JP2009527487A - ココア製品及び心血管状態を無糖ココアで処置する方法 - Google Patents
ココア製品及び心血管状態を無糖ココアで処置する方法 Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
- A23G1/40—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/56—Cocoa products, e.g. chocolate; Substitutes therefor making liquid products, e.g. for making chocolate milk drinks and the products for their preparation, pastes for spreading, milk crumb
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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Abstract
Description
無糖ココア組成物
さまざまなチョコレート組成物が血管内皮機能に及ぼす効果を調査するために、一連のヒト試験を実施する。無糖チョコレート、加糖チョコレート、及びココアを含有していないプラセボから成る組成物群を、体格指数が25〜35kg/m2の間である健常者45名に投与する。血圧(収縮期及び拡張期の両方)、及び血流依存性血管拡張反応(FMD)及び刺激補正反応値(SARM)を測定することにより、血管内皮機能に対するさまざまな組成物の効果を評価する。
ダークチョコレート
ダークチョコレート組成物が血管内皮機能に及ぼす効果を調査するために、一連のヒト試験を実施する。ダークチョコレートから成る組成物(ココアパウダー22グラムに相当する固形のダークチョコレートのバー74グラム)を、ホワイトチョコレートの対照と比較する。一晩絶食の後、各群にダークチョコレート又はホワイトチョコレートを投与し、投与前及び投与2時間後のFMDに及ぼす効果を測定する。7日間の後、ダークチョコレート群をホワイトチョコレート群と交代し、同じ測定内容での別の7日間のクロスオーバー試験を実施する。
表5 人口統計的特性及びベースライン値
*は一部欠測値があることを示す。SD=標準偏差。p値はスチューデントt検定から得ている。
表6 結果測定値のベースラインからの変化
†は処置群間に有意差がある(p値<0.05)ことを示す。SD=標準偏差。*は一部欠測値があることを示す。p値は対応のあるt検定から得ている。
Claims (27)
- アテローム性動脈硬化症、血栓症、心臓発作、卒中、又は血管循環状態を処置する治療的又は予防的な方法であって、天然固形ココアを少なくとも60%含有する配合物を少なくとも約10グラム含む無糖組成物を、それを必要とする対象に1日2回投与することを含む方法。
- 無糖組成物が糖代替品をさらに含む、請求項1に記載の方法。
- 無糖組成物が食欲抑制化合物をさらに含む、請求項1に記載の方法。
- 無糖組成物の投与後約2時間、食事から食用糖及びショ糖を排除することをさらに含む、請求項1に記載の方法。
- 無糖組成物が、天然固形ココアを少なくとも約80%含む、請求項1に記載の方法。
- 無糖組成物が、天然固形ココアを約85〜95%含む、請求項1に記載の方法。
- 無糖組成物が糖代替品をさらに含む、請求項6に記載の方法。
- 糖代替品が糖アルコールである、請求項7に記載の方法。
- 投与後約1時間、前記対象が糖又はショ糖を実質的に含まない食事をとる状態を維持することをさらに含む、請求項1に記載の方法。
- 投与後約2時間、前記対象が糖又はショ糖を実質的に含まない食事をとる状態を維持することをさらに含む、請求項1に記載の方法。
- 天然ココアパウダーを少なくとも約85%と、1種又は複数種の糖代替品とを含む、血管内皮機能を改善するための無糖ココア配合物。
- 香味料をさらに含む、請求項11に記載の無糖配合物。
- 香味料がバニリンである、請求項12に記載の無糖配合物。
- 天然ココアパウダーを少なくとも約90%含む、請求項13に記載の無糖配合物。
- 天然ココアパウダーを約92〜95%含む、請求項15に記載の無糖配合物。
- 錠剤、ゼラチン被覆カプセル、懸濁液、非経口溶液、即時飲用可能なミックス、飲料、粉末状の飲料ミックス、香辛調味料、ヨーグルトベース飲料又はミックス、乳ベース飲料又はミックス、豆乳ベース飲料又はミックス、無糖菓子、無糖のチョコレート又はチョコレートコーティング、及び無糖ベーカリー製品のうちの1つから選択される製品として存在する、請求項11に記載の無糖配合物。
- 錠剤、ゼラチン被覆カプセル、懸濁液、非経口溶液、即時飲用可能なミックス、飲料、粉末状の飲料ミックス、香辛調味料、ヨーグルトベース飲料又はミックス、乳ベース飲料又はミックス、豆乳ベース飲料又はミックス、無糖菓子、無糖のチョコレート又はチョコレートコーティング、及び無糖ベーカリー製品のうちの1つから選択される製品として存在する、請求項14に記載の無糖配合物。
- 糖代替品が、糖アルコール、ace−K、及びアスパルテームのうちの1つ又は複数である、請求項17に記載の無糖配合物。
- 少なくとも1つの心血管リスク因子に効果をもたらすための無糖ココア組成物を含む食事を評価する方法であって、天然ココアパウダーを少なくとも85%含み、さらにショ糖又は栄養甘味料を実質的に含まない少なくとも約10グラムの組成物をヒト対象に経口的に投与すること、投与後少なくとも約1時間ショ糖又は栄養甘味料を実質的に含まない食事を維持すること、及び投与後に前記対象の心血管リスク因子を測定することを含む方法。
- 測定がFMDによる、請求項19に記載の方法。
- 前記対象が10グラムの前記組成物を1日2回投与される、請求項19に記載の方法。
- 前記対象が10グラムの前記組成物を1日2回投与される、請求項20に記載の方法。
- 前記組成物が天然ココアパウダーを約90〜95%含む、請求項21に記載の方法。
- ヒト対象の血圧に及ぼす無糖組成物の効果を試験する方法であって、天然ココアパウダーを少なくとも85%含み、さらにショ糖又は栄養甘味料を実質的に含まない少なくとも約10グラムの組成物をヒト対象に経口的に投与すること、投与後少なくとも約1時間ショ糖又は栄養甘味料を実質的に含まない食事を維持すること、及び投与後に前記対象の血圧を測定することを含む方法。
- 有害なアテローム性動脈硬化症、血栓症、心臓発作、卒中、又は血管循環状態に対するいずれか1つ又は複数の個体リスクの測定可能な状態又は状況に及ぼす無糖組成物の効果を試験する方法であって、天然ココアパウダーを少なくとも85%含み、さらにショ糖又は栄養甘味料を実質的に含まない少なくとも約10グラムの組成物を個体に経口的に投与すること、投与後少なくとも約1〜2時間、ショ糖又は栄養甘味料を実質的に含まない食事を維持すること、及び血管内皮機能の1つ又は複数の状況を、投与後にFMD、LDL濃度、HDL濃度、トリグリセリド濃度、リポタンパク質A濃度、又は総コレステロール濃度により測定することを含む方法。
- 前記試験が繰り返される、請求項25に記載の方法。
- 前記試験が、約2週間から約2ヶ月の期間、実質的に毎日繰り返される、請求項26に記載の方法。
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Application Number | Priority Date | Filing Date | Title |
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US77770806P | 2006-02-16 | 2006-02-16 | |
PCT/US2007/004517 WO2007098205A2 (en) | 2006-02-16 | 2007-02-16 | Cocoa products and methods of treating cardiovascular conditions with sugar-free cocoa |
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JP2013186476A Division JP2013253100A (ja) | 2006-02-16 | 2013-09-09 | ココア製品及び心血管状態を無糖ココアで処置する方法 |
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JP2009527487A5 JP2009527487A5 (ja) | 2010-04-08 |
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JP2008555423A Pending JP2009527487A (ja) | 2006-02-16 | 2007-02-16 | ココア製品及び心血管状態を無糖ココアで処置する方法 |
JP2013186476A Pending JP2013253100A (ja) | 2006-02-16 | 2013-09-09 | ココア製品及び心血管状態を無糖ココアで処置する方法 |
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WO (1) | WO2007098205A2 (ja) |
Cited By (1)
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JP2019089754A (ja) * | 2017-11-14 | 2019-06-13 | 株式会社明治 | 心疾患治療用組成物 |
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US9114114B2 (en) | 2007-06-21 | 2015-08-25 | Mars, Inc. | Edible products having a high cocoa polyphenol content and improved flavor and the milled cocoa extracts used therein |
CA2595096A1 (en) * | 2007-07-27 | 2009-01-27 | Innovative Life Sciences Corporation | Herbal product comprising cinnamon and chocolate |
ITPG20080036A1 (it) * | 2008-07-30 | 2010-01-31 | Silvano Berioli | Procedimento per la produzione di cioccolata mediante l'aggiunta alla massa di composti di natura fenolica. |
EP2323486A4 (en) * | 2008-07-30 | 2012-03-28 | Nestec Sa | METHODS AND COMPOSITIONS FOR THE PREVENTION, REDUCTION OR TREATMENT OF LESIONS CAUSED BY ISCHEMIA AND ISCHEMIC-LIKE DISORDERS |
DE102008050591A1 (de) * | 2008-10-09 | 2010-04-15 | Elger, Melanie, Dr. med. dent. | Getränk zur Förderung der Zahngesundheit |
PT2206438E (pt) * | 2008-12-29 | 2012-05-10 | Unilever Nv | Produtos de confeitaria gelados e bebidas compreendendo teobromina e cafeína |
KR101772139B1 (ko) | 2009-08-28 | 2017-08-28 | 마리 케이 인코포레이티드 | 피부 케어 제형 |
EP2531195A1 (en) * | 2010-02-04 | 2012-12-12 | Unilever NV | Use of theobromine for lowering central blood pressure |
RU2561264C2 (ru) | 2010-03-05 | 2015-08-27 | Марс, Инкорпорейтед | Вкусные напитки и композиции с экстрактом какао |
MY179559A (en) * | 2010-05-10 | 2020-11-10 | Cargill Inc | Cocoa powder compositions |
EP2571502B1 (en) | 2010-05-19 | 2016-04-27 | Unilever N.V. | Theobromine for increasing hdl-cholesterol |
JP6772064B2 (ja) * | 2014-10-17 | 2020-10-21 | 株式会社明治 | ポリフェノール含有機能性経口組成物 |
CH710346A1 (it) * | 2014-11-07 | 2016-05-13 | Tassone Agostino | Composizione nutraceutica di alimenti. |
CN109922664A (zh) * | 2016-11-10 | 2019-06-21 | Immd有限公司 | 功能性巧克力 |
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US5554645A (en) * | 1994-10-03 | 1996-09-10 | Mars, Incorporated | Antineoplastic cocoa extracts and methods for making and using the same |
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US8507018B2 (en) * | 1998-03-12 | 2013-08-13 | Mars, Incorporated | Products containing polyphenol(s) and L-arginine and methods of use thereof |
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US6524630B2 (en) * | 2000-03-22 | 2003-02-25 | Mars, Incorporated | Use of cocoa procyanidins combined with acelylsalicyclic acid as an anti-platelet therapy |
US6610320B2 (en) * | 2000-04-14 | 2003-08-26 | Mars, Incorporated | Compositions and methods for improving vascular health |
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US20050171030A1 (en) * | 2000-05-26 | 2005-08-04 | Peter Rohdewald | Relieving symptoms of erectile dysfunction and attaining sexual wellness and health of the sexual vascular system with proanthocyanidins |
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US20060088617A1 (en) * | 2004-10-23 | 2006-04-27 | Mccurry James M | Chocolate composition and method for benefiting the cardiovascular system |
JP2008097401A (ja) * | 2006-10-13 | 2008-04-24 | Seiko Epson Corp | 電子表示装置 |
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2007
- 2007-02-16 JP JP2008555423A patent/JP2009527487A/ja active Pending
- 2007-02-16 US US11/707,279 patent/US20070207188A1/en not_active Abandoned
- 2007-02-16 WO PCT/US2007/004517 patent/WO2007098205A2/en active Search and Examination
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2013
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2019089754A (ja) * | 2017-11-14 | 2019-06-13 | 株式会社明治 | 心疾患治療用組成物 |
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WO2007098205A2 (en) | 2007-08-30 |
US20070207188A1 (en) | 2007-09-06 |
JP2013253100A (ja) | 2013-12-19 |
WO2007098205A3 (en) | 2008-10-30 |
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