FI944822A - Galantaminderivat, förfarande för framställning av dessa och användning av dessa i läkemedel - Google Patents

Galantaminderivat, förfarande för framställning av dessa och användning av dessa i läkemedel Download PDF

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Publication number
FI944822A
FI944822A FI944822A FI944822A FI944822A FI 944822 A FI944822 A FI 944822A FI 944822 A FI944822 A FI 944822A FI 944822 A FI944822 A FI 944822A FI 944822 A FI944822 A FI 944822A
Authority
FI
Finland
Prior art keywords
pharmaceuticals
processes
preparation
alkylaminocarbonyloxy
galantamine derivatives
Prior art date
Application number
FI944822A
Other languages
English (en)
Finnish (fi)
Other versions
FI944822A0 (sv
FI108724B (sv
Inventor
Raymond W Kosley Jr
Larry Davis
Veronica Taberna
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of FI944822A0 publication Critical patent/FI944822A0/sv
Publication of FI944822A publication Critical patent/FI944822A/sv
Application granted granted Critical
Publication of FI108724B publication Critical patent/FI108724B/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI944822A 1993-10-15 1994-10-13 Förfarande för framställning av terapeutiskt användbara karbamoyloxiderivat av 4a,5,9,10,11,12-hexahydro-11-metyl-6H-bensofuro[3a,3,2-ef][2]bensazepin 3,6-diol och farmaceutiskt godtagbara syraadditionssalter därav FI108724B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13744393 1993-10-15
US08/137,443 US6323196B1 (en) 1993-10-15 1993-10-15 Galanthamine derivatives as acetylcholinesterase inhibitors

Publications (3)

Publication Number Publication Date
FI944822A0 FI944822A0 (sv) 1994-10-13
FI944822A true FI944822A (sv) 1995-04-16
FI108724B FI108724B (sv) 2002-03-15

Family

ID=22477457

Family Applications (1)

Application Number Title Priority Date Filing Date
FI944822A FI108724B (sv) 1993-10-15 1994-10-13 Förfarande för framställning av terapeutiskt användbara karbamoyloxiderivat av 4a,5,9,10,11,12-hexahydro-11-metyl-6H-bensofuro[3a,3,2-ef][2]bensazepin 3,6-diol och farmaceutiskt godtagbara syraadditionssalter därav

Country Status (24)

Country Link
US (1) US6323196B1 (sv)
EP (2) EP1020469A3 (sv)
JP (1) JP2718637B2 (sv)
KR (1) KR100189043B1 (sv)
CN (1) CN1039011C (sv)
AT (1) ATE201687T1 (sv)
AU (1) AU679560B2 (sv)
CA (1) CA2118171C (sv)
CZ (1) CZ283561B6 (sv)
DE (1) DE69427332T2 (sv)
DK (1) DK0648771T3 (sv)
EG (1) EG20747A (sv)
ES (1) ES2158876T3 (sv)
FI (1) FI108724B (sv)
GR (1) GR3036068T3 (sv)
IL (1) IL111273A (sv)
NO (1) NO307463B1 (sv)
NZ (1) NZ264681A (sv)
PL (1) PL177754B1 (sv)
PT (1) PT648771E (sv)
RO (1) RO114132B1 (sv)
RU (1) RU2113438C1 (sv)
TW (1) TW375615B (sv)
ZA (1) ZA948060B (sv)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT403803B (de) 1996-04-19 1998-05-25 Sanochemia Ltd Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
US7939522B1 (en) 1998-11-23 2011-05-10 Bonnie M Davis Dosage formulations for acetylcholinesterase inhibitors
UA79578C2 (en) 1998-12-24 2007-07-10 Janssen Pharmaceutica Nv Controlled release composition containing galantamine, process for the preparation thereof, dosage form and packaging
JP2003516947A (ja) * 1999-12-10 2003-05-20 デイビス、ボニー ニコチン様物質受容体のモジュレーターとしてのガランタミンおよびリコラミンの類似物
EP1181294B1 (de) 2000-03-31 2004-03-31 Sanochemia Pharmazeutika Aktiengesellschaft Neue derivate und analoga von galanthamin
US20030162770A1 (en) * 2002-02-22 2003-08-28 Davis Bonnie M. Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
US20040142970A1 (en) * 2002-11-01 2004-07-22 Kathryn Chung Treatment of hyperkinetic movement disorder with donepezil
US20050048543A1 (en) * 2003-07-11 2005-03-03 Jeroen Aerssens CHRNA2 genetic markers associated with galantamine response
WO2005042762A2 (en) * 2003-10-28 2005-05-12 Genaissance Pharmaceuticals, Inc. Lrpap1 genetic markers associated with galantamine response
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
US7250258B2 (en) * 2003-12-15 2007-07-31 Pgxhealth Llc CDK5 genetic markers associated with galantamine response
US20050142193A1 (en) * 2003-12-31 2005-06-30 Lijuan Tang Galantamine formulations
US20050191349A1 (en) * 2003-12-31 2005-09-01 Garth Boehm Galantamine formulations
EP1779867A4 (en) * 2004-07-01 2009-12-02 Eisai R&D Man Co Ltd MEANS FOR PROMOTING NERVE REVENERATION
EP2316437B1 (en) * 2005-05-13 2014-07-30 Alza Corporation Multilayer drug delivery system with barrier against reservoir material flow
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
US20090253654A1 (en) 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
EP1777222A1 (en) * 2005-09-22 2007-04-25 Galantos Pharma GmbH Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
EP1937226A2 (en) * 2005-09-23 2008-07-02 Alza Corporation Transdermal galantamine delivery system
KR100786371B1 (ko) * 2006-12-07 2007-12-17 한국화학연구원 갈란타민의 제조방법
CN102007129B (zh) 2008-04-14 2014-05-07 神经动力生命科学公司 用作治疗人类脑疾病的前药的雪花胺衍生物
BR112012001551A2 (pt) * 2009-07-23 2017-07-11 Shire Llc profármacos de aminoácido galantamina e peptídeo e usos dos mesmos

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL122665B1 (en) 1978-11-21 1982-08-31 Edinen Zentar Chim Process for preparing novel dienones of narvedine type and their derivatives
US4663318A (en) 1986-01-15 1987-05-05 Bonnie Davis Method of treating Alzheimer's disease
US6150354A (en) * 1987-01-15 2000-11-21 Bonnie Davis Compounds for the treatment of Alzheimer's disease
EP0363415B1 (en) * 1987-05-04 2008-10-15 Davis, Bonnie Compounds for the treatment of alzheimer's disease
NL8800350A (nl) 1988-02-12 1989-09-01 Stichting Biomedical Research Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
US5336675A (en) * 1991-05-14 1994-08-09 Ernir Snorrason Method of treating mania in humans
CA2108880A1 (en) * 1991-05-14 1992-11-15 Ernir Snorrason Treatment of fatigue syndrome with cholinesterase inhibitors
US5153193A (en) 1991-10-01 1992-10-06 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US5231093A (en) * 1991-10-01 1993-07-27 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs

Also Published As

Publication number Publication date
CA2118171C (en) 1999-12-28
EP0648771B1 (en) 2001-05-30
NO943894D0 (no) 1994-10-14
CA2118171A1 (en) 1995-04-16
JPH07188238A (ja) 1995-07-25
FI944822A0 (sv) 1994-10-13
ATE201687T1 (de) 2001-06-15
DK0648771T3 (da) 2001-08-27
DE69427332T2 (de) 2001-10-11
EP1020469A2 (en) 2000-07-19
RU2113438C1 (ru) 1998-06-20
AU679560B2 (en) 1997-07-03
IL111273A (en) 1998-04-05
PL177754B1 (pl) 2000-01-31
RU94036761A (ru) 1996-09-10
CN1039011C (zh) 1998-07-08
GR3036068T3 (en) 2001-09-28
EP0648771A1 (en) 1995-04-19
PL305455A1 (en) 1995-04-18
CN1108658A (zh) 1995-09-20
EP1020469A3 (en) 2000-07-26
TW375615B (en) 1999-12-01
AU7581294A (en) 1995-05-04
ZA948060B (en) 1995-06-09
CZ254794A3 (en) 1995-05-17
KR100189043B1 (ko) 1999-06-01
CZ283561B6 (cs) 1998-05-13
US6323196B1 (en) 2001-11-27
RO114132B1 (ro) 1999-01-29
NZ264681A (en) 1997-12-19
JP2718637B2 (ja) 1998-02-25
ES2158876T3 (es) 2001-09-16
NO307463B1 (no) 2000-04-10
IL111273A0 (en) 1994-12-29
DE69427332D1 (de) 2001-07-05
NO943894L (no) 1995-04-18
FI108724B (sv) 2002-03-15
PT648771E (pt) 2001-09-28
KR950011444A (ko) 1995-05-15
EG20747A (en) 2000-01-31

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Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: HOECHST MARION ROUSSEL, INC.

PC Transfer of assignment of patent

Owner name: AVENTISUB II INC.

Free format text: AVENTISUB II INC.

MA Patent expired