EP0676959A4 - Endothelin receptor antagonists. - Google Patents

Endothelin receptor antagonists.

Info

Publication number
EP0676959A4
EP0676959A4 EP94904877A EP94904877A EP0676959A4 EP 0676959 A4 EP0676959 A4 EP 0676959A4 EP 94904877 A EP94904877 A EP 94904877A EP 94904877 A EP94904877 A EP 94904877A EP 0676959 A4 EP0676959 A4 EP 0676959A4
Authority
EP
European Patent Office
Prior art keywords
receptor antagonists
endothelin receptor
endothelin
antagonists
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94904877A
Other languages
German (de)
French (fr)
Other versions
EP0676959A1 (en
Inventor
John Duncan Elliott
Jack Dale Leber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0676959A1 publication Critical patent/EP0676959A1/en
Publication of EP0676959A4 publication Critical patent/EP0676959A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
EP94904877A 1992-12-22 1993-12-21 Endothelin receptor antagonists. Withdrawn EP0676959A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99546692A 1992-12-22 1992-12-22
US995466 1992-12-22
PCT/US1993/012435 WO1994014434A1 (en) 1992-12-22 1993-12-21 Endothelin receptor antagonists

Publications (2)

Publication Number Publication Date
EP0676959A1 EP0676959A1 (en) 1995-10-18
EP0676959A4 true EP0676959A4 (en) 1996-01-03

Family

ID=25541843

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94904877A Withdrawn EP0676959A4 (en) 1992-12-22 1993-12-21 Endothelin receptor antagonists.

Country Status (7)

Country Link
EP (1) EP0676959A4 (en)
JP (1) JPH08504826A (en)
CN (1) CN1096513A (en)
AU (1) AU5873594A (en)
MX (1) MX9400071A (en)
WO (1) WO1994014434A1 (en)
ZA (1) ZA939516B (en)

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US7208517B1 (en) 1994-08-19 2007-04-24 Abbott Labortories Endothelin antagonists
US5767144A (en) * 1994-08-19 1998-06-16 Abbott Laboratories Endothelin antagonists
US5559135A (en) * 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
US5482960A (en) * 1994-11-14 1996-01-09 Warner-Lambert Company Nonpeptide endothelin antagonists
AU4514496A (en) * 1994-12-13 1996-07-03 Smithkline Beecham Corporation Novel compounds
US5684032A (en) * 1994-12-13 1997-11-04 Smithkline Beecham Corporation Compounds
DE19527568A1 (en) 1995-07-28 1997-01-30 Merck Patent Gmbh Endothelin receptor antagonists
DE19528418A1 (en) * 1995-08-02 1997-02-06 Merck Patent Gmbh Endothelin receptor antagonists
FR2740773B1 (en) * 1995-11-08 1997-12-19 Roussel Uclaf NOVEL IMIDAZOLE DERIVATIVES, PREPARATION PROCESS, INTERMEDIATES OBTAINED, APPLICATION AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE
DE19530032A1 (en) * 1995-08-16 1997-02-20 Merck Patent Gmbh Endothelin receptor antagonists
DE19537548A1 (en) * 1995-10-09 1997-04-10 Merck Patent Gmbh Endothelin receptor antagonists
FR2740774B1 (en) * 1995-11-08 1997-12-19 Roussel Uclaf NOVEL IMIDAZOLE N-BENZYLDIOXOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NEW USE
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US6444668B1 (en) 1999-05-04 2002-09-03 Wyeth Combination regimens using progesterone receptor modulators
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US6369056B1 (en) 1999-05-04 2002-04-09 American Home Products Corporation Cyclic urea and cyclic amide derivatives
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US6329416B1 (en) 1999-05-04 2001-12-11 American Home Products Corporation Combination regimens using 3,3-substituted indoline derivatives
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DK1397130T3 (en) 2001-06-20 2007-11-12 Wyeth Corp Substituted Indole Acid Derivatives as Inhibitors of Plasminogen Activator Inhibitor-1 (PAI-1)
TWI224101B (en) 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
DE10147672A1 (en) 2001-09-27 2003-04-10 Bayer Ag Substituted 2,5-diamidoindoles and their use
US7605156B2 (en) 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
US7713964B2 (en) 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
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US7420083B2 (en) 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
US7265148B2 (en) 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7332521B2 (en) 2003-09-25 2008-02-19 Wyeth Substituted indoles
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US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
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CN107922396B (en) * 2015-07-20 2022-08-05 建新公司 Colony stimulating factor-1 receptor (CSF-1R) inhibitors
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0449196A2 (en) * 1990-03-26 1991-10-02 Takeda Chemical Industries, Ltd. Indole derivatives, their production and use
EP0460679A2 (en) * 1990-06-07 1991-12-11 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic peptide derivatives

Family Cites Families (3)

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DE3131527A1 (en) * 1981-08-08 1983-02-24 Kali-Chemie Pharma Gmbh, 3000 Hannover 1-PHENYL-2-AMINOCARBONYLINDOL COMPOUNDS AND METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
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Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0449196A2 (en) * 1990-03-26 1991-10-02 Takeda Chemical Industries, Ltd. Indole derivatives, their production and use
EP0460679A2 (en) * 1990-06-07 1991-12-11 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic peptide derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9414434A1 *

Also Published As

Publication number Publication date
ZA939516B (en) 1994-06-06
EP0676959A1 (en) 1995-10-18
CN1096513A (en) 1994-12-21
AU5873594A (en) 1994-07-19
MX9400071A (en) 1994-07-29
WO1994014434A1 (en) 1994-07-07
JPH08504826A (en) 1996-05-28

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Legal Events

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