FI954681A - Cykloalkano-indol- och azaindolderivat - Google Patents

Cykloalkano-indol- och azaindolderivat Download PDF

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Publication number
FI954681A
FI954681A FI954681A FI954681A FI954681A FI 954681 A FI954681 A FI 954681A FI 954681 A FI954681 A FI 954681A FI 954681 A FI954681 A FI 954681A FI 954681 A FI954681 A FI 954681A
Authority
FI
Finland
Prior art keywords
opt
substd
alkyl
phenyl
alkoxy
Prior art date
Application number
FI954681A
Other languages
English (en)
Finnish (fi)
Other versions
FI113048B (sv
FI954681A0 (sv
Inventor
Ulrich Mueller
Richard Connell
Siegfried Goldmann
Rudi Gruetzmann
Martin Beuck
Hilmar Bischoff
Dirk Denzer
Anke Domdey-Bette
Stefan Wohlfeil
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI954681A0 publication Critical patent/FI954681A0/sv
Publication of FI954681A publication Critical patent/FI954681A/sv
Application granted granted Critical
Publication of FI113048B publication Critical patent/FI113048B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI954681A 1994-10-04 1995-10-02 Karbolin- och karbazolderivat, förfarande för framställning därav och mellanprodukter användas i förfarandet FI113048B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4435477A DE4435477A1 (de) 1994-10-04 1994-10-04 Cycloalkano-indol- und -azaindol-derivate
DE4435477 1994-10-04

Publications (3)

Publication Number Publication Date
FI954681A0 FI954681A0 (sv) 1995-10-02
FI954681A true FI954681A (sv) 1996-04-05
FI113048B FI113048B (sv) 2004-02-27

Family

ID=6529939

Family Applications (2)

Application Number Title Priority Date Filing Date
FI954681A FI113048B (sv) 1994-10-04 1995-10-02 Karbolin- och karbazolderivat, förfarande för framställning därav och mellanprodukter användas i förfarandet
FI20002693A FI108791B (sv) 1994-10-04 2000-12-08 Förfarande för framställning av karboxylsyror

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20002693A FI108791B (sv) 1994-10-04 2000-12-08 Förfarande för framställning av karboxylsyror

Country Status (36)

Country Link
US (6) US5684014A (sv)
EP (1) EP0705831B1 (sv)
JP (1) JP3901234B2 (sv)
KR (1) KR100355986B1 (sv)
CN (2) CN1183111C (sv)
AT (1) ATE255580T1 (sv)
AU (1) AU700609B2 (sv)
CA (1) CA2159546C (sv)
CZ (1) CZ291348B6 (sv)
DE (2) DE4435477A1 (sv)
DK (1) DK0705831T3 (sv)
DZ (1) DZ1934A1 (sv)
EE (1) EE03527B1 (sv)
ES (1) ES2211890T3 (sv)
FI (2) FI113048B (sv)
HK (1) HK1005139A1 (sv)
HN (1) HN1995009160A (sv)
HR (1) HRP950505B1 (sv)
HU (1) HU225052B1 (sv)
IL (3) IL129641A0 (sv)
MA (1) MA23683A1 (sv)
MY (1) MY117282A (sv)
NO (1) NO305365B1 (sv)
NZ (1) NZ280130A (sv)
PH (1) PH31400A (sv)
PL (1) PL183154B1 (sv)
PT (1) PT705831E (sv)
RU (1) RU2157803C2 (sv)
SG (1) SG63528A1 (sv)
SI (1) SI0705831T1 (sv)
SK (1) SK284260B6 (sv)
SV (1) SV1995000062A (sv)
TN (1) TNSN95098A1 (sv)
TW (1) TW448175B (sv)
UA (1) UA44700C2 (sv)
ZA (1) ZA958297B (sv)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
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DE4435477A1 (de) 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate
DE19525028A1 (de) * 1995-07-10 1997-01-16 Bayer Ag Amide und Sulfonamide von heterocyclisch substituierten Benzylaminen
DE19613549A1 (de) * 1996-04-04 1997-10-09 Bayer Ag Verfahren zur Herstellung von enantiomerenreinen Cycloalkano-indol- und azaindol-carbonsäuren und deren aktivierte Derivate
US6774236B1 (en) 1996-04-04 2004-08-10 Bayer Aktiengesellschaft Process for the preparation of enantiomerically pure cycloalkano-indol -and azaindol -and pyrimido [1,2A]indolcarbocyclic acids and their activated derivatives
DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
DE19615119A1 (de) * 1996-04-17 1997-10-23 Bayer Ag Neue Arylessigsäureamide
EP0802192A1 (de) * 1996-04-17 1997-10-22 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
DE19615265A1 (de) * 1996-04-18 1997-12-04 Bayer Ag Neue Pyridazino-, Pyrimido-, Pyrazino- und Triazino-indole
PL344571A1 (en) * 1998-05-01 2001-11-05 Lilly Co Eli Spla2
ATE258934T1 (de) 1998-10-30 2004-02-15 Lilly Co Eli Azaindol derivate und ihre verwendung als antithrombotische wirkstoffe
AU4616200A (en) * 1999-05-25 2000-12-12 Yamanouchi Pharmaceutical Co., Ltd. Hydrazide derivatives
DE19929065A1 (de) * 1999-06-25 2000-12-28 Bayer Ag Kombination von MTP-Inhibitoren und HMG-CoA-Reduktase-Inhibitoren und ihre Verwendung in Arzneimitteln
DE19934610A1 (de) * 1999-07-23 2001-01-25 Bayer Ag Schnellfreisetzende Extrudate und Verfahren zu ihrer Herstellung sowie daraus erhältliche Zubereitungen
HUP0300894A3 (en) * 2000-03-15 2008-05-28 Sanofi Aventis Deutschland Substituted beta-carbolines, process for their preparation, pharmaceutical compositions containing them and their use
EP1134221A1 (en) * 2000-03-15 2001-09-19 Aventis Pharma Deutschland GmbH Substituted beta-carbolines as lkB kinase inhibitors
WO2001074817A1 (fr) * 2000-03-30 2001-10-11 Yamanouchi Pharmaceutical Co., Ltd. Derives d'hydrazide
DE10030375A1 (de) * 2000-06-21 2002-01-03 Bayer Ag Verwendung von MTP-Inhibitoren zur Senkung von ppTRL
NZ527163A (en) * 2001-01-31 2006-02-24 Synaptic Pharma Corp Use of GAL3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
ZA200502496B (en) * 2002-02-28 2005-10-12 Japan Tobacco Inc Ester compound and medicinal use thereof.
US20050239780A1 (en) * 2002-05-31 2005-10-27 Akira Suga Tetrahydropyran derivative
WO2004063156A1 (en) * 2003-01-08 2004-07-29 Biovitrum Ab Novel indole derivates as fabp-4 inhibitors
WO2005051382A1 (ja) * 2003-11-28 2005-06-09 Astellas Pharma Inc. 脂質低下作用増強剤
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
SI1725234T1 (sl) 2004-03-05 2013-04-30 The Trustees Of The University Of Pennsylvania Postopki zdravljenja nepravilnosti ali bolezni povezanih s hiperlipidemijo in hiperholesterolemijo z minimiziranjem stranskih uäśinkov
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
AU2005230397B2 (en) * 2004-04-09 2010-04-08 Elanco Animal Health Ireland Limited Intermittent dosing regimen for the treatment of overweight with MTP-inhibitors
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
US20060030623A1 (en) * 2004-07-16 2006-02-09 Noboru Furukawa Agent for the treatment or prevention of diabetes, obesity or arteriosclerosis
FR2873694B1 (fr) * 2004-07-27 2006-12-08 Merck Sante Soc Par Actions Si Nouveaux aza-indoles inhibiteurs de la mtp et apob
US8101774B2 (en) * 2004-10-18 2012-01-24 Japan Tobacco Inc. Ester derivatives and medicinal use thereof
WO2006046623A1 (ja) * 2004-10-25 2006-05-04 Japan Tobacco Inc. 溶解性及び安定性の改善された固形製剤及びその製造方法
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
JP2008542255A (ja) * 2005-05-27 2008-11-27 ファイザー・プロダクツ・インク 肥満症の治療または体重減量の維持のためのカンナビノイド−１受容体アンタゴニストおよびミクロソームトリグリセリド輸送タンパク質阻害物質の併用
US20080269233A1 (en) * 2005-08-04 2008-10-30 Mark David Andrews Piperidinoyl-Pyrrolidine and Piperidinoyl-Piperidine Compounds
AU2006304689A1 (en) * 2005-10-18 2007-04-26 Aegerion Pharmaceuticals Compositions for lowering serum cholesterol and/or triglycerides
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US8138188B2 (en) * 2006-02-23 2012-03-20 Pfizer Inc. Melanocortin type 4 receptor agonist piperidinoylpyrrolidines
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
WO2007135461A2 (en) * 2006-05-18 2007-11-29 Bayer Healthcare Ag Pharmaceutical compositions comprising implitapide and methods of using same
EP2084127A1 (en) 2006-11-13 2009-08-05 Pfizer Products Inc. Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
US20080161279A1 (en) * 2006-12-21 2008-07-03 Wisler Gerald L Methods of Treating Obesity
RU2338745C1 (ru) * 2007-03-21 2008-11-20 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
WO2008124384A2 (en) * 2007-04-03 2008-10-16 Aegerion Pharmaceuticals, Inc. Combinations of mtp inhibitors with cholesterol absorption inhibitors or interferon for treating hepatitis c
KR101280786B1 (ko) * 2008-08-06 2013-07-05 화이자 리미티드 멜라노코르틴 4 작용제로서 다이아제핀 및 다이아조칸 화합물
CN105120863B (zh) 2013-03-14 2021-06-04 奥斯特克有限公司 促进骨生长的烷基胺骆驼蓬碱衍生物
CA2960101C (en) * 2014-09-05 2024-05-21 Allosteros Therapeutics, Inc. Substituted carboline derivative and compositions thereof useful as camkii inhibitors
CN108218862B (zh) * 2018-02-07 2020-06-23 贵州医科大学 α-卡波林类衍生物在制备抗心肌缺氧复氧损伤药物中的应用
CN110467560A (zh) * 2018-05-09 2019-11-19 深圳微芯生物科技股份有限公司 一种苯基氨基丙酸钠衍生物、其制备方法和应用
SG11202101151SA (en) 2018-08-14 2021-03-30 Osteoqc Inc Pyrrolo - dipyridine compounds
AU2019320773A1 (en) 2018-08-14 2021-03-04 Osteoqc Inc. Fluoro β-carboline compounds

Family Cites Families (13)

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CH501623A (de) * 1967-12-18 1971-01-15 Ruetgerswerke Ag Verfahren zur Herstellung von 2-Chlorpyridin und seinen Derivaten
US4808608A (en) * 1986-01-23 1989-02-28 Merck & Co., Inc. Tetrahydrocarbazole 1-alkanoic acids, pharmaceutical compositions and use
ES2038653T3 (es) * 1986-01-23 1993-08-01 Merck Frosst Canada Inc. Acidos 1-alcanoicos tetrahidrocarbazol.
US4940719A (en) * 1986-03-27 1990-07-10 Merck Frosst Canada, Inc. Tetrahydrocarbazole esters, pharmaceutical compositions and use
CA1326030C (en) * 1987-07-21 1994-01-11 John W. Gillard Cyclohept[b]indolealkanoic acids
US4775680A (en) * 1987-07-21 1988-10-04 Merck & Co., Inc. Cyclohept[b]indolealkanoic acids, pharmaceutical compositions and use
GB9101375D0 (en) * 1991-01-22 1991-03-06 Erba Carlo Spa N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohepht(b)indole
DE4112533A1 (de) * 1991-04-17 1992-10-22 Bayer Ag Verfahren zur herstellung von enantiomerenreinen substituierten (chinolin-2-yl-methoxy)phenyl-essigsaeuren
DE4200954A1 (de) 1991-04-26 1992-10-29 Bayer Ag Heterocyclisch substituierte phenylessigsaeurederivate
DE4308788A1 (de) * 1993-03-18 1994-09-22 Bayer Ag Hetero-tricyclisch-substituierte Phenyl-cyclohexan-carbonsäurederivate
DE4435477A1 (de) * 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate
DE19613549A1 (de) 1996-04-04 1997-10-09 Bayer Ag Verfahren zur Herstellung von enantiomerenreinen Cycloalkano-indol- und azaindol-carbonsäuren und deren aktivierte Derivate
DE19615119A1 (de) * 1996-04-17 1997-10-23 Bayer Ag Neue Arylessigsäureamide

Also Published As

Publication number Publication date
NO953930L (no) 1996-04-09
MA23683A1 (fr) 1996-07-01
CN1183111C (zh) 2005-01-05
NO953930D0 (no) 1995-10-03
EP0705831A3 (de) 1997-01-22
TW448175B (en) 2001-08-01
CA2159546A1 (en) 1996-04-05
SG63528A1 (en) 1999-03-30
JPH08225526A (ja) 1996-09-03
HU225052B1 (en) 2006-05-29
CN1130631A (zh) 1996-09-11
EP0705831A2 (de) 1996-04-10
AU3292095A (en) 1996-04-18
CN1050605C (zh) 2000-03-22
EP0705831B1 (de) 2003-12-03
AU700609B2 (en) 1999-01-07
DE59510839D1 (de) 2004-01-15
SK284260B6 (sk) 2004-12-01
EE9500071A (et) 1996-04-15
HK1005139A1 (en) 1998-12-24
HRP950505A2 (en) 1997-08-31
HU9502891D0 (en) 1995-11-28
CN1224715A (zh) 1999-08-04
JP3901234B2 (ja) 2007-04-04
US6479503B2 (en) 2002-11-12
ES2211890T3 (es) 2004-07-16
US5684014A (en) 1997-11-04
IL115493A0 (en) 1996-01-19
PH31400A (en) 1998-10-29
MY117282A (en) 2004-06-30
US20020055635A1 (en) 2002-05-09
FI113048B (sv) 2004-02-27
IL129641A (en) 2000-08-31
UA44700C2 (uk) 2002-03-15
PL310756A1 (en) 1996-04-15
ZA958297B (en) 1996-05-06
HUT73240A (en) 1996-07-29
CZ256795A3 (en) 1996-04-17
SV1995000062A (es) 1996-07-10
FI954681A0 (sv) 1995-10-02
CA2159546C (en) 2010-12-14
SI0705831T1 (en) 2004-02-29
FI20002693A (sv) 2000-12-08
KR960014126A (ko) 1996-05-22
SK123995A3 (en) 1996-06-05
PL183154B1 (pl) 2002-05-31
IL129641A0 (en) 2000-02-29
US6858622B2 (en) 2005-02-22
EE03527B1 (et) 2001-10-15
NO305365B1 (no) 1999-05-18
US20030149073A1 (en) 2003-08-07
IL115493A (en) 1999-10-28
HRP950505B1 (en) 2002-04-30
PT705831E (pt) 2004-04-30
RU2157803C2 (ru) 2000-10-20
TNSN95098A1 (fr) 1996-02-06
FI108791B (sv) 2002-03-28
DK0705831T3 (da) 2004-04-05
US6265431B1 (en) 2001-07-24
NZ280130A (en) 1996-05-28
KR100355986B1 (ko) 2003-01-06
DE4435477A1 (de) 1996-04-11
US20020147209A1 (en) 2002-10-10
ATE255580T1 (de) 2003-12-15
HN1995009160A (es) 2000-04-24
DZ1934A1 (fr) 2002-02-17
CZ291348B6 (cs) 2003-02-12
US6245775B1 (en) 2001-06-12

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