FI940393A - Kinatsoliinijohdannaiset asetyylikoliiniesteraasi-inhibiittoreina - Google Patents

Kinatsoliinijohdannaiset asetyylikoliiniesteraasi-inhibiittoreina Download PDF

Info

Publication number
FI940393A
FI940393A FI940393A FI940393A FI940393A FI 940393 A FI940393 A FI 940393A FI 940393 A FI940393 A FI 940393A FI 940393 A FI940393 A FI 940393A FI 940393 A FI940393 A FI 940393A
Authority
FI
Finland
Prior art keywords
quinazoline derivatives
acetylcholinesterase inhibitors
acetylcholinesterase
inhibitors
quinazoline
Prior art date
Application number
FI940393A
Other languages
English (en)
Swedish (sv)
Other versions
FI940393A0 (fi
Inventor
Vlad Edward Gregor
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of FI940393A0 publication Critical patent/FI940393A0/fi
Publication of FI940393A publication Critical patent/FI940393A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI940393A 1991-07-29 1994-01-26 Kinatsoliinijohdannaiset asetyylikoliiniesteraasi-inhibiittoreina FI940393A (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73688891A 1991-07-29 1991-07-29
US91166292A 1992-07-16 1992-07-16
PCT/US1992/005864 WO1993003034A1 (en) 1991-07-29 1992-07-22 Quinazoline derivatives as acetylcholinesterase inhibitors

Publications (2)

Publication Number Publication Date
FI940393A0 FI940393A0 (fi) 1994-01-26
FI940393A true FI940393A (fi) 1994-03-11

Family

ID=27113138

Family Applications (1)

Application Number Title Priority Date Filing Date
FI940393A FI940393A (fi) 1991-07-29 1994-01-26 Kinatsoliinijohdannaiset asetyylikoliiniesteraasi-inhibiittoreina

Country Status (13)

Country Link
US (1) US5486512A (fi)
EP (1) EP0597956A1 (fi)
JP (1) JPH06509576A (fi)
AU (1) AU665207B2 (fi)
CA (1) CA2113115A1 (fi)
CZ (1) CZ281628B6 (fi)
FI (1) FI940393A (fi)
HU (1) HUT66324A (fi)
IE (1) IE922434A1 (fi)
MX (1) MX9204425A (fi)
NO (1) NO940305L (fi)
PT (1) PT100742A (fi)
WO (1) WO1993003034A1 (fi)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030153598A1 (en) * 2000-07-25 2003-08-14 Raymond Pratt Methods for treating Parkinson's disease with cholinesterase inhibitors
EP2140868A1 (en) * 2000-03-03 2010-01-06 Eisai R&D Management Co., Ltd. Use of a cholinesterase inhibitor for the treatment of dementia and cognitive impairments associated with or caused by chemotherapy
BR0107179A (pt) * 2000-09-07 2002-07-02 Bayer Ag Amidinas cìclicas e acìclicas e composições farmacêuticas contendo as mesmas para uso como agentes de ligação de receptor de progesterona
US7022844B2 (en) 2002-09-21 2006-04-04 Honeywell International Inc. Amide-based compounds, production, recovery, purification and uses thereof
UA85706C2 (en) * 2004-05-06 2009-02-25 Уорнер-Ламберт Компани Ллси 4-phenylaminoquinazolin-6-yl amides
US20060142186A1 (en) * 2004-12-23 2006-06-29 Voyager Pharmaceutical Corporation Leuprolide acetate and acetylcholinesterase inhibitors or NMDA receptor antagonists for the treatment of alzheimer's disease
EA013525B1 (ru) * 2005-05-20 2010-06-30 Алантос-Фармасьютикалз Холдинг, Инк. Гетеробициклические ингибиторы металлопротеазы и их применение
US20070155738A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
ATE554085T1 (de) 2006-11-30 2012-05-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
EP2117540A1 (en) 2007-03-01 2009-11-18 Probiodrug AG New use of glutaminyl cyclase inhibitors
JP5667440B2 (ja) 2007-04-18 2015-02-12 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
CN101220043A (zh) * 2008-01-24 2008-07-16 沈阳药科大学 噻唑并[3,2-a]嘧啶类衍生物及其应用
SG178953A1 (en) 2009-09-11 2012-04-27 Probiodrug Ag Heterocylcic derivatives as inhibitors of glutaminyl cyclase
EP2533645B1 (en) 2010-02-09 2016-07-27 The Johns Hopkins University Methods and compositions for improving cognitive function
US9181233B2 (en) 2010-03-03 2015-11-10 Probiodrug Ag Inhibitors of glutaminyl cyclase
AU2011226074B2 (en) 2010-03-10 2015-01-22 Vivoryon Therapeutics N.V. Heterocyclic inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5)
US8541596B2 (en) 2010-04-21 2013-09-24 Probiodrug Ag Inhibitors
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
EP2919788A4 (en) 2012-11-14 2016-05-25 Univ Johns Hopkins METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA
EP2956138B1 (en) 2013-02-15 2022-06-22 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
ES2831625T3 (es) 2013-02-20 2021-06-09 Kala Pharmaceuticals Inc Compuestos terapéuticos y sus usos
DK2968220T3 (da) 2013-03-15 2021-06-14 Agenebio Inc Fremgangsmåder og sammensætninger til forbedring af kognitiv funktion
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
MX355330B (es) 2013-11-01 2018-04-16 Kala Pharmaceuticals Inc Formas cristalinas de compuestos terapeuticos y sus usos.
BR112017025031B1 (pt) 2015-05-22 2023-03-21 Agenebio, Inc Composições farmacêuticas de liberação prolongada de levetiracetam
US10323027B2 (en) 2015-06-26 2019-06-18 Takeda Pharmaceutical Company Limited 2,3-dihydro-4H-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic M1 receptor
JP6787913B2 (ja) * 2015-10-20 2020-11-18 武田薬品工業株式会社 複素環化合物
JP2019533641A (ja) 2016-09-08 2019-11-21 カラ ファーマシューティカルズ インコーポレイテッド 治療用化合物の結晶形態およびその使用
EP3509423A4 (en) 2016-09-08 2020-05-13 Kala Pharmaceuticals, Inc. CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
WO2018048747A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2992221A (en) * 1958-07-03 1961-07-11 Petersen Siegfried Polymethylene-oxoquinazolines and their production
US3271396A (en) * 1964-08-17 1966-09-06 Squibb & Sons Inc Pyrido-quinazoline derivatives
US3745216A (en) * 1969-12-18 1973-07-10 Smith Kline French Lab Compositions and methods for producing hypotensive activity with imidazo and pyrimido(2,1-b)quinazoline compounds
BE794964A (fr) * 1972-02-04 1973-08-02 Bristol Myers Co Nouveaux agents hypotenseurs et procede pour les preparer
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
JPS5752352B2 (fi) * 1974-02-28 1982-11-06
NL7807507A (nl) * 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
HU182009B (en) * 1977-08-19 1983-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted pirido-square bracket-1,2-a-square bracket closed-pyrimidines, pyrrolo-square bracket-1,2-a-square bracket closed-pyrimidines
DE2845766A1 (de) * 1978-10-18 1980-04-30 Schering Ag Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung
AT377586B (de) * 1981-06-30 1985-04-10 Erba Farmitalia Verfahren zur herstellung von substituierten pyrrolo-(2,1-b)-chinazolinen und pyrido(2,1-b)chinazolinen
FR2512674B1 (fr) * 1981-09-16 1986-01-10 Sandoz Sa Nouveaux derives tricycliques de la quinazolinone, leur preparation et medicaments contenant ces derives
US4395554A (en) * 1981-12-01 1983-07-26 Mobil Oil Corporation Process for producing alpha-picoline
HU193409B (en) * 1984-02-15 1987-10-28 Syntex Inc Process for producing 2-square bracket -n-cyclohexyl-4-bracket-oxo-1,2,3,5-tetrahydro-imidazo-square bracket-2,1-b-square bracket closed-quinazolin-7-yl-bracket closed-oxy-alkqne-carboxamidyl-square bracket closed-alkan-acides
US4783467A (en) * 1985-06-05 1988-11-08 Pfizer Inc. Tetrahydroimidazoquinazolinone inotropic agents
US4837239A (en) * 1985-08-23 1989-06-06 Syntex (U.S.A.) Inc. Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
US4766126A (en) * 1986-01-10 1988-08-23 Daiichi Seiyaku Co., Ltd. Process for treatment of nephritis with imidazoquinazolines
US4760065A (en) * 1986-02-13 1988-07-26 Hardtmann Goetz E Trifluoromethyl substituted tetracyclic quinazolin-ones having tranquilizing activity

Also Published As

Publication number Publication date
NO940305D0 (no) 1994-01-28
EP0597956A1 (en) 1994-05-25
CZ281628B6 (cs) 1996-11-13
JPH06509576A (ja) 1994-10-27
IE922434A1 (en) 1993-02-10
US5486512A (en) 1996-01-23
NO940305L (no) 1994-03-28
FI940393A0 (fi) 1994-01-26
AU2397892A (en) 1993-03-02
WO1993003034A1 (en) 1993-02-18
AU665207B2 (en) 1995-12-21
CZ13594A3 (en) 1994-05-18
PT100742A (pt) 1993-10-29
HU9400258D0 (en) 1994-06-28
HUT66324A (en) 1994-11-28
CA2113115A1 (en) 1993-02-18
MX9204425A (es) 1993-01-01

Similar Documents

Publication Publication Date Title
FI940393A (fi) Kinatsoliinijohdannaiset asetyylikoliiniesteraasi-inhibiittoreina
CY2004008I2 (el) ΠΑΡΑΓΩΓΑ ΠΥΡΙΜΙΔΙΝΗΣ ΣΑΝ ΑΝΑΣΤΟΛΕΙΣ HMG-CoA ΑΝΑΓΩΓΑΣΗΣ
ATE182147T1 (de) Substituierte thiazolidindion derivate
DE69208877D1 (de) Chinuclidinderivate
NO922182D0 (no) Krystallinske oksatiolan-derivater
ATA75293A (de) Indolderivate
DE59208415D1 (de) 3-Hydroxy-4-aryl-5-oxo-pyrazolin Derivate
DK0606248T3 (da) Heteroarylaminer som hidtil ukendte acetylcholinesteraseinhibitorer
NO970501D0 (no) Substituerte kinazolinderivater
LV5806B4 (lv) LHL antagonisti
DK0693478T3 (da) Quinolinforbindelser
FI925763A (fi) Fungicida 2-imidazolin-5-on- och 2-imidazolin-5-tionderivat
DE69330497D1 (de) Chinazolin-derivate
DE69329894D1 (de) Arylamidderivate
DE59308714D1 (de) Cyclobutan-benzol-derivate
DK0409676T3 (da) Acetylcholinesterase-inhibitorer
NO930520D0 (no) Bifenyl-substituerte kinolinderivater
DE69216260D1 (de) Piperidinderivate
NO952288D0 (no) Benzazepinon-derivater
FI925469A (fi) Tiazolylsubstituerade kinolylymetoxifenylaettiksyraderivat
DE69313890D1 (de) 5-Aminoflavon-Derivate
DE69211197D1 (de) 1-Hydroxyvitamin D-Derivate
KR930702353A (ko) 2- 카르바페넴 유도체
ZA925660B (en) Quinazoline derivatives as acetylcholinesterase inhibitors
FI37U1 (fi) Tillaegsanordning i samband med personlyftaren

Legal Events

Date Code Title Description
FD Application lapsed