FI95600B - Förfarande för framställning av fusionsproteiner i Streptomyces-arter - Google Patents

Förfarande för framställning av fusionsproteiner i Streptomyces-arter Download PDF

Info

Publication number
FI95600B
FI95600B FI895184A FI895184A FI95600B FI 95600 B FI95600 B FI 95600B FI 895184 A FI895184 A FI 895184A FI 895184 A FI895184 A FI 895184A FI 95600 B FI95600 B FI 95600B
Authority
FI
Finland
Prior art keywords
lys
gene
fusion proteins
insulin
chain
Prior art date
Application number
FI895184A
Other languages
English (en)
Finnish (fi)
Other versions
FI95600C (sv
FI895184A0 (sv
Inventor
Eugen Uhlmann
Klaus-Peter Koller
Guenther Johannes Riess
Holger Wallmeier
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3837273A external-priority patent/DE3837273A1/de
Priority claimed from DE19893927449 external-priority patent/DE3927449A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI895184A0 publication Critical patent/FI895184A0/sv
Application granted granted Critical
Publication of FI95600B publication Critical patent/FI95600B/sv
Publication of FI95600C publication Critical patent/FI95600C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI895184A 1988-11-03 1989-11-01 Förfarande för framställning av fusionsproteiner i Streptomyces-arter FI95600C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3837273A DE3837273A1 (de) 1987-05-05 1988-11-03 Verfahren zur herstellung eines insulin-vorprodukts in streptomyceten
DE3837273 1988-11-03
DE19893927449 DE3927449A1 (de) 1989-08-19 1989-08-19 Verfahren zur herstellung eines insulin-vorprodukts in streptomyceten
DE3927449 1989-08-19

Publications (3)

Publication Number Publication Date
FI895184A0 FI895184A0 (sv) 1989-11-01
FI95600B true FI95600B (sv) 1995-11-15
FI95600C FI95600C (sv) 1996-02-26

Family

ID=25873834

Family Applications (1)

Application Number Title Priority Date Filing Date
FI895184A FI95600C (sv) 1988-11-03 1989-11-01 Förfarande för framställning av fusionsproteiner i Streptomyces-arter

Country Status (18)

Country Link
EP (1) EP0367163B1 (sv)
JP (1) JPH02219588A (sv)
KR (1) KR900008040A (sv)
CN (1) CN1042378A (sv)
AT (1) ATE132531T1 (sv)
AU (1) AU619054B2 (sv)
CA (1) CA2002062A1 (sv)
DE (1) DE58909556D1 (sv)
DK (1) DK546889A (sv)
ES (1) ES2081826T3 (sv)
FI (1) FI95600C (sv)
GR (1) GR3018738T3 (sv)
HU (1) HU209596B (sv)
IE (1) IE893530L (sv)
IL (1) IL92178A (sv)
NO (1) NO894363L (sv)
NZ (1) NZ231222A (sv)
PT (1) PT92177B (sv)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3714866A1 (de) * 1987-05-05 1988-11-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
US5426036A (en) * 1987-05-05 1995-06-20 Hoechst Aktiengesellschaft Processes for the preparation of foreign proteins in streptomycetes
DE4012818A1 (de) * 1990-04-21 1991-10-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
IL99383A (en) 1990-09-05 1996-01-31 Hoechst Ag An enzymatic process for the conversion of pre-insulin into insulin
GB9513967D0 (en) * 1995-07-08 1995-09-06 Univ Leicester Insulin
PL2307441T3 (pl) 2008-08-07 2016-09-30 Sposób otrzymywania związków insuliny

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3418274A1 (de) * 1984-05-17 1985-11-21 Hoechst Ag, 6230 Frankfurt Signalpeptid fuer die exkretion von peptiden in streptomyceten
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
DE3707150A1 (de) * 1987-03-06 1988-09-15 Hoechst Ag Tendamistat-derivate
DE3714866A1 (de) * 1987-05-05 1988-11-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten

Also Published As

Publication number Publication date
FI95600C (sv) 1996-02-26
CA2002062A1 (en) 1990-05-03
PT92177B (pt) 1995-06-30
FI895184A0 (sv) 1989-11-01
EP0367163A2 (de) 1990-05-09
KR900008040A (ko) 1990-06-02
IE893530L (en) 1990-05-03
NZ231222A (en) 1991-08-27
ATE132531T1 (de) 1996-01-15
PT92177A (pt) 1990-05-31
ES2081826T3 (es) 1996-03-16
NO894363D0 (no) 1989-11-02
CN1042378A (zh) 1990-05-23
AU619054B2 (en) 1992-01-16
EP0367163B1 (de) 1996-01-03
HU895649D0 (en) 1990-01-28
NO894363L (no) 1990-05-04
JPH02219588A (ja) 1990-09-03
GR3018738T3 (en) 1996-04-30
EP0367163A3 (de) 1991-03-06
AU4395089A (en) 1990-05-10
HUT53675A (en) 1990-11-28
DE58909556D1 (de) 1996-02-15
DK546889D0 (da) 1989-11-02
DK546889A (da) 1990-05-04
IL92178A0 (en) 1990-07-26
HU209596B (en) 1994-08-29
IL92178A (en) 1995-11-27

Similar Documents

Publication Publication Date Title
JP3129722B2 (ja) 新規インスリン誘導体
JP3043803B2 (ja) 融合タンパク質、その調製及び用途
US5004686A (en) Process for producing human epidermal growth factor and analogs thereof
EP0195691B1 (en) Process for the preparation of insulin precursors and process for the preparation of human insulin
AU648670B2 (en) A-C-B Proinsulin, method of manufacturing and using same, and intermediates in insulin production
FI100250B (sv) Sekretion av hirudinderivat
WO1992006211A1 (fr) Procede pour produire un peptide ou une proteine
PT871718E (pt) Produção de carboxipeptidase b recombinante, activa sob o ponto de vista enzimático.
IE863334L (en) Fusion proteins with a eukaryotic ballast portion
FI95600B (sv) Förfarande för framställning av fusionsproteiner i Streptomyces-arter
US5334532A (en) PDGF-B fusion protein, vectors, and host cells for use in production thereof
AU600891B2 (en) Expression in E. coli of hybrid polypeptides containing the growth hormone releasing factor sequence
JP3005335B2 (ja) プレプロインスリンのインスリンへの酵素的変換方法
CN114380903B (zh) 一种胰岛素或其类似物前体
CA1338469C (en) Cloning and expression of ligninase
JP2637392B2 (ja) 遺伝子操作による生物活性β−ＮＧＦの生産方法
FI97549B (sv) Förfarande för framställning av främmande proteiner i Streptomycesceller
US5426036A (en) Processes for the preparation of foreign proteins in streptomycetes
VÉRTESY et al. Disulphide bridge formation of proinsulin fusion proteins during secretion in Streptomyces
JP2877253B2 (ja) 融合タンパク質の選択的切断方法
CA2232841A1 (en) Process for producing natriuretic peptides via streptavidine fusion proteins
JPH01181796A (ja) 組換えｄｎａ法を用いたポリペプチドの製造法

Legal Events

Date Code Title Description
FG Patent granted

Owner name: HOECHST AKTIENGESELLSCHAFT

BB Publication of examined application
MM Patent lapsed
MM Patent lapsed

Owner name: HOECHST AKTIENGESELLSCHAFT