FI954855A - Förfarande för sållning av närvaro av en genetisk defekt associerad med trombos och/eller svag antikoagulantrespons på aktiverat protein C - Google Patents

Förfarande för sållning av närvaro av en genetisk defekt associerad med trombos och/eller svag antikoagulantrespons på aktiverat protein C Download PDF

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Publication number
FI954855A
FI954855A FI954855A FI954855A FI954855A FI 954855 A FI954855 A FI 954855A FI 954855 A FI954855 A FI 954855A FI 954855 A FI954855 A FI 954855A FI 954855 A FI954855 A FI 954855A
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FI
Finland
Prior art keywords
thrombosis
screening
protein
activated
genetic defect
Prior art date
Application number
FI954855A
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English (en)
Finnish (fi)
Other versions
FI117977B (sv
FI954855A0 (sv
Inventor
Rogier Maria Bertina
Pieter Hendrik Reitsma
Original Assignee
Rijks Universiteit Leiden
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Application filed by Rijks Universiteit Leiden filed Critical Rijks Universiteit Leiden
Publication of FI954855A0 publication Critical patent/FI954855A0/sv
Publication of FI954855A publication Critical patent/FI954855A/sv
Application granted granted Critical
Publication of FI117977B publication Critical patent/FI117977B/sv

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
FI954855A 1994-02-14 1995-10-12 Förfarande för sållning av närvaro av en genetisk defekt associerad med trombos och/eller svag antikoagulantrespons på aktiverat protein C FI117977B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP94200377 1994-02-14
EP94200377 1994-02-14
PCT/EP1995/000553 WO1995021938A1 (en) 1994-02-14 1995-02-14 A method for screening for the presence of a genetic defect associated with thrombosis and/or poor anticoagulant response to activated protein c
EP9500553 1995-02-14

Publications (3)

Publication Number Publication Date
FI954855A0 FI954855A0 (sv) 1995-10-12
FI954855A true FI954855A (sv) 1995-11-17
FI117977B FI117977B (sv) 2007-05-15

Family

ID=8216642

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954855A FI117977B (sv) 1994-02-14 1995-10-12 Förfarande för sållning av närvaro av en genetisk defekt associerad med trombos och/eller svag antikoagulantrespons på aktiverat protein C

Country Status (14)

Country Link
US (3) US6518016B1 (sv)
EP (2) EP0807691B1 (sv)
JP (2) JP3163105B2 (sv)
KR (1) KR100384251B1 (sv)
AT (2) ATE206765T1 (sv)
AU (1) AU690644B2 (sv)
CA (1) CA2159907C (sv)
DE (3) DE69523179T2 (sv)
DK (2) DK0807691T3 (sv)
ES (2) ES2166948T3 (sv)
FI (1) FI117977B (sv)
GR (2) GR960300034T1 (sv)
PT (1) PT807691E (sv)
WO (1) WO1995021938A1 (sv)

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US20030143759A1 (en) * 1995-10-20 2003-07-31 Bjorn Dahlback Assays for determining anticoagulant cofactor activity
US5766869A (en) * 1995-11-30 1998-06-16 Ahs Hospital Corp. Factor V ratio blood test for susceptibility to thromboembolism
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AT404993B (de) * 1997-01-13 1999-04-26 Immuno Ag Verfahren zur bestimmung eines proteins mit einer mutation
US6451526B1 (en) * 1998-01-20 2002-09-17 Mayo Foundation For Medical Education And Research Simplified mutation detection
DE19802377A1 (de) 1998-01-22 1999-08-19 Max Planck Gesellschaft Verwendung von Inhibitoren für die Behandlung von RTK-Überfunktions-bedingten Störungen, insbesondere von Krebs
US6235480B1 (en) 1998-03-13 2001-05-22 Promega Corporation Detection of nucleic acid hybrids
US7090975B2 (en) 1998-03-13 2006-08-15 Promega Corporation Pyrophosphorolysis and incorporation of nucleotide method for nucleic acid detection
US6268146B1 (en) 1998-03-13 2001-07-31 Promega Corporation Analytical methods and materials for nucleic acid detection
US6335162B1 (en) 1998-03-13 2002-01-01 Promega Corporation Nucleic acid detection
US6312902B1 (en) 1998-03-13 2001-11-06 Promega Corporation Nucleic acid detection
US6270974B1 (en) 1998-03-13 2001-08-07 Promega Corporation Exogenous nucleic acid detection
US6391551B1 (en) 1998-03-13 2002-05-21 Promega Corporation Detection of nucleic acid hybrids
US6703211B1 (en) 1998-03-13 2004-03-09 Promega Corporation Cellular detection by providing high energy phosphate donor other than ADP to produce ATP
US6270973B1 (en) 1998-03-13 2001-08-07 Promega Corporation Multiplex method for nucleic acid detection
DE19840897A1 (de) * 1998-09-08 2000-03-09 Dirk Happich Faktor V-Leiden-Test
US6703228B1 (en) * 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1001037A3 (en) * 1998-09-28 2003-10-01 Whitehead Institute For Biomedical Research Pre-selection and isolation of single nucleotide polymorphisms
DE19848665A1 (de) * 1998-10-22 2000-04-27 Bayer Ag Ein automatisierbarer Schnelltest zum direkten Nachweis der APC Resistenz Mutation mit spezifischen Primern und Probes
WO2000049181A1 (en) * 1999-02-18 2000-08-24 Promega Corporation Multiplex method for nucleic acid detection
US6238868B1 (en) * 1999-04-12 2001-05-29 Nanogen/Becton Dickinson Partnership Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification and bioelectronic chip technology
WO2000062036A1 (en) * 1999-04-12 2000-10-19 Nanogen/Becton Dickinson Partnership Amplification and separation of nucleic acid sequences using strand displacement amplification and bioelectronic microchip technology
US6582920B2 (en) * 2000-09-01 2003-06-24 Gen-Probe Incorporated Amplification of HIV-1 RT sequences for detection of sequences associated with drug-resistance mutations
EP1330549A2 (en) * 2000-10-27 2003-07-30 Abbott Laboratories Genotyping using partially-complementary probes
US6855509B2 (en) 2000-12-19 2005-02-15 Instrumentation Laboratory Company Protein S functional assay and kit therefor
EP1483545B1 (en) * 2002-03-13 2006-06-21 Borealis Technology Oy Apparatus for inspecting deformation of pipes
US20030177850A1 (en) * 2002-03-19 2003-09-25 The Washington Post Company System and method for verifying the roll roundness of rolls of paper used for newspapers
US20050026168A1 (en) * 2002-12-13 2005-02-03 Genesis Group Inc. Method for the detection of risk factors associated with myocardial infarction
US20050032066A1 (en) * 2003-08-04 2005-02-10 Heng Chew Kiat Method for assessing risk of diseases with multiple contributing factors
FR2866349B1 (fr) * 2004-02-12 2008-05-16 Biomerieux Sa Procede de diagnostic/pronostic d'une thrombose
US20090004175A1 (en) * 2004-07-16 2009-01-01 Novo Nordick Health Care A/G Methods for Optimizing Forming Vlla-Based Hemostatic Treatment
EP1623996A1 (en) * 2004-08-06 2006-02-08 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Improved method of selecting a desired protein from a library
WO2006027111A1 (en) * 2004-09-06 2006-03-16 Zlb Behring Gmbh Modified coagulation factor viii with enhanced stability
KR100655658B1 (ko) * 2005-07-26 2006-12-08 삼성전자주식회사 게이트 전극 구조물과 그 제조 방법 및 이를 갖는 반도체트랜지스터와 그 제조 방법
AU2007204572A1 (en) * 2006-01-12 2007-07-19 The University Of British Columbia Protein C pathway associated polymorphisms as response predictors to activated protein C or protein C like compound administration
JP2009527487A (ja) * 2006-02-16 2009-07-30 ザ ハーシー カンパニー ココア製品及び心血管状態を無糖ココアで処置する方法
WO2008020090A1 (es) * 2006-08-18 2008-02-21 Laboratorios Indas, S.A. Método y kit para diagnosticar el riesgo de desarrollar una enfermedad trombótica venosa
US20090292214A1 (en) * 2008-05-22 2009-11-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US20090163856A1 (en) * 2007-12-19 2009-06-25 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Treatment indications informed by a prior implant information
US20100036263A1 (en) * 2008-08-07 2010-02-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US8636670B2 (en) * 2008-05-13 2014-01-28 The Invention Science Fund I, Llc Circulatory monitoring systems and methods
US20090292213A1 (en) * 2008-05-21 2009-11-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US20090287120A1 (en) * 2007-12-18 2009-11-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US9717896B2 (en) 2007-12-18 2017-08-01 Gearbox, Llc Treatment indications informed by a priori implant information
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WO2016005564A2 (en) * 2014-07-11 2016-01-14 Novo Nordisk A/S Antibodies against activated factor v

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US5049491A (en) * 1987-11-19 1991-09-17 The University Of Vermont Immunologic detection of factor V(VA) fragments in hemorrhagic and thrombotic clinical settings
US5051357A (en) * 1989-07-14 1991-09-24 Board Of Trustees Operating Michigan State University Method and assay using inactivation of factors Va and VIIIa by activated Protein C to diagnose thrombic disease or assay for Protein C and kit therefor
CA2119761C (en) * 1991-11-13 1997-12-16 Bjorn Dahlback Method for the diagnosis of blood coagulation disorders
SE470274B (sv) * 1991-11-13 1993-12-20 Bjoern Dahlbaeck Användning av en in vitro-metod för diagnos av blodkoagulationssjukdomar
DE69411898T3 (de) 1993-01-29 2004-07-08 T.A.C. Thrombosis And Coagulation Ab Neue antikoagulant-cofaktor aktivität
US5922855A (en) * 1993-12-17 1999-07-13 Oregon Health Sciences University Mammalian DNA mismatch repair genes MLH1 and PMS1
WO1995029259A1 (en) 1994-04-22 1995-11-02 Stichting Centraal Laboratorium Van De Bloedtransfusiedienst Van Het Nederlandse Rode Kruis Method and means for detecting and treating disorders in the blood coagulation cascade
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US5874256A (en) * 1995-06-06 1999-02-23 Rijks Universiteit Leiden Method for diagnosing an increased risk for thrombosis or a genetic defect causing thrombosis and kit for use with the same
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Also Published As

Publication number Publication date
JP3439458B2 (ja) 2003-08-25
PT807691E (pt) 2002-04-29
ES2090001T1 (es) 1996-10-16
EP0696325A1 (en) 1996-02-14
DE69502451D1 (de) 1998-06-18
DE69523179D1 (de) 2001-11-15
US6518016B1 (en) 2003-02-11
KR960702007A (ko) 1996-03-28
CA2159907A1 (en) 1995-08-17
JP2001242170A (ja) 2001-09-07
JPH08509383A (ja) 1996-10-08
CA2159907C (en) 2006-12-12
EP0807691A3 (en) 1998-03-11
DE69502451T2 (de) 1998-09-24
DE696325T1 (de) 1996-08-29
EP0807691B1 (en) 2001-10-10
US5910576A (en) 1999-06-08
GR3027579T3 (en) 1998-11-30
EP0696325B1 (en) 1998-05-13
DE69523179T2 (de) 2002-06-06
ES2166948T3 (es) 2002-05-01
WO1995021938A1 (en) 1995-08-17
JP3163105B2 (ja) 2001-05-08
DK0696325T3 (da) 1999-03-01
DK0807691T3 (da) 2002-02-04
ES2090001T3 (es) 1998-08-01
AU1809195A (en) 1995-08-29
ATE206765T1 (de) 2001-10-15
FI117977B (sv) 2007-05-15
ATE166110T1 (de) 1998-05-15
AU690644B2 (en) 1998-04-30
FI954855A0 (sv) 1995-10-12
EP0807691A2 (en) 1997-11-19
GR960300034T1 (en) 1996-06-30
KR100384251B1 (ko) 2003-09-19
US6558913B1 (en) 2003-05-06

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