FI942944A - Nya 19-nor-steroider med tiokol innehållande kedja i 11beta position, förfarande för deras framställning och mellanprodukter av detta förfarande, deras användning som läkemedel och kompositioner - Google Patents

Nya 19-nor-steroider med tiokol innehållande kedja i 11beta position, förfarande för deras framställning och mellanprodukter av detta förfarande, deras användning som läkemedel och kompositioner Download PDF

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Publication number
FI942944A
FI942944A FI942944A FI942944A FI942944A FI 942944 A FI942944 A FI 942944A FI 942944 A FI942944 A FI 942944A FI 942944 A FI942944 A FI 942944A FI 942944 A FI942944 A FI 942944A
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FI
Finland
Prior art keywords
alkyl
preparation
hydrogen
intermediates
compositions
Prior art date
Application number
FI942944A
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English (en)
Finnish (fi)
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FI114866B (sv
FI942944A0 (sv
Inventor
Andre Claussner
Francois Nique
Jean-Georges Teutsch
Patrick Van De Velde
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of FI942944A0 publication Critical patent/FI942944A0/sv
Publication of FI942944A publication Critical patent/FI942944A/sv
Application granted granted Critical
Publication of FI114866B publication Critical patent/FI114866B/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI942944A 1991-12-20 1994-06-17 Förfarande för framställning av 19-nor-estratriensteroider med tiokolkedja i 11beta position FI114866B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9115856 1991-12-20
FR9115856A FR2685332A1 (fr) 1991-12-20 1991-12-20 Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments.
FR9201193 1992-01-30
PCT/FR1992/001193 WO1993013123A1 (fr) 1991-12-20 1992-12-17 Nouveaux 19-nor steroides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions

Publications (3)

Publication Number Publication Date
FI942944A0 FI942944A0 (sv) 1994-06-17
FI942944A true FI942944A (sv) 1994-06-17
FI114866B FI114866B (sv) 2005-01-14

Family

ID=9420274

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942944A FI114866B (sv) 1991-12-20 1994-06-17 Förfarande för framställning av 19-nor-estratriensteroider med tiokolkedja i 11beta position

Country Status (20)

Country Link
US (2) US6281204B1 (sv)
EP (1) EP0623140B1 (sv)
JP (1) JP3445271B2 (sv)
KR (1) KR100278465B1 (sv)
CN (1) CN1036718C (sv)
AT (1) ATE165365T1 (sv)
AU (1) AU666916B2 (sv)
CA (1) CA2124339C (sv)
DE (1) DE69225243T2 (sv)
DK (1) DK0623140T3 (sv)
ES (1) ES2115754T3 (sv)
FI (1) FI114866B (sv)
FR (1) FR2685332A1 (sv)
HU (1) HU221482B (sv)
IL (1) IL104105A (sv)
MX (1) MX9207421A (sv)
NZ (1) NZ246624A (sv)
RU (1) RU2111213C1 (sv)
WO (1) WO1993013123A1 (sv)
ZA (1) ZA929859B (sv)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2685332A1 (fr) * 1991-12-20 1993-06-25 Roussel Uclaf Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments.
FR2706454B1 (fr) * 1993-06-17 1995-09-15 Roussel Uclaf Nouveaux 19-Nor stéroïdes, procédé et intermédiaires de préparation, application comme médicaments et compositions pharmaceutiques les contenant.
DE19510862A1 (de) * 1995-03-16 1996-09-19 Schering Ag Verwendung von Antiestrogenen zur männlichen Fertilitätskontrolle
DE19526146A1 (de) * 1995-07-07 1997-01-09 Schering Ag Triphenylethylene, Verfahren zu deren Herstellung, diese Triphenylethylene enthaltene pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE19724187A1 (de) 1997-06-02 1998-12-03 Schering Ag 11beta-Arylsubstituierte 14,17-Ethanoestratriene, Verfahren zur Herstellung dieser Verbindungen, sowie ihre Verwendung zur Herstellung von Arzneimitteln
CZ289298A3 (cs) * 1997-10-14 1999-05-12 Bayer Aktiengesellschaft Způsob výroby pentafluorpentanolu
US6503896B1 (en) 1997-12-24 2003-01-07 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6548491B2 (en) 1997-12-24 2003-04-15 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6054446A (en) * 1997-12-24 2000-04-25 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
DE19826213A1 (de) * 1998-06-09 1999-12-16 Schering Ag Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
FR2780060B1 (fr) * 1998-06-23 2000-08-04 Hoechst Marion Roussel Inc Nouveaux 19-nor steroides 17-halogenes, procede et intermediaires de preparation, application comme medicaments et compositions pharmaceutiques les renfermant
ATE222922T1 (de) * 1998-11-20 2002-09-15 Akzo Nobel Nv Estrogenische estra-1,3,5(10)-trien verbindungen mit verschiedenen wirkungen auf estrogenrezeptor alpha und beta mit einer unverzweigten kohlenwasserstoffkette von 5-9 kohlenstoffatomen in position 11
DE19929715A1 (de) * 1999-06-24 2000-12-28 Schering Ag 11ß-langkettig-substituierte Estratriene, Verfahren zur Herstellung , pharmazeutische Präparate, die diese 11ß-langkettig-substituierten Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
EP1238285A1 (en) * 1999-11-30 2002-09-11 Akzo Nobel N.V. Steroid compounds for steroid receptor binding assays
WO2005090379A1 (en) * 2004-03-17 2005-09-29 The Central Science Laboratory, 'csl' Compounds and sensor for detecion of polycyclic aromatic hydrocarbons
EP1630167A1 (en) * 2004-07-09 2006-03-01 Proskelia SAS Polymorphs of 19-Nor steroid derivatives
EP1623713A1 (en) * 2004-07-09 2006-02-08 Proskelia SAS Cominations of pure anti-estrogen with aromatase inhibitors
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
DE102008061722A1 (de) 2008-12-12 2010-06-17 Saltigo Gmbh Verfahren zur Herstellung von Perfluoralkyl- oder Perfluoralkoxyalkanolen
TR201901687T4 (tr) 2014-01-29 2019-02-21 Umecrine Cognition Ab Hepatik ensefalopati tedavisinde kullanıma yönelik steroid bileşik.
TWI748936B (zh) 2015-01-12 2021-12-11 瑞典商優鎂奎認知Ａｂ公司 新穎化合物
US10278977B2 (en) 2016-06-06 2019-05-07 Umecrine Cognition Ab Methods for treating hypersomnolence
CN110117217B (zh) * 2018-12-19 2021-09-28 浙江普洛家园药业有限公司 1-溴代甲基-2,3,5,6-四氟-4-(三氟甲基)苯的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
FR2643638B1 (fr) * 1989-02-24 1991-06-14 Roussel Uclaf Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
DK0471612T3 (da) * 1990-08-14 1999-02-22 Hoechst Marion Roussel Inc Nye 19-nor steroider med carbonkæde omfattende en amidgruppe i 11-beta-stillingen, fremgangsmåde til deres fremstilling, de
FR2685332A1 (fr) * 1991-12-20 1993-06-25 Roussel Uclaf Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments.

Also Published As

Publication number Publication date
CA2124339A1 (fr) 1993-07-08
JP3445271B2 (ja) 2003-09-08
CA2124339C (fr) 2005-02-15
US6281204B1 (en) 2001-08-28
DE69225243D1 (de) 1998-05-28
ATE165365T1 (de) 1998-05-15
FR2685332A1 (fr) 1993-06-25
RU2111213C1 (ru) 1998-05-20
AU3357093A (en) 1993-07-28
JPH07502281A (ja) 1995-03-09
DE69225243T2 (de) 1998-10-29
WO1993013123A1 (fr) 1993-07-08
CN1075722A (zh) 1993-09-01
AU666916B2 (en) 1996-02-29
KR100278465B1 (ko) 2001-02-01
FI114866B (sv) 2005-01-14
IL104105A0 (en) 1993-05-13
US20020072624A1 (en) 2002-06-13
HU221482B (en) 2002-10-28
HU9402134D0 (en) 1994-09-28
FI942944A0 (sv) 1994-06-17
EP0623140B1 (fr) 1998-04-22
CN1036718C (zh) 1997-12-17
RU94031162A (ru) 1996-04-20
MX9207421A (es) 1993-07-01
EP0623140A1 (fr) 1994-11-09
IL104105A (en) 1997-07-13
ES2115754T3 (es) 1998-07-01
FR2685332B1 (sv) 1995-06-02
DK0623140T3 (da) 1999-02-15
NZ246624A (en) 1995-12-21
HUT68068A (en) 1995-05-29
US6596885B2 (en) 2003-07-22
ZA929859B (en) 1993-12-20

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