BR9710074A - "bisfosfanatos esteróides" - Google Patents

"bisfosfanatos esteróides"

Info

Publication number
BR9710074A
BR9710074A BR9710074-9A BR9710074A BR9710074A BR 9710074 A BR9710074 A BR 9710074A BR 9710074 A BR9710074 A BR 9710074A BR 9710074 A BR9710074 A BR 9710074A
Authority
BR
Brazil
Prior art keywords
group
steroidal
derivatives
hydroxy
steroid
Prior art date
Application number
BR9710074-9A
Other languages
English (en)
Inventor
James Aantony Gallagher
Jonathan Paul Granville Moore
Wayne Barry Bowler
Philip Charles Bulman Page
Original Assignee
Univ Liverpool Britanica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Liverpool Britanica filed Critical Univ Liverpool Britanica
Publication of BR9710074A publication Critical patent/BR9710074A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/548—Phosphates or phosphonates, e.g. bone-seeking

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Patente de Invenção: <B>"BISFOSFONATOS EM ESTERóIDES"<D>. Derivados de bisfosfonato de hidróxi-esteróide que são inibidores de resorção óssea ou estimuladores de formação óssea, tendo os derivados pelo menos um grupo A no lugar de um grupo hidróxi sobre a molécula de esteróide, em que A é um grupo de fórmula (A) em que X é (i) St-O-CO- em que St é o resíduo do hidróxi esteróide cedido pela remoção de um grupo OH; (ii) R^ 1^-O-CO-em que R^ 1^ é um grupo alquila, alquenila, cicloalquila, aralquila ou arila, podendo qualquer um deles ser opcionalmente substituído; ou (iii) um átomo de hidrogênio, e os sais e solvatos destes compostos. O esteróide é tipicamente 17<225>-estradiol, estrona, testosterona, noretindrona, androsterona, noretandrolona ou nandrolona. Os derivados podem ser empregados no tratamento de distúrbios ósseos tais como a osteoporose.
BR9710074-9A 1996-06-28 1997-06-26 "bisfosfanatos esteróides" BR9710074A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9613722.9A GB9613722D0 (en) 1996-06-28 1996-06-28 Chemical compounds
PCT/GB1997/001748 WO1998000438A1 (en) 1996-06-28 1997-06-26 Steroid bisphosphonates

Publications (1)

Publication Number Publication Date
BR9710074A true BR9710074A (pt) 2000-01-18

Family

ID=10796129

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9710074-9A BR9710074A (pt) 1996-06-28 1997-06-26 "bisfosfanatos esteróides"

Country Status (23)

Country Link
US (1) US6140518A (pt)
EP (1) EP0912598A1 (pt)
JP (1) JP2000513372A (pt)
KR (1) KR20000022262A (pt)
CN (1) CN1226253A (pt)
AP (1) AP9801431A0 (pt)
AU (1) AU3350697A (pt)
BG (1) BG103123A (pt)
BR (1) BR9710074A (pt)
CA (1) CA2259309A1 (pt)
CZ (1) CZ432398A3 (pt)
EE (1) EE9800454A (pt)
GB (1) GB9613722D0 (pt)
HU (1) HUP9902880A3 (pt)
IL (1) IL127781A0 (pt)
IS (1) IS4931A (pt)
NO (1) NO986112L (pt)
PL (1) PL330781A1 (pt)
SK (1) SK175198A3 (pt)
TR (1) TR199900490T2 (pt)
WO (1) WO1998000438A1 (pt)
YU (1) YU59898A (pt)
ZA (1) ZA975749B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8586781B2 (en) 1998-04-02 2013-11-19 Mbc Pharma, Inc. Bone targeted therapeutics and methods of making and using the same
US7598246B2 (en) * 1998-04-02 2009-10-06 Mbc Pharma, Inc. Bisphosphonate conjugates and methods of making and using the same
US6896871B2 (en) 1998-04-02 2005-05-24 Mbc Research, Inc. Biphosphonate conjugates and methods of making and using the same
ATE451382T1 (de) 1999-01-20 2009-12-15 Takara Bio Inc 4-substituierte-3,6-anhydro-galaktosederivate und ihre pharmazeutische verwendung
AU781068B2 (en) * 1999-08-19 2005-05-05 Sydney Children's Hospitals Network (Randwick and Westmead) (incorporating The Royal Alexandra Hospital for Children), The Drug for treating fractures
AUPQ232599A0 (en) * 1999-08-19 1999-09-09 Royal Alexandra Hospital For Children, The Drug for treating fractures
US6436386B1 (en) 2000-11-14 2002-08-20 Shearwater Corporation Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
US7829074B2 (en) 2001-10-18 2010-11-09 Nektar Therapeutics Hydroxypatite-targeting poly(ethylene glycol) and related polymers
CA2443857C (en) * 2001-04-10 2012-06-26 Mbc Research, Inc. Bisphosphonate conjugates and methods of making and using the same
EA200401565A1 (ru) * 2002-05-24 2005-04-28 Неофарм, Инк. Способ получения кардиолипина или аналога кардиолипина (варианты), способ получения липосомы и композиция кардиолипина для лечения заболеваний (варианты)
JP2006518701A (ja) * 2002-05-24 2006-08-17 ネオファーム、インコーポレイティッド カルジオリピン組成物、その製造方法及び使用
US20050277611A1 (en) * 2002-10-16 2005-12-15 Neopharm, Inc. Cationic cardiolipin analoges and its use thereof
US20060078560A1 (en) * 2003-06-23 2006-04-13 Neopharm, Inc. Method of inducing apoptosis and inhibiting cardiolipin synthesis
FI20070244A0 (fi) 2007-03-23 2007-03-23 Metso Paper Inc Tela
CN101835496B (zh) 2007-10-23 2015-11-25 尼克塔治疗公司 靶向羟基磷灰石的多臂聚合物以及由其制造的偶联物
EP2739154B1 (en) 2011-08-01 2018-06-27 MBC Pharma, Inc. Vitamin b6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates
EP2750711A2 (en) * 2011-08-31 2014-07-09 Mallinckrodt LLC Remote assembly of targeted nanoparticles using h-phosphonate-ene/-yne hydrophosphonylation reactions
WO2017079260A1 (en) * 2015-11-02 2017-05-11 University Of Rochester Phosphonate-chloroquine conjugates and methods using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4029499A1 (de) * 1990-09-18 1992-03-19 Boehringer Mannheim Gmbh Neue 17-(beta)-oestradiolderivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
EP0496520A1 (en) * 1991-01-22 1992-07-29 Merck & Co. Inc. Novel bone acting agents
FR2683527A1 (fr) * 1991-11-12 1993-05-14 Bretagne Occidentale Universit Prodrogues gem-bisphosphonates de sterouides derives de la cortisone.
JP3141053B2 (ja) * 1991-12-26 2001-03-05 アベンティス ファーマ株式会社 ビスホスホン酸誘導体
JP2746041B2 (ja) * 1992-02-14 1998-04-28 三菱化学株式会社 新規なステロイド誘導体

Also Published As

Publication number Publication date
IL127781A0 (en) 1999-10-28
KR20000022262A (ko) 2000-04-25
CA2259309A1 (en) 1998-01-08
BG103123A (en) 1999-10-29
CZ432398A3 (cs) 1999-05-12
NO986112D0 (no) 1998-12-23
AU3350697A (en) 1998-01-21
PL330781A1 (en) 1999-06-07
TR199900490T2 (xx) 1999-05-21
HUP9902880A3 (en) 2001-09-28
CN1226253A (zh) 1999-08-18
GB9613722D0 (en) 1996-08-28
US6140518A (en) 2000-10-31
YU59898A (en) 1999-11-22
JP2000513372A (ja) 2000-10-10
EP0912598A1 (en) 1999-05-06
WO1998000438A1 (en) 1998-01-08
SK175198A3 (en) 1999-06-11
IS4931A (is) 1998-12-22
AP9801431A0 (en) 1998-12-31
NO986112L (no) 1999-02-23
ZA975749B (en) 1998-07-27
EE9800454A (et) 1999-06-15
HUP9902880A2 (hu) 2000-03-28

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]