FI81805B - Ett nytt foerfarande foer framstaellning av cefalosporiner samt i foerfarandet anvaendbara mellanprodukter. - Google Patents
Ett nytt foerfarande foer framstaellning av cefalosporiner samt i foerfarandet anvaendbara mellanprodukter. Download PDFInfo
- Publication number
- FI81805B FI81805B FI854577A FI854577A FI81805B FI 81805 B FI81805 B FI 81805B FI 854577 A FI854577 A FI 854577A FI 854577 A FI854577 A FI 854577A FI 81805 B FI81805 B FI 81805B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- protecting group
- compound
- compounds
- solution
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
- C07D277/74—Sulfur atoms substituted by carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Claims (9)
1. Förfarande för framställning av föreningar med formeln I 5 \-CH-C-NH —-S S \=j \ 1 I m 0R1 J N vA o / Y ch2r3
10 COOR2 väri Rx betecknar väte eller hydroxiskyddsgrupp, R2 betecknar väte eller en i cefalosporinkemin sedvanlig 15 karboxylskyddsgrupp och R3 betecknar en i cefalosporinkemin sedvanlig substituent i 3-position, säsom en heterocyklyltiogrupp, i vilket förfarande en förening med formeln III 20 c "tt ί •«'-'Λ* C00R2 25 acyleras och ifall sd Önskas avlägsnas en skyddsgrupp frän den erhällna slutprodukten och den erhällna produkten om-vandlas eventuellt tili ett sait eller tvärtom, kännetecknat därav, att acyleringen ut-30 förs genom användning av en förening med formeln IV e~\ S \ /—?H_C'S‘\ HeV (IV) OR^ 35 väri Rj1 betecknar en hydroxiskyddsgrupp och C Het' N»/ 17 81 805 betecknar 2-bensotiazololyl, varvid den optiska aktivite-ten fullständigt bibehälls.
2. Förfarande enligt patentkravet 1, k ä n n e -t e c k n a t därav, att Rx betecknar formyl. 5
3. Förening med formeln IV (' N)-CH-C-S-C Het * \=/ I I __y (IV) OR. 10 1 väri betecknar en hydroxiskyddsgrupp och q Het' \ ' 15 betecknar 2-bensotiazololyl.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI884800A FI82472C (sv) | 1984-03-29 | 1988-10-18 | Förfarande för framställning av cefalosporin |
FI884801A FI884801A0 (fi) | 1984-03-29 | 1988-10-18 | Foerfarande foer framstaellning av en foerening, vilken kan anvaendas som mellanprodukt foer framstaellning av kefalosporiner. |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0105584A AT381495B (de) | 1984-03-29 | 1984-03-29 | Verfahren zur herstellung von cephalosporinderivaten |
AT105584 | 1984-03-29 | ||
AT238684 | 1984-07-24 | ||
AT238684 | 1984-07-24 | ||
AT0288484A AT383809B (de) | 1984-09-10 | 1984-09-10 | Verfahren zur herstellung von cephalosporinantibiotika |
AT288484 | 1984-09-10 | ||
EP8500122 | 1985-03-23 | ||
PCT/EP1985/000122 WO1985004404A1 (en) | 1984-03-29 | 1985-03-23 | Cephalosporins |
Publications (4)
Publication Number | Publication Date |
---|---|
FI854577A0 FI854577A0 (fi) | 1985-11-20 |
FI854577A FI854577A (fi) | 1985-11-20 |
FI81805B true FI81805B (fi) | 1990-08-31 |
FI81805C FI81805C (sv) | 1990-12-10 |
Family
ID=27147034
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI854577A FI81805C (sv) | 1984-03-29 | 1985-11-20 | Ett nytt förfarande för framställning av cefalosporiner samt i förfara ndet användbara mellanprodukter |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0156771A3 (sv) |
AU (2) | AU587974B2 (sv) |
CA (1) | CA1277667C (sv) |
ES (3) | ES8706154A1 (sv) |
FI (1) | FI81805C (sv) |
HU (1) | HU196213B (sv) |
IL (1) | IL74751A (sv) |
NZ (1) | NZ211594A (sv) |
PH (1) | PH21445A (sv) |
WO (1) | WO1985004404A1 (sv) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4576937A (en) * | 1984-02-29 | 1986-03-18 | Smithkline Beckman Corporation | 7-D-Mandelamido-3(1-sulfomethyltetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid monosodium salt |
US5442047A (en) * | 1991-12-04 | 1995-08-15 | Schering Corporation | Process for preparing isepamicin |
CA2062788C (en) * | 1989-06-21 | 2001-10-23 | Chou-Hong Tann | Improved process for preparing isepamicin |
TW212181B (sv) * | 1992-02-14 | 1993-09-01 | Hoechst Ag | |
ES2117066T3 (es) * | 1992-05-21 | 1998-08-01 | Hoechst Ag | Procedimiento para la disociacion de esteres profarmacos de cefalosporina para dar acido 7-amino-3-metoximetil-cef-3-em-4-carboxilico. |
IT1265341B1 (it) * | 1993-07-16 | 1996-11-22 | Farmabios Srl | Procedimento per la preparazione di cefalosporine |
IT1283641B1 (it) * | 1996-07-30 | 1998-04-23 | Ribbon Srl | Procedimento per la preparazione di cefalosporine |
KR100467506B1 (ko) * | 2002-10-01 | 2005-01-24 | 경동제약 주식회사 | 이세파마이신의 제조방법 |
CN102212073A (zh) * | 2010-04-08 | 2011-10-12 | 胡梨芳 | 头孢尼西钠水合物及其制备方法和用途 |
CN102276629A (zh) * | 2011-08-22 | 2011-12-14 | 苏州二叶制药有限公司 | 一种头孢孟多酯钠的合成路线 |
WO2013057196A1 (en) * | 2011-10-20 | 2013-04-25 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Process for the preparation of cefamandole nafate |
CN102702232A (zh) * | 2012-04-17 | 2012-10-03 | 山东鲁抗医药股份有限公司 | 一种精制头孢孟多酯钠的方法 |
CN103224504B (zh) * | 2013-04-03 | 2015-04-01 | 海南合瑞制药股份有限公司 | 一种注射用头孢尼西钠化合物、制备方法及药物组合物 |
CN105541867A (zh) * | 2016-02-16 | 2016-05-04 | 顾伟 | 一种头孢尼西钠结晶方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0029202B1 (en) * | 1979-11-16 | 1983-04-13 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel tetrazole-5-thiol esters and process for preparing cefamandole using same |
CY1365A (en) * | 1980-03-28 | 1987-08-07 | Biochemie Gmbh | New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production |
JPS5746967A (en) * | 1980-09-04 | 1982-03-17 | Asahi Chem Ind Co Ltd | Novel mandelic 3-hydroxy-1,2-diazine-6-yl-thiol ester and its preparation |
JPS5748986A (en) * | 1980-09-08 | 1982-03-20 | Asahi Chem Ind Co Ltd | Production of cephalosporanic acid |
JPS6064986A (ja) * | 1983-09-20 | 1985-04-13 | Toyama Chem Co Ltd | セファロスポリン類の製造法 |
-
1985
- 1985-03-22 EP EP85810122A patent/EP0156771A3/en not_active Withdrawn
- 1985-03-23 AU AU42340/85A patent/AU587974B2/en not_active Ceased
- 1985-03-23 WO PCT/EP1985/000122 patent/WO1985004404A1/en active IP Right Grant
- 1985-03-23 HU HU852157D patent/HU196213B/hu not_active IP Right Cessation
- 1985-03-26 PH PH32055A patent/PH21445A/en unknown
- 1985-03-27 NZ NZ211594A patent/NZ211594A/xx unknown
- 1985-03-28 IL IL74751A patent/IL74751A/xx unknown
- 1985-03-28 ES ES541687A patent/ES8706154A1/es not_active Expired
- 1985-11-20 FI FI854577A patent/FI81805C/sv not_active IP Right Cessation
-
1986
- 1986-05-30 ES ES555562A patent/ES8706697A1/es not_active Expired
- 1986-05-30 ES ES555561A patent/ES8706696A1/es not_active Expired
-
1987
- 1987-01-19 CA CA000527644A patent/CA1277667C/en not_active Expired - Lifetime
-
1989
- 1989-06-02 AU AU35994/89A patent/AU3599489A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA1277667C (en) | 1990-12-11 |
ES8706154A1 (es) | 1987-06-01 |
ES555561A0 (es) | 1987-07-01 |
AU4234085A (en) | 1985-11-01 |
AU3599489A (en) | 1989-09-21 |
PH21445A (en) | 1987-10-20 |
IL74751A0 (en) | 1985-06-30 |
EP0156771A2 (en) | 1985-10-02 |
FI854577A0 (fi) | 1985-11-20 |
HU196213B (en) | 1988-10-28 |
NZ211594A (en) | 1990-02-26 |
WO1985004404A1 (en) | 1985-10-10 |
ES555562A0 (es) | 1987-07-01 |
IL74751A (en) | 1990-04-29 |
ES8706696A1 (es) | 1987-07-01 |
HUT39746A (en) | 1986-10-29 |
FI81805C (sv) | 1990-12-10 |
FI854577A (fi) | 1985-11-20 |
ES8706697A1 (es) | 1987-07-01 |
ES541687A0 (es) | 1987-06-01 |
EP0156771A3 (en) | 1986-03-19 |
AU587974B2 (en) | 1989-09-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: BIOCHEMIE GESELLSCHAFT M.B.H |