EP0728145A1 (fr) |
JP (1) | JPH09504302A (fr) |
AU (1) | AU691201B2 (fr) |
BR (1) | BR9407933A (fr) |
CA (1) | CA2173875A1 (fr) |
FI (1) | FI961804A (fr) |
IL (1) | IL111431A0 (fr) |
NO (1) | NO961725D0 (fr) |
RU (1) | RU2126418C1 (fr) |
WO (1) | WO1995012611A1 (fr) |
ZA (1) | ZA948541B (fr) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0821670A1 (fr) * | 1995-04-21 | 1998-02-04 | Novartis AG | Amides de n-aroylaminoacide utilises en tant qu'inhibiteurs d'endotheline |
WO1997011960A1 (fr) * | 1995-09-28 | 1997-04-03 | Japat Ltd. | Antagonistes des recepteurs de l'endotheline |
IT1291823B1 (it) * | 1997-04-08 | 1999-01-21 | Menarini Ricerche Spa | Composti pseudo-peptidici, loro preparazione ed uso in formulazioni farmaceutiche |
GB9708119D0 (en) * | 1997-04-22 | 1997-06-11 | Glaxo Group Ltd | Chemical compounds |
US6221888B1 (en) | 1997-05-29 | 2001-04-24 | Merck & Co., Inc. | Sulfonamides as cell adhesion inhibitors |
US6291511B1 (en) | 1997-05-29 | 2001-09-18 | Merck & Co., Inc. | Biarylalkanoic acids as cell adhesion inhibitors |
DE19745146A1 (de) * | 1997-10-14 | 1999-04-15 | Basf Ag | Neue pharmazeutisch wirksame Verbindungen, ihre Herstellung und Verwendung |
GB9723407D0 (en) | 1997-11-05 | 1998-01-07 | Ciba Geigy Ag | Organic compounds |
US6020347A (en) * | 1997-11-18 | 2000-02-01 | Merck & Co., Inc. | 4-substituted-4-piperidine carboxamide derivatives |
US6191171B1 (en) | 1997-11-20 | 2001-02-20 | Merck & Co., Inc. | Para-aminomethylaryl carboxamide derivatives |
US6090841A (en) * | 1997-11-21 | 2000-07-18 | Merck & Co., Inc. | Substituted pyrrole derivatives as cell adhesion inhibitors |
MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
US6423727B1 (en) | 1998-04-23 | 2002-07-23 | Novartis Ag | Certain thiol inhibitors of endothelin-converting enzyme |
US6426354B1 (en) | 1998-04-23 | 2002-07-30 | Novartis Ag | Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme |
PL343594A1 (en) * | 1998-04-23 | 2001-08-27 | Novartis Ag | Certain thiol inhibitors of endothelin-converting enzyme |
GB9811159D0 (en) * | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
EP1159273A1 (fr) | 1999-03-02 | 2001-12-05 | Boehringer Ingelheim Pharmaceuticals Inc. | Composes utiles en tant qu'inhibiteurs reversibles de la cathepsine s |
EP1452522A3 (fr) * | 1999-03-15 | 2005-02-09 | Axys Pharmaceuticals, Inc. | Nouveaux composés et composiitons comme inhibiteurs de proteases |
US7375085B1 (en) * | 1999-04-26 | 2008-05-20 | Ajinomoto Co., Inc. | Melanocyte-stimulating hormone inhibitors |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
GB0003111D0 (en) | 2000-02-10 | 2000-03-29 | Novartis Ag | Organic compounds |
MY129000A (en) | 2000-08-31 | 2007-03-30 | Tanabe Seiyaku Co | INHIBITORS OF a4 MEDIATED CELL ADHESION |
CA2449999C (fr) * | 2001-06-11 | 2012-07-31 | Shire Biochem Inc. | Composes et methodes de traitement ou de prevention d'infections a flavirus |
MY140707A (en) * | 2002-02-28 | 2010-01-15 | Mitsubishi Tanabe Pharma Corp | Process for preparing a phenylalanine derivative and intermediates thereof |
US7122580B2 (en) * | 2002-08-09 | 2006-10-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
WO2004043916A1 (fr) | 2002-11-12 | 2004-05-27 | Merck & Co., Inc. | Inhibiteurs de beta-secretase phenylcarboxamide utilises dans le traitement de la maladie d'alzheimer |
US7208601B2 (en) | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
JP2007501844A (ja) * | 2003-08-08 | 2007-02-01 | トランス テック ファーマ,インコーポレイテッド | アリール及びヘテロアリール化合物、組成物並びに使用方法 |
WO2005014532A1 (fr) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Composes aryle et heteroaryle, compositions et procedes associes |
GB0514071D0 (en) * | 2005-07-07 | 2005-08-17 | Zealand Pharma As | N- or C- terminally modified small peptides |
US20090012010A1 (en) * | 2007-05-18 | 2009-01-08 | Neuromed Phramaceuticals Ltd. | Amino acid derivatives as calcium channel blockers |
KR20130004579A (ko) * | 2010-02-23 | 2013-01-11 | 제넨테크, 인크. | 종양의 진단 및 치료를 위한 조성물 및 방법 |
EP3008056B8 (fr) * | 2013-06-11 | 2021-03-03 | Receptos Llc | Nouveaux modulateurs du récepteur glp-1 |
EP3626707A1 (fr) | 2014-01-13 | 2020-03-25 | The General Hospital Corporation | Composés hétéroaryle-disulfure utilisés comme effecteurs allostériques pour augmenter l'affinité de fixation d'oxygène de l'hémoglobine |
WO2015106242A2 (fr) * | 2014-01-13 | 2015-07-16 | The General Hospital Corporation | Composés bisamide utilisés comme effecteurs allostériques pour réduire l'affinité de liaison de l'hémoglobine pour l'oxygène |
US10829440B2 (en) * | 2015-06-12 | 2020-11-10 | Brown University | Antibacterial compounds and methods of making and using same |
CN108821994A (zh) * | 2018-05-24 | 2018-11-16 | 三峡大学 | 一类双羟基酰氧基双酰胺类药物中间体及其制备方法 |
US11555010B2 (en) | 2019-07-25 | 2023-01-17 | Brown University | Diamide antimicrobial agents |
RU2716258C1 (ru) * | 2019-07-30 | 2020-03-11 | Автономная некоммерческая образовательная организация высшего образования Сколковский институт науки и технологий | Пептидный антагонист нмда-рецептора |
CN116096714A (zh) | 2020-06-10 | 2023-05-09 | 安力高医药股份有限公司 | 用于治疗冠状病毒、小核糖核酸病毒和诺罗病毒感染的抗病毒化合物 |
FR3111544A1 (fr) * | 2020-06-18 | 2021-12-24 | Universite Paris-Saclay | Nouveaux composés dipeptidiques, leur procédé de fabrication et une nouvelle application thérapeutique de composés dipeptidiques. |
RU2769051C1 (ru) * | 2021-06-30 | 2022-03-28 | Общество с ограниченной ответственностью "ТЕРРАНОВА КАПИТАЛ" | Пептид, улучшающий функциональные свойства эндотелия сосудов, фармацевтическая композиция на его основе и способ ее применения |
IL309732A (en) | 2021-07-09 | 2024-02-01 | Aligos Therapeutics Inc | Antiviral compounds |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5623142B2 (fr) * | 1974-07-01 | 1981-05-29 | ||
US4025644A (en) * | 1974-12-18 | 1977-05-24 | Daiichi Seiyaku Co., Ltd. | Tyrosine derivatives and use |
DE2901667A1 (de) * | 1979-01-17 | 1980-07-31 | Troponwerke Gmbh & Co Kg | Pharmazeutische verwendung von dipeptiden |
EP0072058A1 (fr) * | 1981-08-10 | 1983-02-16 | Duphar International Research B.V | Seringue à compartiments multiples |
US4395401A (en) * | 1981-09-09 | 1983-07-26 | Smithkline Beckman Corporation | Renally active dipeptides |
JPS58133260A (ja) * | 1982-02-02 | 1983-08-08 | 河村 純郎 | 多段注射器 |
DE3332633A1 (de) * | 1983-09-09 | 1985-04-04 | Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München | Substituierte carbonsaeurederivate, verfahren zu ihrer herstellung, und arzneimittel |
AU589665B2 (en) * | 1985-08-14 | 1989-10-19 | G.D. Searle & Co. | Substituted dipeptide amides |
AU598750B2 (en) * | 1985-09-27 | 1990-07-05 | Mitsubishi Chemical Corporation | Phenylalanine derivative and proteinase inhibitor |
EP0219899B1 (fr) * | 1985-10-11 | 1990-08-08 | Duphar International Research B.V | Seringue automatique |
HU199809B (en) * | 1986-03-14 | 1990-03-28 | Syntex Inc | Process for producing aminomethyl-4,5-dihydroisoxazole derivatives and pharmaceutical compositions comprising same |
US5187156A (en) * | 1988-03-16 | 1993-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same |
CA1326108C (fr) * | 1988-04-12 | 1994-01-11 | Sun Hyuk Kim | Antagoniste de la cck |
JPH0347163A (ja) * | 1989-06-30 | 1991-02-28 | Fujisawa Pharmaceut Co Ltd | アントラキノン誘導体およびその製造 |
CA2032559C (fr) * | 1989-12-28 | 2001-11-06 | Kiyofumi Ishikawa | Pentapeptides cycliques antagonistes de l'endotheline |
US5284828A (en) * | 1990-05-14 | 1994-02-08 | Fujisawa Pharmaceutical Co. Ltd. | Peptide compound and its preparation |
CA2043741C (fr) * | 1990-06-07 | 2003-04-01 | Kiyofumi Ishikawa | Derives de peptides antagonistes d'endotheline |
DK220890D0 (da) * | 1990-09-14 | 1990-09-14 | Ole Buchardt | Fremgangsmaade til fremstilling af c-terminalt amiderede peptider |
EP0668770A1 (fr) * | 1991-04-24 | 1995-08-30 | Warner-Lambert Company | POLYPEPTIDES $g(a) SUBSTITUES AYANT DES PROPRIETES THERAPEUTIQUES |
TW270116B (fr) * | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
ES2151888T3 (es) * | 1991-05-16 | 2001-01-16 | Warner Lambert Co | Antagonistas de la endotelina. |
RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
CA2122820A1 (fr) * | 1991-11-05 | 1993-05-13 | Russell Donavan Cousins | Antagonistes des recepteurs a endotheline |
TW224462B (fr) * | 1992-02-24 | 1994-06-01 | Squibb & Sons Inc | |
US5550138A (en) * | 1992-03-25 | 1996-08-27 | Takeda Chemical Industries, Ltd. | Condensed thiadiazole derivative, method of its production, and use thereof |
NZ247440A (en) * | 1992-05-06 | 1995-04-27 | Squibb & Sons Inc | Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof |
JPH07509465A (ja) * | 1992-07-17 | 1995-10-19 | スミスクライン・ビーチャム・コーポレイション | エンドセリン受容体アンタゴニスト |
-
1994
- 1994-10-17 CA CA002173875A patent/CA2173875A1/fr not_active Abandoned
- 1994-10-17 RU RU96112148A patent/RU2126418C1/ru active
- 1994-10-17 BR BR9407933A patent/BR9407933A/pt not_active Application Discontinuation
- 1994-10-17 US US08/637,720 patent/US5780498A/en not_active Expired - Fee Related
- 1994-10-17 JP JP7512982A patent/JPH09504302A/ja active Pending
- 1994-10-17 WO PCT/EP1994/003418 patent/WO1995012611A1/fr not_active Application Discontinuation
- 1994-10-17 EP EP94929557A patent/EP0728145A1/fr not_active Ceased
- 1994-10-17 AU AU78565/94A patent/AU691201B2/en not_active Ceased
- 1994-10-27 IL IL11143194A patent/IL111431A0/xx unknown
- 1994-10-31 ZA ZA948541A patent/ZA948541B/xx unknown
-
1996
- 1996-04-26 FI FI961804A patent/FI961804A/fi unknown
- 1996-04-29 NO NO961725A patent/NO961725D0/no unknown
Also Published As
Publication number | Publication date |
---|---|
IL111431A0 (en) | 1994-12-29 |
AU7856594A (en) | 1995-05-23 |
FI961804A0 (fi) | 1996-04-26 |
US5780498A (en) | 1998-07-14 |
RU2126418C1 (ru) | 1999-02-20 |
AU691201B2 (en) | 1998-05-14 |
NO961725L (no) | 1996-04-29 |
ZA948541B (en) | 1995-05-02 |
EP0728145A1 (fr) | 1996-08-28 |
WO1995012611A1 (fr) | 1995-05-11 |
NO961725D0 (no) | 1996-04-29 |
BR9407933A (pt) | 1996-11-26 |
JPH09504302A (ja) | 1997-04-28 |
CA2173875A1 (fr) | 1995-05-11 |
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DE69636597D1 (de) | Endothelin rezeptor antagonisten | |
FI944905A (fi) | Endoteliiniantagonistit II | |
BR9603432A (pt) | Antagonistas de receptores de endotelina | |
EP0711157A4 (fr) | Antagonistes du recepteur d'endotheline | |
LV10425A (lv) | Fibrinogena receptoru antagonisti |