FI84350B - Foerfarande foer framstaellning av heterocykliska foereningar. - Google Patents

Foerfarande foer framstaellning av heterocykliska foereningar. Download PDF

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Publication number
FI84350B
FI84350B FI863019A FI863019A FI84350B FI 84350 B FI84350 B FI 84350B FI 863019 A FI863019 A FI 863019A FI 863019 A FI863019 A FI 863019A FI 84350 B FI84350 B FI 84350B
Authority
FI
Finland
Prior art keywords
sub
sup
methyl
compound
alkyl group
Prior art date
Application number
FI863019A
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English (en)
Finnish (fi)
Other versions
FI863019A (fi
FI863019A0 (fi
FI84350C (sv
Inventor
Alexander William Oxford
Colin David Eldred
Ian Harold Coates
James Angus Bell
David Cedric Humber
George Blanch Ewan
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FI863019A0 publication Critical patent/FI863019A0/fi
Publication of FI863019A publication Critical patent/FI863019A/fi
Publication of FI84350B publication Critical patent/FI84350B/fi
Application granted granted Critical
Publication of FI84350C publication Critical patent/FI84350C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)

Claims (3)

1. Förfarande för framställning en förening med den allmänna formeln (I) ! r4v=/r3 Oocrv" 5 där R1 är en väteatom eller en Ci-io alkyl-, C3-7 cykloalkyl-, C3-6 alkenyl- eller fenyl-Ci-3 alkylgrupp, R2 är en väteatom eller en Ci-e alkyl-, Ca-7 cykloalkyl-, C2-6 alkenyl- eller fenyl-Ci-s alkylgrupp och R3 och R4, som kan vara lika eller olika, avser var och en väteatom eller en C1-6 alkylgrupp och da R2 är en väteatom eller en Ci-β alkylgrupp, den ena av grupperna R3 och R4 kan ocksä vara en fenyl-Ci-3 alkylgrupp; eller dess sait eller skyddade derivat, kännetecknat därav, att förfarandet omfattar steget, där en förening med den allmänna formeln (II) O R\ m, ^ I N 11 R H där R1, R2, R3 och R4 avser det samma som ovan eller dess sait eller skyddade derivat cykliseras. 17 84350
2. Förfarande enligt patentkravet 1, kännetecknat därav, att man framställer 1,2,3,9-tetrahydro-9-mety1-3-[(2-mety1-lH-imidazol-1-y1)metyl]-4H-karbazol-4-on, eller dess fysiologiskt godtagbar sait eller soivat.
3. Förfarande enligt patentkravet 2, kännetecknat därav, att man framställer föreningens hydrokloriddihydrat.
FI863019A 1985-07-24 1986-07-23 Förfarande för framställning av heterocykliska föreningar FI84350C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8518741 1985-07-24
GB858518741A GB8518741D0 (en) 1985-07-24 1985-07-24 Process

Publications (4)

Publication Number Publication Date
FI863019A0 FI863019A0 (fi) 1986-07-23
FI863019A FI863019A (fi) 1987-01-25
FI84350B true FI84350B (fi) 1991-08-15
FI84350C FI84350C (sv) 1991-11-25

Family

ID=10582813

Family Applications (1)

Application Number Title Priority Date Filing Date
FI863019A FI84350C (sv) 1985-07-24 1986-07-23 Förfarande för framställning av heterocykliska föreningar

Country Status (12)

Country Link
US (1) US4739072A (sv)
EP (1) EP0219929B1 (sv)
JP (1) JPH07612B2 (sv)
KR (1) KR920001670B1 (sv)
AT (1) ATE73451T1 (sv)
CA (1) CA1281722C (sv)
DE (1) DE3684225D1 (sv)
ES (1) ES2000935A6 (sv)
FI (1) FI84350C (sv)
GB (1) GB8518741D0 (sv)
GR (1) GR861926B (sv)
PT (1) PT83043B (sv)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8617994D0 (en) * 1986-07-23 1986-08-28 Glaxo Group Ltd Heterocyclic compounds
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
US5360800A (en) * 1987-09-03 1994-11-01 Glaxo Group Limited Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives
EP0317088A1 (en) * 1987-10-22 1989-05-24 Glaxo Group Limited Ketone derivatives
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
JPH02167280A (ja) * 1988-08-15 1990-06-27 Glaxo Group Ltd ラクタム誘導体
WO1990012569A1 (en) 1989-04-21 1990-11-01 Sandoz Ag Therapeutic use of 5-ht3 receptor antagonists
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
ES2043535B1 (es) * 1992-03-13 1994-08-01 Vita Invest Sa Procedimiento para la obtencion de la 1,2,3,9-tetrahidro-9-metil-3-(2-metil-1h-imidazol-1-il)metil*-4h-carbazol-4-ona.
HU212934B (en) 1992-10-14 1996-12-30 Richter Gedeon Vegyeszet Process for producing novel alkoxalylated carbazolone derivatives
YU32003A (sh) * 2000-10-30 2006-05-25 Teva Pharmaceutical Industries Ltd. Novi kristalni i solvatni oblici ondansteron hlorovodonika i postupci za njihovo pripremanje
US20020115707A1 (en) * 2001-01-11 2002-08-22 Rami Lidor-Hadas Process for preparing pure ondansetron hydrochloride dihydrate
PL373191A1 (en) * 2002-04-29 2005-08-22 Teva Gyogyszergyar Reszvenytarsasag Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-4h-carbazol-4-one
US20050131045A1 (en) * 2002-04-30 2005-06-16 Judith Aronhime Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them
FI6164U1 (sv) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronformer
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
US20090170872A1 (en) * 2005-07-05 2009-07-02 Orchid Research Laboratories Limited Compounds and Their Pharmaceutical Use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
US3892766A (en) * 1974-06-03 1975-07-01 Warner Lambert Co Process for the preparation of 4-keto-1,2,3,4-tetrahydrocarbazole
GR73560B (sv) * 1979-02-24 1984-03-15 Pfizer
EP0073849A1 (en) * 1981-09-03 1983-03-16 Schering Corporation Novel phenyl-1,2,3,4-tetrahydrocarbazoles, their preparation and pharmaceutical compositions containing them
FR2561244B1 (fr) * 1984-01-25 1988-03-04 Glaxo Group Ltd Composes heterocycliques du type tetrahydrocarbazolone, procede pour leur preparation et composition pharmaceutique les comprenant

Also Published As

Publication number Publication date
FI863019A (fi) 1987-01-25
GR861926B (en) 1986-09-05
DE3684225D1 (de) 1992-04-16
JPH07612B2 (ja) 1995-01-11
ATE73451T1 (de) 1992-03-15
ES2000935A6 (es) 1988-04-01
EP0219929A1 (en) 1987-04-29
FI863019A0 (fi) 1986-07-23
US4739072A (en) 1988-04-19
CA1281722C (en) 1991-03-19
PT83043B (pt) 1989-02-28
JPS6277380A (ja) 1987-04-09
KR870001198A (ko) 1987-03-12
EP0219929B1 (en) 1992-03-11
FI84350C (sv) 1991-11-25
KR920001670B1 (ko) 1992-02-22
GB8518741D0 (en) 1985-08-29
PT83043A (en) 1986-08-01

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Owner name: GLAXO GROUP LIMITED

MA Patent expired