FI954067A - Menetelmä valmistaa bentsoehappojohdannaisia välituotteina ja bentsotiofeeneja farmaseuttisina aineina - Google Patents

Menetelmä valmistaa bentsoehappojohdannaisia välituotteina ja bentsotiofeeneja farmaseuttisina aineina Download PDF

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Publication number
FI954067A
FI954067A FI954067A FI954067A FI954067A FI 954067 A FI954067 A FI 954067A FI 954067 A FI954067 A FI 954067A FI 954067 A FI954067 A FI 954067A FI 954067 A FI954067 A FI 954067A
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FI
Finland
Prior art keywords
chem
formula
reaction product
alkyl
reacting
Prior art date
Application number
FI954067A
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English (en)
Swedish (sv)
Other versions
FI114706B (fi
FI954067A0 (fi
Inventor
Douglas Patton Kjell
Fred Mason Perry
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI954067A0 publication Critical patent/FI954067A0/fi
Publication of FI954067A publication Critical patent/FI954067A/fi
Application granted granted Critical
Publication of FI114706B publication Critical patent/FI114706B/fi

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56Radicals substituted by oxygen atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
FI954067A 1994-08-31 1995-08-30 Menetelmä valmistaa bentsoehappojohdannaisia välituotteina ja bentsotiofeeneja farmaseuttisina aineina FI114706B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/298,636 US5631369A (en) 1994-08-31 1994-08-31 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
US29863694 1994-08-31

Publications (3)

Publication Number Publication Date
FI954067A0 FI954067A0 (fi) 1995-08-30
FI954067A true FI954067A (fi) 1996-03-01
FI114706B FI114706B (fi) 2004-12-15

Family

ID=23151367

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954067A FI114706B (fi) 1994-08-31 1995-08-30 Menetelmä valmistaa bentsoehappojohdannaisia välituotteina ja bentsotiofeeneja farmaseuttisina aineina

Country Status (17)

Country Link
US (2) US5631369A (fi)
EP (1) EP0699672B1 (fi)
JP (1) JPH08119964A (fi)
KR (1) KR100359959B1 (fi)
AT (1) ATE165355T1 (fi)
BR (1) BR9503846A (fi)
CA (1) CA2157236A1 (fi)
CY (1) CY2092B1 (fi)
DE (1) DE69502152T2 (fi)
DK (1) DK0699672T3 (fi)
ES (1) ES2114721T3 (fi)
FI (1) FI114706B (fi)
GR (1) GR3026742T3 (fi)
HK (1) HK1006912A1 (fi)
HU (2) HU0003473D0 (fi)
IL (1) IL115092A0 (fi)
TW (1) TW427975B (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR199900403T2 (xx) * 1996-08-28 2002-01-21 Eli Lilly And Company Amorf benzotiofenler, haz�rlama y�ntemleri ve kullanma y�ntemleri.
CA2231013A1 (en) * 1997-04-30 1998-10-30 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
US7124425B1 (en) * 1999-03-08 2006-10-17 Immersion Entertainment, L.L.C. Audio/video system and method utilizing a head mounted apparatus with noise attenuation
WO2001023369A2 (en) * 1999-09-27 2001-04-05 Eli Lilly And Company Process for preparing benzoic acids
FR2817865B1 (fr) * 2000-12-11 2005-02-18 Sanofi Synthelabo Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
AU2003266940B2 (en) 2002-09-30 2007-02-08 A/S Gea Farmaceutisk Fabrik Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these
US7012153B2 (en) * 2003-12-22 2006-03-14 Eli Lilly And Company Process for preparing benzoic acids
CA2960377A1 (en) 2006-06-30 2008-01-03 Iceutica Pty Ltd Methods for the preparation of biologically active compounds in nanoparticulate form
CA2759125C (en) 2009-04-24 2017-08-15 Iceutica Pty Ltd A novel formulation of indomethacin
US9526734B2 (en) 2014-06-09 2016-12-27 Iceutica Pty Ltd. Formulation of meloxicam
KR102117214B1 (ko) 2020-03-26 2020-06-01 유지씨 주식회사 에어 리스 스프레이 건 용 도료 비산 방지 커버 하우징
KR102145873B1 (ko) 2020-06-10 2020-08-20 유지씨 주식회사 에어 리스 스프레이건 용 도료 비산 방지 커버 하우징 및 그 비산 방지 커버 하우징이 결합 된 고소작업대용 도색장치 및 그 비산 방지 커버 하우징이 결합 된 달비계용 도색 장치 및 그 비산 방지 커버 하우징이 결합 된 평면용 도색장치
KR102227020B1 (ko) 2020-12-18 2021-03-12 유지씨 주식회사 스프레이 건 용 도료 비산 방지 커버 하우징 결합체
KR102444617B1 (ko) 2021-05-28 2022-09-16 이다지 도장용 스프레이건의 비산방지장치
KR102607000B1 (ko) 2023-03-24 2023-11-29 이다지 도장용 스프레이 건의 비산방지장치

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
IL65379A0 (en) * 1981-04-03 1982-05-31 Lilly Co Eli Process for preparing acylated benzothiophenes
EP0062503A1 (en) * 1981-04-03 1982-10-13 Eli Lilly And Company Benzothiophene compounds and process for preparing them
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4358593A (en) * 1981-04-03 1982-11-09 Eli Lilly And Company Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4656187A (en) * 1981-08-03 1987-04-07 Eli Lilly And Company Treatment of mammary cancer
CA2020887A1 (en) * 1989-07-28 1991-01-29 Michael Klaus Aromatic carboxylic amides

Also Published As

Publication number Publication date
FI114706B (fi) 2004-12-15
DE69502152D1 (de) 1998-05-28
HU222121B1 (hu) 2003-04-28
GR3026742T3 (en) 1998-07-31
KR100359959B1 (ko) 2003-01-14
HU0003473D0 (fi) 1995-08-30
US5750688A (en) 1998-05-12
EP0699672B1 (en) 1998-04-22
BR9503846A (pt) 1996-09-17
HU9502537D0 (en) 1995-10-30
KR960007543A (ko) 1996-03-22
TW427975B (en) 2001-04-01
JPH08119964A (ja) 1996-05-14
IL115092A0 (en) 1995-12-08
ES2114721T3 (es) 1998-06-01
CY2092B1 (en) 2002-04-05
ATE165355T1 (de) 1998-05-15
CA2157236A1 (en) 1996-03-01
US5631369A (en) 1997-05-20
DE69502152T2 (de) 1998-09-17
EP0699672A1 (en) 1996-03-06
HUT73141A (en) 1996-06-28
DK0699672T3 (da) 1998-10-07
FI954067A0 (fi) 1995-08-30
HK1006912A1 (en) 1999-03-19

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