FI94758B - Makrocykliska föreningar, med en 3,6,9,15-tetra-azabicyklo/9.3.1/pentadekanstruktur, deras användning i NMR-, röntgen- eller radiodiagnostik användbara kompositoner, och sådana kompositioner - Google Patents

Makrocykliska föreningar, med en 3,6,9,15-tetra-azabicyklo/9.3.1/pentadekanstruktur, deras användning i NMR-, röntgen- eller radiodiagnostik användbara kompositoner, och sådana kompositioner Download PDF

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Publication number
FI94758B
FI94758B FI910276A FI910276A FI94758B FI 94758 B FI94758 B FI 94758B FI 910276 A FI910276 A FI 910276A FI 910276 A FI910276 A FI 910276A FI 94758 B FI94758 B FI 94758B
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FI
Finland
Prior art keywords
group
hydrogen atom
solution
water
denotes
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FI910276A
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English (en)
Finnish (fi)
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FI910276A0 (sv
FI910276A (sv
FI94758C (sv
Inventor
Bernd Raduechel
Heinz Gries
Hanns-Joachim Weinmann
Wolf-Ruediger Press
Johannes Platzek
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Schering Ag
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Publication of FI910276A publication Critical patent/FI910276A/sv
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Publication of FI94758C publication Critical patent/FI94758C/sv

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic System without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Claims (5)

1. Makrocykliska föreningar med en 3,6,9,15-tetra-azabicyklo[9.3.1]pentadekanstruktur och med den allmänna 5 formeln (I) g /Cx X1 T X1 il li tOOC-CH M N-CH-COOZ / τ \ B1 C1 CH-X2 15 väri C00Z ... betecknar en enkel bindning eller en dubbel-bindning, Q betecknar en kväveatomeller eller grupp NH, X1 och X2 betecknar oberoende av varandra en väte-20 atom eller en grupp “(CH2)n-0H eller -(CH2)m-(CH)n-CH2OH , i vilka n är ett av talen 1-5 och OH m är ett av talen 0-2, A1, B1, C‘ och D1 betecknar oberoende av varandra en väteatom eller en grupp bensyloximetyl eller -(CH2)n-OH, 25 väri n är ett av talen 1-5, G betecknar en väteatom eller en annan makrocyklisk grupp med den allmänna formeln (II) 30 I [ II' (JI)· ZOOC-CH N N-CH-COOZ 35 -- CH-X2 cooz 44 94758 och Z betecknar en väteatom och/eller en metalljon-ekvivalent av ett grundämne av ordningstalen 21 - 29, 31, 32, 37 - 39, 42 - 44, 49 eller 57 - 83, 5 förutsatt, att X1 och X2 är endast i det fall bägge väteatomer, när ätminstone en av de fyra ringsubstituent-erna A1, B1, C1 och D1 är annan än en väteatom.
2. Användning av ätminstone en fysiologiskt godtag-bar förening enligt patentkrav 1 för framställning av en 10 komposition som används för NMR-, röntgen- eller radio-diagnostik.
3. Kompositioner som används vid diagnostik, kännetecknade därav, att de innehäller ätminstone en förening enligt patentkrav 1, evetuellt till- 15 sammans med sedvanliga galeniska tillsatsämnen.
4. Kompositioner som används vid diagnostik, kännetecknade därav, att de innehäller ätminstone en förening enligt patentkrav 1 i form av liposo-mer. 20
5. Förfarande för framställning av kompositioner enligt patentkrav 3, kännetecknat därav, att en i vatten eller i en fysiologisk saltlösning upplöst eller suspenderad komplexförening, evetuellt tillsammans med sedvanliga galeniska tillsatsämnen, bringas i en form 25 lämplig för enteral eller parenteral administration. 1 9 . . a
FI910276A 1990-01-18 1991-01-18 Makrocykliska föreningar, med en 3,6,9,15-tetra-azabicyklo/9.3.1/pentadekanstruktur, deras användning i NMR-, röntgen- eller radiodiagnostik användbara kompositoner, och sådana kompositioner FI94758C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4001655 1990-01-18
DE4001655A DE4001655A1 (de) 1990-01-18 1990-01-18 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Publications (4)

Publication Number Publication Date
FI910276A0 FI910276A0 (sv) 1991-01-18
FI910276A FI910276A (sv) 1991-07-19
FI94758B true FI94758B (sv) 1995-07-14
FI94758C FI94758C (sv) 1995-10-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
FI910276A FI94758C (sv) 1990-01-18 1991-01-18 Makrocykliska föreningar, med en 3,6,9,15-tetra-azabicyklo/9.3.1/pentadekanstruktur, deras användning i NMR-, röntgen- eller radiodiagnostik användbara kompositoner, och sådana kompositioner

Country Status (19)

Country Link
EP (1) EP0438206B1 (sv)
JP (1) JPH05112567A (sv)
KR (1) KR910014377A (sv)
AT (1) ATE141602T1 (sv)
AU (1) AU6981291A (sv)
CA (1) CA2034242A1 (sv)
DE (2) DE4001655A1 (sv)
DK (1) DK0438206T3 (sv)
ES (1) ES2091865T3 (sv)
FI (1) FI94758C (sv)
GR (1) GR3020973T3 (sv)
HU (1) HUT56569A (sv)
IE (1) IE75898B1 (sv)
IL (1) IL96840A0 (sv)
NO (1) NO910191L (sv)
NZ (1) NZ236803A (sv)
PT (1) PT96505B (sv)
TW (1) TW233298B (sv)
ZA (1) ZA91389B (sv)

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US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
AU4237493A (en) * 1993-05-06 1994-12-12 Dow Chemical Company, The Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals
US5358704A (en) * 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
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HRP20170874T4 (hr) 2013-04-26 2022-09-02 Guerbet Formulacija kontrastnog medija i odgovarajući postupak dobivanja
KR102464647B1 (ko) 2016-11-28 2022-11-08 바이엘 파마 악티엔게젤샤프트 자기 공명 영상화에 사용하기 위한 높은 이완도 가돌리늄 킬레이트 화합물
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FR3091872B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese
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Also Published As

Publication number Publication date
EP0438206B1 (de) 1996-08-21
ES2091865T3 (es) 1996-11-16
ZA91389B (en) 1991-10-30
NO910191L (no) 1991-07-19
FI910276A0 (sv) 1991-01-18
HU910156D0 (en) 1991-08-28
FI910276A (sv) 1991-07-19
IE75898B1 (en) 1997-09-24
ATE141602T1 (de) 1996-09-15
HUT56569A (en) 1991-09-30
PT96505A (pt) 1991-10-15
FI94758C (sv) 1995-10-25
EP0438206A1 (de) 1991-07-24
IL96840A0 (en) 1991-09-16
IE910162A1 (en) 1991-07-31
NO910191D0 (no) 1991-01-17
KR910014377A (ko) 1991-08-31
DE4001655A1 (de) 1991-07-25
TW233298B (sv) 1994-11-01
CA2034242A1 (en) 1991-07-19
NZ236803A (en) 1993-08-26
GR3020973T3 (en) 1996-12-31
DE59108091D1 (de) 1996-09-26
PT96505B (pt) 1998-07-31
DK0438206T3 (sv) 1997-01-20
AU6981291A (en) 1991-08-22
JPH05112567A (ja) 1993-05-07

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