FI803277L - Morfolinderivat - Google Patents

Morfolinderivat

Info

Publication number
FI803277L
FI803277L FI803277A FI803277A FI803277L FI 803277 L FI803277 L FI 803277L FI 803277 A FI803277 A FI 803277A FI 803277 A FI803277 A FI 803277A FI 803277 L FI803277 L FI 803277L
Authority
FI
Finland
Prior art keywords
lower alkyl
alkyl
hydrogen
represents hydrogen
tetrahydrofurylmethyl
Prior art date
Application number
FI803277A
Other languages
English (en)
Finnish (fi)
Other versions
FI803277A7 (fi
Inventor
Alan Chapman White
Edwin Trevor Edington
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Publication of FI803277A7 publication Critical patent/FI803277A7/fi
Publication of FI803277L publication Critical patent/FI803277L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)
  • Signal Processing For Digital Recording And Reproducing (AREA)
  • Hydrogenated Pyridines (AREA)
FI803277A 1979-10-20 1980-10-17 Morfolinderivat FI803277L (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7936502 1979-10-20

Publications (2)

Publication Number Publication Date
FI803277A7 FI803277A7 (fi) 1981-04-21
FI803277L true FI803277L (fi) 1981-04-21

Family

ID=10508675

Family Applications (1)

Application Number Title Priority Date Filing Date
FI803277A FI803277L (fi) 1979-10-20 1980-10-17 Morfolinderivat

Country Status (17)

Country Link
US (1) US4360519A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0027695B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5665880A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (2) KR840002427B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE4980T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU531586B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1126731A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3065304D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK151800C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8107201A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI803277L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB2061272B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR70235B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE50355B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (1) MY8500468A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT71940B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA806017B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2125793B (en) * 1982-08-19 1985-10-02 Wyeth John & Brother Ltd Morpholine derivatives
GB8305638D0 (en) * 1983-03-01 1983-03-30 Wyeth John & Brother Ltd Morpholine derivatives
FR2553412B1 (fr) * 1983-10-17 1986-03-21 Lafon Labor Derives de 4-alkyl-2-methyl-2-phenyl-morpholine, procede de preparation et utilisation en therapeutique
GB8418657D0 (en) * 1984-07-21 1984-08-22 Beecham Group Plc Compounds
FR2581383A1 (fr) * 1985-05-03 1986-11-07 Cerm Cent Europ Rech Mauvernay 2-alkyl-2-aryl morpholines substituees, leur preparation et les compositions pharmaceutiques les contenant
DE3621775A1 (de) * 1986-03-13 1988-01-07 Thomae Gmbh Dr K Neue substituierte thiazole und oxazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB9108629D0 (en) * 1991-04-23 1991-06-12 Wellcome Found Heterocyclic pharmaceutical compounds,preparation and use
US5719147A (en) * 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US6048859A (en) * 1992-06-29 2000-04-11 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US5637699A (en) * 1992-06-29 1997-06-10 Merck & Co., Inc. Process for preparing morpholine tachykinin receptor antagonists
IL112778A0 (en) * 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
ATE198326T1 (de) * 1995-04-20 2001-01-15 Pfizer Arylsulfonamido-substituierte hydroxamsäure derivate als inhibitoren von mmp und tnf
AU2003300967B2 (en) * 2002-12-19 2009-05-28 Merck Sharp & Dohme Corp. Substituted amides
MXPA05013364A (es) 2003-06-17 2006-03-17 Arena Pharm Inc Procedimiento para preparar 3-benzazepinas.
SG10201508066VA (en) 2006-04-03 2015-10-29 Arena Pharm Inc Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
CN101547892B (zh) 2006-12-05 2014-08-20 艾尼纳制药公司 制备(r)-8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的方法和其中间体
JP5491421B2 (ja) 2008-03-04 2014-05-14 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
EP2571859B1 (en) 2010-05-21 2015-07-22 Research Triangle Institute 1-phenylmorpholine derivatives as hydroxybupropion analogues for treating drug dependence
ES2687095T3 (es) 2010-05-21 2018-10-23 Research Triangle Institute Fenilimorfolinas y análogos de las mismas
WO2011153206A1 (en) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
EP3485878A1 (en) 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
SG10201506896RA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Administration of lorcaserin to individuals with renal impairment
CN103189359A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 5-ht2c激动剂的光学活性酸盐
SG188361A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Non-hygroscopic salts of 5-ht2c agonists
WO2014058441A1 (en) 2012-10-09 2014-04-17 Arena Pharmaceuticals, Inc. Method of weight management
AU2024270866A1 (en) * 2023-05-16 2025-09-11 Katholieke Universiteit Leuven Benzopiperazine and related analogs for inhibiting yap/taz-tead

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2835669A (en) * 1958-05-20 Process for the production of substi-
US2997469A (en) * 1961-08-22 Preparation of substituted
GB773780A (en) 1953-07-01 1957-05-01 Albert Boehringer Improvements in or relating to the preparation of substituted morpholines
GB791416A (en) 1956-04-09 1958-03-05 Albert Boehringer Improvements in or relating to the production of substituted tetrahydrooxazines
US3112311A (en) * 1957-04-05 1963-11-26 Geigy Chem Corp 2-phenyl-5, 6-dimethyl-morpholines and 2-phenyl-5, 6-tetramethylene-morpholines
ES247829A1 (es) 1958-03-13 1960-03-16 Boehringer Sohn Ingelheim Procedimeinto para la obtencion de tetrahidro-oxazinas sustituidas
US3296076A (en) * 1962-06-11 1967-01-03 Boehringer Sohn Ingelheim Pilomotor shaving compositions and method of using same
GB1336732A (en) * 1970-10-28 1973-11-07 Istituto Gentili Spa Pisa Diethanolamine derivatives
GB1452701A (en) * 1974-05-07 1976-10-13 Ici Ltd Morpholine derivatives

Also Published As

Publication number Publication date
IE801995L (en) 1981-04-20
DK151800C (da) 1988-06-06
CA1126731A (en) 1982-06-29
GB2061272A (en) 1981-05-13
PT71940A (en) 1980-11-01
EP0027695B1 (en) 1983-10-12
FI803277A7 (fi) 1981-04-21
US4360519A (en) 1982-11-23
MY8500468A (en) 1985-12-31
ES496074A0 (es) 1981-10-01
JPS5665880A (en) 1981-06-03
KR840002428B1 (ko) 1984-12-27
ZA806017B (en) 1982-04-28
IE50355B1 (en) 1986-04-02
DK441080A (da) 1981-04-21
AU6292280A (en) 1981-04-30
DE3065304D1 (en) 1983-11-17
KR830004277A (ko) 1983-07-09
DK151800B (da) 1988-01-04
ATE4980T1 (de) 1983-10-15
EP0027695A1 (en) 1981-04-29
PT71940B (pt) 1981-08-31
KR840002427B1 (ko) 1984-12-27
GB2061272B (en) 1983-08-10
GR70235B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1982-09-01
AU531586B2 (en) 1983-09-01
ES8107201A1 (es) 1981-10-01

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Legal Events

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Owner name: JOHN WYETH & BROTHER LIMITED