DE69902684D1 - Estrogenische estra-1,3,5(10)-trien verbindungen mit verschiedenen wirkungen auf estrogenrezeptor alpha und beta mit einer unverzweigten kohlenwasserstoffkette von 5-9 kohlenstoffatomen in position 11 - Google Patents

Estrogenische estra-1,3,5(10)-trien verbindungen mit verschiedenen wirkungen auf estrogenrezeptor alpha und beta mit einer unverzweigten kohlenwasserstoffkette von 5-9 kohlenstoffatomen in position 11

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Publication number
DE69902684D1
DE69902684D1 DE69902684T DE69902684T DE69902684D1 DE 69902684 D1 DE69902684 D1 DE 69902684D1 DE 69902684 T DE69902684 T DE 69902684T DE 69902684 T DE69902684 T DE 69902684T DE 69902684 D1 DE69902684 D1 DE 69902684D1
Authority
DE
Germany
Prior art keywords
estrogen receptor
carbon atoms
compounds
beta
receptor alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69902684T
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English (en)
Other versions
DE69902684T2 (de
Inventor
Jan Loozen
Gerardus Schoonen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of DE69902684D1 publication Critical patent/DE69902684D1/de
Publication of DE69902684T2 publication Critical patent/DE69902684T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
DE69902684T 1998-11-20 1999-11-18 Estrogenische estra-1,3,5(10)-trien verbindungen mit verschiedenen wirkungen auf estrogenrezeptor alpha und beta mit einer unverzweigten kohlenwasserstoffkette von 5-9 kohlenstoffatomen in position 11 Expired - Lifetime DE69902684T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98203914 1998-11-20
PCT/EP1999/009053 WO2000031112A1 (en) 1998-11-20 1999-11-18 Estrogenic estra-1,3,5(10)-trienes with differential effects on the alpha and beta estrogen receptors, having a linear hydrocarbon chain of from 5-9 carbon atoms in position 11

Publications (2)

Publication Number Publication Date
DE69902684D1 true DE69902684D1 (de) 2002-10-02
DE69902684T2 DE69902684T2 (de) 2003-04-24

Family

ID=8234361

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69902684T Expired - Lifetime DE69902684T2 (de) 1998-11-20 1999-11-18 Estrogenische estra-1,3,5(10)-trien verbindungen mit verschiedenen wirkungen auf estrogenrezeptor alpha und beta mit einer unverzweigten kohlenwasserstoffkette von 5-9 kohlenstoffatomen in position 11

Country Status (6)

Country Link
US (1) US7528123B1 (de)
EP (1) EP1131336B1 (de)
AT (1) ATE222922T1 (de)
AU (1) AU1967300A (de)
DE (1) DE69902684T2 (de)
WO (1) WO2000031112A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19929715A1 (de) 1999-06-24 2000-12-28 Schering Ag 11ß-langkettig-substituierte Estratriene, Verfahren zur Herstellung , pharmazeutische Präparate, die diese 11ß-langkettig-substituierten Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
AU2001258341B2 (en) * 2000-04-12 2007-03-15 Schering Aktiengesellschaft 8beta-hydrocarbyl-substituted estratrienes for use as selective estrogens
ATE294812T1 (de) 2000-07-28 2005-05-15 Akzo Nobel Nv 16alpha-methyl oder ethyl substituierte oestrogene
UA83620C2 (ru) 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
US6884814B2 (en) 2001-12-13 2005-04-26 Wyeth Phenyl benzisoxazoles as estrogenic agents
US6835745B2 (en) 2002-01-15 2004-12-28 Wyeth Phenyl substituted thiophenes as estrogenic agents
US7235539B2 (en) 2002-01-23 2007-06-26 Wyeth 6-Hydroxyequilenins as estrogenic agents
US9315539B2 (en) 2002-10-01 2016-04-19 Yale University 11 beta-short chain substituted estradiol analogs and their use in the treatment of menopausal symptoms and estrogen sensitive cancer
UA89964C2 (ru) 2004-09-08 2010-03-25 Н.В. Органон 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ
WO2008137038A1 (en) 2007-05-03 2008-11-13 Yale University Locally active 'soft' antiandrogens
CZ300376B6 (cs) * 2008-05-05 2009-05-06 Prírodovedecká Fakulta Uk Ligandy estrogenových receptoru alfa a beta, zpusob jejich prípravy a farmaceutické prostredky, které je obsahují
JP6853833B2 (ja) 2016-05-26 2021-03-31 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア エストロゲン受容体調節物質の組合せ
WO2019236901A1 (en) * 2018-06-06 2019-12-12 The Regents Of The University Of California Estrogen receptor inhibitors and uses therof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3755301A (en) * 1972-06-23 1973-08-28 Searle & Co Manufacture of 11-alkyl steroids
DE4132182A1 (de) 1991-09-24 1993-03-25 Schering Ag 11(beta)-substituierte 14, 17-ethanoestratriene, verfahren zur herstellung dieser verbindungen, sowie ihre verwendung zur herstellung von arzneimitteln
FR2685332A1 (fr) * 1991-12-20 1993-06-25 Roussel Uclaf Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments.
CA2200423C (en) 1996-03-26 2006-12-19 Sietse Mosselman Novel estrogen receptor

Also Published As

Publication number Publication date
AU1967300A (en) 2000-06-13
EP1131336B1 (de) 2002-08-28
ATE222922T1 (de) 2002-09-15
DE69902684T2 (de) 2003-04-24
EP1131336A1 (de) 2001-09-12
US7528123B1 (en) 2009-05-05
WO2000031112A1 (en) 2000-06-02

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Legal Events

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8327 Change in the person/name/address of the patent owner

Owner name: N.V. ORGANON, OSS, NL

8364 No opposition during term of opposition