FI952677A0 - Menetelmä fenyylipropionihapon oleellisesti puhtaiden enantiomeerien valmistamiseksi - Google Patents

Menetelmä fenyylipropionihapon oleellisesti puhtaiden enantiomeerien valmistamiseksi

Info

Publication number
FI952677A0
FI952677A0 FI952677A FI952677A FI952677A0 FI 952677 A0 FI952677 A0 FI 952677A0 FI 952677 A FI952677 A FI 952677A FI 952677 A FI952677 A FI 952677A FI 952677 A0 FI952677 A0 FI 952677A0
Authority
FI
Finland
Prior art keywords
pct
phenylpropionic acid
stage
preparation
date jun
Prior art date
Application number
FI952677A
Other languages
English (en)
Swedish (sv)
Other versions
FI952677A (fi
FI110776B (fi
Inventor
Robert Hardy
Paul Frederick Coe
Adrian Hirst
Hugh Owen O'donnell
Original Assignee
Boots Co Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929225202A external-priority patent/GB9225202D0/en
Priority claimed from GB929225203A external-priority patent/GB9225203D0/en
Application filed by Boots Co Plc filed Critical Boots Co Plc
Publication of FI952677A publication Critical patent/FI952677A/fi
Publication of FI952677A0 publication Critical patent/FI952677A0/fi
Application granted granted Critical
Publication of FI110776B publication Critical patent/FI110776B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI952677A 1992-12-02 1995-06-01 Menetelmä substituoitujen fenyylipropionihappojen oleellisesti puhtaiden enantiomeerien valmistamiseksi FI110776B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB929225202A GB9225202D0 (en) 1992-12-02 1992-12-02 Process
GB929225203A GB9225203D0 (en) 1992-12-02 1992-12-02 Process
GB9225203 1992-12-02
GB9225202 1992-12-02
EP9303376 1993-11-30
PCT/EP1993/003376 WO1994012460A1 (en) 1992-12-02 1993-11-30 Process for preparing substantially pure enantiomers of phenylpropionic acids

Publications (3)

Publication Number Publication Date
FI952677A FI952677A (fi) 1995-06-01
FI952677A0 true FI952677A0 (fi) 1995-06-01
FI110776B FI110776B (fi) 2003-03-31

Family

ID=26302084

Family Applications (1)

Application Number Title Priority Date Filing Date
FI952677A FI110776B (fi) 1992-12-02 1995-06-01 Menetelmä substituoitujen fenyylipropionihappojen oleellisesti puhtaiden enantiomeerien valmistamiseksi

Country Status (12)

Country Link
US (1) US5599969A (fi)
EP (1) EP0672030B1 (fi)
JP (1) JPH08504193A (fi)
KR (1) KR100280766B1 (fi)
AT (1) ATE151740T1 (fi)
AU (1) AU672269B2 (fi)
CA (1) CA2150355C (fi)
DE (1) DE69309958T2 (fi)
ES (1) ES2100037T3 (fi)
FI (1) FI110776B (fi)
RU (1) RU2133733C1 (fi)
WO (1) WO1994012460A1 (fi)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380867A (en) * 1992-12-02 1995-01-10 Hoechst Celanese Corporation Selective precipitation of α-aryl carboxylic acid salts
IN189741B (fi) * 1998-11-09 2003-04-19 Council Scient Ind Res
JP2003530437A (ja) * 2000-04-13 2003-10-14 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ Ａβ４２低下物質
JP2002069030A (ja) * 2000-08-30 2002-03-08 Kyowa Hakko Kogyo Co Ltd ナトリウム２−｛４−［（２−オキソシクロペンチル）メチル］フェニル｝プロピオネート２水和物の製造法
JP2006335639A (ja) * 2003-01-23 2006-12-14 Nagase & Co Ltd 光学活性なフルルビプロフェンの製造方法
WO2004071431A2 (en) * 2003-02-05 2004-08-26 Myriad Genetics, Inc. Method and composition for treating neurodegenerative disorders
CA2532207A1 (en) * 2003-07-11 2005-07-21 Myriad Genetics, Inc. Pharmaceutical methods, dosing regimes and dosage forms for the treatment of alzheimer's disease
WO2006001877A2 (en) * 2004-04-13 2006-01-05 Myriad Genetics, Inc. Combination treatment for neurodegenerative disorders comprising r-flurbiprofen
WO2005108683A1 (en) * 2004-04-29 2005-11-17 Keystone Retaining Wall Systems, Inc. Veneers for walls, retaining walls and the like
WO2006020852A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
WO2006020850A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
CA2580363A1 (en) * 2004-10-28 2006-05-11 Idexx Laboratories, Inc. Compositions for controlled delivery of pharmaceutically active compounds
NZ564789A (en) * 2005-07-22 2010-07-30 Myriad Genetics Inc High drug load formulations and dosage forms
US8114440B2 (en) * 2005-11-16 2012-02-14 Idexx Laboratories Inc. Pharmaceutical compositions for the administration of aptamers
US7754679B2 (en) * 2005-11-16 2010-07-13 Idexx Laboratories, Inc. Pharmaceutical compositions for the administration of aptamers
EP2046119A2 (en) * 2006-07-07 2009-04-15 Myriad Genetics, Inc. Treatment of psychiatric disorders
EP2117302A1 (en) * 2007-02-01 2009-11-18 Myriad Genetics, Inc. Drug substance preparations, pharmaceutical compositions and dosage forms
US8828960B2 (en) * 2007-07-17 2014-09-09 Idexx Laboratories, Inc. Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds
GB0811851D0 (en) * 2008-06-30 2008-07-30 Aesica Pharmaceuticals Ltd Process
GB201216893D0 (en) * 2012-09-21 2012-11-07 Aesica Pharmaceuticals Ltd Drug substance preparations, pharmaceutical compositions and dosage forms comprising s-(+)-flurbiprofen
GB201405456D0 (en) * 2014-03-26 2014-05-07 Aesica Pharmaceuticals Ltd Process for the manufacture of S-(+)-Flurbiprofen
CN115286501A (zh) * 2022-08-10 2022-11-04 浙江新和成股份有限公司 一种布洛芬结晶母液的综合利用方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1497044A (en) * 1974-03-07 1978-01-05 Prodotti Antibiotici Spa Salts of phenyl-alkanoic acids
IT1059677B (it) * 1974-03-22 1982-06-21 Neopharmed Spa Sale di lisina ad azione terapeutica
JPS55136245A (en) * 1979-04-09 1980-10-23 Sumitomo Chem Co Ltd Optical resolution of alpha-isopropyl-p-chlorophenyl-acetic acid
DE3824353A1 (de) * 1988-07-19 1990-01-25 Paz Arzneimittelentwicklung Verfahren zur trennung von gemischen enantiomerer arylpropionsaeuren
FI902435A0 (fi) * 1989-05-16 1990-05-16 Puetter Medice Chem Pharm Foerfarande foer framstaellning av 2-asylalkanoinsyror.
US5200558A (en) * 1989-10-17 1993-04-06 Merck & Co., Inc. S(+)-ibuprofen-L-amino acid and S(+)-ibuprofen-D-amino acid as onset-hastened enhanced analgesics
PT95564B (pt) * 1989-10-17 1997-11-28 Merck & Co Inc Processo para a preparacao de (+)-ibuprofen-d-aminoacido uteis como analgesicos intensificados de ataque acelerado
US4994604A (en) * 1990-01-10 1991-02-19 Merck & Co., Inc. Formation and resolution of ibuprofen lysinate
US5015764A (en) * 1990-06-18 1991-05-14 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
DE4028906A1 (de) * 1990-09-12 1992-03-19 Paz Arzneimittelentwicklung Arzneimittel sowie deren herstellung und deren verwendung bei der bekaempfung von schmerzen und/oder entzuendungen und/oder fieber an tieren und menschen
HUT59692A (en) * 1990-11-15 1992-06-29 Puetter Medice Chem Pharm Process for producing complexes containing s/+/-phenyl-alkanoic acids and aminosugars
HUT59656A (en) * 1990-11-15 1992-06-29 Puetter Medice Chem Pharm Process for producing s/+/-phenyl-alkanoic acids and alpha-amino-acids containing complexes and pharmaceutical compositions containing them as active components
ES2093192T3 (es) * 1991-03-22 1996-12-16 Merck & Co Inc Formulacion farmaceutica con elevado contenido de lisinato de ibuprofeno.
HU219242B (en) * 1991-05-13 2001-03-28 Boots Co Plc S(+)-ibuprofen sodium salt dihydrate, pharmaceutical composition comprising this compound and process for production of them
FR2687673B1 (fr) * 1992-01-13 1995-07-07 Jung Jean Sels amines d'acides arylcarboxyliques, sterilisables, solubles dans l'eau, utilises en ophtalmologie et/ou dans la sphere otorhinolaryngologique.
US5302751A (en) * 1992-01-21 1994-04-12 Ethyl Corporation Profen resolution
WO1994003209A1 (en) * 1992-07-29 1994-02-17 Merck & Co., Inc. Dexibuprofen/antacid/simethicone combinations
US5288507A (en) * 1992-07-29 1994-02-22 Merck & Co., Inc. Ibuprofen antacid combinations
JPH08501796A (ja) * 1992-09-29 1996-02-27 メルク エンド カンパニー インコーポレーテッド イブプロフェン−カフェイン配合物
US5248813A (en) * 1992-10-14 1993-09-28 Ethyl Corporation Enantiomeric resolution
US5278337A (en) * 1992-10-14 1994-01-11 Ethyl Corporation Enantiomeric resolution of aryl-substituted aliphatic carboxylic acids
US5260482A (en) * 1992-10-14 1993-11-09 Ethyl Corporation Enantiomeric resolution
US5380867A (en) * 1992-12-02 1995-01-10 Hoechst Celanese Corporation Selective precipitation of α-aryl carboxylic acid salts

Also Published As

Publication number Publication date
RU2133733C1 (ru) 1999-07-27
DE69309958T2 (de) 1997-07-24
ATE151740T1 (de) 1997-05-15
FI952677A (fi) 1995-06-01
DE69309958D1 (de) 1997-05-22
JPH08504193A (ja) 1996-05-07
RU95113445A (ru) 1997-06-10
ES2100037T3 (es) 1997-06-01
AU5650494A (en) 1994-06-22
EP0672030A1 (en) 1995-09-20
CA2150355C (en) 2008-03-11
FI110776B (fi) 2003-03-31
CA2150355A1 (en) 1994-06-09
WO1994012460A1 (en) 1994-06-09
AU672269B2 (en) 1996-09-26
KR950704226A (ko) 1995-11-17
US5599969A (en) 1997-02-04
KR100280766B1 (ko) 2001-02-01
EP0672030B1 (en) 1997-04-16

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Owner name: AESICA PHARMACEUTICALS LTD.

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