FI891538A - Menetelmä farmaseuttisesti käyttökelpoisten fenolisubstituoitujen gem-difosfonaattijohdannaisten valmistamiseksi - Google Patents

Menetelmä farmaseuttisesti käyttökelpoisten fenolisubstituoitujen gem-difosfonaattijohdannaisten valmistamiseksi Download PDF

Info

Publication number
FI891538A
FI891538A FI891538A FI891538A FI891538A FI 891538 A FI891538 A FI 891538A FI 891538 A FI891538 A FI 891538A FI 891538 A FI891538 A FI 891538A FI 891538 A FI891538 A FI 891538A
Authority
FI
Finland
Prior art keywords
preparation
pharmaceutically useful
useful phenol
diphosphonate derivatives
substituted gem
Prior art date
Application number
FI891538A
Other languages
English (en)
Swedish (sv)
Other versions
FI92933B (fi
FI92933C (fi
FI891538A0 (fi
Inventor
Lan Nguyen
Eric Niesor
Hieu Phan
Pierre Maechler
Craig Bentzen
Original Assignee
Symphar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symphar Sa filed Critical Symphar Sa
Publication of FI891538A0 publication Critical patent/FI891538A0/fi
Publication of FI891538A publication Critical patent/FI891538A/fi
Publication of FI92933B publication Critical patent/FI92933B/fi
Application granted granted Critical
Publication of FI92933C publication Critical patent/FI92933C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/404—Esters of poly(thio)phosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4423—Amides of poly (thio)phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI891538A 1988-03-31 1989-03-30 Menetelmä farmaseuttisesti käyttökelpoisten fenolisubstituoitujen gem-difosfonaattijohdannaisten valmistamiseksi FI92933C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1239/88A CH675422A5 (fi) 1988-03-31 1988-03-31
CH123988 1988-03-31

Publications (4)

Publication Number Publication Date
FI891538A0 FI891538A0 (fi) 1989-03-30
FI891538A true FI891538A (fi) 1989-10-01
FI92933B FI92933B (fi) 1994-10-14
FI92933C FI92933C (fi) 1995-01-25

Family

ID=4205733

Family Applications (1)

Application Number Title Priority Date Filing Date
FI891538A FI92933C (fi) 1988-03-31 1989-03-30 Menetelmä farmaseuttisesti käyttökelpoisten fenolisubstituoitujen gem-difosfonaattijohdannaisten valmistamiseksi

Country Status (25)

Country Link
US (2) US5043330A (fi)
EP (1) EP0339237B1 (fi)
JP (1) JPH0822865B2 (fi)
KR (1) KR0147830B1 (fi)
CN (2) CN1086820A (fi)
AR (1) AR247569A1 (fi)
AT (1) ATE84040T1 (fi)
AU (1) AU612475B2 (fi)
CA (1) CA1338495C (fi)
CH (1) CH675422A5 (fi)
DE (2) DE339237T1 (fi)
DK (1) DK173936B1 (fi)
ES (1) ES2011210T3 (fi)
FI (1) FI92933C (fi)
GR (2) GR900300002T1 (fi)
HU (1) HU203556B (fi)
IE (1) IE62692B1 (fi)
IL (1) IL89649A (fi)
MY (1) MY103850A (fi)
NO (1) NO891317L (fi)
NZ (1) NZ228516A (fi)
PH (1) PH27603A (fi)
PT (1) PT90175B (fi)
ZA (1) ZA892126B (fi)
ZW (1) ZW3789A1 (fi)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物
US5157027A (en) * 1991-05-13 1992-10-20 E. R. Squibb & Sons, Inc. Bisphosphonate squalene synthetase inhibitors and method
JPH05163150A (ja) * 1991-05-13 1993-06-29 E R Squibb & Sons Inc アテローム性動脈硬化症の抑制・治療剤
CA2067974A1 (en) * 1991-05-13 1992-11-14 Scott A. Biller Method for lowering cholesterol employing a phosphonomethylphosphinate squalene synthetase inhibitor
ATE165603T1 (de) * 1991-09-05 1998-05-15 Toray Industries Methandiphosphonsäurederivat, herstellung davon und verwendung davon als arzneimittel
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
JPH06172372A (ja) * 1991-11-06 1994-06-21 Takeda Chem Ind Ltd スクアレン合成酵素阻害剤およびその用途
FR2683529B1 (fr) * 1991-11-12 1994-02-04 Bretagne Occidentale Universite Composes pharmaceutiques gem-diphosphonates analogues du cis-platine.
CH683996A5 (fr) * 1992-03-05 1994-06-30 Symphar Sa Dérivés aminophosphonates substitués, leur procédé de préparation et compositions pharmaceutiques les contenant.
ES2155446T3 (es) * 1992-07-10 2001-05-16 Toray Industries Derivado de metanodifosfonato, su produccion y su uso farmaceutico.
US5332728A (en) * 1992-11-23 1994-07-26 Bristol-Myers Squibb Company Method for treating a fungal infection
US5434288A (en) * 1992-12-01 1995-07-18 Monsanto Company PLA2 inhibitors
ZA941088B (en) * 1993-02-19 1995-09-27 Symphar Sa Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them
KR950701338A (ko) * 1993-02-25 1995-03-23 마에다 가쓰노스케 메탄디포스폰산 화합물의 제조방법(Process for producing methanediphosphonate compound)
US5419845A (en) * 1994-03-15 1995-05-30 Basf Corporation Perfluorinated gemdiphosphonates as corrosion inhibitors for antifreeze coolants and other functional fluids
US5886206A (en) * 1994-08-24 1999-03-23 Toray Industries, Inc. Process for production of methanediphosphonic acid compound
CH690163A5 (fr) * 1995-07-28 2000-05-31 Symphar Sa Dérivés gem-diphosphonates substitués utiles en tant qu'agents anti-cancers.
GB9603637D0 (en) * 1996-02-21 1996-04-17 Smithkline Beecham Plc Process
WO1997043437A2 (en) * 1996-05-15 1997-11-20 The University Of Sheffield Isopentenyl pyrophosphate isomerase (ipi) and/or prenyl transferase inhibitors
EA009370B1 (ru) * 1997-05-14 2007-12-28 Атеродженикс, Инк. Соединение и фармацевтическая композиция для ингибирования экспрессии vcam-1
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
US6984400B2 (en) 1998-07-14 2006-01-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treating restenosis using bisphosphonate nanoparticles
US7008645B2 (en) 1998-07-14 2006-03-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of inhibiting restenosis using bisphosphonates
IL125336A0 (en) * 1998-07-14 1999-03-12 Yissum Res Dev Co Compositions for inhibition and treatment of restinosis
AUPQ872800A0 (en) * 2000-07-12 2000-08-03 Heart Research Institute, The Compositions and methods for treating cardiovascular disorders
GB0019272D0 (en) * 2000-08-04 2000-09-27 Symphar Sa Pharmaceutical compounds
CA2444429A1 (en) * 2001-04-11 2002-11-07 Atherogenics, Inc. Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
EP1435970A4 (en) * 2001-10-18 2005-05-04 Ilex Products Inc METHOD OF TREATING SKIN WITH DIPHOSPHONATE DERIVATIVES
WO2003070179A2 (en) * 2002-02-19 2003-08-28 Ilex Products, Inc. Phosphonate-phosphate and diphosphonate apolipoprotein e modulators
EP1506208A4 (en) * 2002-05-11 2006-05-24 Ilex Products Inc USE OF 1,1 AND 1,2-DIPHOSPHONATES AS MODULATORS OF APOLIPOPROTEIN E
US7479507B2 (en) * 2003-01-14 2009-01-20 Adam Heller Anti-inflammatory substituted phenols and elastomeric compositions for oral delivery of drugs
US10517883B2 (en) 2003-06-27 2019-12-31 Zuli Holdings Ltd. Method of treating acute myocardial infarction
AU2007226964B2 (en) * 2006-03-17 2012-03-22 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods
WO2008118948A1 (en) * 2007-03-26 2008-10-02 Atherogenics, Inc. Methods and compositions of derivatives of probucol for the treatment of diabetes
WO2008118946A1 (en) * 2007-03-27 2008-10-02 Atherogenics, Inc. Methods and compositions using certain phenolic derivatives for the treatment of diabetes
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
WO2016063297A1 (en) * 2014-10-21 2016-04-28 Council Of Scientific & Industrial Research Alkylidene phosphonate esters as p-glycoprotein inducers
WO2018236221A2 (en) * 2017-06-03 2018-12-27 Can Holding B.V. DISSOLUTION OF NEURODEGENERATIVE PEPTIDE DEPOSITION

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA777769A (en) * 1963-03-18 1968-02-06 H. Roy Clarence Substituted methylene diphosphonic acid compounds and detergent compositions
DE1302557B (fi) * 1963-04-09 1971-08-26
GB2043072B (en) * 1979-02-13 1983-11-23 Symphar Sa Diphosphonate compounds
US4416877A (en) * 1979-02-13 1983-11-22 Symphar S.A. Anti-atherosclerotic pharmaceutical compositions containing diphosphonate compounds
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
CH664158A5 (fr) * 1984-07-18 1988-02-15 Symphar Sa Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant.
US6259935B1 (en) * 1997-06-24 2001-07-10 Matsushita Electrical Industrial Co., Ltd. Electro-mechanical-acoustic transducing device

Also Published As

Publication number Publication date
AU612475B2 (en) 1991-07-11
KR890014569A (ko) 1989-10-24
NO891317D0 (no) 1989-03-29
KR0147830B1 (ko) 1998-08-17
JPH0222285A (ja) 1990-01-25
MY103850A (en) 1993-09-30
ZW3789A1 (en) 1989-08-23
CH675422A5 (fi) 1990-09-28
US5043330A (en) 1991-08-27
CN1086820A (zh) 1994-05-18
AU3224389A (en) 1989-10-05
NO891317L (no) 1989-10-02
DK173936B1 (da) 2002-02-25
ES2011210A4 (es) 1990-01-01
GR3007442T3 (fi) 1993-07-30
CN1036772A (zh) 1989-11-01
AR247569A1 (es) 1995-01-31
ZA892126B (en) 1989-11-29
IL89649A0 (en) 1989-09-28
IE890802L (en) 1989-09-30
PT90175A (pt) 1989-11-10
JPH0822865B2 (ja) 1996-03-06
EP0339237A3 (en) 1991-01-09
DE68904104D1 (de) 1993-02-11
FI92933B (fi) 1994-10-14
HUT50482A (en) 1990-02-28
ATE84040T1 (de) 1993-01-15
ES2011210T3 (es) 1994-01-01
DE68904104T2 (de) 1993-06-17
DK148189A (da) 1989-10-17
FI92933C (fi) 1995-01-25
EP0339237B1 (en) 1992-12-30
PH27603A (en) 1993-08-31
NZ228516A (en) 1990-12-21
DK148189D0 (da) 1989-03-28
CN1024555C (zh) 1994-05-18
IL89649A (en) 1995-07-31
PT90175B (pt) 1994-06-30
DE339237T1 (de) 1990-02-08
HU203556B (en) 1991-08-28
FI891538A0 (fi) 1989-03-30
GR900300002T1 (en) 1991-06-07
CA1338495C (en) 1996-07-30
IE62692B1 (en) 1995-02-22
US5128331A (en) 1992-07-07
EP0339237A2 (en) 1989-11-02

Similar Documents

Publication Publication Date Title
FI891538A (fi) Menetelmä farmaseuttisesti käyttökelpoisten fenolisubstituoitujen gem-difosfonaattijohdannaisten valmistamiseksi
FI92934B (fi) Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-deoksinojirimysiinijohdannaisten valmistamiseksi
FI890282A (fi) Menetelmä terapeuttisesti käyttökelpoisten 23,24-didehydro-25-hydroksikalsiferolijohdannaisten valmistamiseksi
FI893520A (fi) Menetelmä intravenoosisen farmaseuttisen koostumuksen valmistamiseksi
FI892182A (fi) Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi
FI874459A0 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten piperidiinijohdannaisten valmistamiseksi
FI892058A0 (fi) Fenolin valmistusmenetelmä
FI881303A0 (fi) Menetelmä ibuprofeenin valmistamiseksi
NO173334C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive alkylaminoalkylenderivater 2H-1-benzopyraner
FI93215C (fi) Menetelmä terapeuttisesti käyttökelpoisten aminoalkoksifenyylijohdannaisten valmistamiseksi
FI104171B1 (fi) Menetelmä mono-N-alkyloitujen polyatsamakrosyklisten yhdisteiden valmistamiseksi
FI884910A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten bentsopyraanijohdannaisten valmistamiseksi
FI892948A (fi) Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi
FI902727A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi
FI903863A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi
FI92065C (fi) Menetelmä farmaseuttisten piperidiinijohdannaisten valmistamiseksi
FI893003A0 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten neplanosiinijohdannaisten valmistamiseksi
FI903077A0 (fi) Menetelmä valmistaa terapeuttisesti aktiivisia R(-)-3-kinuklidinolijohdannaisia
FI93107B (fi) Menetelmä lääkeaineina käyttökelpoisten 2-imino-6-polyfluorialkoksibentsotiatsolijohdannaisten valmistamiseksi
FI94351B (fi) Menetelmä terapeuttisesti käyttökelpoisten peptidijohdannaisten valmistamiseksi
FI900145A (fi) Menetelmä farmaseuttisesti käyttökelpoisten 1,1-diokso-kefem-4-karbotiolihappojohdannaisten valmistamiseksi
FI92188C (fi) Menetelmä terapeuttisesti käyttökelpoisten fenoksialkyylipyrokatekolijohdannaisten valmistamiseksi
FI911855A0 (fi) Menetelmä anti-inflammatorisesti vaikuttavien 3-asyyli-2-oksindoli-1-karboksiamidi-esilääkkeiden valmistamiseksi
FI893434A0 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten sykloalkyylitiatsolijohdannaisten valmistamiseksi
FI891111A0 (fi) Menetelmä 1,4-dihydropyridiinijohdannaisten valmistamiseksi

Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed
MM Patent lapsed

Owner name: SYMPHAR S.A.