FI84023B - Foerfarande foer framstaellning av en stabil farmaceutisk doseringsform, vilken laempar sig foer oral administration av etoposid. - Google Patents

Foerfarande foer framstaellning av en stabil farmaceutisk doseringsform, vilken laempar sig foer oral administration av etoposid. Download PDF

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Publication number
FI84023B
FI84023B FI851040A FI851040A FI84023B FI 84023 B FI84023 B FI 84023B FI 851040 A FI851040 A FI 851040A FI 851040 A FI851040 A FI 851040A FI 84023 B FI84023 B FI 84023B
Authority
FI
Finland
Prior art keywords
weight
etoposide
water
parts
acid
Prior art date
Application number
FI851040A
Other languages
English (en)
Finnish (fi)
Other versions
FI851040A0 (fi
FI84023C (sv
FI851040L (fi
Inventor
Selima Begum
Ismat Ullah
Bernard C Nunning
Original Assignee
Squibb Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co
Publication of FI851040A0 publication Critical patent/FI851040A0/fi
Publication of FI851040L publication Critical patent/FI851040L/fi
Application granted granted Critical
Publication of FI84023B publication Critical patent/FI84023B/fi
Publication of FI84023C publication Critical patent/FI84023C/sv

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Claims (6)

1. Förfarande för framställning av en stabil farma-ceutisk doseringsform, vilken lämpar sig för oral adminis- 5 tration av etoposid, kännetecknat därav, att 1 viktdel etoposid löses i en blandning som bildas av 5 - 9 viktdelar polyetylenglykol, 0,1 - 0,5 viktdelar av en vat-tenlöslig syra, 2,0 - 10 viktdelar taurokolsyra och, be-räknat pä blandningens totala vikt, 5-20 vikt-% etanol 10 samt eventuellt cirka 1 viktdel vatten.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att polyetylenglykolens molekylvikt är ca 200 - 400, företrädesvis ca 300.
3. Förfarande enligt patentkravet 1, k ä n n e -15 tecknat därav, att den vattenlösliga syran är en organisk syra.
4. Förfarande enligt patentkravet 3, kännetecknat därav, att den organiska syran är citron-syra. 20
5. Förfarande enligt nägot av patentkraven 1-4, kännetecknat därav, att 3,5 viktdelar taurokolsyra används per viktdel etoposid.
6. Förfarande enligt patentkravet 1, kännetecknat därav, att 6,8 viktdelar polyetylenglykol 25 300, 0,2 viktdelar citronsyra, 1,0 viktdel etanol, 3,5 viktdelar taurokolsyra och 1,0 viktdel vatten används per viktdel mikroniserad etoposid.
FI851040A 1984-03-19 1985-03-15 Förfarande för framställning av en stabil farmaceutisk doseringsform, vilken lämpar sig för oral administration av etoposid FI84023C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59114484A 1984-03-19 1984-03-19
US59114484 1984-03-19

Publications (4)

Publication Number Publication Date
FI851040A0 FI851040A0 (fi) 1985-03-15
FI851040L FI851040L (fi) 1985-09-20
FI84023B true FI84023B (fi) 1991-06-28
FI84023C FI84023C (sv) 1991-10-10

Family

ID=24365235

Family Applications (1)

Application Number Title Priority Date Filing Date
FI851040A FI84023C (sv) 1984-03-19 1985-03-15 Förfarande för framställning av en stabil farmaceutisk doseringsform, vilken lämpar sig för oral administration av etoposid

Country Status (28)

Country Link
JP (1) JPS60209516A (sv)
KR (1) KR850006136A (sv)
AT (1) AT392904B (sv)
AU (1) AU571308B2 (sv)
BE (1) BE901963A (sv)
CA (1) CA1238578A (sv)
CH (1) CH662731A5 (sv)
DE (1) DE3509741A1 (sv)
DK (1) DK164535C (sv)
EG (1) EG17521A (sv)
ES (1) ES8702140A1 (sv)
FI (1) FI84023C (sv)
FR (1) FR2561104B1 (sv)
GB (1) GB2155789B (sv)
GR (1) GR850688B (sv)
IE (1) IE58340B1 (sv)
IL (1) IL74615A (sv)
IT (1) IT1187640B (sv)
LU (1) LU85812A1 (sv)
MY (1) MY101916A (sv)
NL (1) NL8500739A (sv)
NO (1) NO170569C (sv)
NZ (1) NZ211078A (sv)
OA (1) OA07968A (sv)
PT (1) PT80131B (sv)
SE (1) SE8501312L (sv)
YU (1) YU45243B (sv)
ZA (1) ZA851935B (sv)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60239418A (ja) * 1984-05-15 1985-11-28 Nippon Kayaku Co Ltd エトポシド軟カプセル製剤
JPS61189230A (ja) * 1985-02-19 1986-08-22 Nippon Kayaku Co Ltd エトポシド製剤
DE3629386A1 (de) * 1986-08-29 1988-03-03 Scherer Gmbh R P Gelatinekapseln und verfahren zu ihrer herstellung
US4927638A (en) * 1986-10-08 1990-05-22 Bristol-Myers Company Etoposide solutions
US5154930A (en) * 1987-03-05 1992-10-13 The Liposome Company, Inc. Pharmacological agent-lipid solution preparation
US5376381A (en) * 1988-02-25 1994-12-27 The Liposome Company, Inc. Integrity protected gelatin
JP2000247911A (ja) * 1999-02-26 2000-09-12 Hisamitsu Pharmaceut Co Inc 大腸用吸収促進剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH580255A5 (sv) * 1974-06-04 1976-09-30 Calinter Sa
DE2452785A1 (de) * 1974-11-07 1976-05-13 Universal Oil Prod Co Verfahren zum betrieb einer verbrennungsmaschine
FR2358144A1 (fr) * 1976-07-13 1978-02-10 Lipha Nouvelle composition medicamenteuse pour le traitement de la lithiase biliaire
JPS5940137B2 (ja) * 1976-10-14 1984-09-28 武田薬品工業株式会社 経口投与用医薬組成物
FR2410504A1 (fr) * 1977-12-05 1979-06-29 Air Liquide Procede de reglage de securite d'un reacteur chimique et installation de reaction d'oxydation mettant en oeuvre ce procede
DE2809543A1 (de) * 1978-03-06 1979-09-13 Werner Henke Verfahren und vorrichtung zum neutralisieren von gasen bei oel- und gasbohrungen
JPS60239418A (ja) * 1984-05-15 1985-11-28 Nippon Kayaku Co Ltd エトポシド軟カプセル製剤

Also Published As

Publication number Publication date
DE3509741A1 (de) 1985-09-26
DK122285A (da) 1985-09-20
MY101916A (en) 1992-02-15
DK164535C (da) 1992-11-30
LU85812A1 (fr) 1985-12-12
NO170569C (no) 1992-11-04
FI851040A0 (fi) 1985-03-15
GB8506943D0 (en) 1985-04-24
NL8500739A (nl) 1985-10-16
DK122285D0 (da) 1985-03-18
FI84023C (sv) 1991-10-10
JPS60209516A (ja) 1985-10-22
ZA851935B (en) 1985-10-30
CA1238578A (en) 1988-06-28
EG17521A (en) 1990-06-30
IT8519897A0 (it) 1985-03-14
FR2561104B1 (fr) 1988-04-08
KR850006136A (ko) 1985-10-02
IL74615A (en) 1988-07-31
AT392904B (de) 1991-07-10
PT80131A (en) 1985-04-01
NZ211078A (en) 1987-08-31
DK164535B (da) 1992-07-13
IE58340B1 (en) 1993-09-08
ATA81985A (de) 1990-12-15
IL74615A0 (en) 1985-06-30
GR850688B (sv) 1985-07-08
PT80131B (pt) 1987-10-20
NO851022L (no) 1985-09-20
ES8702140A1 (es) 1986-12-16
AU571308B2 (en) 1988-04-14
AU3897585A (en) 1985-09-26
SE8501312D0 (sv) 1985-03-18
GB2155789A (en) 1985-10-02
FR2561104A1 (fr) 1985-09-20
YU42085A (en) 1988-02-29
IE850686L (en) 1985-09-19
SE8501312L (sv) 1985-09-20
GB2155789B (en) 1987-10-21
ES541370A0 (es) 1986-12-16
IT1187640B (it) 1987-12-23
YU45243B (en) 1992-05-28
OA07968A (fr) 1987-01-31
FI851040L (fi) 1985-09-20
BE901963A (fr) 1985-09-18
CH662731A5 (de) 1987-10-30
NO170569B (no) 1992-07-27

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Owner name: BRISTOL-MYERS SQUIBB COMPANY