FI88152B - Foerfarande foer framstaellning av 1-/(4-morfolinyl)alkyl/-1h-indoler, vilka aer anvaendbara som smaertstillande medel - Google Patents
Foerfarande foer framstaellning av 1-/(4-morfolinyl)alkyl/-1h-indoler, vilka aer anvaendbara som smaertstillande medel Download PDFInfo
- Publication number
- FI88152B FI88152B FI880117A FI880117A FI88152B FI 88152 B FI88152 B FI 88152B FI 880117 A FI880117 A FI 880117A FI 880117 A FI880117 A FI 880117A FI 88152 B FI88152 B FI 88152B
- Authority
- FI
- Finland
- Prior art keywords
- acid
- compound
- morpholinyl
- formula
- arylcarbonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (5)
1. Förfarande för framställning av 4-arylkarbonyl-l-[(4-morfolinyl)-(lägre alkyl)]-lH-indoler, vilka har 5 formeln 1 och vilka är användbara som smärtstillande me-del, ArCO A-n CO ^ ITI I /—\ ,n Alk - N O 15 där Ar är lägre alkoxifenyl eller 1-naftyl och Alk är läg-re alkylen, som innehäller 1-5 kolatomer, eller farma-ceutiskt godtagbara syradditionssalter därav, känne-t e c k n a t därav, att motsvarande förening, som har formeln II 20 ArCO A—, CO
25 H omsätts med en förening, som har formeln 4-(X-Alk)-morfo-lin, där X är halogen och Ar och Alk betecknar samma som ovan, i närvaro av en stark bas, och om s& önskas, omvand-30 las den erhällna fria basen tili ett farmaceutiskt godtag-bart syraadditionssalt.
2. Förfarande enligt patentkravet 1, känne- t e c k n a t därav, att föreningen med formeln II fram-ställs sä, att motsvarande 3-arylkarbonyl-2-metylnitroben- 17 88152 sen omsätts med DMF-dimetylacetal och det blldade 3-aryl-karbonyl-2-(2-dlmetylamlnoetenyl)nitrobensenet cykllseras reduktivt med väte 1 närvaro av en katalysator.
3. Förfarande enligt patentkravet 1 eller 2, k ä n- 5 netecknat därav, att föreningen, som skall fram- ställas, är 4-(4-metoxibensoyl)-l-[2-(4-morfolinyl)etyl]-lH-lndolhydroklorld.
4. Förfarande enligt patentkravet 1 eller 2, k ä n-netecknat därav, att föreningen, som skall fram- 10 ställas, är 4-(4-metoxibensoyl)-l-[3-(4-morfolinyl)pro- pyl]-lH-indolhydroklorid.
5. Förfarande enligt patentkravet 1 eller 2, k ä n-netecknat därav, att föreningen, som skall fram-ställas, är l-[2-(4-morfolinyl)etyl]-4-(l-naftylkarbonyl)- 15 lH-indol-p-toluensulfonathydrat.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1331387 | 1987-02-11 | ||
| US07/013,313 US4840950A (en) | 1987-02-11 | 1987-02-11 | 4-arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI880117A0 FI880117A0 (fi) | 1988-01-12 |
| FI880117A FI880117A (fi) | 1988-08-12 |
| FI88152B true FI88152B (fi) | 1992-12-31 |
| FI88152C FI88152C (sv) | 1993-04-13 |
Family
ID=21759325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI880117A FI88152C (sv) | 1987-02-11 | 1988-01-12 | Förfarande för framställning av 1-/(4-morfolinyl)alkyl/-1H-indoler, vi lka är användbara som smärtstillande medel |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4840950A (sv) |
| EP (1) | EP0278265B1 (sv) |
| JP (1) | JP2561939B2 (sv) |
| KR (1) | KR960007523B1 (sv) |
| AR (1) | AR243184A1 (sv) |
| AT (1) | ATE80386T1 (sv) |
| AU (1) | AU596494B2 (sv) |
| CA (1) | CA1299180C (sv) |
| DE (1) | DE3874361T2 (sv) |
| DK (1) | DK167921B1 (sv) |
| ES (1) | ES2052608T3 (sv) |
| FI (1) | FI88152C (sv) |
| GR (1) | GR3005855T3 (sv) |
| IE (1) | IE63264B1 (sv) |
| IL (1) | IL84922A (sv) |
| MX (1) | MX174421B (sv) |
| NO (1) | NO169713C (sv) |
| NZ (1) | NZ223146A (sv) |
| PH (1) | PH25902A (sv) |
| PT (1) | PT86527B (sv) |
| ZA (1) | ZA879723B (sv) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5081122A (en) * | 1990-03-05 | 1992-01-14 | Sterling Drug Inc. | Antiglaucoma compositions containing 4-arylcarbonyl-1-(4-morpholinyl)-lower-alkyl)-1H-indoles and method of use thereof |
| EP2865381A1 (en) | 2006-05-18 | 2015-04-29 | Pharmacyclics, Inc. | ITK inhibitors for treating blood cell malignancies |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3215699A (en) * | 1961-06-27 | 1965-11-02 | Warner Lambert Pharmaceutical | Substituted acetylphenyl hydrazones of 2,3-piperidine diones |
| US3182071A (en) * | 1961-06-27 | 1965-05-04 | Warner Lambert Pharmaceutical | Acylated indole derivatives |
| US3489429A (en) * | 1967-12-18 | 1970-01-13 | American Home Prod | 1-loweralkanoyl-3-(2-substituted ethyl)indoles |
| GB1374414A (en) * | 1972-06-12 | 1974-11-20 | Sterling Drug Inc | 1-acyl-3-amino-alkyl-indoles and their preparation |
| GB1436771A (en) * | 1973-02-16 | 1976-05-26 | Labaz | Indole derivatives and process for preparing the same |
| US4581354A (en) * | 1984-08-06 | 1986-04-08 | Sterling Drug Inc. | 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use |
| PH23498A (en) * | 1984-08-06 | 1989-08-16 | Sterling Drug Inc | 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof |
-
1987
- 1987-02-11 US US07/013,313 patent/US4840950A/en not_active Expired - Lifetime
- 1987-12-22 IL IL84922A patent/IL84922A/xx not_active IP Right Cessation
- 1987-12-29 ZA ZA879723A patent/ZA879723B/xx unknown
-
1988
- 1988-01-04 PH PH36317A patent/PH25902A/en unknown
- 1988-01-08 IE IE4788A patent/IE63264B1/en not_active IP Right Cessation
- 1988-01-11 NZ NZ223146A patent/NZ223146A/en unknown
- 1988-01-12 PT PT86527A patent/PT86527B/pt not_active IP Right Cessation
- 1988-01-12 FI FI880117A patent/FI88152C/sv not_active IP Right Cessation
- 1988-01-13 MX MX010085A patent/MX174421B/es unknown
- 1988-01-19 ES ES88100694T patent/ES2052608T3/es not_active Expired - Lifetime
- 1988-01-19 NO NO880206A patent/NO169713C/no not_active IP Right Cessation
- 1988-01-19 EP EP88100694A patent/EP0278265B1/en not_active Expired - Lifetime
- 1988-01-19 DK DK021588A patent/DK167921B1/da not_active IP Right Cessation
- 1988-01-19 KR KR1019880000361A patent/KR960007523B1/ko not_active IP Right Cessation
- 1988-01-19 AT AT88100694T patent/ATE80386T1/de not_active IP Right Cessation
- 1988-01-19 DE DE8888100694T patent/DE3874361T2/de not_active Expired - Lifetime
- 1988-01-19 AU AU10387/88A patent/AU596494B2/en not_active Expired
- 1988-01-20 AR AR88309876A patent/AR243184A1/es active
- 1988-01-20 JP JP63010552A patent/JP2561939B2/ja not_active Expired - Lifetime
- 1988-01-26 CA CA000557313A patent/CA1299180C/en not_active Expired - Lifetime
-
1992
- 1992-10-01 GR GR920401725T patent/GR3005855T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TC | Name/ company changed in patent |
Owner name: SANOFI |
|
| PC | Transfer of assignment of patent |
Owner name: SANOFI |
|
| FG | Patent granted |
Owner name: SANOFI-SYNTHELABO |
|
| MA | Patent expired |