FI920217A7 - Angiotensiini II reseptoria salpaavia 2,3,6-substituoituja kinatsolinoneja - Google Patents
Angiotensiini II reseptoria salpaavia 2,3,6-substituoituja kinatsolinoneja Download PDFInfo
- Publication number
- FI920217A7 FI920217A7 FI920217A FI920217A FI920217A7 FI 920217 A7 FI920217 A7 FI 920217A7 FI 920217 A FI920217 A FI 920217A FI 920217 A FI920217 A FI 920217A FI 920217 A7 FI920217 A7 FI 920217A7
- Authority
- FI
- Finland
- Prior art keywords
- angiotensin
- receptor antagonists
- substituted quinazolinones
- quinazolinones
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacture Of Tobacco Products (AREA)
- Fats And Perfumes (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64849291A | 1991-01-30 | 1991-01-30 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI920217A0 FI920217A0 (fi) | 1992-01-17 |
| FI920217L FI920217L (fi) | 1992-07-31 |
| FI920217A7 true FI920217A7 (fi) | 1992-07-31 |
Family
ID=24601009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI920217A FI920217A7 (fi) | 1991-01-30 | 1992-01-17 | Angiotensiini II reseptoria salpaavia 2,3,6-substituoituja kinatsolinoneja |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US5290780A (enExample) |
| EP (1) | EP0497150B1 (enExample) |
| JP (1) | JP2758766B2 (enExample) |
| KR (1) | KR920014805A (enExample) |
| CN (1) | CN1037440C (enExample) |
| AT (1) | ATE164158T1 (enExample) |
| AU (2) | AU642573B2 (enExample) |
| CA (1) | CA2060154A1 (enExample) |
| CZ (1) | CZ281429B6 (enExample) |
| DE (1) | DE69224763T2 (enExample) |
| DK (1) | DK0497150T3 (enExample) |
| ES (1) | ES2117014T3 (enExample) |
| FI (1) | FI920217A7 (enExample) |
| GR (1) | GR3026592T3 (enExample) |
| HU (1) | HUT61748A (enExample) |
| IE (1) | IE920142A1 (enExample) |
| IL (1) | IL100711A0 (enExample) |
| NO (1) | NO920298L (enExample) |
| NZ (1) | NZ241343A (enExample) |
| PL (1) | PL293316A1 (enExample) |
| SK (1) | SK279004B6 (enExample) |
| TW (1) | TW282467B (enExample) |
| ZA (1) | ZA92392B (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5290780A (en) * | 1991-01-30 | 1994-03-01 | American Cyanamid Co. | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones |
| US5385894A (en) * | 1991-03-06 | 1995-01-31 | Merck & Co., Inc. | Disubstituted 6-aminoquinazolinones |
| EP0618207B1 (en) * | 1993-03-24 | 1999-01-07 | American Home Products Corporation | Substituted pyridopyrimidines as antihypertensives |
| US5358951A (en) * | 1993-04-23 | 1994-10-25 | American Cyanamid Company | Angiotensin II receptor blocking 2, 3, 6 substituted quinazolinones |
| US5610301A (en) * | 1993-07-01 | 1997-03-11 | American Cyanamid Company | Process for the regioselective n-alkylation of quinazolinones |
| US5342944A (en) * | 1993-07-19 | 1994-08-30 | American Cyanamid Company | Process for the preparation of 2-alkyl-3,5,6,7- or 8-substituted-4(3H)-quinazolinones |
| US5338736A (en) * | 1993-10-07 | 1994-08-16 | American Cyanamid Company | Angiotensin II receptor blocking 2,3,6-substituted quinazolinones |
| DK0782996T3 (da) * | 1994-09-20 | 1999-09-20 | Wakunaga Seiyaku Kk | Fremgangsmåde til fremstilling af N-biphenylmethylthiadiazolinderivat eller salt deraf og mellemprodukt til fremstilling af |
| US5760220A (en) * | 1995-06-07 | 1998-06-02 | American Home Products Corporation | Process for preparation of biphenyl derivatives |
| CA2223783A1 (en) * | 1995-06-07 | 1996-12-19 | Michel Bernatchez | Process for preparation of biphenyl derivatives |
| US5739330A (en) * | 1996-02-05 | 1998-04-14 | Hoechst Celanese Corporation | Process for preparing quinazolones |
| US5763608A (en) * | 1996-02-05 | 1998-06-09 | Hoechst Celanese Corporation | Process for preparing pyrimidine derivatives |
| US6638937B2 (en) | 1998-07-06 | 2003-10-28 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| GB0223730D0 (en) * | 2002-10-11 | 2002-11-20 | Novartis Ag | Organic compounds |
| US20060047952A1 (en) * | 2002-10-18 | 2006-03-02 | Koninklijke Philips Electronics, N.V. | Method, system, device , signal and computer program product for metadata protection in tv-anytime |
| AU2003291761A1 (en) * | 2002-11-04 | 2004-06-07 | Nps Pharmaceuticals, Inc. | Quinazolinone compounds as calcilytics |
| GB0412769D0 (en) * | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
| WO2008041118A2 (en) * | 2006-10-04 | 2008-04-10 | Pfizer Products Inc. | Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| JP5546451B2 (ja) | 2007-06-04 | 2014-07-09 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト |
| US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| PT2861566T (pt) | 2012-06-13 | 2017-02-08 | Hoffmann La Roche | Novos diazaspirocicloalcanos e azaspirocicloalcanos |
| AU2013322838B2 (en) | 2012-09-25 | 2018-02-01 | F. Hoffmann-La Roche Ag | New bicyclic derivatives |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| HK1220696A1 (zh) | 2013-03-15 | 2017-05-12 | Bausch Health Ireland Limited | 鸟苷酸环化酶激动剂及其用途 |
| EP4424697A3 (en) | 2013-06-05 | 2024-12-25 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
| AU2014356583B2 (en) | 2013-11-26 | 2019-02-28 | F. Hoffmann-La Roche Ag | New octahydro-cyclobuta (1,2-c;3,4-c')dipyrrol-2-yl |
| WO2015144609A1 (en) | 2014-03-26 | 2015-10-01 | F. Hoffmann-La Roche Ag | Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| AU2015238537B2 (en) | 2014-03-26 | 2019-08-01 | F. Hoffmann-La Roche Ag | Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| UA123362C2 (uk) | 2015-09-04 | 2021-03-24 | Ф. Хоффманн-Ля Рош Аг | Феноксиметильні похідні |
| CR20180072A (es) | 2015-09-24 | 2018-02-26 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores de atx |
| CR20180057A (es) | 2015-09-24 | 2018-04-02 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de atx/ca. |
| KR20180053408A (ko) | 2015-09-24 | 2018-05-21 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서의 신규한 이환형 화합물 |
| AU2016328535A1 (en) | 2015-09-24 | 2017-11-09 | F. Hoffmann-La Roche Ag | Bicyclic compounds as ATX inhibitors |
| SG11201908560SA (en) | 2017-03-16 | 2019-10-30 | Hoffmann La Roche | Heterocyclic compounds useful as dual atx/ca inhibitors |
| CN110382484B (zh) | 2017-03-16 | 2022-12-06 | 豪夫迈·罗氏有限公司 | 新的作为atx抑制剂的二环化合物 |
| CN107056715B (zh) * | 2017-04-07 | 2019-07-30 | 江南大学 | 一种增强TRPV4-KCa2.3复合体耦联度的化合物及其在抗高血压中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607683D0 (en) * | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
| MX7829A (es) * | 1986-08-21 | 1993-08-01 | Pfizer | Quinazolindionas y piridopirimindionas y procedimiento para su preparacion |
| CS272018B1 (en) * | 1988-11-01 | 1990-12-13 | Fisnerova Ludmila | Ethereal derivatives of 4/3h/-quinazolinone |
| CA2020073A1 (en) * | 1989-07-03 | 1991-01-04 | Eric E. Allen | Substituted quinazolinones as angiotensin ii antagonists |
| US5240928A (en) * | 1989-07-03 | 1993-08-31 | Merck & Co., Inc. | Substituted quinazolinones as angiotensin II antagonists |
| EP0407342A3 (en) * | 1989-07-06 | 1991-07-10 | Ciba-Geigy Ag | Pyrimidine derivatives |
| CA2037630C (en) * | 1990-03-07 | 2001-07-03 | Akira Morimoto | Nitrogen-containing heterocylic compounds, their production and use |
| CA2053148A1 (en) * | 1990-10-16 | 1992-04-17 | Karnail Atwal | Dihydropyrimidine derivatives |
| US5290780A (en) * | 1991-01-30 | 1994-03-01 | American Cyanamid Co. | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones |
-
1992
- 1992-01-14 US US07/818,721 patent/US5290780A/en not_active Expired - Lifetime
- 1992-01-16 ES ES92100640T patent/ES2117014T3/es not_active Expired - Lifetime
- 1992-01-16 DK DK92100640.9T patent/DK0497150T3/da active
- 1992-01-16 DE DE69224763T patent/DE69224763T2/de not_active Expired - Fee Related
- 1992-01-16 AT AT92100640T patent/ATE164158T1/de not_active IP Right Cessation
- 1992-01-16 EP EP92100640A patent/EP0497150B1/en not_active Expired - Lifetime
- 1992-01-17 IE IE014292A patent/IE920142A1/en not_active Application Discontinuation
- 1992-01-17 FI FI920217A patent/FI920217A7/fi unknown
- 1992-01-20 ZA ZA92392A patent/ZA92392B/xx unknown
- 1992-01-20 IL IL100711A patent/IL100711A0/xx unknown
- 1992-01-21 NZ NZ241343A patent/NZ241343A/en unknown
- 1992-01-22 NO NO92920298A patent/NO920298L/no unknown
- 1992-01-22 AU AU10397/92A patent/AU642573B2/en not_active Ceased
- 1992-01-28 CA CA002060154A patent/CA2060154A1/en not_active Abandoned
- 1992-01-29 SK SK255-92A patent/SK279004B6/sk unknown
- 1992-01-29 PL PL29331692A patent/PL293316A1/xx unknown
- 1992-01-29 JP JP4038746A patent/JP2758766B2/ja not_active Expired - Lifetime
- 1992-01-29 CZ CS92255A patent/CZ281429B6/cs unknown
- 1992-01-30 KR KR1019920001413A patent/KR920014805A/ko not_active Ceased
- 1992-01-30 HU HU9200278A patent/HUT61748A/hu unknown
- 1992-01-30 CN CN92100545A patent/CN1037440C/zh not_active Expired - Fee Related
- 1992-01-31 TW TW081100762A patent/TW282467B/zh active
-
1993
- 1993-08-25 AU AU44906/93A patent/AU647992B2/en not_active Ceased
- 1993-10-29 US US08/145,458 patent/US5405849A/en not_active Expired - Lifetime
-
1998
- 1998-04-10 GR GR980400781T patent/GR3026592T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU642573B2 (en) | 1993-10-21 |
| IE920142A1 (en) | 1992-07-29 |
| FI920217L (fi) | 1992-07-31 |
| DE69224763T2 (de) | 1998-07-09 |
| EP0497150A1 (en) | 1992-08-05 |
| JPH0578332A (ja) | 1993-03-30 |
| CS25592A3 (en) | 1992-08-12 |
| JP2758766B2 (ja) | 1998-05-28 |
| AU4490693A (en) | 1993-11-18 |
| DK0497150T3 (da) | 1998-06-02 |
| CA2060154A1 (en) | 1992-07-31 |
| GR3026592T3 (en) | 1998-07-31 |
| TW282467B (enExample) | 1996-08-01 |
| NO920298L (no) | 1992-07-31 |
| HUT61748A (en) | 1993-03-01 |
| HU9200278D0 (en) | 1992-04-28 |
| CZ281429B6 (cs) | 1996-09-11 |
| ATE164158T1 (de) | 1998-04-15 |
| US5405849A (en) | 1995-04-11 |
| FI920217A0 (fi) | 1992-01-17 |
| AU1039792A (en) | 1992-08-06 |
| PL293316A1 (en) | 1993-08-23 |
| CN1037440C (zh) | 1998-02-18 |
| CN1066847A (zh) | 1992-12-09 |
| KR920014805A (ko) | 1992-08-25 |
| EP0497150B1 (en) | 1998-03-18 |
| SK279004B6 (sk) | 1998-05-06 |
| AU647992B2 (en) | 1994-03-31 |
| IL100711A0 (en) | 1992-09-06 |
| ZA92392B (en) | 1992-10-28 |
| NO920298D0 (no) | 1992-01-22 |
| ES2117014T3 (es) | 1998-08-01 |
| NZ241343A (en) | 1994-06-27 |
| US5290780A (en) | 1994-03-01 |
| DE69224763D1 (de) | 1998-04-23 |
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