FI942623L - Keinotekoisen proteolyyttisen pilkkomiskohdan sisältävät yhdistelmävirukset - Google Patents

Keinotekoisen proteolyyttisen pilkkomiskohdan sisältävät yhdistelmävirukset Download PDF

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Publication number
FI942623L
FI942623L FI942623A FI942623A FI942623L FI 942623 L FI942623 L FI 942623L FI 942623 A FI942623 A FI 942623A FI 942623 A FI942623 A FI 942623A FI 942623 L FI942623 L FI 942623L
Authority
FI
Finland
Prior art keywords
cleavage site
proteolytic cleavage
recombinant viruses
viruses containing
artificial proteolytic
Prior art date
Application number
FI942623A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI942623A0 (fi
FI942623A7 (fi
Inventor
Mark Feinberg
Raul Andino
Carolyn Louise Weeks-Levy
Patricia Anne Reilly
Original Assignee
Whitehead Biomedical Inst
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitehead Biomedical Inst, American Cyanamid Co filed Critical Whitehead Biomedical Inst
Publication of FI942623A0 publication Critical patent/FI942623A0/fi
Publication of FI942623A7 publication Critical patent/FI942623A7/fi
Publication of FI942623L publication Critical patent/FI942623L/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
FI942623A 1991-12-06 1992-12-04 Keinotekoisen proteolyyttisen pilkkomiskohdan sisältävät yhdistelmävirukset FI942623L (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80489391A 1991-12-06 1991-12-06
US94779092A 1992-09-18 1992-09-18
PCT/US1992/010543 WO1993011251A1 (en) 1991-12-06 1992-12-04 Recombinant viruses comprising artificial proteolytic cleavage site

Publications (3)

Publication Number Publication Date
FI942623A0 FI942623A0 (fi) 1994-06-03
FI942623A7 FI942623A7 (fi) 1994-07-21
FI942623L true FI942623L (fi) 1994-07-21

Family

ID=27122734

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942623A FI942623L (fi) 1991-12-06 1992-12-04 Keinotekoisen proteolyyttisen pilkkomiskohdan sisältävät yhdistelmävirukset

Country Status (20)

Country Link
EP (1) EP0672157B1 (da)
JP (1) JPH07502403A (da)
KR (1) KR100272419B1 (da)
CN (1) CN1055726C (da)
AT (1) ATE206762T1 (da)
AU (1) AU674134B2 (da)
CA (1) CA2123804A1 (da)
CZ (1) CZ127394A3 (da)
DE (1) DE69232122T2 (da)
DK (1) DK0672157T3 (da)
ES (1) ES2163405T3 (da)
FI (1) FI942623L (da)
HU (1) HUT67346A (da)
IL (1) IL104003A0 (da)
MX (1) MX9206981A (da)
NO (1) NO942075L (da)
NZ (1) NZ246276A (da)
PT (1) PT672157E (da)
TW (1) TW403784B (da)
WO (1) WO1993011251A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012048A1 (en) * 1995-09-27 1997-04-03 Medical Research Council Recombinant viruses incorporating a protease cleavable protein
FI20075063A0 (fi) 2007-02-01 2007-02-01 Vactech Oy Allergisen herkistymisen estäminen
JP7387623B2 (ja) * 2018-03-19 2023-11-28 ベーリンガー インゲルハイム フェトメディカ （チャイナ） カンパニー リミテッド 標的タンパク質を安定して発現できる組換えウイルス

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1293591C (en) * 1985-01-11 1991-12-24 Charles A. Kettner Peptide substrates for detecting virus-specified protease activity
EP0321973B1 (de) * 1987-12-23 1993-11-03 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Expression der viral kodierten Protease P2A des HRV2
AU638411B2 (en) * 1988-02-26 1993-07-01 Large Scale Biology Corporation Non-nuclear chromosomal transformation
DD275259A1 (de) * 1988-08-30 1990-01-17 Akad Wissenschaften Ddr Verfahren zur konstruktion eines neuen expressionsvektors
WO1990011359A1 (en) * 1989-03-20 1990-10-04 Whitehead Institute For Biomedical Research Intracellular method of inhibiting hiv in mammalian cells
CA2055613A1 (en) * 1989-05-31 1990-12-01 Jeffrey W. Almond Poliovirus chimaeras
GB8912496D0 (en) * 1989-05-31 1989-07-19 Medical Res Council Vaccines
HUT62654A (en) * 1990-05-28 1993-05-28 Univ Osaka Res Found Process for producing plasmid capable of expressing retrovirus gene and processing it after translation, as well its expression products
WO1992003559A2 (de) * 1990-08-28 1992-03-05 Boehringer Ingelheim International Gmbh Testsystem zur aktivitätsüberprüfung viraler proteinasen

Also Published As

Publication number Publication date
FI942623A0 (fi) 1994-06-03
CZ127394A3 (en) 1995-11-15
PT672157E (pt) 2002-04-29
KR950700421A (ko) 1995-01-16
WO1993011251A1 (en) 1993-06-10
AU3242493A (en) 1993-06-28
JPH07502403A (ja) 1995-03-16
CN1075334A (zh) 1993-08-18
TW403784B (en) 2000-09-01
DK0672157T3 (da) 2001-12-03
HU9401689D0 (en) 1994-09-28
MX9206981A (es) 1994-08-31
HUT67346A (en) 1995-03-28
ES2163405T3 (es) 2002-02-01
FI942623A7 (fi) 1994-07-21
AU674134B2 (en) 1996-12-12
DE69232122T2 (de) 2002-05-16
NO942075L (no) 1994-08-03
IL104003A0 (en) 1993-05-13
CN1055726C (zh) 2000-08-23
CA2123804A1 (en) 1993-06-10
DE69232122D1 (de) 2001-11-15
KR100272419B1 (ko) 2001-02-01
NZ246276A (en) 1996-08-27
EP0672157B1 (en) 2001-10-10
ATE206762T1 (de) 2001-10-15
NO942075D0 (no) 1994-06-03
EP0672157A1 (en) 1995-09-20

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