FI935072A7 - Uudet perhydroisoindolit ja niiden valmistus - Google Patents

Uudet perhydroisoindolit ja niiden valmistus Download PDF

Info

Publication number
FI935072A7
FI935072A7 FI935072A FI935072A FI935072A7 FI 935072 A7 FI935072 A7 FI 935072A7 FI 935072 A FI935072 A FI 935072A FI 935072 A FI935072 A FI 935072A FI 935072 A7 FI935072 A7 FI 935072A7
Authority
FI
Finland
Prior art keywords
perhydroisoindoles
preparation
new
new perhydroisoindoles
Prior art date
Application number
FI935072A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI935072A0 (fi
FI935072L (fi
Inventor
Claude Moutonnier
Michel Tabart
Alain Truchon
Daniel Achard
Serge Grisoni
Jean-Francois Peyronel
Stephen Hanessian
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of FI935072A0 publication Critical patent/FI935072A0/fi
Publication of FI935072L publication Critical patent/FI935072L/fi
Publication of FI935072A7 publication Critical patent/FI935072A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI935072A 1991-05-17 1992-05-15 Uudet perhydroisoindolit ja niiden valmistus FI935072A7 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9106036A FR2676443B1 (fr) 1991-05-17 1991-05-17 Nouveaux derives de perhydroisoindole et leur preparation.
PCT/FR1992/000430 WO1992020654A1 (fr) 1991-05-17 1992-05-15 Nouveaux derives de perhydroisoindole et leur preparation

Publications (3)

Publication Number Publication Date
FI935072A0 FI935072A0 (fi) 1993-11-16
FI935072L FI935072L (fi) 1993-11-16
FI935072A7 true FI935072A7 (fi) 1993-11-16

Family

ID=9412908

Family Applications (1)

Application Number Title Priority Date Filing Date
FI935072A FI935072A7 (fi) 1991-05-17 1992-05-15 Uudet perhydroisoindolit ja niiden valmistus

Country Status (23)

Country Link
US (1) US5508433A (enExample)
EP (2) EP0586471B1 (enExample)
JP (1) JPH06507628A (enExample)
AT (1) ATE116295T1 (enExample)
AU (1) AU1884092A (enExample)
CA (1) CA2109297A1 (enExample)
CZ (1) CZ244893A3 (enExample)
DE (1) DE69201058T2 (enExample)
DK (1) DK0586471T3 (enExample)
ES (1) ES2066620T3 (enExample)
FI (1) FI935072A7 (enExample)
FR (1) FR2676443B1 (enExample)
HU (1) HUT68913A (enExample)
IE (1) IE921579A1 (enExample)
IL (1) IL101867A0 (enExample)
MX (1) MX9202288A (enExample)
NO (1) NO933976L (enExample)
NZ (1) NZ242773A (enExample)
SK (1) SK126893A3 (enExample)
TW (1) TW226991B (enExample)
WO (1) WO1992020654A1 (enExample)
YU (1) YU51692A (enExample)
ZA (1) ZA923541B (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676442B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2689889B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, et leur preparation.
US5508424A (en) * 1993-03-26 1996-04-16 Ortho Pharmaceutical Corporation 4-arylisoindole analgesics
FR2703679B1 (fr) * 1993-04-05 1995-06-23 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2709752B1 (fr) * 1993-07-30 1995-10-06 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
TW365603B (en) * 1993-07-30 1999-08-01 Rhone Poulenc Rorer Sa Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
FR2710913B1 (fr) * 1993-10-07 1995-11-24 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
CN1414953A (zh) 1999-11-03 2003-04-30 阿尔巴尼分子研究公司 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和5－羟色胺重摄取的用途
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
BR0112350A (pt) 2000-07-11 2003-06-24 Albany Molecular Res Inc Composto, composição farmacêutica, e, método de tratar um animal afligido por um distúrbio neurológico ou psicológico
US6709651B2 (en) 2001-07-03 2004-03-23 B.M.R.A. Corporation B.V. Treatment of substance P-related disorders
WO2006020049A2 (en) 2004-07-15 2006-02-23 Amr Technology, Inc. Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
WO2006123182A2 (en) 2005-05-17 2006-11-23 Merck Sharp & Dohme Limited Cyclohexyl sulphones for treatment of cancer
CA2615403C (en) 2005-07-15 2015-06-16 Amr Technology, Inc. Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EP2336120B1 (en) 2007-01-10 2014-07-16 MSD Italia S.r.l. Combinations containing amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
JP5501227B2 (ja) 2007-06-27 2014-05-21 メルク・シャープ・アンド・ドーム・コーポレーション ヒストンデアセチラーゼ阻害剤としての４−カルボキシベンジルアミノ誘導体
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es) 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
WO2010132442A1 (en) 2009-05-12 2010-11-18 Albany Molecular Reserch, Inc. 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
US9034899B2 (en) 2009-05-12 2015-05-19 Albany Molecular Research, Inc. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
WO2010132487A1 (en) 2009-05-12 2010-11-18 Bristol-Myers Squibb Company CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
BR112012008849A2 (pt) 2009-10-14 2015-09-22 Schering Corp composto, composição farmacêutica, e, uso de um composto
AU2011285909B2 (en) 2010-08-02 2016-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
US9029341B2 (en) 2010-08-17 2015-05-12 Sirna Therapeutics, Inc. RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
EP2613782B1 (en) 2010-09-01 2016-11-02 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
DK2632472T3 (en) 2010-10-29 2018-03-19 Sirna Therapeutics Inc RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA)
WO2012087772A1 (en) 2010-12-21 2012-06-28 Schering Corporation Indazole derivatives useful as erk inhibitors
AU2012245971A1 (en) 2011-04-21 2013-10-17 Piramal Enterprises Limited A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
WO2013063214A1 (en) 2011-10-27 2013-05-02 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
WO2013165816A2 (en) 2012-05-02 2013-11-07 Merck Sharp & Dohme Corp. SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
EP2900241B1 (en) 2012-09-28 2018-08-08 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
ES2651347T3 (es) 2012-11-28 2018-01-25 Merck Sharp & Dohme Corp. Composiciones y métodos para el tratamiento del cáncer
CA2895504A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
EP2951180B1 (en) 2013-01-30 2018-05-02 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
EP3041938A1 (en) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Circular polynucleotides
WO2018071283A1 (en) 2016-10-12 2018-04-19 Merck Sharp & Dohme Corp. Kdm5 inhibitors
WO2019094311A1 (en) 2017-11-08 2019-05-16 Merck Sharp & Dohme Corp. Prmt5 inhibitors
WO2019094312A1 (en) 2017-11-08 2019-05-16 Merck Sharp & Dohme Corp. Prmt5 inhibitors
EP3833667B1 (en) 2018-08-07 2024-03-13 Merck Sharp & Dohme LLC Prmt5 inhibitors
US12173026B2 (en) 2018-08-07 2024-12-24 Merck Sharp & Dohme Llc PRMT5 inhibitors
WO2020033282A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042707A (en) * 1976-02-19 1977-08-16 E. I. Du Pont De Nemours And Company 3α-Arylhydroisoindoles
AU502760B2 (en) * 1977-02-28 1979-08-09 Science Union Et Cie, Societe Francaise De Recherche Medicale Azabicycloalkanes and their preparation
EP0058567B1 (en) * 1981-02-17 1984-07-25 Warner-Lambert Company Substituted acyl derivatives of octahydro-1h-isoindole-1-carboxylic acids and esters
US4439229A (en) * 1981-06-29 1984-03-27 Rohm And Haas Company Substituted phthalimides herbicides
JPH0278659A (ja) * 1988-09-12 1990-03-19 Shionogi & Co Ltd アザビシクロアルカン類化合物
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
NO933976D0 (no) 1993-11-03
MX9202288A (es) 1992-11-01
NO933976L (no) 1993-11-03
FI935072A0 (fi) 1993-11-16
HU9303250D0 (en) 1994-03-28
EP0586471B1 (fr) 1994-12-28
YU51692A (sh) 1994-06-10
CA2109297A1 (fr) 1992-11-18
WO1992020654A1 (fr) 1992-11-26
AU1884092A (en) 1992-12-30
SK126893A3 (en) 1994-11-09
EP0514274A1 (fr) 1992-11-19
FI935072L (fi) 1993-11-16
HUT68913A (en) 1995-08-28
NZ242773A (en) 1994-06-27
TW226991B (enExample) 1994-07-21
JPH06507628A (ja) 1994-09-01
US5508433A (en) 1996-04-16
DE69201058T2 (de) 1995-05-11
IE921579A1 (en) 1992-11-18
DK0586471T3 (da) 1995-06-06
ZA923541B (en) 1993-01-27
EP0586471A1 (fr) 1994-03-16
FR2676443A1 (fr) 1992-11-20
ATE116295T1 (de) 1995-01-15
CZ244893A3 (en) 1994-04-13
FR2676443B1 (fr) 1993-08-06
IL101867A0 (en) 1992-12-30
ES2066620T3 (es) 1995-03-01
DE69201058D1 (de) 1995-02-09

Similar Documents

Publication Publication Date Title
FI935072A7 (fi) Uudet perhydroisoindolit ja niiden valmistus
FI935074A7 (fi) Uusia tiopyranopyrrolijohdannaisia ja niiden valmistus
FI932103A7 (fi) Uusia 4-aryylipiperatsiineja ja 4-aryylipiperidiinejä
FI20000516A7 (fi) Bis-indolyylimaleimidijohdannaiset ja niiden valmistus
FI952179A7 (fi) Uusia 3,3-difenyylipropyyliamiineja, niiden käyttö ja valmistus
FI945625L (fi) Indolokarbatsoli-imidit ja niiden käyttö
FI941747L (fi) Koostumuksia ja niiden käyttöjä
FI914826A7 (fi) Kinatsoliinijohdokset ja niiden valmistus
FI900887A7 (fi) Piperidiiniyhdisteitä ja niiden valmistus ja käyttö
FI924747A7 (fi) PEG-imidaatteja ja niiden proteiinijohdannaisia
FI940851A7 (fi) Uudet glykosfingolipidit ja niiden käyttö
FI896236A7 (fi) Kinoksaliiniyhdisteitä ja niiden valmistus ja käyttö
FI935728A7 (fi) Substituoituja 4-fenyylipyridoneja ja 4-fenyyli-2-alkoksipyridiinejä
FI902629A7 (fi) Aryylioksifenyylipropyyliamiineja, niiden valmistus ja käyttö
FI902597A7 (fi) Bentsosykloalkaanijohdannaiset ja niiden valmistus
FI896235A7 (fi) Kinoksaliiniyhdisteitä ja niiden valmistus ja käyttö
FI941287A0 (fi) Triatsolokinoksalin-1,4-dioneja ja niiden valmistus ja käyttö
FI900461A7 (fi) Imidatsopyridatsiinit, niiden valmistus ja käyttö
FI942963A7 (fi) Imidatsokinatsoliiniyhdisteitä ja niiden valmistus ja käyttö
FI894449A7 (fi) Polyamidi-imidiliuokset ja niiden valmistus
FI906425A7 (fi) Kinatsoliinijohdokset ja niiden valmistaminen
FI934680A7 (fi) Aryylimorfoliini, valmistus ja käyttö
FI904421A7 (fi) Pyridinyylikinoloniyhdisteitä sekä niiden valmistus ja käyttö
FI934325A7 (fi) Hyönteismyrkkykoostumus ja hyönteismyrkky-yksiköitä
FI930716A7 (fi) Uusia aryylikarbonyyliaminoalkyylidihydro-oksopyridiinejä, niiden valmistus ja käyttö

Legal Events

Date Code Title Description
FD Application lapsed