FI934154A0 - Oligoribonukleotid- och ribozymanaloger med terminala 3'-3'- eller 5'-5'-bindningar - Google Patents

Oligoribonukleotid- och ribozymanaloger med terminala 3'-3'- eller 5'-5'-bindningar

Info

Publication number
FI934154A0
FI934154A0 FI934154A FI934154A FI934154A0 FI 934154 A0 FI934154 A0 FI 934154A0 FI 934154 A FI934154 A FI 934154A FI 934154 A FI934154 A FI 934154A FI 934154 A0 FI934154 A0 FI 934154A0
Authority
FI
Finland
Prior art keywords
terminal
ribozymanaloger
oligoribonucleotid
bindningar
eller
Prior art date
Application number
FI934154A
Other languages
English (en)
Other versions
FI934154A (fi
FI115400B (fi
Inventor
Heinz Hartmut Seliger
Flavio Ramalho Ortigao
Hannelore Roesch
Rudi Roesch
Bernd Krist
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6468696&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI934154(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI934154A0 publication Critical patent/FI934154A0/fi
Publication of FI934154A publication Critical patent/FI934154A/fi
Application granted granted Critical
Publication of FI115400B publication Critical patent/FI115400B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Shaping Of Tube Ends By Bending Or Straightening (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI934154A 1992-09-24 1993-09-22 Menetelmä oligoribonukleotidi- ja ribotsyymianalogien valmistamiseksi, joissa on terminaaliset 3 '-3'- tai 5'-5'-sidokset FI115400B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4231949 1992-09-24
DE4231949 1992-09-24

Publications (3)

Publication Number Publication Date
FI934154A0 true FI934154A0 (fi) 1993-09-22
FI934154A FI934154A (fi) 1994-03-25
FI115400B FI115400B (fi) 2005-04-29

Family

ID=6468696

Family Applications (1)

Application Number Title Priority Date Filing Date
FI934154A FI115400B (fi) 1992-09-24 1993-09-22 Menetelmä oligoribonukleotidi- ja ribotsyymianalogien valmistamiseksi, joissa on terminaaliset 3 '-3'- tai 5'-5'-sidokset

Country Status (14)

Country Link
US (1) US6420546B1 (fi)
EP (1) EP0593901B2 (fi)
JP (1) JP3653102B2 (fi)
AT (1) ATE151773T1 (fi)
AU (1) AU665113B2 (fi)
CA (1) CA2106819C (fi)
DE (1) DE59306170D1 (fi)
DK (1) DK0593901T3 (fi)
ES (1) ES2103408T3 (fi)
FI (1) FI115400B (fi)
GR (1) GR3023858T3 (fi)
HU (1) HU219638B (fi)
NO (1) NO307656B1 (fi)
NZ (1) NZ248739A (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646042A (en) * 1992-08-26 1997-07-08 Ribozyme Pharmaceuticals, Inc. C-myb targeted ribozymes
US5998203A (en) 1996-04-16 1999-12-07 Ribozyme Pharmaceuticals, Inc. Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
PT808898E (pt) * 1996-05-24 2004-10-29 Aventis Pharma Gmbh Reagente e metodo para inibicao da expressao de n-ras
US7572582B2 (en) 1997-09-12 2009-08-11 Exiqon A/S Oligonucleotide analogues
EP1071753A2 (en) * 1998-04-20 2001-01-31 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
DE19935303A1 (de) 1999-07-28 2001-02-08 Aventis Pharma Gmbh Oligonukleotide zur Inhibierung der Expression von humanem eg5
EP2351855A1 (en) 2000-09-26 2011-08-03 Duke University RNA aptamers and methods for identifying the same
DE60237768D1 (de) 2001-05-25 2010-11-04 Univ Duke Modulatoren pharmakologischer mittel
KR101147147B1 (ko) 2004-04-01 2012-05-25 머크 샤프 앤드 돔 코포레이션 Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
CN1980947B (zh) 2004-04-22 2013-01-30 雷加多生物科学公司 改良的凝血因子调节物
US7923206B2 (en) 2004-11-22 2011-04-12 Dharmacon, Inc. Method of determining a cellular response to a biological agent
US7923207B2 (en) 2004-11-22 2011-04-12 Dharmacon, Inc. Apparatus and system having dry gene silencing pools
US7935811B2 (en) 2004-11-22 2011-05-03 Dharmacon, Inc. Apparatus and system having dry gene silencing compositions
EP1820804A1 (en) * 2006-02-20 2007-08-22 Humboldt-Universität zu Berlin Lipidated oligonucleotides
AU2007299705B2 (en) 2006-09-22 2012-09-06 Dharmacon, Inc. Duplex oligonucleotide complexes and methods for gene silencing by RNA interference
US7845686B2 (en) * 2007-12-17 2010-12-07 S & B Technical Products, Inc. Restrained pipe joining system for plastic pipe
US8188060B2 (en) 2008-02-11 2012-05-29 Dharmacon, Inc. Duplex oligonucleotides with enhanced functionality in gene regulation
EP2781523A1 (en) 2013-03-18 2014-09-24 Miltenyi Biotec GmbH Lipophilic oligonucleotide analogs
US11981703B2 (en) 2016-08-17 2024-05-14 Sirius Therapeutics, Inc. Polynucleotide constructs
US11597744B2 (en) 2017-06-30 2023-03-07 Sirius Therapeutics, Inc. Chiral phosphoramidite auxiliaries and methods of their use
US11104941B2 (en) 2018-09-28 2021-08-31 Bioo Scientific Corporation 5′ adapter comprising an internal 5′-5′ linkage

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3916871A1 (de) 1989-05-24 1990-11-29 Boehringer Mannheim Gmbh Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
US5399676A (en) * 1989-10-23 1995-03-21 Gilead Sciences Oligonucleotides with inverted polarity
EP0464638B1 (de) * 1990-07-02 1997-04-02 Hoechst Aktiengesellschaft Oligonucleotid-analoge mit terminalen 3'-3'-bzw. 5'-5'-Internucleotidverknüpfungen
US5672697A (en) * 1991-02-08 1997-09-30 Gilead Sciences, Inc. Nucleoside 5'-methylene phosphonates
KR930016437A (ko) * 1992-01-22 1993-08-26 귀틀라인, 슈미트 올리고뉴클레오티드 유사체, 이의 제조방법 및 용도
US5646261A (en) * 1992-01-22 1997-07-08 Hoechst Aktiengesellschaft 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use

Also Published As

Publication number Publication date
FI934154A (fi) 1994-03-25
HU9302697D0 (en) 1993-12-28
EP0593901A2 (de) 1994-04-27
US6420546B1 (en) 2002-07-16
NO933397L (no) 1994-03-25
HU219638B (hu) 2001-06-28
GR3023858T3 (en) 1997-09-30
CA2106819C (en) 2007-04-17
CA2106819A1 (en) 1994-03-25
JPH06189753A (ja) 1994-07-12
FI115400B (fi) 2005-04-29
ES2103408T3 (es) 1997-09-16
AU665113B2 (en) 1995-12-14
DE59306170D1 (de) 1997-05-22
NO933397D0 (no) 1993-09-23
EP0593901A3 (en) 1994-09-28
ATE151773T1 (de) 1997-05-15
NO307656B1 (no) 2000-05-08
EP0593901B1 (de) 1997-04-16
DK0593901T3 (da) 1997-10-27
AU4755193A (en) 1994-03-31
HUT66458A (en) 1994-11-28
JP3653102B2 (ja) 2005-05-25
EP0593901B2 (de) 2008-04-09
NZ248739A (en) 1995-08-28

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