FI940393A - Kinatsoliinijohdannaiset asetyylikoliiniesteraasi-inhibiittoreina - Google Patents
Kinatsoliinijohdannaiset asetyylikoliiniesteraasi-inhibiittoreina Download PDFInfo
- Publication number
- FI940393A FI940393A FI940393A FI940393A FI940393A FI 940393 A FI940393 A FI 940393A FI 940393 A FI940393 A FI 940393A FI 940393 A FI940393 A FI 940393A FI 940393 A FI940393 A FI 940393A
- Authority
- FI
- Finland
- Prior art keywords
- quinazoline derivatives
- acetylcholinesterase inhibitors
- acetylcholinesterase
- inhibitors
- quinazoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73688891A | 1991-07-29 | 1991-07-29 | |
US91166292A | 1992-07-16 | 1992-07-16 | |
PCT/US1992/005864 WO1993003034A1 (en) | 1991-07-29 | 1992-07-22 | Quinazoline derivatives as acetylcholinesterase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
FI940393A0 FI940393A0 (fi) | 1994-01-26 |
FI940393A true FI940393A (fi) | 1994-03-11 |
Family
ID=27113138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI940393A FI940393A (fi) | 1991-07-29 | 1994-01-26 | Kinatsoliinijohdannaiset asetyylikoliiniesteraasi-inhibiittoreina |
Country Status (13)
Country | Link |
---|---|
US (1) | US5486512A (pt) |
EP (1) | EP0597956A1 (pt) |
JP (1) | JPH06509576A (pt) |
AU (1) | AU665207B2 (pt) |
CA (1) | CA2113115A1 (pt) |
CZ (1) | CZ281628B6 (pt) |
FI (1) | FI940393A (pt) |
HU (1) | HUT66324A (pt) |
IE (1) | IE922434A1 (pt) |
MX (1) | MX9204425A (pt) |
NO (1) | NO940305L (pt) |
PT (1) | PT100742A (pt) |
WO (1) | WO1993003034A1 (pt) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2133078A1 (en) * | 2000-03-03 | 2009-12-16 | Eisai R&D Management Co., Ltd. | Use of a cholinesterase inhibitor for the treatment of dementia and cognitive impairments |
US20030153598A1 (en) * | 2000-07-25 | 2003-08-14 | Raymond Pratt | Methods for treating Parkinson's disease with cholinesterase inhibitors |
AU8852901A (en) * | 2000-09-07 | 2002-03-22 | Bayer Corporation | Cyclic and acyclic amidines and pharmaceutical compositions containing them for use as progesterone receptor binding agents |
US7022844B2 (en) | 2002-09-21 | 2006-04-04 | Honeywell International Inc. | Amide-based compounds, production, recovery, purification and uses thereof |
ME01267B (me) * | 2004-05-06 | 2013-06-20 | Warner Lambert Co | 4-fenilaminokinazolin-6-ilamidi |
EP2425846A1 (en) * | 2004-12-23 | 2012-03-07 | Voyager Pharmaceutical Corporation | Acetylcholinesterase Inhibitors and leuprolide acetate for the treatment of Alzheimer's disease |
CN101238127A (zh) * | 2005-05-20 | 2008-08-06 | 艾伦托斯制药控股公司 | 嘧啶或三嗪稠合的二环金属蛋白酶抑制剂 |
US20070155738A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての3−ヒドロキシ−1,5−ジヒドロ−ピロール−2−オン誘導体 |
EP2091948B1 (en) | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
ES2533484T3 (es) | 2007-04-18 | 2015-04-10 | Probiodrug Ag | Derivados de tiourea como inhibidores de la glutaminil ciclasa |
CN101220043A (zh) * | 2008-01-24 | 2008-07-16 | 沈阳药科大学 | 噻唑并[3,2-a]嘧啶类衍生物及其应用 |
NZ598685A (en) | 2009-09-11 | 2013-05-31 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
CN109662964A (zh) | 2010-02-09 | 2019-04-23 | 约翰斯.霍普金斯大学 | 用于改善认知功能的方法和组合物 |
ES2586231T3 (es) | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
EP2545047B9 (en) | 2010-03-10 | 2015-06-10 | Probiodrug AG | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
ES2570167T3 (es) | 2011-03-16 | 2016-05-17 | Probiodrug Ag | Derivados de benzimidazol como inhibidores de glutaminil ciclasa |
US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
AU2014216178B2 (en) | 2013-02-15 | 2018-06-28 | KALA BIO, Inc. | Therapeutic compounds and uses thereof |
US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
KR102277833B1 (ko) | 2013-02-20 | 2021-07-14 | 칼라 파마슈티컬스, 인크. | 치료 화합물 및 그의 용도 |
EP3827820A1 (en) | 2013-03-15 | 2021-06-02 | The Johns Hopkins University | Brivaracetam for improving cognitive function |
AU2014228512A1 (en) | 2013-03-15 | 2015-10-01 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
AU2014342042B2 (en) | 2013-11-01 | 2017-08-17 | KALA BIO, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
CN112843005B (zh) | 2015-05-22 | 2023-02-21 | 艾吉因生物股份有限公司 | 左乙拉西坦的延时释放药物组合物 |
KR20180019234A (ko) | 2015-06-26 | 2018-02-23 | 다케다 야쿠힌 고교 가부시키가이샤 | 콜린성 무스카린 m1 수용체의 조절제로서의 2,3-디히드로-4h-1,3-벤족사진-4-온 유도체 |
JP6787913B2 (ja) * | 2015-10-20 | 2020-11-18 | 武田薬品工業株式会社 | 複素環化合物 |
CA3036065A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
EP3509422A4 (en) | 2016-09-08 | 2020-05-20 | Kala Pharmaceuticals, Inc. | CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF |
EP3509423A4 (en) | 2016-09-08 | 2020-05-13 | Kala Pharmaceuticals, Inc. | CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF |
ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2992221A (en) * | 1958-07-03 | 1961-07-11 | Petersen Siegfried | Polymethylene-oxoquinazolines and their production |
US3271396A (en) * | 1964-08-17 | 1966-09-06 | Squibb & Sons Inc | Pyrido-quinazoline derivatives |
US3745216A (en) * | 1969-12-18 | 1973-07-10 | Smith Kline French Lab | Compositions and methods for producing hypotensive activity with imidazo and pyrimido(2,1-b)quinazoline compounds |
US3932407A (en) * | 1973-11-19 | 1976-01-13 | Bristol-Myers Company | Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones |
BE794964A (fr) * | 1972-02-04 | 1973-08-02 | Bristol Myers Co | Nouveaux agents hypotenseurs et procede pour les preparer |
JPS5752352B2 (pt) * | 1974-02-28 | 1982-11-06 | ||
NL7807507A (nl) * | 1977-07-25 | 1979-01-29 | Hoffmann La Roche | Tricyclische verbindingen. |
HU182009B (en) * | 1977-08-19 | 1983-12-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing substituted pirido-square bracket-1,2-a-square bracket closed-pyrimidines, pyrrolo-square bracket-1,2-a-square bracket closed-pyrimidines |
DE2845766A1 (de) * | 1978-10-18 | 1980-04-30 | Schering Ag | Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung |
AT377586B (de) * | 1981-06-30 | 1985-04-10 | Erba Farmitalia | Verfahren zur herstellung von substituierten pyrrolo-(2,1-b)-chinazolinen und pyrido(2,1-b)chinazolinen |
FR2512674B1 (fr) * | 1981-09-16 | 1986-01-10 | Sandoz Sa | Nouveaux derives tricycliques de la quinazolinone, leur preparation et medicaments contenant ces derives |
US4395554A (en) * | 1981-12-01 | 1983-07-26 | Mobil Oil Corporation | Process for producing alpha-picoline |
EP0153152A3 (en) * | 1984-02-15 | 1987-07-15 | Syntex (U.S.A.) Inc. | (2-oxo-1,2,3,5-tetrahydroimidazo-/2,1-b/quinnazolinyl)-oxyalkylamides, their preparation, compositions containing them and their use in making medicaments |
US4783467A (en) * | 1985-06-05 | 1988-11-08 | Pfizer Inc. | Tetrahydroimidazoquinazolinone inotropic agents |
US4837239A (en) * | 1985-08-23 | 1989-06-06 | Syntex (U.S.A.) Inc. | Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins |
US4670434A (en) * | 1985-11-14 | 1987-06-02 | Syntex (U.S.A.) Inc. | (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors |
US4766126A (en) * | 1986-01-10 | 1988-08-23 | Daiichi Seiyaku Co., Ltd. | Process for treatment of nephritis with imidazoquinazolines |
US4760065A (en) * | 1986-02-13 | 1988-07-26 | Hardtmann Goetz E | Trifluoromethyl substituted tetracyclic quinazolin-ones having tranquilizing activity |
-
1992
- 1992-07-22 WO PCT/US1992/005864 patent/WO1993003034A1/en not_active Application Discontinuation
- 1992-07-22 CA CA002113115A patent/CA2113115A1/en not_active Abandoned
- 1992-07-22 JP JP5503581A patent/JPH06509576A/ja active Pending
- 1992-07-22 AU AU23978/92A patent/AU665207B2/en not_active Ceased
- 1992-07-22 HU HU9400258A patent/HUT66324A/hu unknown
- 1992-07-22 EP EP92916726A patent/EP0597956A1/en not_active Withdrawn
- 1992-07-22 CZ CZ94135A patent/CZ281628B6/cs unknown
- 1992-07-24 IE IE243492A patent/IE922434A1/en not_active Application Discontinuation
- 1992-07-29 MX MX9204425A patent/MX9204425A/es unknown
- 1992-07-29 PT PT100742A patent/PT100742A/pt not_active Application Discontinuation
-
1994
- 1994-01-26 FI FI940393A patent/FI940393A/fi not_active Application Discontinuation
- 1994-01-28 NO NO940305A patent/NO940305L/no unknown
- 1994-03-17 US US08/214,911 patent/US5486512A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO940305D0 (no) | 1994-01-28 |
EP0597956A1 (en) | 1994-05-25 |
WO1993003034A1 (en) | 1993-02-18 |
NO940305L (no) | 1994-03-28 |
CZ281628B6 (cs) | 1996-11-13 |
PT100742A (pt) | 1993-10-29 |
AU665207B2 (en) | 1995-12-21 |
US5486512A (en) | 1996-01-23 |
MX9204425A (es) | 1993-01-01 |
IE922434A1 (en) | 1993-02-10 |
CZ13594A3 (en) | 1994-05-18 |
HUT66324A (en) | 1994-11-28 |
AU2397892A (en) | 1993-03-02 |
HU9400258D0 (en) | 1994-06-28 |
JPH06509576A (ja) | 1994-10-27 |
FI940393A0 (fi) | 1994-01-26 |
CA2113115A1 (en) | 1993-02-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |