ATE222922T1 - Estrogenische estra-1,3,5(10)-trien verbindungen mit verschiedenen wirkungen auf estrogenrezeptor alpha und beta mit einer unverzweigten kohlenwasserstoffkette von 5-9 kohlenstoffatomen in position 11 - Google Patents
Estrogenische estra-1,3,5(10)-trien verbindungen mit verschiedenen wirkungen auf estrogenrezeptor alpha und beta mit einer unverzweigten kohlenwasserstoffkette von 5-9 kohlenstoffatomen in position 11Info
- Publication number
- ATE222922T1 ATE222922T1 AT99963327T AT99963327T ATE222922T1 AT E222922 T1 ATE222922 T1 AT E222922T1 AT 99963327 T AT99963327 T AT 99963327T AT 99963327 T AT99963327 T AT 99963327T AT E222922 T1 ATE222922 T1 AT E222922T1
- Authority
- AT
- Austria
- Prior art keywords
- estrogen receptor
- carbon atoms
- compounds
- beta
- receptor alpha
- Prior art date
Links
- 108010007005 Estrogen Receptor alpha Proteins 0.000 title abstract 2
- 102100038595 Estrogen receptor Human genes 0.000 title abstract 2
- HLCRYAZDZCJZFG-BDXSIMOUSA-N (8s,9s,13s,14s)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene Chemical class C1CC2=CC=CC=C2[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 HLCRYAZDZCJZFG-BDXSIMOUSA-N 0.000 title 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 230000001076 estrogenic effect Effects 0.000 title 1
- 150000002430 hydrocarbons Chemical group 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 abstract 1
- 102000000509 Estrogen Receptor beta Human genes 0.000 abstract 1
- 108010041356 Estrogen Receptor beta Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960005309 estradiol Drugs 0.000 abstract 1
- 229930182833 estradiol Natural products 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- -1 steroid compounds Chemical class 0.000 abstract 1
- 150000003431 steroids Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98203914 | 1998-11-20 | ||
| PCT/EP1999/009053 WO2000031112A1 (en) | 1998-11-20 | 1999-11-18 | Estrogenic estra-1,3,5(10)-trienes with differential effects on the alpha and beta estrogen receptors, having a linear hydrocarbon chain of from 5-9 carbon atoms in position 11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE222922T1 true ATE222922T1 (de) | 2002-09-15 |
Family
ID=8234361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99963327T ATE222922T1 (de) | 1998-11-20 | 1999-11-18 | Estrogenische estra-1,3,5(10)-trien verbindungen mit verschiedenen wirkungen auf estrogenrezeptor alpha und beta mit einer unverzweigten kohlenwasserstoffkette von 5-9 kohlenstoffatomen in position 11 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7528123B1 (de) |
| EP (1) | EP1131336B1 (de) |
| AT (1) | ATE222922T1 (de) |
| AU (1) | AU1967300A (de) |
| DE (1) | DE69902684T2 (de) |
| WO (1) | WO2000031112A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19929715A1 (de) | 1999-06-24 | 2000-12-28 | Schering Ag | 11ß-langkettig-substituierte Estratriene, Verfahren zur Herstellung , pharmazeutische Präparate, die diese 11ß-langkettig-substituierten Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
| IL152248A0 (en) * | 2000-04-12 | 2003-05-29 | Schering Ag | 8beta-HYDROCARBYL-SUBSTITUTED ESTRATRIENES FOR USE AS SELECTIVE ESTROGENS |
| BR0112791A (pt) | 2000-07-28 | 2003-06-24 | Akzo Nobel Nv | Composto esteroidal 16alfa-substituido, uso do mesmo, métodos de tratamento para ativação seletiva de receptores de estrogênio do subtipo alfa, e para terapia de reposição hormonal ou contracepção, e, composição farmacêutica |
| UA83620C2 (ru) | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
| US6884814B2 (en) | 2001-12-13 | 2005-04-26 | Wyeth | Phenyl benzisoxazoles as estrogenic agents |
| US6835745B2 (en) | 2002-01-15 | 2004-12-28 | Wyeth | Phenyl substituted thiophenes as estrogenic agents |
| US7235539B2 (en) | 2002-01-23 | 2007-06-26 | Wyeth | 6-Hydroxyequilenins as estrogenic agents |
| US9315539B2 (en) | 2002-10-01 | 2016-04-19 | Yale University | 11 beta-short chain substituted estradiol analogs and their use in the treatment of menopausal symptoms and estrogen sensitive cancer |
| UA89964C2 (ru) | 2004-09-08 | 2010-03-25 | Н.В. Органон | 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ |
| US8552061B2 (en) | 2007-05-03 | 2013-10-08 | Yale University | Locally active “soft” antiandrogens |
| CZ2008275A3 (cs) * | 2008-05-05 | 2009-05-06 | Prírodovedecká Fakulta Uk | Ligandy estrogenových receptoru alfa a beta, zpusob jejich prípravy a farmaceutické prostredky, které je obsahují |
| WO2016085825A1 (en) * | 2014-11-26 | 2016-06-02 | The Regents Of The University Of California | Estrogen receptor modulators |
| EP3463342B1 (de) | 2016-05-26 | 2023-09-06 | The Regents of The University of California | Kombinationen von östrogenrezeptormodulatoren |
| US20220133747A1 (en) * | 2018-06-06 | 2022-05-05 | The Regents Of The University Of California | Estrogen receptor inhibitors and uses therof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3755301A (en) * | 1972-06-23 | 1973-08-28 | Searle & Co | Manufacture of 11-alkyl steroids |
| DE4132182A1 (de) * | 1991-09-24 | 1993-03-25 | Schering Ag | 11(beta)-substituierte 14, 17-ethanoestratriene, verfahren zur herstellung dieser verbindungen, sowie ihre verwendung zur herstellung von arzneimitteln |
| FR2685332A1 (fr) * | 1991-12-20 | 1993-06-25 | Roussel Uclaf | Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments. |
| CA2200423C (en) | 1996-03-26 | 2006-12-19 | Sietse Mosselman | Novel estrogen receptor |
-
1999
- 1999-11-18 AU AU19673/00A patent/AU1967300A/en not_active Abandoned
- 1999-11-18 WO PCT/EP1999/009053 patent/WO2000031112A1/en not_active Ceased
- 1999-11-18 US US09/831,954 patent/US7528123B1/en not_active Expired - Fee Related
- 1999-11-18 DE DE69902684T patent/DE69902684T2/de not_active Expired - Lifetime
- 1999-11-18 AT AT99963327T patent/ATE222922T1/de not_active IP Right Cessation
- 1999-11-18 EP EP99963327A patent/EP1131336B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1131336A1 (de) | 2001-09-12 |
| US7528123B1 (en) | 2009-05-05 |
| EP1131336B1 (de) | 2002-08-28 |
| DE69902684D1 (de) | 2002-10-02 |
| AU1967300A (en) | 2000-06-13 |
| DE69902684T2 (de) | 2003-04-24 |
| WO2000031112A1 (en) | 2000-06-02 |
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Legal Events
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|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |