FI86777B - Foerfarande foer diagnosticering av bristningen av fosterhinnorna samt reagensfoerpackning foer anvaendning daervid. - Google Patents
Foerfarande foer diagnosticering av bristningen av fosterhinnorna samt reagensfoerpackning foer anvaendning daervid. Download PDFInfo
- Publication number
- FI86777B FI86777B FI906469A FI906469A FI86777B FI 86777 B FI86777 B FI 86777B FI 906469 A FI906469 A FI 906469A FI 906469 A FI906469 A FI 906469A FI 86777 B FI86777 B FI 86777B
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- FI
- Finland
- Prior art keywords
- igfbp
- reagent
- antibody
- sample
- binding agent
- Prior art date
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/814—Pregnancy
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Peptides Or Proteins (AREA)
Claims (13)
1. Förfarande för diagnosticering av bristningen av foster- hinnorna vilket förfarande baserar sig pä en bestämning av ett protein som finns i ett vaginalt sekretprov, kanne-tecknat av att proteinet som skall detekteras är den insulinlika tili växtf aktorns bindningsprotein 1, IGFBP-1, varvid man med tillhjälp av minst ett ämne som specifikt binder till IGFBP-1 detekterar den förekomst av IGFBP-1, som beror pä en bristning i fosterhinnorna, genom att reglera testförhällandena sä, att ett positivt testresultat erhälls endast dä koncentrationen av IGFBP-1 i provet överskrider ett gränsvärde av IGFBP-1 som kan härröra sig frän annat än före-komsten av fostervatten.
2. Förfarande enligt patentkravet 1, kännetecknat av att som bindande ämne används en antikropp för IGFBP-1.
3. Förfarande enligt patentkravet 2, kännetecknat av att antikroppen är en monoklonal antikropp.
4. Förfarande enligt nägot av de föregäende patentkraven, kännetecknat av att bestämningen utförs genom att man använder ett reagens baserat pä ett ämne som binder IGFBP-1 samt ett annat märkt bindande ämne, vars signal kan detekteras .
5. Förfarande enligt nägot av de föregäende patentkraven, kännetecknat av att det vaginala provet späds ut innan testet utförs för att sanka koncentrationen av IGFBP-1 i provet.
6. Förfarande enligt patentkravet 5, kännetecknat av att utspädningen är minst 1: 10, fördelaktigt 1: 20.
7. Förfarande enligt patentkravet 1, 2 eller 3, kännetecknat av att man använder ett märkt reagens, vars 23 8 6777 signal inte ger ett positivt resultat innan koncentrationen av IGFBP-1 ar tillräckligt hög.
8. Reagensförpackning för utförande av diagnosticeringen av bristningen av fosterhinnorna enligt patentkravet 1, k ä n -netecknatav att förpackningen innehaller minst ett reagens med ett ämne som specifikt binder till den insulinlika tillväxtfaktorns bindningsprotein 1, IGFBP-1, för att i ett vaginalt sekretprov detektera den förekomst av IGFBP-1 som beror pä en bristning i fosterhinnorna.
9. Reagensförpackning enligt patentkravet 8, kanne-tecknad av att den därtill innehaller ett märkningsmedel som detekterar bindningsreaktionen.
10. Reagensförpackning enligt patentkravet 9, kanne-tecknad av att känslighetsomradet för den signal märk-ningsmedlet avger har justerats sä, att ett positivt resultat erhälls endast vid den höga koncentration av IGFBP-1 som här-rör sig frän förekomsten av fostervatten.
11. Reagensförpackning enligt patentkravet 8, 9 eller 10, kännetecknadav att reagensets ämne som specifikt binder till IGFBP-1 är en specifik antikropp för IGFBP-1, för-delaktigt en monoklonal antikropp.
12. Reagensförpackning enligt patentkravet 9 eller 10, k ä n -netecknad av att märkningen som detekterar bindningsreaktionen är ett signalavgivande ämne som kopplats tili ett annat ämne som binder till IGFBP-1.
13. Reagensförpackning enligt patentkravet 8, k ä n n e -tecknad av att det pä det specifikä bindande ämnet baserade reagenset innefattar bindande ämnen bundna tili en fast yta eller tili olösliga partiklar, eller lösningar av bindande ämne.
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI906469A FI86777C (sv) | 1990-12-31 | 1990-12-31 | Förfarande för diagnosticering av bristningen av fosterhinnorna samt r eagensförpackning för användning därvid |
| DK92901167.4T DK0565541T3 (da) | 1990-12-31 | 1991-12-30 | Diagnostisk fremgangsmåde til påvisning af brud på føtalmembraner og testkit til anvendelse ved fremgangsmåden |
| KR1019930701750A KR0162504B1 (ko) | 1990-12-31 | 1991-12-30 | 양막파열을 감지하는 진단방법과 이 방법을 이용한 테스트키트 |
| EP92901167A EP0565541B1 (en) | 1990-12-31 | 1991-12-30 | Diagnostic method for detecting the rupture of fetal membranes and test kit employing the method |
| DE69128428T DE69128428T2 (de) | 1990-12-31 | 1991-12-30 | Diagnostisches verfahren zum nachweis des zerreissens von fetalen membranen und testsatz zur ausführung des verfahrens |
| CA002099374A CA2099374C (en) | 1990-12-31 | 1991-12-30 | Diagnostic method for detecting the rupture of fetal membranes and test kit employing the method |
| US08/081,286 US5554504A (en) | 1990-12-31 | 1991-12-30 | Diagnostic method for detecting the rupture of fetal membranes |
| PCT/FI1991/000413 WO1992012426A1 (en) | 1990-12-31 | 1991-12-30 | Diagnostic method for detecting the rupture of fetal membranes and test kit employing the method |
| JP4501180A JP2592386B2 (ja) | 1990-12-31 | 1991-12-30 | 胎児膜の破裂を検出する方法およびその方法を利用する試験キット |
| AU90880/91A AU652598B2 (en) | 1990-12-31 | 1991-12-30 | Diagnostic method for detecting the rupture of fetal membranes and test kit employing the method |
| ES92901167T ES2110487T3 (es) | 1990-12-31 | 1991-12-30 | Metodo de diagnostico para detectar la rotura de las membranas fetales y kit de ensayo que emplea. |
| NO19932363A NO310992B1 (no) | 1990-12-31 | 1993-06-28 | Diagnostisk metode for detektering av ruptur av fotale membraner og testkit som anvender denne |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI906469 | 1990-12-31 | ||
| FI906469A FI86777C (sv) | 1990-12-31 | 1990-12-31 | Förfarande för diagnosticering av bristningen av fosterhinnorna samt r eagensförpackning för användning därvid |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI906469A0 FI906469A0 (fi) | 1990-12-31 |
| FI906469A FI906469A (fi) | 1992-06-30 |
| FI86777B true FI86777B (fi) | 1992-06-30 |
| FI86777C FI86777C (sv) | 1992-10-12 |
Family
ID=8531673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI906469A FI86777C (sv) | 1990-12-31 | 1990-12-31 | Förfarande för diagnosticering av bristningen av fosterhinnorna samt r eagensförpackning för användning därvid |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5554504A (sv) |
| EP (1) | EP0565541B1 (sv) |
| JP (1) | JP2592386B2 (sv) |
| KR (1) | KR0162504B1 (sv) |
| AU (1) | AU652598B2 (sv) |
| CA (1) | CA2099374C (sv) |
| DE (1) | DE69128428T2 (sv) |
| DK (1) | DK0565541T3 (sv) |
| ES (1) | ES2110487T3 (sv) |
| FI (1) | FI86777C (sv) |
| NO (1) | NO310992B1 (sv) |
| WO (1) | WO1992012426A1 (sv) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI94181C (sv) * | 1992-06-29 | 1995-07-25 | Medix Biochemica Ab Oy | Förfarande för diagnosticering av födseltiden samt reagensförpackning för användning därvid |
| EP0680607A4 (en) * | 1993-01-22 | 1997-06-04 | Adeza Biomedical Corp | ASSAY METHOD FOR IDENTIFYING BREAKAGE OF MEMBRANES IN WOMEN AT RISK OF IMMINENT DELIVERY. |
| EP0689552B1 (en) * | 1993-03-23 | 2002-10-30 | VOROTELIAK, Victor | A method of detecting rupture of the amniotic membranes in pregant mammals |
| US5597700A (en) * | 1994-04-28 | 1997-01-28 | California Research, Llc | Method for detecting free insulin-like growth-factor-binding protein 1 and a test device for detecting the ruptures of fetal membranes using the above method |
| US5712103A (en) * | 1995-02-13 | 1998-01-27 | Regents Of The University Of California | Diagnostic assay for the prediction of preeclampsia |
| DE29514562U1 (de) * | 1995-09-04 | 1995-11-16 | Rühl, Britta, 23623 Ahrensbök | Fruchtwasserindikator zur Selbstkontrolle über Fruchtwasserverlust |
| US5747273A (en) * | 1996-05-07 | 1998-05-05 | Diagnostic Systems Laboratories, Inc. | Immunoassay of total insulin-like growth factor binding protein-1 |
| DE19719001C2 (de) * | 1997-05-06 | 2001-05-10 | Schuetzdeller Angelika | Verfahren zum immunologisch-funktionalen Nachweis biologisch aktiver Insulin-Like Growth Factor Binding Proteine oder löslicher Insulin-Like Growth Factor - Rezeptoren im Immunoassay |
| FI981049A (sv) * | 1998-05-12 | 1999-11-13 | Medix Biochemica Ab Oy | Förfarande och testanordning för att bedöma livmodermunnens mogenhet med fosforylerade isoformer av IGFBP-1 |
| US6126597A (en) | 1998-07-22 | 2000-10-03 | Smith; Ramada S. | System for identifying premature rupture of membrane during pregnancy |
| US7790690B2 (en) | 2000-10-11 | 2010-09-07 | U.S. Department Of Veterans Affairs | Glucose sensitive regulator of insulin transcription |
| EP2204654B1 (en) | 2002-08-13 | 2012-12-12 | N-Dia, Inc. | Use of devices and methods for detecting amniotic fluid in vaginal secretions |
| US20050131287A1 (en) * | 2003-12-16 | 2005-06-16 | Kimberly-Clark Worldwide, Inc. | Detection of premature rupture of the amniotic membrane |
| US8172767B2 (en) | 2004-07-07 | 2012-05-08 | Johan Itzel | Method for monitoring a childbirth process |
| EP1778874B1 (en) | 2004-07-30 | 2011-11-23 | Adeza Biomedical Corporation | Oncofetal fibronectin as a marker for cervical cancer |
| JP5374682B2 (ja) * | 2008-03-24 | 2013-12-25 | 静岡県公立大学法人 | ストレス状態の評価方法及びストレス状態の評価試薬キット |
| FR2960974B1 (fr) * | 2010-06-03 | 2016-12-30 | Biosynex | Procede de detection de rupture de membranes |
| US10338065B2 (en) * | 2010-09-01 | 2019-07-02 | Clinical Innovations, Llc | Detection of amniotic fluid in vaginal secretions of pregnant women due to premature rupture of fetal membranes |
| US11555816B2 (en) | 2010-09-01 | 2023-01-17 | Clinical Innovations, Llc | Detection of amniotic fluid in vaginal secretions of pregnant women due to premature rupture of fetal membranes |
| US8765487B2 (en) | 2010-09-01 | 2014-07-01 | Clinical Innovations | Detection of amniotic fluid in vaginal secretions of pregnant women due to premature rupture of fetal membranes |
| DE102010040687A1 (de) * | 2010-09-14 | 2012-03-15 | Hamilton Bonaduz Ag | Verfahren zum Herstellen von Wirkstoff-Beads |
| CN103175968A (zh) * | 2011-12-20 | 2013-06-26 | 安徽深蓝医疗科技有限公司 | 一种胎膜早破检测试剂盒及制备方法 |
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| US10935555B2 (en) | 2016-12-22 | 2021-03-02 | Qiagen Sciences, Llc | Determining candidate for induction of labor |
| US10656164B2 (en) | 2016-12-22 | 2020-05-19 | Qiagen Sciences, Llc | Screening asymptomatic pregnant woman for preterm birth |
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| US5096830A (en) * | 1987-11-17 | 1992-03-17 | Adeza Biomedical Corporation | Preterm labor and membrane rupture test |
| CA1337394C (en) * | 1987-11-17 | 1995-10-24 | Nelson N. H. Teng | Vaginal sample test and reagents |
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| US5258287A (en) * | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
| US5037735A (en) * | 1988-06-24 | 1991-08-06 | Microgenics Corporation | Visual discrimination qualitative enzyme complementation assay |
| WO1990000569A1 (en) * | 1988-07-15 | 1990-01-25 | Central Sydney Area Health Service | Acid-labile subunit (als) of insulin-like-growth factor (igf) binding protein complex |
| US5252459A (en) * | 1988-09-23 | 1993-10-12 | Abbott Laboratories | Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles |
-
1990
- 1990-12-31 FI FI906469A patent/FI86777C/sv active IP Right Grant
-
1991
- 1991-12-30 CA CA002099374A patent/CA2099374C/en not_active Expired - Lifetime
- 1991-12-30 JP JP4501180A patent/JP2592386B2/ja not_active Expired - Fee Related
- 1991-12-30 ES ES92901167T patent/ES2110487T3/es not_active Expired - Lifetime
- 1991-12-30 KR KR1019930701750A patent/KR0162504B1/ko not_active IP Right Cessation
- 1991-12-30 DE DE69128428T patent/DE69128428T2/de not_active Ceased
- 1991-12-30 EP EP92901167A patent/EP0565541B1/en not_active Expired - Lifetime
- 1991-12-30 US US08/081,286 patent/US5554504A/en not_active Expired - Lifetime
- 1991-12-30 AU AU90880/91A patent/AU652598B2/en not_active Expired
- 1991-12-30 WO PCT/FI1991/000413 patent/WO1992012426A1/en active IP Right Grant
- 1991-12-30 DK DK92901167.4T patent/DK0565541T3/da active
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1993
- 1993-06-28 NO NO19932363A patent/NO310992B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2099374C (en) | 2003-09-16 |
| ES2110487T3 (es) | 1998-02-16 |
| EP0565541B1 (en) | 1997-12-10 |
| FI906469A (fi) | 1992-06-30 |
| FI906469A0 (fi) | 1990-12-31 |
| JP2592386B2 (ja) | 1997-03-19 |
| DK0565541T3 (da) | 1998-04-14 |
| DE69128428D1 (de) | 1998-01-22 |
| NO932363D0 (no) | 1993-06-28 |
| WO1992012426A1 (en) | 1992-07-23 |
| CA2099374A1 (en) | 1992-07-01 |
| NO310992B1 (no) | 2001-09-24 |
| AU652598B2 (en) | 1994-09-01 |
| KR930703611A (ko) | 1993-11-30 |
| KR0162504B1 (ko) | 1999-05-01 |
| DE69128428T2 (de) | 1998-07-09 |
| JPH06504841A (ja) | 1994-06-02 |
| US5554504A (en) | 1996-09-10 |
| NO932363L (no) | 1993-08-23 |
| FI86777C (sv) | 1992-10-12 |
| AU9088091A (en) | 1992-08-17 |
| EP0565541A1 (en) | 1993-10-20 |
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| FG | Patent granted |
Owner name: OY MEDIX BIOCHEMICA AB |