ATE206762T1 - Rekombinante viren, enthaltend eine künstliche proteolytische schnittstelle. - Google Patents
Rekombinante viren, enthaltend eine künstliche proteolytische schnittstelle.Info
- Publication number
- ATE206762T1 ATE206762T1 AT93900925T AT93900925T ATE206762T1 AT E206762 T1 ATE206762 T1 AT E206762T1 AT 93900925 T AT93900925 T AT 93900925T AT 93900925 T AT93900925 T AT 93900925T AT E206762 T1 ATE206762 T1 AT E206762T1
- Authority
- AT
- Austria
- Prior art keywords
- recombinant viruses
- replication
- viral
- interface
- nucleic acid
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 4
- 230000002797 proteolythic effect Effects 0.000 title 1
- 206010017533 Fungal infection Diseases 0.000 abstract 2
- 150000007523 nucleic acids Chemical group 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 239000002243 precursor Substances 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000003612 virological effect Effects 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 208000030852 Parasitic disease Diseases 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 230000002538 fungal effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000006337 proteolytic cleavage Effects 0.000 abstract 1
- 241000897111 recombinant polioviruses Species 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80489391A | 1991-12-06 | 1991-12-06 | |
| US94779092A | 1992-09-18 | 1992-09-18 | |
| PCT/US1992/010543 WO1993011251A1 (en) | 1991-12-06 | 1992-12-04 | Recombinant viruses comprising artificial proteolytic cleavage site |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE206762T1 true ATE206762T1 (de) | 2001-10-15 |
Family
ID=27122734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93900925T ATE206762T1 (de) | 1991-12-06 | 1992-12-04 | Rekombinante viren, enthaltend eine künstliche proteolytische schnittstelle. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0672157B1 (de) |
| JP (1) | JPH07502403A (de) |
| KR (1) | KR100272419B1 (de) |
| CN (1) | CN1055726C (de) |
| AT (1) | ATE206762T1 (de) |
| AU (1) | AU674134B2 (de) |
| CA (1) | CA2123804A1 (de) |
| CZ (1) | CZ127394A3 (de) |
| DE (1) | DE69232122T2 (de) |
| DK (1) | DK0672157T3 (de) |
| ES (1) | ES2163405T3 (de) |
| FI (1) | FI942623A (de) |
| HU (1) | HUT67346A (de) |
| IL (1) | IL104003A0 (de) |
| MX (1) | MX9206981A (de) |
| NO (1) | NO942075L (de) |
| NZ (1) | NZ246276A (de) |
| PT (1) | PT672157E (de) |
| TW (1) | TW403784B (de) |
| WO (1) | WO1993011251A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU716466B2 (en) * | 1995-09-27 | 2000-02-24 | Medical Research Council | Recombinant viruses incorporating a protease cleavable protein |
| FI20075063A0 (fi) | 2007-02-01 | 2007-02-01 | Vactech Oy | Allergisen herkistymisen estäminen |
| WO2019179345A1 (en) | 2018-03-19 | 2019-09-26 | Boehringer Ingelheim (China) Investment Co., Ltd. | Recombinant virus capable of stably expressing target proteins |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1293591C (en) * | 1985-01-11 | 1991-12-24 | Charles A. Kettner | Peptide substrates for detecting virus-specified protease activity |
| EP0321973B1 (de) * | 1987-12-23 | 1993-11-03 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Expression der viral kodierten Protease P2A des HRV2 |
| EP0406267A1 (de) * | 1988-02-26 | 1991-01-09 | Biosource Genetics Corporation | Nichtnukleare chromosomale transformation |
| DD275259A1 (de) * | 1988-08-30 | 1990-01-17 | Akad Wissenschaften Ddr | Verfahren zur konstruktion eines neuen expressionsvektors |
| WO1990011359A1 (en) * | 1989-03-20 | 1990-10-04 | Whitehead Institute For Biomedical Research | Intracellular method of inhibiting hiv in mammalian cells |
| CA2055613A1 (en) * | 1989-05-31 | 1990-12-01 | Jeffrey W. Almond | Poliovirus chimaeras |
| GB8912496D0 (en) * | 1989-05-31 | 1989-07-19 | Medical Res Council | Vaccines |
| DE69033006T2 (de) * | 1990-05-28 | 1999-09-23 | Univ Osaka Res Found | Herstellungsverfahren für ein plasmid mit fähigkeiten zu expression und prozessierung nach translation eines retroviralen gens, so erhaltenes plasmid und dessen expressionsprodukt |
| JPH05506999A (ja) * | 1990-08-28 | 1993-10-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウイルスプロティナーゼの活性をモニターするためのテスト系 |
-
1992
- 1992-12-03 MX MX9206981A patent/MX9206981A/es unknown
- 1992-12-04 WO PCT/US1992/010543 patent/WO1993011251A1/en active IP Right Grant
- 1992-12-04 KR KR1019940701920A patent/KR100272419B1/ko not_active IP Right Cessation
- 1992-12-04 DK DK93900925T patent/DK0672157T3/da active
- 1992-12-04 PT PT93900925T patent/PT672157E/pt unknown
- 1992-12-04 ES ES93900925T patent/ES2163405T3/es not_active Expired - Lifetime
- 1992-12-04 CN CN92115173A patent/CN1055726C/zh not_active Expired - Fee Related
- 1992-12-04 AU AU32424/93A patent/AU674134B2/en not_active Ceased
- 1992-12-04 EP EP93900925A patent/EP0672157B1/de not_active Expired - Lifetime
- 1992-12-04 AT AT93900925T patent/ATE206762T1/de not_active IP Right Cessation
- 1992-12-04 CZ CZ941273A patent/CZ127394A3/cs unknown
- 1992-12-04 NZ NZ246276A patent/NZ246276A/en unknown
- 1992-12-04 HU HU9401689A patent/HUT67346A/hu unknown
- 1992-12-04 JP JP5510379A patent/JPH07502403A/ja active Pending
- 1992-12-04 CA CA002123804A patent/CA2123804A1/en not_active Abandoned
- 1992-12-04 DE DE69232122T patent/DE69232122T2/de not_active Expired - Fee Related
- 1992-12-04 IL IL104003A patent/IL104003A0/xx unknown
-
1993
- 1993-03-16 TW TW082101918A patent/TW403784B/zh not_active IP Right Cessation
-
1994
- 1994-06-03 FI FI942623A patent/FI942623A/fi unknown
- 1994-06-03 NO NO942075A patent/NO942075L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HU9401689D0 (en) | 1994-09-28 |
| MX9206981A (es) | 1994-08-31 |
| IL104003A0 (en) | 1993-05-13 |
| CA2123804A1 (en) | 1993-06-10 |
| JPH07502403A (ja) | 1995-03-16 |
| DE69232122T2 (de) | 2002-05-16 |
| ES2163405T3 (es) | 2002-02-01 |
| KR100272419B1 (ko) | 2001-02-01 |
| WO1993011251A1 (en) | 1993-06-10 |
| NO942075D0 (no) | 1994-06-03 |
| DK0672157T3 (da) | 2001-12-03 |
| CZ127394A3 (en) | 1995-11-15 |
| EP0672157A1 (de) | 1995-09-20 |
| CN1075334A (zh) | 1993-08-18 |
| CN1055726C (zh) | 2000-08-23 |
| AU674134B2 (en) | 1996-12-12 |
| NZ246276A (en) | 1996-08-27 |
| DE69232122D1 (de) | 2001-11-15 |
| NO942075L (no) | 1994-08-03 |
| EP0672157B1 (de) | 2001-10-10 |
| TW403784B (en) | 2000-09-01 |
| AU3242493A (en) | 1993-06-28 |
| FI942623A (fi) | 1994-07-21 |
| HUT67346A (en) | 1995-03-28 |
| KR950700421A (ko) | 1995-01-16 |
| FI942623A0 (fi) | 1994-06-03 |
| PT672157E (pt) | 2002-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |