FI95372B - Förfarande för framställning av terapeutiskt värdefulla arylsulfonamider - Google Patents
Förfarande för framställning av terapeutiskt värdefulla arylsulfonamider Download PDFInfo
- Publication number
- FI95372B FI95372B FI902358A FI902358A FI95372B FI 95372 B FI95372 B FI 95372B FI 902358 A FI902358 A FI 902358A FI 902358 A FI902358 A FI 902358A FI 95372 B FI95372 B FI 95372B
- Authority
- FI
- Finland
- Prior art keywords
- group
- pyridyl
- formula
- acid
- compound
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Claims (2)
1. Förfarande för framställning av terapeutiskt värdefulla arylsulfonamider med formeln Ri R4 R= I I I R1 - S02 -N-A-C-CH-B-CO-R6 (I) ^3 där R^ avser en fenylalkyl-, trialkylfenyl-, tetrametylfenyl-eller pentametylfenylgrupp, eventuellt med en halogenatom eller alkylgruppe substituerad tienylgrupp eller fenylgrupp, som med en nitrogruppe kan vara monosubstituerad eller med en halogenatom, alkyl-, trifluormetyl- eller alkoxigrupp mono-eli er disubstituerad, varvid substituenterna kan vara lika eller olika, R2, R4 och Rg, som kan vara lika eller olika, avser repektive en väteatom eller alkylgrupp eller R2 avser en väteatom eller alkylgrupp och R4 och Rg tillsammans en kol-kol-bindning, r3 är en 3-pyridylgrupp, Rg är en hydroxi-, alkoxi-, amino-, alkylamino- eller dialkyl-aminogrupp, A är en grupp med formeln ... OfV tai lii' n8 joissa R7 avser en väteatom eller alkylgrupp, Rg en väteatom tai r7 och Rg tillsammans avser en metylen- eller etylengrupp och 70 9537? t X en med en alkylgrupp substituerad iminogrupp, syre- eller svavelatom, varvid en -CHR^-grupp är ansluten till -NR2-grup-pen, och B avser en koi-kol-bindning eller eventuellt med en eller tva alkylgrupper substituerad rakkedig alkylengrupp med 1-4 kolatomer, varvid alla ovan nämnda alkyl- och alkoxidelar respektive kan innehälla 1-3 kolatomer, deras enantiomerer, deras cis- och trans-isomerer, savida R^ och Rg tillsammans bildar en kol-kol-bindning, och deras additionssalter, kännetecknat därav, att a. ) en förening med formeln R4 R5 H-N-A-i-CH-B-CO-Ri· (II) A I K2 K3 där R2 ~ R5' A och B avser det samma som ovan, acyl eras med ett sulfonsyraderivat med formeln Rx - S02Y (III) där R^ avser det samma som ovan och Y avser en nukleofil avgäende grupp, säsom en halogenatom eller alkoxigrupp, t.ex. klor- eller bromatom, metoxi- eller etoxigrupp, eller b. ) för framställning av en förening med formeln I, där Rg avser en hydroxigrupp, en förening med formeln * Ro R^ Κς I I I R-i - SO, - N- A- C-CH-B-CO-Z (IV) R3 där R1 - R5, A och B avser det samma som ovan och 71 95372 Z är en hydrolytiskt, termolytiskt eller hydrogenolytiskt avspjälkbar karboxigrupp eller karboxigruppens funktionella derivats skyddsgrupp, avspjälks skyddsgruppen, eller c. ) för framställning av en förening med formeln I, där R4 och R5 resspektive avser väteatomer, en förening med formeln I2 Hi - S02 - N - A - C = CH - B - CO - Rg (V) där Rl - R3, Rg/ A och B avser det samma som ovan, hydreras eller d. ) för framställning av en förening med formeln I, där R4 och R5 tillsammans bildar en koi-koi-bindning, en förening med formeln I2 R1 - S02 - N - A - CO - R3 (VI) där Rl - R3 och A avser det samma som ovan, omsätts med en förening med formeln ' r W - CH - B - CO - Rg (VII) där B och Rg avser det samma som ovan, . R51 avser en väteatom eller alkylgrupp med 1-3 kolatomer och W avser en trifenylfosfoniumhalogenid-, dialkylfosfonsyra-eller magnesiumhalogenidrest och eventuellt därefter avspjälks vatten och vid behov därefter en sä erhällen förening med formeln I, där R2 avser en väteatom, omvandlas genom alkylering tili motsva-rande förening med formeln I, där R2 avser en alkylgrupp tai * 72 95372 en si erhillen förening med formeln I, där Rg avser en hydro-xigrupp, omvandlas genom forestring eller amidbildningsreakti-on till motsvarande förening med formeln I, där Rg avser en alkoxi-, amino-, alkylamino- eller dialkylaminogrupp eller en si erhillen förening med formeln I, där R^ och Rg tillsam-mans avser en koi-koi-bindning, separeras i sina cis- och trans-isomerer eller en si erhillen förening med formeln I separeras i sin enantiomerer eller en si erhillen förening med formeln I omvandlas till sina additionssalter, särskilt fysio-logiskt lämpliga additionssaalter med ooganiska eller organis-ka baser.
2. Förfarande enligt patentkravef 1, kännetecknat därav, att en förening, som är 6-(2-(4-toluensulfonylamino)indan-5-yl)-6-(3-pyridyl)-hex-5-ensyra, 6-(4-(2-(4-klorbensensulfonylamino)etyl)fenyl)-6-(3-pyridyl)-hex-5-ensyra och 6-(4-(2-(4-trifluormetylbensensulfonylamino)etyl)feny1)-6-(3-pyridyl)-hex-5-ensyra och deras syraadditionssalter, frams-tälIs. !l Ht-h
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3915506A DE3915506A1 (de) | 1989-05-12 | 1989-05-12 | Neue arylsulfonamide, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE3915506 | 1989-05-12 | ||
| DE3932403 | 1989-09-28 | ||
| DE3932403A DE3932403A1 (de) | 1989-05-12 | 1989-09-28 | Neue arylsulfonamide, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI902358A0 FI902358A0 (sv) | 1990-05-11 |
| FI95372B true FI95372B (sv) | 1995-10-13 |
| FI95372C FI95372C (sv) | 1996-01-25 |
Family
ID=25880794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI902358A FI95372C (sv) | 1989-05-12 | 1990-05-11 | Förfarande för framställning av terapeutiskt värdefulla arylsulfonamider |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US5294626A (sv) |
| EP (1) | EP0397044B1 (sv) |
| JP (1) | JP2868283B2 (sv) |
| KR (1) | KR0153527B1 (sv) |
| AT (1) | ATE132138T1 (sv) |
| AU (1) | AU627024B2 (sv) |
| CA (1) | CA2016646C (sv) |
| DE (2) | DE3932403A1 (sv) |
| DK (1) | DK0397044T3 (sv) |
| ES (1) | ES2083394T3 (sv) |
| FI (1) | FI95372C (sv) |
| GR (1) | GR3019044T3 (sv) |
| HU (1) | HU214586B (sv) |
| IE (1) | IE74207B1 (sv) |
| IL (1) | IL94347A0 (sv) |
| MX (1) | MX9202816A (sv) |
| NO (1) | NO176176C (sv) |
| NZ (1) | NZ233638A (sv) |
| PT (1) | PT93994B (sv) |
| RU (1) | RU2096405C1 (sv) |
| UA (1) | UA26136C2 (sv) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5153214A (en) * | 1989-06-28 | 1992-10-06 | Ciba-Geigy Corporation | Certain (arylsulfonamido- and imidazolyl-)-substituted carboxylic acids and derivatives thereof and use for suppressing thromboxane activity |
| DE4025818A1 (de) * | 1990-08-16 | 1992-02-20 | Bayer Ag | Phenylsulfonamid substituierte pyridinalken- und -aminooxyalkancarbonsaeure-derivate |
| DE4037112A1 (de) * | 1990-11-22 | 1992-05-27 | Thomae Gmbh Dr K | Neue pyridylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US5286736A (en) * | 1990-11-22 | 1994-02-15 | Dr. Karl Thomae Gmbh | Pyridyl compounds and pharmaceutical compositions containing these compounds |
| US5374641A (en) * | 1991-02-25 | 1994-12-20 | Terumo Kabushiki Kaisha | N-(3-pyridylalkyl)sulfonamide compounds which have useful pharmaceutical activity |
| GB9107043D0 (en) * | 1991-04-04 | 1991-05-22 | Pfizer Ltd | Therapeutic agents |
| DE4216364A1 (de) * | 1991-12-14 | 1993-11-25 | Thomae Gmbh Dr K | Neue Pyridylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| FR2686339B1 (fr) * | 1992-01-22 | 1994-03-11 | Adir Cie | Nouveaux amides et sulfonamides naphtaleniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| DE4213919A1 (de) * | 1992-04-28 | 1993-11-04 | Thomae Gmbh Dr K | Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| CA2347939C (en) | 1998-10-23 | 2006-10-10 | Akira Matsumori | Composition for the treatment of rheumatism, hepatitis or pancreatitis |
| EP2417101B1 (en) * | 2009-04-09 | 2013-10-23 | Merck Sharp & Dohme B.V. | Indane derivatives |
| US9492422B2 (en) | 2009-11-13 | 2016-11-15 | Toray Industries, Inc. | Therapeutic or prophylactic agent for diabetes |
| US9955802B2 (en) | 2015-04-08 | 2018-05-01 | Fasteners For Retail, Inc. | Divider with selectively securable track assembly |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1134828A (en) * | 1978-12-28 | 1982-11-02 | Tadao Tanouchi | Pyridine derivatives |
| EP0098690B1 (en) * | 1982-06-14 | 1987-09-09 | Takeda Chemical Industries, Ltd. | Vinyl carboxylic acid derivatives, their production and use |
| US4518602A (en) * | 1982-10-07 | 1985-05-21 | Takeda Chemical Industries, Ltd. | Vinyl carboxylic acid derivatives, their production and use as inhibitors of thromboxane synthetase |
| US4563446A (en) * | 1983-07-27 | 1986-01-07 | Takeda Chemical Industries, Ltd. | Thromboxane synthetase inhibiting 3-(1-alkenyl) pyridines |
| ES2061432T3 (es) * | 1985-10-09 | 1994-12-16 | Shell Int Research | Nuevas amidas de acido acrilico. |
| DE3623944A1 (de) * | 1986-07-16 | 1988-02-11 | Thomae Gmbh Dr K | Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| GB8708233D0 (en) * | 1987-04-07 | 1987-05-13 | Smith Kline French Lab | Pharmaceutically active compounds |
| EP0304271A3 (en) * | 1987-08-20 | 1992-09-02 | Smith Kline & French Laboratories Limited | Omega-arylsulphonamidoalkanoic acids for treatment of thromboxane medited diseases |
-
1989
- 1989-09-28 DE DE3932403A patent/DE3932403A1/de not_active Withdrawn
-
1990
- 1990-05-04 AT AT90108433T patent/ATE132138T1/de not_active IP Right Cessation
- 1990-05-04 DK DK90108433.5T patent/DK0397044T3/da active
- 1990-05-04 DE DE59009994T patent/DE59009994D1/de not_active Expired - Fee Related
- 1990-05-04 ES ES90108433T patent/ES2083394T3/es not_active Expired - Lifetime
- 1990-05-04 EP EP90108433A patent/EP0397044B1/de not_active Expired - Lifetime
- 1990-05-10 PT PT93994A patent/PT93994B/pt not_active IP Right Cessation
- 1990-05-10 IL IL94347A patent/IL94347A0/xx not_active IP Right Cessation
- 1990-05-10 NZ NZ233638A patent/NZ233638A/en unknown
- 1990-05-10 KR KR1019900006587A patent/KR0153527B1/ko not_active IP Right Cessation
- 1990-05-11 IE IE170890A patent/IE74207B1/en not_active IP Right Cessation
- 1990-05-11 HU HU903013A patent/HU214586B/hu not_active IP Right Cessation
- 1990-05-11 AU AU54924/90A patent/AU627024B2/en not_active Ceased
- 1990-05-11 JP JP2122825A patent/JP2868283B2/ja not_active Expired - Lifetime
- 1990-05-11 CA CA002016646A patent/CA2016646C/en not_active Expired - Fee Related
- 1990-05-11 FI FI902358A patent/FI95372C/sv not_active IP Right Cessation
- 1990-05-11 NO NO902099A patent/NO176176C/no not_active IP Right Cessation
- 1990-05-14 US US07/523,167 patent/US5294626A/en not_active Expired - Fee Related
-
1992
- 1992-01-08 RU SU925010477A patent/RU2096405C1/ru active
- 1992-06-12 MX MX9202816A patent/MX9202816A/es unknown
-
1993
- 1993-05-12 UA UA93002789A patent/UA26136C2/uk unknown
- 1993-11-18 US US08/154,647 patent/US5426119A/en not_active Expired - Fee Related
-
1995
- 1995-03-21 US US08/407,180 patent/US5681961A/en not_active Expired - Fee Related
-
1996
- 1996-02-21 GR GR960400447T patent/GR3019044T3/el unknown
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Owner name: DR. KARL THOMAE GESELLSCHAFT MIT |