FI886005A - Nya, sulfhydrylgrupper innehaollande tricykliska laktamer och deras farmakologiska anvaendningsfoerfaranden. - Google Patents

Nya, sulfhydrylgrupper innehaollande tricykliska laktamer och deras farmakologiska anvaendningsfoerfaranden. Download PDF

Info

Publication number
FI886005A
FI886005A FI886005A FI886005A FI886005A FI 886005 A FI886005 A FI 886005A FI 886005 A FI886005 A FI 886005A FI 886005 A FI886005 A FI 886005A FI 886005 A FI886005 A FI 886005A
Authority
FI
Finland
Prior art keywords
pharmacological
sulfhydrylgrupper
laktamer
anvaendningsfoerfaranden
innehaollande
Prior art date
Application number
FI886005A
Other languages
English (en)
Finnish (fi)
Inventor
Gary A Flynn
Douglas W Beight
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI886005A publication Critical patent/FI886005A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI886005A 1987-12-30 1988-12-28 Nya, sulfhydrylgrupper innehaollande tricykliska laktamer och deras farmakologiska anvaendningsfoerfaranden. FI886005A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/139,485 US4824832A (en) 1987-12-30 1987-12-30 Sulfhydryl containing tricyclic lactams and their pharmacological methods of use

Publications (1)

Publication Number Publication Date
FI886005A true FI886005A (fi) 1989-07-01

Family

ID=22486887

Family Applications (1)

Application Number Title Priority Date Filing Date
FI886005A FI886005A (fi) 1987-12-30 1988-12-28 Nya, sulfhydrylgrupper innehaollande tricykliska laktamer och deras farmakologiska anvaendningsfoerfaranden.

Country Status (18)

Country Link
US (1) US4824832A (pt)
EP (1) EP0322914B1 (pt)
JP (1) JP2681291B2 (pt)
KR (1) KR0128158B1 (pt)
CN (1) CN1034721A (pt)
AT (1) ATE100453T1 (pt)
AU (1) AU611984B2 (pt)
CA (1) CA1336191C (pt)
DE (1) DE3887307T2 (pt)
DK (1) DK725988A (pt)
ES (1) ES2061621T3 (pt)
FI (1) FI886005A (pt)
HU (2) HU200181B (pt)
IL (1) IL88810A (pt)
NO (1) NO885812L (pt)
NZ (1) NZ227432A (pt)
PT (1) PT89346B (pt)
ZA (1) ZA889542B (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
CA2057786C (en) * 1990-12-21 2002-06-18 Gary A. Flynn Amino and nitro containing tricyclic compounds useful as inhibitors or ace
ZA927211B (en) * 1991-09-27 1993-03-24 Merrell Dow Pharma Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE.
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
ATE155143T1 (de) * 1991-09-27 1997-07-15 Merrell Pharma Inc 2-substituierte indan-2-mercaptoacetylamid- verbindungen mit enkephalinase und ace- hemmwirkung
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
CA2130116C (en) * 1992-02-14 1998-04-07 Gary A. Flynn Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
US5646276A (en) * 1992-05-13 1997-07-08 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
DK0640086T3 (da) * 1992-05-15 1999-12-06 Merrell Pharma Inc Mercaptoacetylamido-pyridazo[1,2-a][1,2]diazepin-derivateranvendelige som enkephalinase- og ACE-inhibitorer
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
CA2146238C (en) * 1992-10-30 2001-03-13 Gary A. Flynn Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
AU683956B2 (en) * 1993-11-19 1997-11-27 Aventis Inc. Novel process for preparing (S)-1-(2(S)-(1,3-dihydro-1,3-dioxo-isoindo-2-yl)-1-oxo-3- phenylpropyl)-1,2,3,4-tetrahydro-2-pyridine-carboxylic acid methyl ester and intermediates thereof
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
US5750521A (en) * 1994-02-14 1998-05-12 Hoechst Marion Roussel Inc. Mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE
EP0750631B1 (en) * 1994-02-14 2000-04-05 Merrell Pharmaceuticals Inc. Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo(c)azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
ES2168355T3 (es) * 1994-02-14 2002-06-16 Merrell Pharma Inc Derivados de bisulfuro de indano-2-mercaptoacetilamida utiles como inhibidores de la encefalinasa.
EP0746566A1 (en) * 1994-02-14 1996-12-11 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
CN1144482A (zh) * 1994-03-24 1997-03-05 默里尔药物公司 降低胆固醇、抗动脉粥样硬化和降低甘油三酯的巯基乙酰胺二硫化物衍生物
PT751783E (pt) * 1994-03-24 2000-05-31 Merrell Pharma Inc Derivados aminoacetilmercapto hipocolesterolemicos antiateroscleroticos e hipotrigliceridemicos
MX9704677A (es) * 1994-12-21 1997-09-30 Hoechst Marion Roussel Inc Procedimientos novedosos para preparar intermediarios de inhibidores de encefalinasa y enzima de conversion a angiotensina y sus intermediarios.
US5641880A (en) * 1994-12-21 1997-06-24 Hoechst Marion Roussel, Inc. Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
US20030229007A1 (en) * 2002-05-30 2003-12-11 Roberto Levi Form of human renin and its use as a target in treatments for cardiac ischemia and arrhythmia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3185680A (en) * 1962-10-16 1965-05-25 American Home Prod Reduced benzodiazepinium compounds
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
CA1337654C (en) * 1986-06-13 1995-11-28 Gary A. Flynn Fused tricyclic lactams as antihypertensive agents

Also Published As

Publication number Publication date
JPH01203382A (ja) 1989-08-16
EP0322914A2 (en) 1989-07-05
ES2061621T3 (es) 1994-12-16
IL88810A (en) 1993-08-18
ZA889542B (en) 1989-09-27
IL88810A0 (en) 1989-07-31
NO885812D0 (no) 1988-12-29
PT89346B (pt) 1993-08-31
AU611984B2 (en) 1991-06-27
HU200181B (en) 1990-04-28
DE3887307T2 (de) 1994-05-05
CA1336191C (en) 1995-07-04
JP2681291B2 (ja) 1997-11-26
AU2736888A (en) 1989-07-06
EP0322914A3 (en) 1990-12-27
DK725988A (da) 1989-07-01
DE3887307D1 (de) 1994-03-03
EP0322914B1 (en) 1994-01-19
KR890009927A (ko) 1989-08-04
US4824832A (en) 1989-04-25
HU204050B (en) 1991-11-28
DK725988D0 (da) 1988-12-28
NZ227432A (en) 1990-11-27
HU895880D0 (en) 1990-02-28
KR0128158B1 (ko) 1998-04-04
ATE100453T1 (de) 1994-02-15
PT89346A (pt) 1989-12-29
NO885812L (no) 1989-07-03
HUT49137A (en) 1989-08-28
CN1034721A (zh) 1989-08-16

Similar Documents

Publication Publication Date Title
FI886005A (fi) Nya, sulfhydrylgrupper innehaollande tricykliska laktamer och deras farmakologiska anvaendningsfoerfaranden.
NZ212750A (en) 3-acylamino-2-azetidinone derivatives useful as intermediates in the preparation of antibacterial agents
DK77090D0 (da) Immunmodulerende azaspiraner
TNSN87033A1 (fr) TOLUNITRILES SUBSTITUES PAR DESα - HETEROCYCLES
PT87552A (pt) Process for the preparation of novel tetrazole intermediates toantihypertensive compounds
ES8604128A1 (es) Un procedimiento para la preparacion de nuevos derivados de bencenosulfonamida
EP0435321A3 (en) Novel a-nor-steroid-3-carboxylic acid derivatives
FI943313A (fi) Heterosykliset yhdisteet ja niiden valmistus ja käyttö
ES8706149A1 (es) Procedimiento para preparar 4h-1-benzopiran-4-onas
SE8302694L (sv) Immunomudulerande medel
EP0207681A3 (en) Pyrrolidone derivatives
FR2358388A1 (fr) Nouvelles 1,2,3,4-tetrahydro-4-imino-1-naphtylurees substituees, utiles notamment comme agents de croissance pour animaux, et leur procede de preparation
FR2361879A2 (fr) Nouvelles 4,5,6,7- tetrahydro-7-oxo (ou hydroxy)benzo (b)thienyl-4-amines utiles notamment comme agents de croissance pour animaux et leur procede de preparation
EP0574271A3 (pt)
FR2445838A1 (fr) Nouveaux 1a,3b-dihydroxy-5-steroides
LT2199B (lt) 2-triazolidinono dariniu gavimo budas
DE3666430D1 (en) Condensed seven-membered heterocyclic compounds, their production and use
HU911945D0 (en) Process for the production of intermediers of anti dopamin-betha-hydroxylase
FR2396011A1 (fr) Nouvelles 2,3-dihydro-1,4-benzoxathines pour inhibition de lipogenese
LU88449I2 (fr) Fleroxacine et ses dérivés pharmaceutiquement acceptables.

Legal Events

Date Code Title Description
FD Application lapsed

Owner name: MERRELL DOW PHARMACEUTICALS INC.