FI891538A0 - Förfarande för framställning av farmaceutiskt användbara fenolsubstituerade gem-difosfonatderivat - Google Patents

Förfarande för framställning av farmaceutiskt användbara fenolsubstituerade gem-difosfonatderivat

Info

Publication number
FI891538A0
FI891538A0 FI891538A FI891538A FI891538A0 FI 891538 A0 FI891538 A0 FI 891538A0 FI 891538 A FI891538 A FI 891538A FI 891538 A FI891538 A FI 891538A FI 891538 A0 FI891538 A0 FI 891538A0
Authority
FI
Finland
Prior art keywords
preparation
pharmaceutically useful
useful phenol
diphosphonate derivatives
substituted gem
Prior art date
Application number
FI891538A
Other languages
English (en)
Finnish (fi)
Other versions
FI891538A (sv
FI92933C (sv
FI92933B (sv
Inventor
Lan Nguyen
Eric Niesor
Hieu Phan
Pierre Maechler
Craig Bentzen
Original Assignee
Symphar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symphar Sa filed Critical Symphar Sa
Publication of FI891538A0 publication Critical patent/FI891538A0/sv
Publication of FI891538A publication Critical patent/FI891538A/sv
Application granted granted Critical
Publication of FI92933B publication Critical patent/FI92933B/sv
Publication of FI92933C publication Critical patent/FI92933C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/404—Esters of poly(thio)phosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/44—Amides thereof
    • C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4423—Amides of poly (thio)phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
FI891538A 1988-03-31 1989-03-30 Förfarande för framställning av farmaceutiskt användbara fenolsubstituerade gem-difosfonatderivat FI92933C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH123988 1988-03-31
CH1239/88A CH675422A5 (sv) 1988-03-31 1988-03-31

Publications (4)

Publication Number Publication Date
FI891538A0 true FI891538A0 (sv) 1989-03-30
FI891538A FI891538A (sv) 1989-10-01
FI92933B FI92933B (sv) 1994-10-14
FI92933C FI92933C (sv) 1995-01-25

Family

ID=4205733

Family Applications (1)

Application Number Title Priority Date Filing Date
FI891538A FI92933C (sv) 1988-03-31 1989-03-30 Förfarande för framställning av farmaceutiskt användbara fenolsubstituerade gem-difosfonatderivat

Country Status (25)

Country Link
US (2) US5043330A (sv)
EP (1) EP0339237B1 (sv)
JP (1) JPH0822865B2 (sv)
KR (1) KR0147830B1 (sv)
CN (2) CN1086820A (sv)
AR (1) AR247569A1 (sv)
AT (1) ATE84040T1 (sv)
AU (1) AU612475B2 (sv)
CA (1) CA1338495C (sv)
CH (1) CH675422A5 (sv)
DE (2) DE339237T1 (sv)
DK (1) DK173936B1 (sv)
ES (1) ES2011210T3 (sv)
FI (1) FI92933C (sv)
GR (2) GR900300002T1 (sv)
HU (1) HU203556B (sv)
IE (1) IE62692B1 (sv)
IL (1) IL89649A (sv)
MY (1) MY103850A (sv)
NO (1) NO891317L (sv)
NZ (1) NZ228516A (sv)
PH (1) PH27603A (sv)
PT (1) PT90175B (sv)
ZA (1) ZA892126B (sv)
ZW (1) ZW3789A1 (sv)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物
US5157027A (en) * 1991-05-13 1992-10-20 E. R. Squibb & Sons, Inc. Bisphosphonate squalene synthetase inhibitors and method
JPH05163150A (ja) * 1991-05-13 1993-06-29 E R Squibb & Sons Inc アテローム性動脈硬化症の抑制・治療剤
CA2067974A1 (en) * 1991-05-13 1992-11-14 Scott A. Biller Method for lowering cholesterol employing a phosphonomethylphosphinate squalene synthetase inhibitor
CA2095128C (en) * 1991-09-05 1998-01-06 Norio Kawabe Methanediphosphonate derivative, its manufacturing process and its pharmaceutical applications
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
JPH06172372A (ja) * 1991-11-06 1994-06-21 Takeda Chem Ind Ltd スクアレン合成酵素阻害剤およびその用途
FR2683529B1 (fr) * 1991-11-12 1994-02-04 Bretagne Occidentale Universite Composes pharmaceutiques gem-diphosphonates analogues du cis-platine.
CH683996A5 (fr) * 1992-03-05 1994-06-30 Symphar Sa Dérivés aminophosphonates substitués, leur procédé de préparation et compositions pharmaceutiques les contenant.
EP0603401B1 (en) * 1992-07-10 2001-04-11 Toray Industries, Inc. Methanediphosphonate derivative, production thereof, and pharmaceutical use thereof
US5332728A (en) * 1992-11-23 1994-07-26 Bristol-Myers Squibb Company Method for treating a fungal infection
US5434288A (en) * 1992-12-01 1995-07-18 Monsanto Company PLA2 inhibitors
ZA941088B (en) * 1993-02-19 1995-09-27 Symphar Sa Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them
CN1038033C (zh) * 1993-02-25 1998-04-15 东丽株式会社 甲基二膦酸化合物的制备方法
US5419845A (en) * 1994-03-15 1995-05-30 Basf Corporation Perfluorinated gemdiphosphonates as corrosion inhibitors for antifreeze coolants and other functional fluids
CA2174435A1 (en) * 1994-08-24 1996-02-29 Norio Kawabe Process for production of methanediphosphonic acid
CH690163A5 (fr) * 1995-07-28 2000-05-31 Symphar Sa Dérivés gem-diphosphonates substitués utiles en tant qu'agents anti-cancers.
GB9603637D0 (en) * 1996-02-21 1996-04-17 Smithkline Beecham Plc Process
EP0952834A2 (en) * 1996-05-15 1999-11-03 The University of Sheffield Isopentenyl pyrophosphate isomerase (ipi) and/or prenyl transferase inhibitors
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
EP0994853B1 (en) 1997-05-14 2005-04-27 Atherogenics, Inc. A monoether of probucol and methods for the inhibition of the expression of vcam-1
US6984400B2 (en) 1998-07-14 2006-01-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treating restenosis using bisphosphonate nanoparticles
IL125336A0 (en) * 1998-07-14 1999-03-12 Yissum Res Dev Co Compositions for inhibition and treatment of restinosis
US7008645B2 (en) 1998-07-14 2006-03-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of inhibiting restenosis using bisphosphonates
AUPQ872800A0 (en) * 2000-07-12 2000-08-03 Heart Research Institute, The Compositions and methods for treating cardiovascular disorders
GB0019272D0 (en) * 2000-08-04 2000-09-27 Symphar Sa Pharmaceutical compounds
EP1385501A2 (en) * 2001-04-11 2004-02-04 Atherogenics, Inc. Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
AU2002337862A1 (en) * 2001-10-18 2003-04-28 Ilex Products, Inc. Methods of treating skin with diphosphonate derivatives
WO2003070179A2 (en) * 2002-02-19 2003-08-28 Ilex Products, Inc. Phosphonate-phosphate and diphosphonate apolipoprotein e modulators
WO2003094851A2 (en) * 2002-05-11 2003-11-20 Ilex Products, Inc. 1,1- and 1,2-bisphosphonates as apoliprotein e modulators
US7479507B2 (en) * 2003-01-14 2009-01-20 Adam Heller Anti-inflammatory substituted phenols and elastomeric compositions for oral delivery of drugs
US10517883B2 (en) 2003-06-27 2019-12-31 Zuli Holdings Ltd. Method of treating acute myocardial infarction
KR20080111070A (ko) * 2006-03-17 2008-12-22 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 비스포스포네이트 화합물 및 방법
CA2682258A1 (en) * 2007-03-26 2008-10-02 Salutria Pharmaceuticals Llc Methods and compositions of derivatives of probucol for the treatment of diabetes
US20080280985A1 (en) * 2007-03-27 2008-11-13 Scott Robert A D Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
EP3209671B8 (en) * 2014-10-21 2019-07-31 Council of Scientific and Industrial Research Alkylidene phosphonate esters as p-glycoprotein inducers
WO2018236221A2 (en) * 2017-06-03 2018-12-27 Can Holding B.V. DISSOLUTION OF NEURODEGENERATIVE PEPTIDE DEPOSITION

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA777769A (en) * 1963-03-18 1968-02-06 H. Roy Clarence Substituted methylene diphosphonic acid compounds and detergent compositions
DE1302557B (sv) * 1963-04-09 1971-08-26
US4416877A (en) * 1979-02-13 1983-11-22 Symphar S.A. Anti-atherosclerotic pharmaceutical compositions containing diphosphonate compounds
GB2043072B (en) * 1979-02-13 1983-11-23 Symphar Sa Diphosphonate compounds
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
CH664158A5 (fr) * 1984-07-18 1988-02-15 Symphar Sa Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant.
US6259935B1 (en) * 1997-06-24 2001-07-10 Matsushita Electrical Industrial Co., Ltd. Electro-mechanical-acoustic transducing device

Also Published As

Publication number Publication date
CN1086820A (zh) 1994-05-18
NO891317D0 (no) 1989-03-29
HU203556B (en) 1991-08-28
DE68904104D1 (de) 1993-02-11
JPH0822865B2 (ja) 1996-03-06
DE339237T1 (de) 1990-02-08
NZ228516A (en) 1990-12-21
CN1036772A (zh) 1989-11-01
ES2011210T3 (es) 1994-01-01
HUT50482A (en) 1990-02-28
AU612475B2 (en) 1991-07-11
GR3007442T3 (sv) 1993-07-30
PT90175A (pt) 1989-11-10
FI891538A (sv) 1989-10-01
PH27603A (en) 1993-08-31
DK148189A (da) 1989-10-17
CH675422A5 (sv) 1990-09-28
ZA892126B (en) 1989-11-29
DK173936B1 (da) 2002-02-25
ZW3789A1 (en) 1989-08-23
CA1338495C (en) 1996-07-30
EP0339237A3 (en) 1991-01-09
IE890802L (en) 1989-09-30
GR900300002T1 (en) 1991-06-07
EP0339237B1 (en) 1992-12-30
KR0147830B1 (ko) 1998-08-17
DK148189D0 (da) 1989-03-28
KR890014569A (ko) 1989-10-24
IL89649A0 (en) 1989-09-28
AR247569A1 (es) 1995-01-31
US5128331A (en) 1992-07-07
EP0339237A2 (en) 1989-11-02
ATE84040T1 (de) 1993-01-15
IE62692B1 (en) 1995-02-22
FI92933C (sv) 1995-01-25
MY103850A (en) 1993-09-30
DE68904104T2 (de) 1993-06-17
ES2011210A4 (es) 1990-01-01
NO891317L (no) 1989-10-02
US5043330A (en) 1991-08-27
CN1024555C (zh) 1994-05-18
AU3224389A (en) 1989-10-05
FI92933B (sv) 1994-10-14
PT90175B (pt) 1994-06-30
IL89649A (en) 1995-07-31
JPH0222285A (ja) 1990-01-25

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MM Patent lapsed
MM Patent lapsed

Owner name: SYMPHAR S.A.