FI91860B - Förfarande för framställning av terapeutiskt användbara stilbenderivat - Google Patents
Förfarande för framställning av terapeutiskt användbara stilbenderivat Download PDFInfo
- Publication number
- FI91860B FI91860B FI890842A FI890842A FI91860B FI 91860 B FI91860 B FI 91860B FI 890842 A FI890842 A FI 890842A FI 890842 A FI890842 A FI 890842A FI 91860 B FI91860 B FI 91860B
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- FI
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- Prior art keywords
- denotes
- lower alkyl
- compound
- tetrahydro
- ethyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/16—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/09—Diamines
- C07C211/10—Diaminoethanes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/53—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having the nitrogen atom of at least one of the amino groups further bound to a hydrocarbon radical substituted by amino groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (7)
1. Förfarande för framställning av terapeutiskt användbara stilbenderivat med den allmänna formeln I 5 TJ 3 R X~CH2_CH2_Y väri R1 och R2 tillsamraans bildar en rakkedig alkylen med 3 - 5 kolatomer;
15 R3 är en lägre alkyl; X är -O-, -S- eller -NR9-, varvid R9 är väte eller en lägre alkyl; Y är -S(O)mR10 eller -NHet, och da X är -NR9- eller - S-, kan det även vara -N(Rll)2/ varvid R10 och R11 är lägre 20 alkyler; -NHet är morfolinyl, tiomorfolinyl-4,4-dioxid, piperidinyl eller pyrrolidinyl; och m är 0, 1 eller 2, kännetecknat därav, att a) en förening med den allmänna formeln II 25 R3 + ^ I] p (Q)3 (II)
30. JJ A~ R bringas att reagera med en förening med den allmänna formeln III li 23 91860 X-CH2“CH2-Y sJJ I (III) H 5 eller b) en förening med den allxnänna formeln VI r3 r^V"Z R1 f I 10 (VI) bringas att reagera med en förening med den allmänna for-15 mein VII L-CH2-CH2-Y VII och om önskas oxideras i den sä erhällna föreningen med formeln I en sulfidgrupp enligt beteckningen Y till en 2 0 sulfoxid- eller sulfongrupp, varvid symbolerna R1, R2, R3, X och Y i nämnda formlerna II, III, VI och VII har ovan angivna betydelse, Q är aryl, A' är en anjon av en oorga-nisk eller organisk syra, Z är hydroxyl, merkapto, -NHR9 eller -SO^*, M+ är katjon och L är en avlägsnande grupp. 25
2. Förfarande enligt patentkrav 1, känne- t e c k n a t därav, att 4-[2-[p-[(E)-2-(5,6,7,8-tetra-hydro-5,5,8,8-tetramety 1-2-naf ty 1) propeny 1 ] f enoxi ] ety 1 ] -morfolin framställs.
3. Förfarande enligt patentkrav 1, känne-; 30 tecknat därav, att l-[2-[p-[(E)-2-(5,6,7,8-tetra- hydro-5,5,8,8-tetrametyl-2-naf tyl) propeny 1 ] f enoxi ] etyl ] pi-peridin framställs.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH68988 | 1988-02-24 | ||
CH68988 | 1988-02-24 | ||
CH462288 | 1988-12-14 | ||
CH462288 | 1988-12-14 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI890842A0 FI890842A0 (sv) | 1989-02-22 |
FI890842A FI890842A (sv) | 1989-08-25 |
FI91860B true FI91860B (sv) | 1994-05-13 |
FI91860C FI91860C (sv) | 1994-08-25 |
Family
ID=25685375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI890842A FI91860C (sv) | 1988-02-24 | 1989-02-22 | Förfarande för framställning av terapeutiskt användbara stilbenderivat |
Country Status (24)
Country | Link |
---|---|
US (2) | US4940707A (sv) |
EP (1) | EP0331983B1 (sv) |
JP (1) | JP2556577B2 (sv) |
KR (1) | KR0148217B1 (sv) |
CN (1) | CN1030702C (sv) |
AT (1) | ATE115573T1 (sv) |
AU (1) | AU623880B2 (sv) |
BG (1) | BG60935B2 (sv) |
CA (1) | CA1340955C (sv) |
CS (1) | CS277022B6 (sv) |
DE (1) | DE58908751D1 (sv) |
DK (1) | DK84889A (sv) |
ES (1) | ES2065929T3 (sv) |
FI (1) | FI91860C (sv) |
GR (1) | GR3015268T3 (sv) |
HU (1) | HU204766B (sv) |
IE (1) | IE66675B1 (sv) |
IL (1) | IL89327A (sv) |
IS (1) | IS1593B (sv) |
MC (1) | MC2011A1 (sv) |
NO (1) | NO169836C (sv) |
NZ (1) | NZ228028A (sv) |
PT (1) | PT89814B (sv) |
YU (1) | YU48067B (sv) |
Families Citing this family (28)
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JPS5734030A (en) * | 1980-07-30 | 1982-02-24 | Ishizuka Glass Ltd | Preparation of glassware having opening with irregular shape |
DE3926148A1 (de) * | 1989-08-08 | 1991-02-28 | Basf Ag | Diarylacetylene, ihre herstellung und verwendung |
AU651998B2 (en) * | 1990-10-12 | 1994-08-11 | F. Hoffmann-La Roche Ag | Use of a retinoid |
US5430062A (en) * | 1992-05-21 | 1995-07-04 | Research Corporation Technologies, Inc. | Stilbene derivatives as anticancer agents |
US5449638A (en) * | 1994-06-06 | 1995-09-12 | United Microelectronics Corporation | Process on thickness control for silicon-on-insulator technology |
DE19526146A1 (de) * | 1995-07-07 | 1997-01-09 | Schering Ag | Triphenylethylene, Verfahren zu deren Herstellung, diese Triphenylethylene enthaltene pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
FR2772512B1 (fr) | 1997-12-16 | 2004-04-16 | Commissariat Energie Atomique | Microsysteme a element deformable sous l'effet d'un actionneur thermique |
US6624197B1 (en) | 1998-05-08 | 2003-09-23 | Calyx Therapeutics, Inc. | Diphenylethylene compounds |
US7105552B2 (en) * | 1998-05-08 | 2006-09-12 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
US6331633B1 (en) | 1998-05-08 | 2001-12-18 | Calyx Therapeutics Inc. | Heterocyclic analogs of diphenylethylene compounds |
US6245814B1 (en) | 1998-05-08 | 2001-06-12 | Calyx Therapeutics, Inc. | Diphenylethylene compounds |
US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US7407978B2 (en) | 1999-04-06 | 2008-08-05 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
JP3498634B2 (ja) | 1999-05-31 | 2004-02-16 | 関西日本電気株式会社 | 半導体装置の製造方法 |
US6525093B1 (en) | 1999-11-08 | 2003-02-25 | Calyx Therapeutics Inc. | Compounds to treat diabetes and associated conditions |
US20020002200A1 (en) * | 2000-02-04 | 2002-01-03 | Bishwagit Nag | Novel diphenylethylene compounds |
US20080108825A1 (en) * | 1999-11-08 | 2008-05-08 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
US7323496B2 (en) * | 1999-11-08 | 2008-01-29 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
US20080103302A1 (en) * | 2000-02-04 | 2008-05-01 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
FR2830860A1 (fr) * | 2001-10-12 | 2003-04-18 | Univ Pasteur | Procede de synthese du (z)-3, 5, 4'-trimethoxystilbene, compose obtenu et utilisations dudit compose, notamment comme medicament, en particulier comme anticancereux |
US20050014729A1 (en) * | 2003-07-16 | 2005-01-20 | Pharmacia Corporation | Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith |
US20070276172A1 (en) | 2006-03-28 | 2007-11-29 | Sinha Arun K | Single step microwave induced process for the preparation of substituted stilbenes and its analogs |
US20100298402A1 (en) * | 2007-11-06 | 2010-11-25 | Orchid Research Laboratories Limited | Stilbene derivatives as pstat3/il-6 inhibitors |
WO2010113005A2 (en) | 2009-03-27 | 2010-10-07 | Council Of Scientific & Industrial Research | One pot multicomponent synthesis of some novel hydroxy stilbene derivatives with alpha, beta-carbonyl conjugation under microwave irradiation |
WO2013003112A1 (en) | 2011-06-27 | 2013-01-03 | The Jackson Laboratory | Methods and compositions for treatment of cancer and autoimmune disease |
TW201702218A (zh) | 2014-12-12 | 2017-01-16 | 美國杰克森實驗室 | 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法 |
CN112190688A (zh) * | 2020-09-09 | 2021-01-08 | 广州医科大学附属第一医院(广州呼吸中心) | 粘蛋白muc1在制备具有延缓肺衰老功效的药物中的应用 |
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DE3040911A1 (de) * | 1980-10-30 | 1982-06-03 | Bayer Ag, 5090 Leverkusen | Kationische styrylfarbstoffe, ihre herstellung und ihre verwendung zum faerben von natuerlichen und synthetischen kationisch anfaerbbaren substraten |
CA1162200A (en) * | 1981-02-13 | 1984-02-14 | Michael Klaus | Process for the manufacture of indanyl (or tetrahydronaphthyl)propenyl phenyl derivatives |
JPS62964A (ja) * | 1985-06-26 | 1987-01-06 | Minolta Camera Co Ltd | 電子写真感光体 |
DE3770547D1 (de) * | 1986-02-18 | 1991-07-11 | Electronics For Industry Ltd | Verfahren und geraet zum kochen von teigwaren. |
CH668962A5 (de) * | 1986-05-13 | 1989-02-15 | Hoffmann La Roche | Tetrahydronaphthyl-propenyl-phenole. |
ZW7487A1 (en) * | 1986-05-23 | 1987-12-16 | Hoffmann La Roche | Tetrahydronaphthaline and indane derivatives |
-
1989
- 1989-01-30 CA CA000589502A patent/CA1340955C/en not_active Expired - Fee Related
- 1989-02-14 CS CS89962A patent/CS277022B6/cs unknown
- 1989-02-14 US US07/310,442 patent/US4940707A/en not_active Expired - Fee Related
- 1989-02-17 IL IL8932789A patent/IL89327A/en not_active IP Right Cessation
- 1989-02-17 NZ NZ228028A patent/NZ228028A/xx unknown
- 1989-02-20 HU HU89816A patent/HU204766B/hu not_active IP Right Cessation
- 1989-02-21 JP JP1039496A patent/JP2556577B2/ja not_active Expired - Lifetime
- 1989-02-21 MC MC892034A patent/MC2011A1/xx unknown
- 1989-02-22 FI FI890842A patent/FI91860C/sv not_active IP Right Cessation
- 1989-02-22 YU YU39589A patent/YU48067B/sh unknown
- 1989-02-23 EP EP89103182A patent/EP0331983B1/de not_active Expired - Lifetime
- 1989-02-23 DE DE58908751T patent/DE58908751D1/de not_active Expired - Fee Related
- 1989-02-23 CN CN89100484A patent/CN1030702C/zh not_active Expired - Fee Related
- 1989-02-23 KR KR1019890002126A patent/KR0148217B1/ko not_active IP Right Cessation
- 1989-02-23 AT AT89103182T patent/ATE115573T1/de not_active IP Right Cessation
- 1989-02-23 PT PT89814A patent/PT89814B/pt not_active IP Right Cessation
- 1989-02-23 IS IS3437A patent/IS1593B/is unknown
- 1989-02-23 AU AU30257/89A patent/AU623880B2/en not_active Ceased
- 1989-02-23 IE IE58189A patent/IE66675B1/en not_active IP Right Cessation
- 1989-02-23 ES ES89103182T patent/ES2065929T3/es not_active Expired - Lifetime
- 1989-02-23 DK DK084889A patent/DK84889A/da not_active Application Discontinuation
- 1989-02-23 NO NO890767A patent/NO169836C/no unknown
-
1990
- 1990-04-19 US US07/510,705 patent/US5106981A/en not_active Expired - Fee Related
-
1994
- 1994-02-24 BG BG098548A patent/BG60935B2/bg unknown
-
1995
- 1995-03-02 GR GR950400454T patent/GR3015268T3/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB | Publication of examined application | ||
MM | Patent lapsed |
Owner name: F. HOFFMANN-LA ROCHE AG |