FI84023B - Foerfarande foer framstaellning av en stabil farmaceutisk doseringsform, vilken laempar sig foer oral administration av etoposid. - Google Patents
Foerfarande foer framstaellning av en stabil farmaceutisk doseringsform, vilken laempar sig foer oral administration av etoposid. Download PDFInfo
- Publication number
- FI84023B FI84023B FI851040A FI851040A FI84023B FI 84023 B FI84023 B FI 84023B FI 851040 A FI851040 A FI 851040A FI 851040 A FI851040 A FI 851040A FI 84023 B FI84023 B FI 84023B
- Authority
- FI
- Finland
- Prior art keywords
- weight
- etoposide
- water
- parts
- acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Claims (6)
1. Förfarande för framställning av en stabil farma-ceutisk doseringsform, vilken lämpar sig för oral adminis- 5 tration av etoposid, kännetecknat därav, att 1 viktdel etoposid löses i en blandning som bildas av 5 - 9 viktdelar polyetylenglykol, 0,1 - 0,5 viktdelar av en vat-tenlöslig syra, 2,0 - 10 viktdelar taurokolsyra och, be-räknat pä blandningens totala vikt, 5-20 vikt-% etanol 10 samt eventuellt cirka 1 viktdel vatten.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att polyetylenglykolens molekylvikt är ca 200 - 400, företrädesvis ca 300.
3. Förfarande enligt patentkravet 1, k ä n n e -15 tecknat därav, att den vattenlösliga syran är en organisk syra.
4. Förfarande enligt patentkravet 3, kännetecknat därav, att den organiska syran är citron-syra. 20
5. Förfarande enligt nägot av patentkraven 1-4, kännetecknat därav, att 3,5 viktdelar taurokolsyra används per viktdel etoposid.
6. Förfarande enligt patentkravet 1, kännetecknat därav, att 6,8 viktdelar polyetylenglykol 25 300, 0,2 viktdelar citronsyra, 1,0 viktdel etanol, 3,5 viktdelar taurokolsyra och 1,0 viktdel vatten används per viktdel mikroniserad etoposid.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59114484A | 1984-03-19 | 1984-03-19 | |
US59114484 | 1984-03-19 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI851040A0 FI851040A0 (fi) | 1985-03-15 |
FI851040L FI851040L (fi) | 1985-09-20 |
FI84023B true FI84023B (fi) | 1991-06-28 |
FI84023C FI84023C (sv) | 1991-10-10 |
Family
ID=24365235
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI851040A FI84023C (sv) | 1984-03-19 | 1985-03-15 | Förfarande för framställning av en stabil farmaceutisk doseringsform, vilken lämpar sig för oral administration av etoposid |
Country Status (28)
Country | Link |
---|---|
JP (1) | JPS60209516A (sv) |
KR (1) | KR850006136A (sv) |
AT (1) | AT392904B (sv) |
AU (1) | AU571308B2 (sv) |
BE (1) | BE901963A (sv) |
CA (1) | CA1238578A (sv) |
CH (1) | CH662731A5 (sv) |
DE (1) | DE3509741A1 (sv) |
DK (1) | DK164535C (sv) |
EG (1) | EG17521A (sv) |
ES (1) | ES8702140A1 (sv) |
FI (1) | FI84023C (sv) |
FR (1) | FR2561104B1 (sv) |
GB (1) | GB2155789B (sv) |
GR (1) | GR850688B (sv) |
IE (1) | IE58340B1 (sv) |
IL (1) | IL74615A (sv) |
IT (1) | IT1187640B (sv) |
LU (1) | LU85812A1 (sv) |
MY (1) | MY101916A (sv) |
NL (1) | NL8500739A (sv) |
NO (1) | NO170569C (sv) |
NZ (1) | NZ211078A (sv) |
OA (1) | OA07968A (sv) |
PT (1) | PT80131B (sv) |
SE (1) | SE8501312L (sv) |
YU (1) | YU45243B (sv) |
ZA (1) | ZA851935B (sv) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60239418A (ja) * | 1984-05-15 | 1985-11-28 | Nippon Kayaku Co Ltd | エトポシド軟カプセル製剤 |
JPS61189230A (ja) * | 1985-02-19 | 1986-08-22 | Nippon Kayaku Co Ltd | エトポシド製剤 |
DE3629386A1 (de) * | 1986-08-29 | 1988-03-03 | Scherer Gmbh R P | Gelatinekapseln und verfahren zu ihrer herstellung |
US4927638A (en) * | 1986-10-08 | 1990-05-22 | Bristol-Myers Company | Etoposide solutions |
US5154930A (en) * | 1987-03-05 | 1992-10-13 | The Liposome Company, Inc. | Pharmacological agent-lipid solution preparation |
US5376381A (en) * | 1988-02-25 | 1994-12-27 | The Liposome Company, Inc. | Integrity protected gelatin |
JP2000247911A (ja) * | 1999-02-26 | 2000-09-12 | Hisamitsu Pharmaceut Co Inc | 大腸用吸収促進剤 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH580255A5 (sv) * | 1974-06-04 | 1976-09-30 | Calinter Sa | |
DE2452785A1 (de) * | 1974-11-07 | 1976-05-13 | Universal Oil Prod Co | Verfahren zum betrieb einer verbrennungsmaschine |
FR2358144A1 (fr) * | 1976-07-13 | 1978-02-10 | Lipha | Nouvelle composition medicamenteuse pour le traitement de la lithiase biliaire |
JPS5940137B2 (ja) * | 1976-10-14 | 1984-09-28 | 武田薬品工業株式会社 | 経口投与用医薬組成物 |
FR2410504A1 (fr) * | 1977-12-05 | 1979-06-29 | Air Liquide | Procede de reglage de securite d'un reacteur chimique et installation de reaction d'oxydation mettant en oeuvre ce procede |
DE2809543A1 (de) * | 1978-03-06 | 1979-09-13 | Werner Henke | Verfahren und vorrichtung zum neutralisieren von gasen bei oel- und gasbohrungen |
JPS60239418A (ja) * | 1984-05-15 | 1985-11-28 | Nippon Kayaku Co Ltd | エトポシド軟カプセル製剤 |
-
1985
- 1985-02-08 NZ NZ211078A patent/NZ211078A/en unknown
- 1985-02-20 AU AU38975/85A patent/AU571308B2/en not_active Ceased
- 1985-03-05 FR FR8503221A patent/FR2561104B1/fr not_active Expired
- 1985-03-14 IT IT19897/85A patent/IT1187640B/it active
- 1985-03-14 ZA ZA851935A patent/ZA851935B/xx unknown
- 1985-03-14 NL NL8500739A patent/NL8500739A/nl not_active Application Discontinuation
- 1985-03-15 FI FI851040A patent/FI84023C/sv not_active IP Right Cessation
- 1985-03-15 NO NO851022A patent/NO170569C/no unknown
- 1985-03-15 YU YU420/85A patent/YU45243B/xx unknown
- 1985-03-15 IL IL74615A patent/IL74615A/xx unknown
- 1985-03-15 IE IE68685A patent/IE58340B1/en not_active IP Right Cessation
- 1985-03-16 EG EG164/85A patent/EG17521A/xx active
- 1985-03-18 GB GB08506943A patent/GB2155789B/en not_active Expired
- 1985-03-18 LU LU85812A patent/LU85812A1/fr unknown
- 1985-03-18 JP JP60054088A patent/JPS60209516A/ja active Pending
- 1985-03-18 BE BE0/214666A patent/BE901963A/fr not_active IP Right Cessation
- 1985-03-18 ES ES541370A patent/ES8702140A1/es not_active Expired
- 1985-03-18 PT PT80131A patent/PT80131B/pt not_active IP Right Cessation
- 1985-03-18 DE DE19853509741 patent/DE3509741A1/de not_active Withdrawn
- 1985-03-18 DK DK122285A patent/DK164535C/da not_active IP Right Cessation
- 1985-03-18 SE SE8501312A patent/SE8501312L/sv not_active Application Discontinuation
- 1985-03-18 CA CA000476750A patent/CA1238578A/en not_active Expired
- 1985-03-18 KR KR1019850001736A patent/KR850006136A/ko not_active Application Discontinuation
- 1985-03-19 AT AT819/85A patent/AT392904B/de not_active IP Right Cessation
- 1985-03-19 CH CH1223/85A patent/CH662731A5/de not_active IP Right Cessation
- 1985-03-19 OA OA58543A patent/OA07968A/xx unknown
- 1985-03-19 GR GR850688A patent/GR850688B/el unknown
-
1987
- 1987-09-29 MY MYPI87002211A patent/MY101916A/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed | ||
MM | Patent lapsed |
Owner name: BRISTOL-MYERS SQUIBB COMPANY |