FI83662B - Diagnostik antikropp och foerfarande foer dess framstaellning. - Google Patents
Diagnostik antikropp och foerfarande foer dess framstaellning. Download PDFInfo
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- FI83662B FI83662B FI812092A FI812092A FI83662B FI 83662 B FI83662 B FI 83662B FI 812092 A FI812092 A FI 812092A FI 812092 A FI812092 A FI 812092A FI 83662 B FI83662 B FI 83662B
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Claims (8)
1. Diagnostisk antikropp, som bildats och tagits till vara frän en värdorganism, som givits en effektiv mängd antigenpeptid eller -peptider, kännnetecknad därav, att anti-genpeptiden innehäller en aminosyrasekvens, som i huvudsak motsvarar en naturlig, till patogenen anslutande proteins antigenaminosyrasekvens, dä nämnda peptid är ansluten till en bärare och är given ät en animal värdorganism, som inducerar bildningen av antikroppar, som reagerar med till nämnda natur-liga patogen anslutna protein, och peptiden, frän vänster till höger och i riktningen frän ändaminogruppen till ändkarboxi-gruppen, har nägon av följande formler: (a) LeuThrGlnGlnPheHisGlnLeuLysProIleGluCysGluPro; (b) I1eLeuAsnArgLeuValGlnPheValLysAspArgI1eSerValValGlnAlaLeu VaiLeuThrGlnGlnPheHisGlnLeuLysProI1eGluCysGluPro; (c) PheProGlySerSerThrThrSerThrGlyProCysArgThrCysMetThrThrAla GlnGlyThrSerMetTyrProSerCys; (d) PheProGlySerSerThrThrSerThrGlyProCysArgThr; (e) GlnAspLeuProGlyAsnAspAsnAsnSerThrAlaThrLeuCysLeuGlyHisHis AiaValProAsnGlyThrLeuValLysThrl1eThrAsnAspGlnl1eGlu; (f) AsnAlaThrGluLeuValGlnSerSerSerThrGlyLysI1eCysAsnAsnProHis Argil eLeuAspGlylleAsnCys; (g) CysAsnAsnProHisArgI1eLeuAspGlyI1eAsnCysThrLeuI1eAspAlaLeu LeuGlyAspProHisCysAspGlyPheGlnAsnGluLysTrpAspLeuPhe; (h) AspTyrAlaSerLeuArgSerLeuValAlaSerSerGlyThrLeuGluPhel1eAsn GluGlyPheAsnTrpThrGlyValThrGlnAsnGlyGlySerSerAlaCys; (i) SerGlyLysValThrValSerThrLysArgSerGlnGlnThrl1 elleProAsnVal GlySerArgProTrpValArgGlyLeu; (j) CysProLysTyrValLysGlnAsnThrLeuLysLeuAlaThrGlyMetArgAsnVal ProGluLysGlnThrArg; (k) GlnAspLeuProGlyAsnAspAsnAsnSerThrAlaThrLeuCys; (l) CysLeuGlyHisHisAlaValProÄsnGlyThrLeuValLysThrI1eThrAsnAsp Gini1eGluValThrAsnAlaThrGluLeuValGlnSerSerSerThrGlyLysI1e Cys; 62 83 662 (m) CysAsnAsnProHisArgI1eLeuAspGly11eAsnCys; (n) CysAsnAsnProHisArgI1eLeu; (o) HisCysAspGlyPheGlnAsnGluLysTrpAspLeuPheValGlu; (p) HisCysAspGlyPheGlnAsnGluLysTrpAspLeuPheValGluArgSerLysAla PheSerAsnCyrTyrProTyrAspValProAspTyrAlaSerLeuArgSer; (q) ValThrGlnAsnGlyGlySerSerAlaCysLysArgGlyProAspSer; (r) CysLysArgGlyProAspSerLysArgGlyProAspSerGlyPhePheSerArgLeu AsnTrpLeuTyr; (s) CysLysArgGlyProAspSerLysArgGlyProAspSerGlyPhePheSerArgLeu AsnTrpLeuTyrLysSerGlySerTrpTyrProValGlnAsnValTrpMetProAsn AsnAspAsnSer; (t) AsnSerAspLysLeuTyrIleTrpGlyValHisHisProSerThrAspLysGluGln ThrAsnLeuTyrVal; (u) HisHisProSerThrAspLysGluGlnThrAsnLeuTyrVal; (v) AspProValThrThrThrValGluAsnTyrGlyGlyGluThrGlnlle; (w) AsnTyrGlyGlyGluThrGlnl1eGlnArgArgGlnHisThrAspVal; (x) GlnArgArgGlnHisThrAspValSerPhelleMetAspArgPheValLys; (y) ThrThrSerAlaGlyGluSerAlaAspProValThrThrThrValGluAsnTyr G1yGlyG1uThrG1nl1eG1nArgArgG1nHi sThrAspVa1SerPhe11eMet . . AspArgPheValLys; (z) CysLeuGlyGlnAsnSerGlnSerProThrSerAsnHisSerProThrSerAsnHis SerProThrSerCysProProThrCysProGlyTyrArgTrpMetCysLeuArgArg Phelle; (aa) GluAsnlleThrSerGlyPheLeuGlyProLeuLeuValLeuGln; (bb) LeuThrArglleLeuThrlleProGlnSerLeuAspSerTrp; (cc) SerLeuAsnPheLeuGlyGlyThrThrValCysLeuGlyGlnAsn; (dd) ValCysLeuGlyGlnAsn; (ee) LeuValLeuLeuAspTyrGlnGlyMetLeuProValCysProLeu; och (ff) vilken som heist peptid som innehäller ätminstone en minst sex aminosyror innehällande sekvens, vilka aminosyror angivits - i sekvenserna (a) - (ee).
2. Antikropp enligt patentkravet 1, kännetecknad därav, att peptiderna frän vänster tili höger och i riktning 63 83 662 frän ändaminogruppen till ändkarboxigruppen, motsvarar nägon av följande formler: (a) LeuThrGlnGlnPheHisGlnLeuLysProI1eGluCysGluPro; (b) IleLeuAsnArgLeuValGlnPheValLysAspArgIleSerValValGlnAlaLeu VaiLeuThrGlnGlnPheHisGlnLeuLysProI1eGluCysGluPro; (c) PheProGlySerSerThrThrSerThrGlyProCysArgThrCysMetThrThrAla GlnGlnThrSerMetTyrProSerCys; (d) PheProGlySerSerThrThrSerThrGlyProCysArgThr; (e) GlnAspLeuProGlyAsnAspAsnAsnSerThrAlaThrLeuCysLeuGlyHisHis AiaValProAsnGlyThrLeuValLysThrI1eThrAsnAspGlnl1eGlu; (f ) AsnAlaThrGluLeuValGlnSerSerSerThrGlyLys11eCysAsnAsnProHis ArgileLeuAspGlyl1eAsnCys; (g) CysAsnAsnProHisArgI1eLeuAspGlyl1eAsnCysThrLeuI1eAspAla LeuLeuGlyAspProHisCysAspGlyPheGlnAsnGluLysTrpAspLeuPhe; (h) AspTyrAlaSerLeuArgSereuValAiaSerSerGlyThrLeuGluPhel1eAsn GluGlyPheAsnTrpThrGlyValThrGlnAsnGlyGlySerSerAlaCys; (i) SerGlyLysVaiThrValSerThrLysArgSerGlnGlnThrFlel1eProAsnVal GlySerArgProTrpValArgGlyLeu; (j) CysProLysTyrValLysGlnAsnThrLeuLysLeuAlaThrGlyMetArgAsn ValProGluLysGlnThrArg, och (k) peptid som innehäller ätminstone en minst sex aminosyror innehallande sekvens, vilka syror valts bland sekvenserna (a) - (j).
3. Antikropp enligt patentkravet 1 eller 2, kanne- t e c k n a d därav, att den syntetiska peptiden är bunden tili en bärare.
4. Antikropp enligt patentkravet 4, kännetecknad därav, att bäraren är en lipidgrupp.
5. Antikropp enligt nägot av föregäende patentkrav, kännetecknad därav, att de syntetiska peptiderna är anslutna tili varandra som upprepande enheter. 64 83662
6. Antikropp enligt patentkravet 7, kännetecknad därav, att den i huvudsak innehäller tvä skilda syntetiska peptider enligt nägot av patentkravet 1 eller 2, vilka är anslutna till varandra som kopolymerer.
7. Antikropp enligt nägot av föregäende patentkrav, kännetecknad därav, att den i huvudsak innehäller en lipidrik kärngrupp, som innehäller flera syntetiska peptider enligt nägot av patentkraven 1-3, anslutna tili fettsyra-gruppen.
8. Förfarande för framstälIning av ett diagnostiskt anti-kroppspreparat, som efterliknar en antigendeterminant av ett naturligt, till animalpatogen anslutande protein, k ä n -netecknat därav, att (a) en bestämd mängd peptid syntetiseras kemiskt, vilken peptid inte innehäller (1) i naturen förekommande protein eller dess fragment, (2) konkurerande och störande proteiner, och (3) virala genomer, bakterienukleinsyror och endotoxiner, vilken peptid har ätminstone en fyra aminosyrors sekvens, som efterliknar en aminosyrasekvens av en antigen-determinant, som förekommer i naturligr, tili en patogen anslutande protein och vars molekylvikt är mindre än ett naturligt, tili patogen anslutande protein (b) antigenpeptiden binds kemiskt vid bararen för bildande av ett konjugat, (c) värdorganismen ges en sädan mängd kemiskt syntetiserad peptid, vilken mängd är tillräcklig för att inducera bildningen av antikroppar i värdorganismen, 11 65 8 3 6 62 (d) de sä bildade antikropparnas förmSga att reagera med de naturliga, tili animala patogenen anslutna proteinet och skydda värden analyseras, (e) större mängder än i steget (a) kemiskt syntetiserad peptid produceras, som inducerar antikroppar, vilka reagerar med naturligt till animalpatogen anslutande protein och skyddar värden, och (f) antikropparna tas tili vara frän värdorganismen.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16975880A | 1980-07-17 | 1980-07-17 | |
| US16975880 | 1980-07-17 | ||
| US20243180A | 1980-10-30 | 1980-10-30 | |
| US20243180 | 1980-10-30 | ||
| US24805981A | 1981-03-27 | 1981-03-27 | |
| US24805981 | 1981-03-27 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI812092L FI812092L (fi) | 1982-01-18 |
| FI83662B true FI83662B (fi) | 1991-04-30 |
| FI83662C FI83662C (sv) | 1991-08-12 |
Family
ID=27389709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI812092A FI83662C (sv) | 1980-07-17 | 1981-07-02 | Diagnostik antikropp och förfarande för dess framställning |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0044710B2 (sv) |
| KR (1) | KR870000702B1 (sv) |
| AU (1) | AU559234B2 (sv) |
| CA (1) | CA1194794A (sv) |
| DE (1) | DE3174241D1 (sv) |
| DK (1) | DK318481A (sv) |
| ES (1) | ES8305419A1 (sv) |
| FI (1) | FI83662C (sv) |
| GR (1) | GR74319B (sv) |
| IE (1) | IE51410B1 (sv) |
| IL (1) | IL63224A (sv) |
| NO (1) | NO812341L (sv) |
| NZ (1) | NZ197734A (sv) |
| PH (5) | PH20629A (sv) |
| PT (1) | PT73346B (sv) |
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| DE3112338C2 (de) * | 1981-03-28 | 1995-02-23 | Klaus Von Der Helm | Verwendung von Hybridisierungssonden zum Nachweis von HAV |
| DE3275998D1 (en) * | 1981-12-22 | 1987-05-14 | Baylor College Medicine | Immunological composition and method for hepatitis b virus |
| ZA831547B (en) * | 1982-03-15 | 1984-10-31 | New York Blood Center Inc | Fatty acid carriers for synthetic vaccines |
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| WO1983003547A1 (en) * | 1982-04-14 | 1983-10-27 | Bittle, James, L. | Synthetic picornavirus antigen |
| DE3228501A1 (de) * | 1982-07-30 | 1984-02-02 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung eines herpes-antigens, dazu geeignetes mittel sowie verfahren zu seiner herstellung und die verwendung dieses antigens |
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| EP0107436A1 (en) * | 1982-10-11 | 1984-05-02 | The National Biological Standards Board | Polypeptides useful in vaccination against enteroviruses |
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| US5030565A (en) * | 1983-08-17 | 1991-07-09 | Scripps Clinic And Research Foundation | Polypeptide-induced monoclonal receptors to protein ligands |
| DE3484244D1 (de) * | 1983-09-30 | 1991-04-11 | Massachusetts Inst Technology | Herstellung von cdna die hepatitis a virale sequenzen darstellen. |
| US4615973A (en) * | 1983-09-30 | 1986-10-07 | The Rockefeller University | Genetically engineered organisms expressing surface proteins of T. cruzi |
| US4777240A (en) * | 1984-03-08 | 1988-10-11 | Scripps Clinic And Research Foundation | SV40 expression vector containing HBxAg as an expression marker |
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| US4794168A (en) * | 1984-04-24 | 1988-12-27 | Scripps Clinic And Research Foundation | Leukemia-associated virus immunogen, vaccine and assay |
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| WO1988010300A1 (en) * | 1987-06-22 | 1988-12-29 | Medico Labs Ag | Heterologous viral peptide particle immunogens |
| EP0433276A1 (en) * | 1987-07-06 | 1991-06-26 | Peptide Technology Ltd | Growth hormone related peptide |
| US5128319A (en) * | 1987-08-28 | 1992-07-07 | Board Of Regents, The University Of Texas System | Prophylaxis and therapy of acquired immunodeficiency syndrome |
| US5055396A (en) * | 1987-11-03 | 1991-10-08 | Scripps Clinic And Research Foundation | Diagnostic methods and systems for quantifying apo ai |
| EP0364560A4 (en) * | 1988-03-29 | 1990-12-05 | Scripps Clinic And Research Foundation | Diagnostic methods and systems for quantifying apo ai |
| DE3911794A1 (de) * | 1989-04-11 | 1990-10-18 | Thomae Gmbh Dr K | Monoklonale antikoerper gegen rekombinaten humanen gewebeplasminogenaktivator mit definierter epitopspezifitaet, deren herstellung und deren verwendung |
| AU630496B2 (en) * | 1989-07-14 | 1992-10-29 | Schering Corporation | Antagonists of gm-csf derived from the carboxyl terminus |
| EP0491077A1 (en) * | 1990-12-19 | 1992-06-24 | Medeva Holdings B.V. | A composition used as a therapeutic agent against chronic viral hepatic diseases |
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| ATE256702T1 (de) * | 1993-12-09 | 2004-01-15 | Univ Utah Res Found | Zusammensetzungen und kits zur fluoreszenzpolarisierungsdosierung von grossen molekülen |
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| US7244580B2 (en) * | 2001-11-08 | 2007-07-17 | The Regents Of The University Of California | Epsilon immunoglobulin chain derived peptides for induction of anti-IgE antibodies |
| DK2508596T3 (en) | 2002-02-21 | 2015-10-19 | Inst Virology | MN / CA IX-specific monoclonal antibodies generated from MN / CA IX-poor mice, as well as methods of use. |
| WO2008075788A1 (ja) * | 2006-12-20 | 2008-06-26 | Shino-Test Corporation | ヒトｈｍｇｂ１と特異的に結合する鳥類由来の抗体、ヒトｈｍｇｂ１の免疫学的測定方法及びヒトｈｍｇｂ１の免疫学的測定試薬 |
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|---|---|---|---|---|
| US4237224A (en) * | 1974-11-04 | 1980-12-02 | Board Of Trustees Of The Leland Stanford Jr. University | Process for producing biologically functional molecular chimeras |
| US4075194A (en) * | 1976-12-09 | 1978-02-21 | Yeda Research And Development Co., Ltd. | Novel synthetic undecapeptide and clinical assay |
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| US4193915A (en) * | 1978-04-13 | 1980-03-18 | Mckerns Kenneth W | Contraceptive, antibody generating, polypeptides |
| JP2530801B2 (ja) * | 1978-12-22 | 1996-09-04 | バイオゲン インコーポレイテッド | 組換えｄｎａ分子 |
| US4220565A (en) * | 1979-01-18 | 1980-09-02 | Scripps Clinic & Research Foundation | Immunochemical conjugates: method and composition |
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| IE52036B1 (en) * | 1979-05-24 | 1987-05-27 | Univ California | Non-passageable viruses |
-
1981
- 1981-07-02 IL IL63224A patent/IL63224A/xx unknown
- 1981-07-02 FI FI812092A patent/FI83662C/sv not_active IP Right Cessation
- 1981-07-06 PH PH25866A patent/PH20629A/en unknown
- 1981-07-09 NO NO812341A patent/NO812341L/no unknown
- 1981-07-10 PT PT73346A patent/PT73346B/pt unknown
- 1981-07-14 AU AU72836/81A patent/AU559234B2/en not_active Ceased
- 1981-07-15 IE IE1595/81A patent/IE51410B1/en unknown
- 1981-07-16 DE DE8181303266T patent/DE3174241D1/de not_active Expired
- 1981-07-16 CA CA000381825A patent/CA1194794A/en not_active Expired
- 1981-07-16 EP EP81303266A patent/EP0044710B2/en not_active Expired - Lifetime
- 1981-07-16 GR GR65525A patent/GR74319B/el unknown
- 1981-07-16 KR KR1019810002588A patent/KR870000702B1/ko active
- 1981-07-16 NZ NZ197734A patent/NZ197734A/en unknown
- 1981-07-16 DK DK318481A patent/DK318481A/da not_active Application Discontinuation
- 1981-07-16 ES ES504033A patent/ES8305419A1/es not_active Expired
-
1983
- 1983-06-13 PH PH29041A patent/PH20603A/en unknown
- 1983-06-13 PH PH29043A patent/PH20598A/en unknown
- 1983-06-13 PH PH29044A patent/PH20133A/en unknown
- 1983-06-13 PH PH29042A patent/PH20597A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO812341L (no) | 1982-01-18 |
| NZ197734A (en) | 1985-05-31 |
| PH20603A (en) | 1987-02-24 |
| PH20597A (en) | 1987-02-24 |
| EP0044710B1 (en) | 1986-04-02 |
| PH20133A (en) | 1986-10-02 |
| ES504033A0 (es) | 1983-04-01 |
| FI812092L (fi) | 1982-01-18 |
| AU559234B2 (en) | 1987-03-05 |
| PT73346A (en) | 1981-08-01 |
| DE3174241D1 (en) | 1986-05-07 |
| EP0044710A1 (en) | 1982-01-27 |
| FI83662C (sv) | 1991-08-12 |
| GR74319B (sv) | 1984-06-22 |
| IL63224A0 (en) | 1981-10-30 |
| ES8305419A1 (es) | 1983-04-01 |
| AU7283681A (en) | 1982-01-21 |
| IE811595L (en) | 1982-01-17 |
| KR870000702B1 (ko) | 1987-04-07 |
| PH20629A (en) | 1987-03-06 |
| PH20598A (en) | 1987-02-24 |
| IL63224A (en) | 1985-05-31 |
| DK318481A (da) | 1982-01-18 |
| PT73346B (en) | 1982-09-02 |
| CA1194794A (en) | 1985-10-08 |
| IE51410B1 (en) | 1986-12-24 |
| EP0044710B2 (en) | 1991-02-06 |
| KR830006423A (ko) | 1983-09-24 |
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| Date | Code | Title | Description |
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| MM | Patent lapsed |
Owner name: SCRIPPS CLINIC AND RESEARCH FOUNDATION |