FI895261A0 - Förfarande för framställning av terapeutiskt användbara (1,2-bensioxazol-3-yl)-1-piperidinylalkyl-6,7,8,9-tetrahydro-4H-pyrido/1,2-a/pyrimidinderivat - Google Patents

Förfarande för framställning av terapeutiskt användbara (1,2-bensioxazol-3-yl)-1-piperidinylalkyl-6,7,8,9-tetrahydro-4H-pyrido/1,2-a/pyrimidinderivat

Info

Publication number
FI895261A0
FI895261A0 FI895261A FI895261A FI895261A0 FI 895261 A0 FI895261 A0 FI 895261A0 FI 895261 A FI895261 A FI 895261A FI 895261 A FI895261 A FI 895261A FI 895261 A0 FI895261 A0 FI 895261A0
Authority
FI
Finland
Prior art keywords
piperidinylalkyl
benzisoxazol
pyrido
tetrahydro
preparation
Prior art date
Application number
FI895261A
Other languages
English (en)
Finnish (fi)
Other versions
FI92201B (sv
FI92201C (sv
Inventor
Cornelus Gerardus Mari Janssen
Alfonsus Guilielmus Knaeps
Ludo Edmond Josephine Kennis
Jan Vandenberk
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of FI895261A0 publication Critical patent/FI895261A0/sv
Publication of FI92201B publication Critical patent/FI92201B/sv
Application granted granted Critical
Publication of FI92201C publication Critical patent/FI92201C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI895261A 1988-11-07 1989-11-06 Förfarande för framställning av terapeutiskt användbara (1,2-bensioxazol-3-yl)-1-piperidinylalkyl-6,7,8,9-tetrahydro-4H-pyrido/1,2-a/pyrimidinderivat FI92201C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26785788A 1988-11-07 1988-11-07
US26785788 1988-11-07

Publications (3)

Publication Number Publication Date
FI895261A0 true FI895261A0 (sv) 1989-11-06
FI92201B FI92201B (sv) 1994-06-30
FI92201C FI92201C (sv) 1994-10-10

Family

ID=23020416

Family Applications (1)

Application Number Title Priority Date Filing Date
FI895261A FI92201C (sv) 1988-11-07 1989-11-06 Förfarande för framställning av terapeutiskt användbara (1,2-bensioxazol-3-yl)-1-piperidinylalkyl-6,7,8,9-tetrahydro-4H-pyrido/1,2-a/pyrimidinderivat

Country Status (21)

Country Link
EP (1) EP0368388B1 (sv)
JP (1) JP2758045B2 (sv)
KR (1) KR0146053B1 (sv)
AT (1) ATE122349T1 (sv)
AU (1) AU614437B2 (sv)
CA (1) CA2000786C (sv)
CL (1) CL43432B (sv)
CY (2) CY1926A (sv)
DE (2) DE122007000081I2 (sv)
DK (1) DK169923B1 (sv)
ES (1) ES2075036T3 (sv)
FI (1) FI92201C (sv)
HK (1) HK131696A (sv)
IE (1) IE66370B1 (sv)
IL (1) IL92208A0 (sv)
LU (1) LU91362I2 (sv)
NL (1) NL300298I2 (sv)
NO (2) NO173015C (sv)
NZ (1) NZ231062A (sv)
PT (1) PT92206B (sv)
ZA (1) ZA898436B (sv)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9008850D0 (en) * 1990-04-19 1990-06-13 Janssen Pharmaceutica Nv Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones
WO1993010742A2 (en) * 1991-11-27 1993-06-10 Novo Nordisk A/S Chemical compounds, their preparation and use
US5378714A (en) * 1991-11-27 1995-01-03 Novo Nordisk A/S Antipsychotic piperidine derivatives
ES2050069B1 (es) * 1992-07-10 1994-12-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-il)piperidino)etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido(1,2-a) pirimidin-4-ona.
DK60793D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
DK60593D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
DK0729357T3 (da) 1993-11-19 2005-06-06 Janssen Pharmaceutica Nv Mikroindkapslede 1,2-benzazoler
JP3553951B2 (ja) * 1993-11-23 2004-08-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 新規な９−ヒドロキシ−ピリド［１，２−ａ］ピリミジン−４−オンエーテル誘導体
ES2085234B1 (es) * 1994-02-24 1997-01-16 Vita Invest Sa Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
TW487572B (en) * 1996-05-20 2002-05-21 Janssen Pharmaceutica Nv Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
US6028083A (en) * 1997-07-25 2000-02-22 Hoechst Marion Roussel, Inc. Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol
UA72189C2 (uk) * 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
ES2141671B1 (es) * 1997-12-26 2001-01-01 Vita Invest Sa Compuesto pirimidinico activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
US6326362B1 (en) 1998-05-18 2001-12-04 Sepracor Inc. (-)-phosphonorisperidone and (-)-sulforisperidone compositions and methods
US6500833B1 (en) 1998-05-18 2002-12-31 Sepracor Inc. (+)-Hydroxyrisperidone compositions and methods
WO2000010572A1 (en) * 1998-08-18 2000-03-02 Sepracor Inc. Use of hydroxyrisperidone for the manufacture of a medicament for the treatment and prevention of psychoses, emesis and symptoms of withdrawal from alcohol and nicotine
ES2197801B1 (es) * 2002-03-05 2005-03-16 Ferrer Internacional,S.A Procedimiento de obtencion de la 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il) piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a ) pirimidin-4-ona.
KR20040025224A (ko) * 2002-09-18 2004-03-24 주식회사 대웅 2-(2-메틸-4-옥소-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-3-일)아세트알데히드 및 그 제조방법
EP1560814A1 (en) 2002-11-13 2005-08-10 Synthon B.V. Process for making risperidone and intermediates therefor
EP1791839B1 (en) * 2004-09-09 2015-06-10 Janssen Pharmaceutica NV Preparation of 9-hydroxy-3-(2-hydroxyethyl)-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one and crystalls thereof
US20070197591A1 (en) 2005-12-12 2007-08-23 Sandra Boom Use of paliperidone for the treatment of a mental disorder in a psychiatric patient with reduced hepatic function
DE07811307T1 (de) 2006-08-14 2008-07-31 Teva Pharmaceutical Industries Ltd. Amorphe und Kristlline Formen von 9-Hydroxyrisperidon (Paliperidon)
EP2133352A3 (en) * 2006-08-14 2010-01-13 Teva Pharmaceutical Industries Ltd. Crystal form of 9-hydroxy-risperidone (paliperidone)
EP2133351A3 (en) * 2006-08-14 2010-01-13 Teva Pharmaceutical Industries Ltd. Crystal form of 9-hydroxy-risperidone (paliperidone)
US7820816B2 (en) 2006-08-23 2010-10-26 Teva Pharmaceutical Industries Ltd. Process for the synthesis of CMHTP and intermediates thereof
EP1924583A2 (en) * 2006-08-23 2008-05-28 Teva Pharmaceutical Industries Ltd. Process for the synthesis of cmhtp and intermediates thereof
US8071767B2 (en) 2007-01-08 2011-12-06 Actavis Group Ptc Ehf Process for preparation of 9-hydroxy-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-A]pyrimidin-4-one hydrochloride
KR101244185B1 (ko) * 2007-04-19 2013-03-25 유씬 리 정신 장애 치료용 신규 화합물, 그의 제조 방법 및 용도
WO2009010988A1 (en) * 2007-07-19 2009-01-22 Natco Pharma Limited An improved, industrially viable process for the preparation of high purity paliperidone
WO2009015828A1 (en) * 2007-07-27 2009-02-05 Synthon B.V. Paliperidone derivatives
WO2009045489A2 (en) * 2007-10-03 2009-04-09 Teva Pharmaceutical Industries Ltd. Process for the synthesis of cmhtp, a paliperidone intermediate
CA2700803A1 (en) * 2007-10-09 2009-04-16 Rajendra Narayanrao Kankan Processes for the preparation of paliperidone and pharmaceutically acceptable salts thereof and intermediates for use in the processes
AR069621A1 (es) 2007-12-10 2010-02-03 Synthon Bv Sintesis de paliperidona
BRPI0905938A2 (pt) * 2008-02-05 2018-05-29 Watson Pharma Private Ltd processo para preparação de 3-(2 cloroetil)- 2- metil hidróxi- 4h-pirido [l, 2-a] pirimidina-4- ona, de 3- (2-cloroetil)-6,7,8,9- tetraidro 9- hidróxil-2-metil-4h-pirido[1,2-a]pirimidina-4-ona, de 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-il)-1-piperidinil]etil]-6,7,8,9-tetaidro-9-hidróxi-2-metil-4h-pirido[1,2-a]pirimidina-4-ona bruta, e processo para a purificação da paliperidona
EP2285804A4 (en) * 2008-04-21 2011-09-14 Glenmark Generics Ltd METHOD FOR MANUFACTURING PALIPERIDONE INTERMEDIATES
ES2625323T3 (es) * 2008-05-29 2017-07-19 Inke, S.A. Proceso para preparar paliperidona e intermedios de la misma
WO2010004578A2 (en) * 2008-06-16 2010-01-14 Msn Laboratories Limited Novel and improved processes for the preparation of paliperidone
EP2318405A2 (en) * 2008-07-11 2011-05-11 Synthon B.V. Paliperidone ketone
EP2321311B1 (en) * 2008-07-11 2012-09-19 Synthon B.V. Synthesis of paliperidone
SI22856A (sl) * 2008-07-31 2010-02-26 Krka, Tovarna Zdravil, D.D., Novo Mesto Proces za pripravo paliperidona
EP2161019A1 (en) 2008-09-05 2010-03-10 KRKA, D.D., Novo Mesto Prolonged release multiparticulate pharmaceutical composition comprising paliperidone
EP2199293A1 (en) 2008-12-22 2010-06-23 Chemo Ibérica, S.A. One-step process for preparing paliperidone and its oxalate salt
EP2202234A1 (en) 2008-12-24 2010-06-30 Laboratorios Lesvi, S.L. Purification of paliperidone
EP2275423B9 (en) 2009-07-13 2012-08-15 KRKA, d.d., Novo mesto Process for the synthesis of paliperidone
WO2011018246A2 (en) 2009-08-13 2011-02-17 Synthon B.V. Controlled release paliperidone composition
EP2343296A1 (en) 2009-12-01 2011-07-13 Chemo Ibérica, S.A. A process for the purification of paliperidone
US20120259116A1 (en) * 2009-12-17 2012-10-11 Rajiv Kumar Novel Process for the Preparation of Paliperidone
US8088594B2 (en) * 2010-03-16 2012-01-03 Saladax Biomedical Inc. Risperidone immunoassay
WO2012035554A1 (en) * 2010-09-14 2012-03-22 Megafine Pharma (P) Ltd. An improved process for the preparation of highly pure paliperidone
WO2012068161A1 (en) 2010-11-15 2012-05-24 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
CN102153552B (zh) * 2011-03-01 2012-08-22 吉林大学 两种帕潘立酮药物共晶及其制备方法
CN102206210B (zh) * 2011-04-01 2014-07-02 常州市第四制药厂有限公司 一种6-氟-3-(4-哌啶基)-1，2-苯并异噁唑盐酸盐的生产方法
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
EP3083569B1 (en) 2013-12-20 2022-01-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CA2990004C (en) 2015-06-19 2024-04-23 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
WO2019162746A1 (en) * 2018-02-21 2019-08-29 Zenvision Pharma Llp Novel derivatives of paliperidone and process for the preparation thereof
EA202190076A1 (ru) 2018-06-19 2021-09-22 Эйджинбайо, Инк. Производные бензодиазепина, композиции и способы лечения когнитивных нарушений
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment
CN116003404B (zh) * 2022-12-14 2024-10-01 杭州同舟生物技术有限公司 一种利培酮人工半抗原、人工抗原及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342870A (en) * 1980-03-28 1982-08-03 Janssen Pharmaceutica N.V. Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles

Also Published As

Publication number Publication date
DE122007000081I1 (de) 2008-02-28
DE68922577D1 (de) 1995-06-14
EP0368388A2 (en) 1990-05-16
KR910009700A (ko) 1991-06-28
CA2000786A1 (en) 1990-05-07
AU614437B2 (en) 1991-08-29
LU91362I2 (fr) 2007-11-12
NO2007017I2 (no) 2010-01-25
CA2000786C (en) 1999-01-26
IL92208A0 (en) 1990-07-26
DK551989D0 (da) 1989-11-06
DK551989A (da) 1990-05-08
CY2007025I1 (el) 2009-11-04
NO2007017I1 (no) 2008-01-14
HK131696A (en) 1996-07-26
DK169923B1 (da) 1995-04-03
EP0368388B1 (en) 1995-05-10
CL43432B (es) 2005-06-03
PT92206A (pt) 1990-05-31
IE66370B1 (en) 1995-12-27
NO173015B (no) 1993-07-05
EP0368388A3 (en) 1991-07-17
ATE122349T1 (de) 1995-05-15
ZA898436B (en) 1991-07-31
DE68922577T2 (de) 1995-09-28
CY2007025I2 (el) 2009-11-04
KR0146053B1 (ko) 1998-08-17
ES2075036T3 (es) 1995-10-01
NZ231062A (en) 1991-09-25
JP2758045B2 (ja) 1998-05-25
CY1926A (en) 1989-10-30
FI92201B (sv) 1994-06-30
NL300298I2 (nl) 2008-03-03
DE122007000081I2 (de) 2010-01-28
NL300298I1 (nl) 2007-12-03
NO173015C (no) 1993-10-13
FI92201C (sv) 1994-10-10
IE893564L (en) 1990-05-07
NO894411L (no) 1990-05-08
PT92206B (pt) 1995-07-06
NO894411D0 (no) 1989-11-06
AU4443689A (en) 1990-05-10
JPH02191276A (ja) 1990-07-27

Similar Documents

Publication Publication Date Title
FI895261A0 (sv) Förfarande för framställning av terapeutiskt användbara (1,2-bensioxazol-3-yl)-1-piperidinylalkyl-6,7,8,9-tetrahydro-4H-pyrido/1,2-a/pyrimidinderivat
FI900085A0 (sv) Förfarande för framställning av terapeutiskt användbara N-(pyrimidin- och kondenserad pyrimidin-4-on)etyl-piperidin- och piperatzinderivat
AU588890B2 (en) (4-Piperidinylmethyl and - hetero) Purines
ES2057016T3 (es) Compuestos de acido 3-pirrolidiniltio-1-azabiciclo (3.2.0) hept-2-eno-2-carboxilico.
NO176051C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-piperazinylbenzazol-derivater
FI882909A (sv) Förfarande för framställning av terapeutiskt användbara furanylmetylsubstituerade bensimidazol- och imidazopyridinderivat
NO176608C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-piperidinylindazol-derivater

Legal Events

Date Code Title Description
BB Publication of examined application
FG Patent granted

Owner name: JANSSEN PHARMACEUTICA N.V.

SPCF Supplementary protection certificate application filed

Spc suppl protection certif: L20070029

SPCG Supplementary protection certificate granted

Spc suppl protection certif: 220

Extension date: 20141106